blood transfusion
type: Class
type: QualityValue
subclass of: SIO_001024
notation: 380

Lab confirmed result
type: Class
subclass of: SIO_001167

2, 2', 3, 4, 4'-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE85
editorial note: To Do: align with CHEBI.

Vineland Motor Skills Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Daily exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Frequently exposed to second hand smoke
notation: 250

environmental tobacco smoke exposure frequency
type: Class
type: QuantityVariable
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
subclass of: SIO_001367
comment: The frequency at which a subject is exposed to second hand tobacco smoke; measured in days per week, hours per day, etc.

unit per liter
type: SIO_000074
notation: U/l

Endotoxin
type: Class
subclass of: Thing

N-Acetyl-S- (2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HEMA2

(aminomethyl)phosphonic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A member of the class of phosphonic acids that is phosphonic acid substituted by an aminomethyl group. It is a metabolite of the herbicide glyphosate. Source: CHEBI
notation: AMPA

noninvasive positve-pressure ventilation
type: Class
subclass of: Medical History
subclass of: artificial respiration

2, 2', 4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE17
editorial note: To Do: align with CHEBI.

Study Location
type: Class
type: NodeShape
subclass of: Location
subclass of: Restriction
  some values from: Study
  on property: SIO_000145
comment: The location where a clinical study is conducted; this could be a hospital, medical school, university, or other research institution.

Vineland Communication Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Several times a week exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Frequently exposed to second hand smoke
notation: 251

unit per milliliter
type: SIO_000074
notation: U/ml

Uses Penicillin
type: Class
type: QualityValue
subclass of: Uses Antibiotics
subclass of: Restriction
  some values from: penicillin
  on property: SIO_000139
notation: 632
definition: Has used or uses penicillin

Cell

sequence_alteration
type: Class
type: NodeShape
subclass of: allele
comment: A sequence_alteration is a sequence_feature whose extent is the deviation from another sequence.

trans, trans -Muconic acid
type: Class
subclass of: Volatile Organic Compound
notation: MU
editorial note: To Do: align with CHEBI.

2-(1-Hydroxy-7-methyloctoxy)carbonylbenzoate
type: Class
type: NodeShape
subclass of: Phthalate
notation: MHINP

2, 2', 3, 3', 4, 4', 5, 5', 6, 6'-Decabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE209
editorial note: To Do: align with CHEBI.

Lipemic
type: Class
subclass of: SIO_001167

Neurological Issues from Infectious Causes of Airway Obstruction
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Infectious conditions that cause airway obstruction, e.g. Croup
notation: 412

Interferon gamma
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IFNG

Vineland Daily Living Skills Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Language
type: Class
type: QualityVariable
subclass of: Acculturation
editorial note: Needs to be rooted in sio

invasive mechanical ventilation
type: Class
subclass of: Medical History
subclass of: artificial respiration

glyphosate
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS). Source: ChEBI
notation: GPS

Heptyl paraben
type: Class
subclass of: Paraben
notation: HePB

2, 2', 3, 4, 4', 5', 6-Heptabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE183
editorial note: To Do: align with CHEBI.

Laboratory Result
type: Class
subclass of: Indicator
definition: A measurement taken on a sample.

Neurological Issues from Non-infectious Causes of Airway Obstruction
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Non-infectious (mostly congenital or cancer) causes for airway obstruction
notation: 413

Vineland Socialization Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

FEF 25-75 Predicted Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FEF 25-75 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Strontium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Sr
definition: STRONTIUM is an element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.

Perfluorooctanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFOA

Some College
type: Class
type: QualityValue
subclass of: Some College or Technical School
subclass of: High School to Some College
subclass of: Trade School Graduate or Some College
notation: 85
definition: Indicates that a person has attended college but that they did not receive any degree.
was approved by: PER-Jeanette-Stingone

metalaxyl
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A racemate comprising equal amounts of (R)- and (S)-metalaxyl. A systemic fungicide, it is active against phytopathogens of the order Peronosporales and is used to conrtrol Pythium in a number of vegetable crops. Source: ChEBI
notation: MET

Recruited At UPMC Magee-Womens Hospital
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q30253944
comment: A population group of study participants that were recruited at UPMC Magee-Womens Hospital
notation: 699

Washing Machine Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of machines used for washing clothes in the home.
was approved by: PER-Jeanette-Stingone

Mullens Verbal Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: CAO_03174
  on property: wasDerivedFrom
subclass of: Restriction
  some values from: CAO_03173
  on property: wasDerivedFrom
definition: A composite score derived from the Mullens Receptive Language and Mullens Expressive Language scales.

Neurological Issues with Spinal Cord
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: These would include spinal cord and spine injuries our conditions.
notation: 409

vitamin B6
type: Class
subclass of: CHEBI_24431

abnormal cell
type: Class
subclass of: Cell

Nitrogen Oxides
label: Nitrogen Oxide
type: Class
subclass of: Air Pollutant
subclass of: Metabolite

Weight for Height Z-Score
type: Class
type: QuantityVariable
subclass of: Z-Score
subclass of: SIO_001245
definition: Z-Score of the weight/height ratio at a given age.

t, t-Muconic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMUC
editorial note: To Do: align with CHEBI.

Neurological Issues with Cerebral Spinal Fluid
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Conditions that cause obstruction to cerebral spinal fluid flow or absorption
notation: 410

docosanoic acid
type: Class
subclass of: Fatty Acid
notation: C220
definition: A straight-chain, C22, long-chain saturated fatty acid.

Mullens Non-Verbal Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: CAO_03172
  on property: wasDerivedFrom
subclass of: Restriction
  some values from: CAO_03171
  on property: wasDerivedFrom
definition: A composite score derived from the Mullens Visual Reception and Mullens Fine Motor scales..

microgram per gram
type: SIO_000074
notation: ug/g

Recruited At Columbia University
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q49088
comment: A population group of study participants that were recruited at Columbia University
notation: 571

mono-isodecyl phthalate
type: Class
subclass of: Phthalate
notation: mIDP

Asian Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: Asian
notation: 217

VCR Player Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of devices that play VCRs in the home.
was approved by: PER-Jeanette-Stingone

Postnatal Period
type: Class
type: NodeShape
subclass of: SIO_000417
comment: The time period after birth.

kilodalton
type: SIO_000074
notation: kDa

Interleukin-17F
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL17F

SIO_000980
type: QualityValue
notation: 107

Behavioral Experimental Paradigm Condition
type: Class
subclass of: Neurocognitive Assessment

American Indian Non-Hispanic
type: Class
type: QualityValue
subclass of: American Indian Or Alaskan Native
subclass of: Non-Hispanic Ethnicity
notation: 218

Recruited At Indiana University
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q1079140
comment: A population group of study participants that were recruited at Indiana University
notation: 696

Vacuum Cleaner Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of appliances in home used for cleaning rugs.
was approved by: PER-Jeanette-Stingone

e-cigarette behavior
type: Class
type: NodeShape
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: GO_0007610
comment: Inhaling and exhaling the vapors produced by electronic cigarette, or "vaping" devices.

Skin rash
type: Class
type: QualityValue
subclass of: Inflammatory abnormality of the skin
comment: A red eruption of the skin.
notation: 426

dalton
type: SIO_000074
notation: Da

SIO_000981
type: QualityValue
notation: 108

central venous cannula insertion
type: Class
subclass of: Medical History
subclass of: Activity

Rarely exposed to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure measurement
notation: 258

Autism Spectrum Disorder
type: Class
type: QualityValue
subclass of: Developmental Disorder of Mental Health
notation: 151

Has Breastfed At Least Once
type: Class
type: QualityValue
type: NodeShape
subclass of: Breast Feeding
comment: Child has breastfed at least once
notation: 566

Markedly hemolyzed
type: Class
subclass of: SIO_001167

Lack of spontaneous play
type: Class
subclass of: SIO_000475

Monocyte
type: Class
subclass of: Lymphocyte
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.

parts per trillion
type: SIO_000074
notation: ppt

perfluoroundecanoic acid
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: PFUNDA

American Indian Or Alaskan Native
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 5
definition: A person having origins in any of the original peoples of North and South America (including Central America) and who maintains tribal affiliation or community attachment.
was approved by: PER-Jeanette-Stingone

HHEAR Ontology v1.8
root class: Thing
imports: stato.owl
imports: doid.owl
imports: cmo.obo
type: Ontology
default namespace: http://purl.org/twc/
status: UnderDevelopmentStatus
imports: hasco
imports: core
imports: vstoi
imports: time
subject matter expert: bengos01
imports: pato.owl
imports: cl.owl
imports: uo.owl
imports: graphql
imports: http://dublincore.org/specifications/dublin-core/dcmi-terms/2020-01-20/
imports: prov-o
subject matter expert: stingj01
imports: COGAT
test graph: true
comment: The Human Health Exposure Analysis Resource (HHEAR) measures exposures that cover the breadth of the “exposome,” which encompasses all environmental exposures including chemical, physical, and biological stressors, as well as lifestyle and social environments, from conception through adulthood. Read more at: https://hhearprogram.org
imports: sio.owl
subject area: HHEAR Ontology
version IRI: http://purl.org/twc/HHEAR/1.8

Agree Street Traffic Makes It Dangerous To Walk Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Street Traffic Makes It Dangerous To Walk Response
notation: 484

Count of Food or Beverage Reheated in Plastic Consumption
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_000794
subclass of: Environmental Exposure
subclass of: Restriction
  some values from: Consumes Food Or Beverage Reheated in Plastic
  on property: SIO_000215
comment: A count of the number of times a person has consumed a food or beverage that has been reheated in a plastic container during a given time interval

Probiotic Beverage
type: Class
type: NodeShape
subclass of: beverage
subclass of: Restriction
  some values from: Probiotic
  on property: SIO_000139
comment: A beverage that contains probiotics
equivalent class: Class
  intersection of: beverage
  intersection of: Restriction
    some values from: Probiotic
    on property: SIO_000139
  equivalent class: Probiotic Beverage

Has Never Breastfed
type: Class
type: QualityValue
type: NodeShape
subclass of: Does Not Breastfeed
subclass of: Class
  complement of: Has Breastfed At Least Once
comment: Has never breastfed
notation: 567
equivalent class: Class
  intersection of: Feeding Method
  intersection of: Class
    complement of: Has Breastfed At Least Once
  equivalent class: Has Never Breastfed

gastrointestinal system disease
type: Class
subclass of: Comorbidity Disease

Antimalarial Use
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: Antimalarial
  on property: SIO_000230
definition: A subclass of medical intervention that characterizes a patient's experience with using an antimalarial. Subclasses detail the level to which a patient has used such a medication to prevent or treat malaria.

Liquid Chromotography-Multistage Mass Spectrometery
type: Class
subclass of: MassSpectrometry

domestic garden
type: Class
type: NodeShape
subclass of: SIO_000955
comment: A garden that is associated with a human house. This association is generally one of spatial proximity or parthood.

Bisphenol F
type: Class
subclass of: phenol
notation: BPF

Computer
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: A machine used for computation and much more.
was approved by: PER-Jeanette-Stingone

Drinking Water
type: Class
subclass of: Environmental Material
definition: Drinking water is water which may be consumed by humans with no adverse effects on their health.
definition: Drinking Water

parts per billion
type: SIO_000074
notation: ppb

waist height ratio
type: Class
type: NodeShape
subclass of: Anthropometry
subclass of: SIO_001018
comment: A quantification of the waist-height WHtR - a measurement of body fat distribution.

Count of Canned Food Consumption
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_000794
subclass of: Environmental Exposure
subclass of: Restriction
  some values from: Eats Canned Food
  on property: SIO_000215
comment: A count of the number of times a person has consumed canned food in a given time interval

Drinks Probiotic Beverage
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Probiotic Beverage
  on property: SIO_000230
comment: The act of drinking a probiotic beverage

Disagree Street Traffic Makes It Dangerous To Walk Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Street Traffic Makes It Dangerous To Walk Response
notation: 485

Fms-related tyrosine kinase 3 ligand
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: FLT3L

Several times a week exposure to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure measurement
notation: 256

Smokes 36-44 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 44
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 36
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
comment: The act of smoking between 36 and 44 cigarettes per day

glucose
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: An aldohexose used as a source of energy and metabolic intermediate.

Perfluorobutanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFBA

Count of Plastic Packaged Food Consumption
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_000794
subclass of: Environmental Exposure
subclass of: Restriction
  some values from: Eats Food Packaged in Plastic
  on property: SIO_000215
comment: A count of the number of times a person has consumed food packaged in plastic during a given time interval

gram per milliliter
type: SIO_000074
notation: g/ml

Perfluoro-n-pentanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFPeA

millimole
type: SIO_000074
notation: mmol

One Year After Menarche
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Menarche
  on property: intervalAfter
comment: A time interval that begins one year after menarche

nanogram per gram
type: SIO_000074
notation: ng/g

Several times a month exposure to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure measurement
notation: 257

systemic lupus erythematosus
type: Class
subclass of: Disease

Smokes 45+ Cigarettes Per Day
type: Class
type: QualityValue
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 45
  on property: SIO_000216
comment: The act of smoking 45 or more cigarettes per day
notation: 595

Mass Spectrometer
type: Class
subclass of: PhysicalInstrument
definition: Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.
was approved by: PER-Jim-McCusker

Strongly Agree Street Traffic Makes It Dangerous To Walk Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Street Traffic Makes It Dangerous To Walk Response
notation: 486

Perfluorohexanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFHxA

parts per quadrillion
type: SIO_000074
notation: ppq

Two Years After Menarche
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Menarche
  on property: intervalAfter
comment: A time interval that begins two years after menarche

Count of Plastic Packaged Beverage Consumption
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_000794
subclass of: Environmental Exposure
subclass of: Restriction
  some values from: Drinks Beverage Packaged in Plastic
  on property: SIO_000215
comment: A count of the number of times a person has consumed a beverage packaged in plastic during a given time interval

Stepmother
type: Class
type: QualityValue
type: NodeShape
subclass of: Mother
subclass of: Step Parent
comment: A female who is married to a spouse with children whom are not biologically related to her. (Source: NCI Thesaurus)
notation: 656

Uses Iron Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: Iron Vitamin Supplement
  on property: SIO_000139
notation: 332

Never exposed to second hand smoke
type: Class
type: QualityValue
subclass of: Second Hand Smoke Exposure by Frequency
subclass of: Has Not Been Exposed to Second Hand Smoke
notation: 254

Lipemic sample, clarified before running
type: Class
subclass of: SIO_001167

beverage
type: Class
type: NodeShape
subclass of: beverage food product
comment: A liquid prepared for consumption

HLA Complex
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: Protein Family
comment: A family of proteins that are essential for the presentation of peptide antigens on cell surfaces that modulate the host defensive activities of T-cells. This protein family includes major histocompatibility complex (MHC) class I and class II proteins. [Definition Source: NCI]

gram per liter
type: SIO_000074
notation: g/L

picomole
type: SIO_000074
notation: pmol

Subungual Exostosis
type: Class
type: NodeShape
subclass of: Disease
comment: A benign lesion that affects the distal phalanx, most often the great toe. Grossly it consists of a cartilage cap and a bony stalk. Microscopically it is characterized by an osteochondromatous proliferation with a gradual transition of a peripheral spindle-cell proliferation to hyaline cartilage to trabecular bone. Pain and swelling are present. Simple resection is usually curative. [Definition Source: NCI]

Second Hand Smoke Exposure by Location
type: Class
type: QualityVariable
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
comment: A class to indicate where a person was exposed to second hand smoke; subclasses of this class detail where a person may have been exposed to second hand smoke.

Uses Azithromycin
type: Class
type: QualityValue
subclass of: Uses Antibiotics
subclass of: Restriction
  some values from: azithromycin
  on property: SIO_000139
notation: 635
definition: Has used or uses azithromycin

fine respirable suspended particulate matter
type: Class
type: QualityVariable
subclass of: Air Pollutant

Perfluorooctanesulfonic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFOS
definition: Perfluoroalkyls are stable, synthetic chemicals. Perfluoroalkyls are unique because they repel oil, grease, and water. The two perfluoroalkyls made in the largest amounts in the U. S. areperflurooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). Perfluoroalkyls have been used in surface protection products such as carpet and clothing treatments and coating for paper and cardboard packaging. They have also been used in fire-fighting foams.

Folic Acid Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: folic acid
  on property: SIO_000369

Daily Exposure to Second Hand Smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure measurement
notation: 255

Lipemic and turbid
type: Class
subclass of: SIO_001167

3,5,6-trichloropyridine-2-one
type: Class
subclass of: Metabolite
definition: A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.

2-hydroxynaphthalene
type: Class
subclass of: polycyclic hydrocarbon
notation: NAP2

kilogram per liter
type: SIO_000074
notation: kg/L

Seven Days Prior to Baseline
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Baseline
  on property: SIO_000668
comment: Seven days prior to a study baseline

nanomole
type: SIO_000074
notation: nmol

surgical procedure
type: Class
type: QualityVariable
subclass of: SIO_001024

kilocalories per day
type: Class
type: SIO_000074
subclass of: UO_0000280
notation: kcal/day

Feeding Method
type: Class
type: NodeShape
subclass of: nutrition intake
subclass of: Diet and Nutrition
comment: A description of the technique for the manner in which a subject is administered food. [Definition Source: NCI]

Study Hospital
type: Class
type: NodeShape
subclass of: Hospital
subclass of: Study Location
comment: The hospital at which a study is conducted

Several times a month exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Not Frequently Exposed to Second Hand Smoke
notation: 252

hematopoietic system disease
type: Class
subclass of: Comorbidity Disease

Has Used Cannabinoids But No Longer
type: Class
type: QualityValue
subclass of: Consumption Behavior
notation: 331

Liquid Chromotography-Mass Spectrometery
type: Class
subclass of: MassSpectrometry

compound eye retinal cell
type: Class
subclass of: Cell

(15Z)-tetracosenoic acid
type: Class
subclass of: Fatty Acid
notation: C241N9
definition: A tetracosenoic acid having a cis-double bond at position 15.

attomole
type: SIO_000074
notation: amol

Uses Cloxacillin
type: Class
type: QualityValue
subclass of: Uses Antibiotics
subclass of: Restriction
  some values from: cloxacillin
  on property: SIO_000139
notation: 633
definition: Has used or uses cloxacillin

Nasal congestion
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: Reduced ability to pass air through the nasal cavity often leading to mouth breathing.

Iron Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: CHEBI_18248
  on property: SIO_000369

Rarely exposed to second hand smoke
type: Class
type: QualityValue
subclass of: Not Frequently Exposed to Second Hand Smoke
notation: 253

Liquid Chromotography -tandem mass spectrometry
type: Class
subclass of: MassSpectrometry

Imidaclothiz
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: IMZ

femtomole
type: SIO_000074
notation: fmol

milligram per milliliter
type: SIO_000074
notation: mg/ml

Uses Erythromycin A
type: Class
type: QualityValue
subclass of: Uses Antibiotics
subclass of: Restriction
  some values from: erythromycin A
  on property: SIO_000139
notation: 634
definition: Has used or uses erythromycin A

Disagree Major Barriers Or Dangers To Walking Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Major Barriers Or Dangers To Walking Response
notation: 481

Smokes 15-24 Cigarettes Per Day
type: Class
type: QualityValue
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 24
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 15
  on property: SIO_000216
comment: The act of smoking between 15 and 24 cigarettes per day
notation: 578

N-Acetyl-S-(phenyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPMA
editorial note: To Do: align with CHEBI.

Result repeated with diluted sample
type: Class
subclass of: SIO_001167

Boiler Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: A boiler is an object that heats up water. This attribute quantifies the number of boilers in the home.
was approved by: PER-Jeanette-Stingone

nutrient
type: Class
subclass of: Nutrient

Boron
type: Class
subclass of: Metal
notation: B
definition: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.

Developmental Disorder of Mental Health
type: Class
type: QualityValue
subclass of: Disease
notation: 341

Does Not Use Antibiotics
type: Class
type: QualityValue
type: NodeShape
subclass of: Pharmacotherapy
comment: Indicates that a subject does not currently (or during a specified time period) use antibiotics
notation: 647
disjoint with: Uses Antibiotics

Zileuton (Zyflo)
type: Class
subclass of: Asthma Controller Medication

Smokes 25-35 Cigarettes Per Day
type: Class
type: QualityValue
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 35
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 25
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
comment: The act of smoking between 25 and 35 cigarettes per day
notation: 592

Strongly Disagree Major Barriers Or Dangers To Walking Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Major Barriers Or Dangers To Walking Response
notation: 483

PCB28
type: Class
subclass of: Polychlorobiphenyl
notation: PCB28

Result repeated and confirmed
type: Class
subclass of: SIO_001167

N-Acetyl-S-(trichlorovinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCTCV
editorial note: To Do: align with CHEBI.

Buccal Cell
type: Class
subclass of: Cell
definition: Cells collected from the inner epithelium of the cheek

Bottle Feeding
type: Class
type: NodeShape
subclass of: Feeding Method
comment: Provision of liquid nutrition via a closed container system with a rubber like mouthpiece resembling a nipple. [Definition Source: NCI]

Does Not Breastfeed
type: Class
type: QualityValue
type: NodeShape
subclass of: Feeding Method
comment: Indicates that a mother does not currently (or during a specified period of time) breastfeed her child.
notation: 648

Smokes 1-4 Cigarettes Per Day
type: Class
type: QualityValue
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 1
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 4
  on property: SIO_000216
comment: The act of smoking between 1 and 4 cigarettes per day
notation: 579

NFGS Blinded Population Group #9
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #9
notation: 562

Strongly Agree Major Barriers Or Dangers To Walking Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Major Barriers Or Dangers To Walking Response
notation: 482

Assessment
type: Class
type: NodeShape
subclass of: AnalyticalMethod
comment: A measurement, evaluation, or judgment for a study variable pertaining to the status of a subject.

N-Acetyl-S-(n-propyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCBPM
editorial note: To Do: align with CHEBI.

Reverse-Phase Mass Spectrometry Profiling
type: Class
subclass of: MassSpectrometry

Bathroom Count
type: Class
type: QuantityVariable
subclass of: Room Count
definition: Total Number of Bathrooms in the Home
was approved by: PER-Jeanette-Stingone

Mono-2-(carboxymethyl) hexyl phthalate
type: Class
subclass of: Phthalate
notation: MCMHP

Agree Major Barriers Or Dangers To Walking Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Major Barriers Or Dangers To Walking Response
notation: 480

Montelukast (Singulair)
type: Class
subclass of: Asthma Controller Medication

Smokes 5-14 Cigarettes Per Day
type: Class
type: QualityValue
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 14
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 5
  on property: SIO_000216
comment: The act of smoking between 5 and 14 cigarettes per day
notation: 577

Second Hand Smoke Exposure by Household Member
type: Class
type: QualityVariable
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
comment: A class used to indicate the level of second hand smoke exposure that occurs in a person's household

3-(Ethylcarbamoyl)benzoic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: ECBA

Result reported based on fewer replicates than required
type: Class
subclass of: SIO_001167

N-Acetyl-S-(phenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: PMA
editorial note: To Do: align with CHEBI.

Bedroom Count
type: Class
type: QuantityVariable
subclass of: Room Count
definition: Total Number of Bedrooms in the Home
was approved by: PER-Jeanette-Stingone

Living Quarters
type: Class
subclass of: Thing

Uses Amoxicillin
type: Class
type: QualityValue
subclass of: Uses Antibiotics
subclass of: Restriction
  some values from: amoxicillin
  on property: SIO_000139
notation: 631
definition: Has used or uses amoxicillin

NFGS Blinded Population Group #7
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #7
notation: 560

Often Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001291
subclass of: Child Stress Assessment

N-Acetyl-S-(benzyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCBMA
editorial note: To Do: align with CHEBI.

Apgar Score
type: Class
type: QuantityVariable
subclass of: SIO_001112
subclass of: Birth Outcome
subclass of: Restriction
  on property: SIO_000300
  all values from: Datatype
    intersection of: Datatype
      with restrictions:
        min inclusive: 0
      on datatype: integer
    intersection of: Datatype
      with restrictions:
        max inclusive: 10
      on datatype: integer
definition: A method to quickly summarize the health of newborn children. The Apgar score was invented by Virginia Apgar in 1952 when Apgar was an anesthesiologist who developed the score in order to ascertain the effects of obstetric anesthesia on babies. The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).
was approved by: PER-Jeanette-Stingone

sequence_variant
type: Class
type: NodeShape
subclass of: SIO_000030

Strongly Disagree Local Streets Have Usable Footpaths Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Local Streets Have Usable Footpaths Response
notation: 479

Major Barriers Or Dangers To Walking Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "There are major barriers or dangers to walking with my child in my neighborhood that make it hard to get from place to place (e.g., major roads, railway lines, storm water drains or rivers)."

Chronic Maternal Hypertension
type: Class
type: QualityValue
type: NodeShape
subclass of: hypertension
comment: Hypertension that predates pregnancy. (Source: NCI Thesaurus)
notation: 585

NFGS Blinded Population Group #8
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #8
notation: 561

Always Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001292
subclass of: Child Stress Assessment

Bisphenol A bis(2,3-dihydroxypropyl) ether
type: Class
type: NodeShape
subclass of: Phenol
notation: BADGE2H2O

Administrative Claims, Healthcare
type: Class
type: NodeShape
subclass of: SIO_001027
comment: Information relating to itemized coding of procedures and costs associated with healthcare delivery, used as a means for tracking healthcare utilization, patterns of care, and treatment outcomes. (Source: Medical Subject Headings Ontology)

Kaufman ABC Sequence Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of Kaufman ABC designed to measure the ability to solve problems by remembering and using an ordered series of images or ideas

N-Acetyl-S-(n-propyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: BPMA
editorial note: To Do: align with CHEBI.

Arsenic Species
type: Class
subclass of: Targeted Analyte
notation: UAS
definition: A molecular entity with arsenic components.

8-isoprostane
type: Class
subclass of: Biological Response
subclass of: Biomolecule

Infectious Disorder
type: Class
subclass of: Disease

rs10517086
type: Class
type: NodeShape
subclass of: SNP

Segmented Neutrophil Percentage
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

FEF 25-75 Best Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FEF 25-75 value achieved by a subject during a series of FEF 25-75 measurements.

Rarely Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001290
subclass of: Child Stress Assessment

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: AMCC
editorial note: To Do: align with CHEBI.

community species diversity
type: Class
subclass of: SIO_000052

Fourth
type: Class
subclass of: Thing

NFGS Blinded Population Group #5
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #5
notation: 558

Uses Multiflora
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Multiflora
  on property: SIO_000139
notation: 629

Agree Local Streets Have Usable Footpaths Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Local Streets Have Usable Footpaths Response
notation: 476

Does Not Use Probiotic Supplements
type: Class
type: QualityValue
type: NodeShape
subclass of: nutrition intake
comment: Does not (currently or during a specified time period) use a probiotic supplement
notation: 630
disjoint with: Uses Probiotic Supplement

Nitric Oxide
type: Class
subclass of: Air Pollutant

Sometimes Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001290
subclass of: Child Stress Assessment

mono(2-ethylhexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEHP
definition: PHYSICAL DESCRIPTION: Clear colorless to cloudy white viscous liquid. (NTP, 1992)

N-Acetyl-S-(benzyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: BMA
editorial note: To Do: align with CHEBI.

Dialkyl Phosphate Pesticide Metabolite
type: Class
subclass of: Targeted Analyte
notation: UPEST

Fifth
type: Class
subclass of: Thing

Carbon Tetrachloride
type: Class
subclass of: Volatile Organic Compound
notation: CTET
definition: CARBON TETRACHLORIDE is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

Disagree Local Streets Have Usable Footpaths Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Local Streets Have Usable Footpaths Response
notation: 477

Blood Segmented Neurophil Count
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

NFGS Blinded Population Group #6
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #6
notation: 559

3-(4-(1-(4-(2,3-Epoxypropoxy)phenyl)-1-methylethyl)phenoxy)propane-1,2-diol
type: Class
type: NodeShape
subclass of: Phenol
notation: BADGEH2O

Associate's Degree or Technical Degree
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
subclass of: Class
  union of: Associate's Degree
  union of: Technical School
comment: Completed either an associate's degree or a technical degree
notation: 591
equivalent class: Class
  union of: Associate's Degree
  union of: Technical School
  equivalent class: Associate's Degree or Technical Degree

Pre-Menarche
type: Class
type: QualityValue
type: NodeShape
subclass of: Life Stage
subclass of: Restriction
  some values from: Menarche
  on property: intervalMeets
comment: The time period for a child that ends at the onset of menarche.
notation: 676

mono-carboxy isononyl phthalate
type: Class
subclass of: Phthalate
notation: mCINP

Less than High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 215

Tibia
type: Class
subclass of: SIO_010046
definition: The major preaxial endochondral bone in the posterior zeugopod.

Unknown Race
type: Class
type: QualityValue
subclass of: Race
notation: 48
definition: Unknown Race

Selenium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Se
definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.

Phenanthrene tetrol
type: Class
subclass of: polycyclic hydrocarbon
notation: PHET

Screening
type: Class
subclass of: SIO_000417
definition: The time period during which a screening process is used to determine the inclusion of a subject in a study.
was approved by: PER-Jeanette-Stingone

SIO_000982
type: QualityValue
notation: 106

triglyceride
type: Class
type: NodeShape
subclass of: Lipid in Blood
notation: TG

Post-Menarche
type: Class
type: QualityValue
type: NodeShape
subclass of: Life Stage
subclass of: Restriction
  some values from: Menarche
  on property: intervalMetBy
comment: The time period for a child that begins at the ending of menarche.
notation: 675

Recruited At Case Western Reserve University
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q1047060
comment: A population group of study participants that were recruited at Case Western Reserve University
notation: 570

Black Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: African American
notation: 216

Unmarried
type: Class
type: QualityValue
subclass of: Marital Status
notation: 46
definition: Indicates a person not currently joined in a legally binding matrimonial union.

mono-carboxy isooctyl phthalate
type: Class
subclass of: Phthalate
notation: mCIOP

plaque forming unit
type: SIO_000074
notation: pfu

Prenatal Period
type: Class
type: NodeShape
subclass of: SIO_000417
comment: The time period prior to birth.

Mono-2-ethyl-5-oxohexylterephthalate
type: Class
subclass of: Phthalate
notation: MEOHTP

Samples Arrived Thawed and Analyzed
type: Class
subclass of: SIO_001167

milk
type: Class
subclass of: UBERON_0006314
subclass of: UBERON_0006539
notation: BR
IAO_0000115: An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation.

Coma
type: Class
type: QualityValue
subclass of: Phenotype
notation: 124
definition: Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli.

folates
type: Class
type: NodeShape
subclass of: Nutrient
comment: An N-acyl-L-α-amino acid anion obtained by deprotonation of any folic acid. (Source: ChEBI)
notation: FOL

Has Used Illegal Drugs or Non-Prescribed Pharmaceutical Drugs
type: Class
type: QualityValue
type: NodeShape
subclass of: Drug History
comment: Has used illegal drugs, or non-prescribed pharmaceutical drugs, either currently or in the past
notation: 610

Tanner Scale For Female Pubic Hair Development (Assigned By Child)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: A rating of the Tanner Scale for Female Pubic Hair Development as assigned by the child

plaque forming unit per milliliter
type: SIO_000074
notation: pfu/ml

mono-2-heptyl phthalate
type: Class
subclass of: Phthalate
notation: mHpP

Educational Status
type: Class
subclass of: Thing

Difference of Z-Scores
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Z-Score
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Z-Score
  on property: SIO_000008
definition: The arithmetic difference of two Z-Scores

Full Time Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 64
definition: Employed for a standard number of hours of working time, at least 50% or 20 hours per week.

international units per litre
type: SIO_000074
notation: IU/L

Vitamin D
type: Class
subclass of: Biomolecule
subclass of: Diet and Nutrition
subclass of: Nutrient
notation: VITD
definition: Vitamin D is a group of fat-soluble prohormones, which can be obtained from sun exposure, food and supplements. Vitamin D is biologically inactive and converted to the biologically active calcitriol via double hydroxylation in the body.

Tanner Scale For Male Pubic Hair Development (Assigned By Child)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: A rating of the Tanner Scale for Male Pubic Hair Development as assigned by the child

Associate's Degree
type: Class
type: QualityValue
type: NodeShape
subclass of: College Graduate
subclass of: Associate's Degree or Technical Degree
comment: Completed an associate's degree
notation: 681

malathion diacid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: MDA

Earth
type: QualityValue
notation: 182

White Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: White
notation: 214

colony forming unit per milliliter
type: SIO_000074
notation: cfu/ml

billion parts per microgram
type: SIO_000074
notation: x109 µL

Bisphenol S
type: Class
subclass of: phenol
notation: BPS

cortisone
type: Class
type: NodeShape
subclass of: Psychosocial Stress Marker
notation: CORTE

Gestational Age From 32 to 34 Weeks
type: Class
type: QualityValue
type: NodeShape
subclass of: Gestational Age
comment: The gestational age range of a fetus beginning at the start of week 32 and ending immediately before the beginning of week 34
notation: 589

Tanner Scale For Breast Development (Assigned By Child)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: A rating of the Tanner Scale for Breast Development as assigned by the child

Never Smoked
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 56
definition: The quality of never smoking in the past.
was approved by: PER-Jeanette-Stingone

Cement Floor
type: Class
type: QualityValue
subclass of: Floor Type
notation: 10
definition: Cement Floor Type
was approved by: PER-Jeanette-Stingone

Subtrahend
type: Class
type: QuantityVariable
subclass of: SIO_000052
definition: In a difference expression, the subtrahend is the quantity or number to be subtracted from another.

Sample frozen
type: Class
subclass of: SIO_001167

granulomatosis with polyangiitis
type: Class
subclass of: Disease

Tanner Scale For Genital Development (Assigned By Child)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: A rating of the Tanner Scale for Genital Development as assigned by the child

Gestational Age From 34 to 36 Weeks
type: Class
type: QualityValue
type: NodeShape
subclass of: Gestational Age
comment: The gestational age range of a fetus beginning at the start of week 34 and ending immediately before the beginning of week 36
notation: 590

disintegrations per second
type: SIO_000074
notation: dps

Minuend
type: Class
type: QuantityVariable
subclass of: SIO_000052
definition: In a difference expression, the minuend is the quantity or number from which another is to be subtracted.

Vanadium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: V
definition: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN2PHEN3

Run out-of-contol; insufficient sample for repeat analysis
type: Class
subclass of: SIO_001167

mono (2-ethyl-5-oxohexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEOHP

Perfluoroheptanesulfonic acid
type: Class
type: NodeShape
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFHpS

alpha-linolenic acid
type: Class
subclass of: Fatty Acid
notation: C183N3
definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.

Concentration
type: Class
type: QuantityVariable
subclass of: Laboratory Result

Received Special Education
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
comment: Indicates that a subject received special education.
notation: 649

Asian
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 6
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
was approved by: PER-Jeanette-Stingone

Street Traffic Makes It Dangerous To Walk Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "There is so much traffic along the streets that it makes it difficult or dangerous to walk with my child in my neighborhood."

Caesarian Section
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
notation: 20
definition: Caesarian Section Medical Procedure. One-third of pregnancies in the US end in C-Sections.

milligrams-microunits per deciliter-milliliter
type: SIO_000074
notation: (mg/dL)*(µU/mL)

Indoor Air
type: Class
subclass of: air
subclass of: Restriction
  some values from: ExO_0000019
  on property: SIO_000128

Sample older than 2 weeks
type: Class
subclass of: SIO_001167

Budesonide DPI (Pulmicort)
type: Class
subclass of: Asthma Controller Medication

Gender
type: Class
type: QualityVariable
subclass of: Demographic

Total Cholesterol
type: Class
type: NodeShape
subclass of: cholesterol
subclass of: Restriction
  some values from: high-density lipoprotein cholesterol
  on property: BFO_0000051
subclass of: Restriction
  some values from: low-density lipoprotein cholesterol
  on property: BFO_0000051
subclass of: Restriction
  some values from: very-low-density lipoprotein cholesterol
  on property: BFO_0000051
comment: The mereological sum of all three cholesterols, VLDL, LDL, and HDL

Gestational Age From 28 to 32 Weeks
type: Class
type: QualityValue
type: NodeShape
subclass of: Gestational Age
comment: The gestational age range of a fetus beginning at the start of week 28 and ending immediately before the beginning of week 32
notation: 588

Canned Food Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Eats Canned Food
  on property: SIO_000215
definition: Frequency of Canned Food Consumption.
was approved by: PER-Jeanette-Stingone
editorial note: Also want to list this under Environmental Exposures (b/c canned food has chemicals in the lining so sometimes it is used as a proxy)

Cadmium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Cd
definition: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

volt
type: SIO_000074
notation: Volt

Beclomethasone HFA
type: Class
subclass of: Asthma Controller Medication

Outdoor Air
type: Class
subclass of: air
subclass of: Restriction
  some values from: ExO_0000020
  on property: SIO_000128

Sample integrity/quality compromised preventing analysis
type: Class
subclass of: SIO_001167

Arsenic
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: As
definition: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

umbilical cord blood
type: Class
subclass of: Pregnancy Sample
subclass of: Whole Blood
definition: Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Cord_blood]

Dipropyl hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DPRP

Hemoglobin Genotype AS
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
notation: 347

Physical Activity
type: Class
type: QuantityVariable
subclass of: Physical Activity and Fitness

mono(7-carboxyheptyl)phthalate
type: Class
subclass of: Phthalate
notation: mCHpP

Stress Frequency
type: Class
type: QualityVariable
subclass of: Mental Health
subclass of: SIO_000475
definition: How frequently a person gets stressed.
was approved by: PER-Jeanette-Stingone
editorial note: Again, we might want to link this to a specific assessment?

Scoliosis or Spinal Surgery
type: Class
type: QualityValue
subclass of: Thing
notation: 443
equivalent class: Class
  union of: scoliosis
  union of: Spinal Surgery
  equivalent class: Scoliosis or Spinal Surgery

Overweight (BMI 25-29.9) and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Overweight BMI
subclass of: Class
  intersection of: Overweight BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 328

Fluticasone furoate DPI (Arnuity Ellipta)
type: Class
subclass of: Asthma Controller Medication

chromosomal disease
type: Class
subclass of: Comorbidity Disease

meconium
type: Class
subclass of: feces
subclass of: Pregnancy Sample
definition: A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth. [database_cross_reference: BTO:0000838]

Inorganic Mercury (Hg2+)
type: Class
subclass of: Mercury Species
notation: Hg2

eclampsia
type: QualityValue
subclass of: Eclampsia or Severe Pre-eclampsia
notation: 582

Toaster Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of appliances used to toast bread.
was approved by: PER-Jeanette-Stingone

Obese (BMI >30) and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Obese BMI
subclass of: Class
  intersection of: Obese BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 329

allele
type: Class
type: NodeShape
subclass of: SIO_010277
subclass of: genomic feature
comment: One of a set of sequence features known to exist at a particular genomic location.

Pacific Islander or Native Hawaiian, non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: Native Hawaiian or Other Pacific Islander
notation: 242

Three Months Prior to Pregnancy
type: Class
type: NodeShape
subclass of: SIO_000417
comment: A subclass of Pre-pregnancy; the three months immediately prior to conception.

food product organismal source
type: Class
subclass of: SIO_010046

Unemployment
type: Class
type: QualityValue
subclass of: Occupation
notation: 67
definition: The state of not having a job.

PCB52
type: Class
subclass of: Polychlorobiphenyl
notation: PCB52

tracheostomy
type: Class
subclass of: SIO_001024

Housing Characteristic
type: Class
subclass of: StudyIndicator
definition: Housing Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

Soil Floor
type: Class
type: QualityValue
subclass of: Floor Type
notation: 84
definition: The flooring is made of soil.
was approved by: PER-Jeanette-Stingone

mono (6-COOH-2-methylheptyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMHP

Stroke, Cerebral Ischemia, or Cerebral infarction
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 400
equivalent class: Class
  union of: stroke
  union of: brain ischemia
  union of: cerebral infarction
  equivalent class: Stroke, Cerebral Ischemia, or Cerebral infarction

Breast Fibroglandular Tissue
type: Class
type: NodeShape
subclass of: Mammary Gland Tissue
comment: Breast tissue that contains glandular epithelial and fibrous tissue. (Source: NCI Thesaurus)

Any hypertensive disorder or any diabetes, any BMI
type: Class
type: QualityValue
subclass of: Health Outcome
notation: 330
union of: hypertension
union of: diabetes mellitus

kilovolt-hour
type: SIO_000074
notation: kVh

Seizures
type: Class
type: QualityValue
subclass of: Phenotype
notation: 125
definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.

Part Time Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 65
definition: Employment involving less than the standard or customary working time.

exposure
type: Class
type: NodeShape
subclass of: Medical History
subclass of: Process
comment: The act of subjecting someone or something to an influencing experience. E.g. exposure to cigarette smoke

artificial respiration
type: Class
subclass of: SIO_001398

mono (7-COOH-2-methyloctyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMOP

Uses Steroid Treatment
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: CHEBI_35341
  on property: SIO_000139
notation: 28
definition: Had a form of treatment which uses steroids.
was approved by: PER-Jeanette-Stingone

Spinal Surgery
type: Class
type: QualityVariable
subclass of: surgical procedure
subclass of: Scoliosis or Spinal Surgery
subclass of: Restriction
  some values from: spinal cord
  on property: SIO_000230

Healthy (BMI <25) weight and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Healthy BMI
subclass of: Class
  intersection of: Healthy BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 327

N-(6-Chloro-3-pyridylmethyl)-N'-cyano-acetamidine
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: NDMA

Student
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Occupation
notation: 66

Abnormality of the spinal cord
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord
comment: An abnormality of the spinal cord (myelon).

Annual Income $40,001 to $70,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 207

Small Molecule
type: Class
subclass of: Biomolecule
definition: A small molecule is a low molecular weight (< 900 daltons) organic compound that may help regulate a biological process, with a size on the order of 1 nm. Most drugs are small molecules.

dimethylphosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DMP
editorial note: To Do: align with CHEBI.

Rheumatology disorder (SLE, Wegeners, JRA)
type: Class
type: QualityValue
subclass of: Disease
notation: 398
equivalent class: Class
  union of: granulomatosis with polyangiitis
  union of: juvenile rheumatoid arthritis
  union of: systemic lupus erythematosus
  equivalent class: Rheumatology disorder (SLE, Wegeners, JRA)

Disease
type: Class
subclass of: SIO_010299
subclass of: Health Outcome

SIO_000554
type: QualityValue
notation: 134

flame retardant
type: Class
type: NodeShape
subclass of: Targeted Analyte
comment: Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire. (Source: CHEBI)

Insulin
type: Class
subclass of: Protein
subclass of: Metabolite
definition: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.

3-phenoxybenzoic acid
type: Class
subclass of: Metabolite
definition: A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.

dimethylthiophosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DMTP
editorial note: To Do: align with CHEBI.

Annual Income More Than $70,001
type: Class
type: QualityValue
subclass of: Annual Income More Than $65,000
notation: 208

Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 105
definition: The quality of smoking cigarettes.

rs3184504
type: Class
type: NodeShape
subclass of: SNP

Sepsis, Septic Shock, or SIRS
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 399
equivalent class: Class
  union of: Sepsis
  union of: septic shock
  union of: Systemic Inflammatory Response Syndrome
  equivalent class: Sepsis, Septic Shock, or SIRS

Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 245

Five Months Prior to Followup 4
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 4
  on property: intervalMeets
comment: A time interval that begins five months prior to a study's fourth follow-up and ends at the beginning of the study's fourth follow-up.

Asthma Related Clinic Visit
type: Class
type: QuantityVariable
subclass of: Healthcare Access
subclass of: Clinical Encounter
subclass of: Restriction
  some values from: asthma
  on property: SIO_000635

Annual Income $10,001 to $20,000
type: Class
type: QualityValue
subclass of: Annual Income $24,999 or Less
notation: 205

Relative
type: Class
subclass of: Demographic
subclass of: SIO_000016
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Relative
    intersection of: SIO_000485
definition: Broadly, kinship patterns may be considered to include people related by both descent – i.e. social relations during development – and by marriage. Human kinship relations through marriage are commonly called "affinity" in contrast to the relationships that arise in one's group of origin, which may be called one's descent group. In some cultures, kinship relationships may be considered to extend out to people an individual has economic or political relationships with, or other forms of social connections. Within a culture, some descent groups may be considered to lead back to gods or animal ancestors (totems). This may be conceived of on a more or less literal basis.
was approved by: PER-Jeanette-Stingone

diethylthiophosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DETP
editorial note: To Do: align with CHEBI.

RNA
type: Class
subclass of: Macromolecule

kilobyte
type: SIO_000074
notation: kB

microliter
type: SIO_000074
notation: µl

Six Months Prior to Followup 4
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 4
  on property: intervalMeets
subclass of: Restriction
  some values from: Five Months Prior to Followup 4
  on property: intervalContains
comment: A time interval that begins six months prior to a study's fourth follow-up and ends at the beginning of the study's fourth follow-up.

dimethyldithiophosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DMDP
editorial note: To Do: align with CHEBI.

C-C motif chemokine 20
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MIP3A

Annual Income $20,001 to $40,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 206

Severe Malarial Anemia
type: Class
type: QualityValue
subclass of: Anemia
notation: 127
definition: In holoendemic transmission areas, Severe Malarial Anemia (SMA) is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases. Mortality rates from SMA can exceed 30% in pediatric populations residing in holoendemic transmission areas. The pathophysiological processes that contribute to SMA involve direct and indirect destruction of parasitized and non-parasitized red blood cells (RBCs), inefficient and/or suppression of erythropoiesis, and dyserythropoiesis.

Non-infectious Respiratory Distress
type: Class
type: QualityValue
subclass of: Respiratory distress
notation: 397
equivalent class: Class
  intersection of: Respiratory distress
  intersection of: Class
    complement of: Restriction
      some values from: Infectious Disorder
      on property: SIO_001157
  equivalent class: Non-infectious Respiratory Distress

byte
type: SIO_000074
notation: Byte

cubic decimeter
type: SIO_000074
notation: dm3

Composite Score
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Score
definition: A single value that is calculated from multiple scores. This composite score can then be used as a single variable in further analysis and comparison. [def-source: NCI]

FEV1 Best Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FEV1 value achieved by a subject during a series of FEV1 measurements.

mono (3-carboxypropyl) phthalate (multiple)
type: Class
subclass of: Phthalate
notation: MCPP

Child Stress Assessment
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Assessment
subclass of: Restriction
  some values from: CAO_00518
  on property: SIO_000215
subclass of: Restriction
  some values from: Child
  on property: SIO_000139
comment: A qualitative assessment of the level of stress experienced by a child.

Interfering substances present
type: Class
subclass of: SIO_001167

N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMMA
editorial note: To Do: align with CHEBI.

Uses Biogaia
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Biogaia
  on property: SIO_000139
notation: 627

azithromycin
type: Class
type: NodeShape
subclass of: CHEBI_24431
comment: A macrolide antibiotic useful for the treatment of bacterial infections.

NFGS Blinded Population Group #3
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #3
notation: 556

FEV1 Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FEV1 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Rhinorrhea
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: Increased discharge of mucus from the nose.

Never Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001289
subclass of: Child Stress Assessment

Initial concentration higher than the highest standard, insufficient volume for repeat analysis (93, 18)
type: Class
subclass of: SIO_001167

http://rdf.ncbi.nlm.nih.gov/pubchem/compound/18134
type: Class
type: NodeShape
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: NETFOSAA

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA3
editorial note: To Do: align with CHEBI.

Strongly Agree Local Streets Have Usable Footpaths Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Local Streets Have Usable Footpaths Response
notation: 478

NFGS Blinded Population Group #4
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #4
notation: 557

Uses Biolactus
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Biolactus
  on property: SIO_000139
notation: 628

FVC Best Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FVC value achieved by a subject during a series of FVC measurements.

Pre-Pregnancy and Pregnancy Month 1
type: Class
subclass of: SIO_000417
definition: The time period that begins three months prior to conception and ends at the end of the first month of pregnancy.

Kaufman ABC
type: Class
subclass of: Neurocognitive Assessment
definition: culturally fair, cognitive ability test for children

Household
type: Class
subclass of: SIO_001064
subclass of: Housing Characteristic
definition: A household consists of one or more people who live in the same dwelling and also share meals or living accommodation, and may consist of a single family or some other grouping of people. A single dwelling will be considered to contain multiple households if either meals or living space are not shared. The household is the basic unit of analysis in many social, microeconomic and government models, and is important to the fields of economics and inheritance.

NFGS Blinded Population Group #1
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #1
notation: 554

mass density unit
type: SIO_000074
notation: mdu

Uses Bio-flora
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Bio-flora
  on property: SIO_000139
notation: 625

Smoking Status
type: Class
type: QualityValue
type: QualityVariable
subclass of: SIO_001326
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: health status
notation: 197
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history
editorial note: We need to discuss this entire hierarchy.

PM 10
type: Class
subclass of: Environmental Exposure

environmental tobacco smoke exposure measurement
type: Class
type: QualityValue
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: environmental exposure measurement
notation: 153

FVC Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FVC value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Development Quotient
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Quotient
definition: A development quotient is a numerical indicator of a (infant to preschool age) child's growth to maturity across a range of psychosocial competencies.

Menopause
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: GO_0008150
comment: The permanent cessation of menses, usually defined by 6 to 12 months of amenorrhea in a woman over 45 years of age. (Source: NCI Thesaurus)

Irregular result, no concentration reported
type: Class
subclass of: SIO_001167

NFGS Blinded Population Group #2
type: Class
type: QualityValue
type: NodeShape
subclass of: NFGS Blinded Population Group
comment: NICHD Fetal Growth Study blinded population group #2
notation: 555

kilogram per meter
type: SIO_000074
notation: kg/m

Methyl mercury (CH3Hg+)
type: Class
subclass of: Mercury Species
notation: CH3Hg

Uses Lactil
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Lactil
  on property: SIO_000139
notation: 626

mono (2-ethyl-5-hydroxyhexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEHHP

Respiratory distress
type: Class
subclass of: SIO_000475

food transformation process
type: Class
type: NodeShape
subclass of: Process
comment: A process involving the physical transformation of a food source or food product into some derived organic material or food product

Number of Smokers in Household
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_000794
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: Restriction
  some values from: Household
  on property: SIO_000215
comment: The number of smokers who live in a household

Childhood Year 1
type: Class
subclass of: Childhood Period
definition: The time period of a child that begins at birth and ends after one year

environmental e-cigarette smoke exposure measurement
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: environmental exposure measurement
definition: Exposure to secondhand smoke via e-cigarettes

Inductively Coupled Plasma Mass Spectrometry
type: Class
subclass of: MassSpectrometry

area density unit
type: SIO_000074
notation: adu

percent
type: SIO_000074
notation: %

Uses Vivera
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Vivera
  on property: SIO_000139
notation: 623

Homemaker
type: Class
type: QualityValue
subclass of: Occupation
notation: 68
definition: A person who manages a home as their main daily activity.

spinal cord disease
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Childhood Year 2 and Later
type: Class
subclass of: Childhood Period
definition: The time period that begins at the beginning of a child's second year and ends at the end of childhood.

Asthma Severity Index Composite Score (CASI)
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: Clinical Observations Severity
subclass of: Composite Score
definition: The Composite Asthma Severity Index (CASI) is a comprehensive severity scale combining multiple facets of asthma severity: impairment, risk, and treatment The CASI score, which was developed as a research tool for intervention studies, ranges from 0 to 20 points, with higher scores indicating higher levels of severity, and includes 5 domains: day symptoms and albuterol use, night symptoms and albuterol use, controller treatment, lung function measures, and exacerbations. (Source: Minimally Important Differences and Risk Levels for the Composite Asthma Severity Index Rebecca Z. Krouse, et al.)

Interleukin-23 subunit alpha
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL23

Icteric
type: Class
subclass of: SIO_001167

Tooth
type: Class
subclass of: Tissue
definition: Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Tooth_(animal)]

Allergic rhinitis
type: Class
type: QualityValue
type: NodeShape
subclass of: Allergy
comment: It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.
notation: 596

Uses Vintix
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Vintix
  on property: SIO_000139
notation: 624

Tobacco Metabolite
type: Class
subclass of: Targeted Analyte
notation: USMOKE

Second Hand Smoke Exposure by Frequency
type: Class
type: QualityVariable
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
comment: Second Hand Smoke Exposure by Frequency
notation: 408

cigarettes per day
type: SIO_000074
notation: cigs / day

Initial concentration higher than the highest standard
type: Class
subclass of: SIO_001167

Uses Cannabinoids
type: Class
type: QualityValue
subclass of: Consumption Behavior
subclass of: Restriction
  some values from: cannabinoid
  on property: SIO_000230
notation: 692

count unit
type: SIO_000074
notation: count

Supper
type: Class
type: NodeShape
subclass of: Meal
comment: The evening meal, usually the main meal of the day.

Ultra High Performance Liquid Chromatography Instrument
type: Class
subclass of: High-Performance Liquid Chromatography
definition: Modern HPLC systems have been improved to work at much higher pressures, and therefore are able to use much smaller particle sizes in the columns (<2 μm). These "Ultra High Performance Liquid Chromatography" systems or UHPLCs can work at up to 120 MPa (17, 405 lbf/in^2), or about 1200 atmospheres.
was approved by: PER-Jim-McCusker

Frequently exposed to second hand smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Frequency
subclass of: Has Been Exposed to Second Hand Smoke
comment: Frequently exposed to second hand smoke
notation: 407

Human Dwelling
type: Class
type: QualityVariable
subclass of: Housing Characteristic
definition: Any enclosed space that may be considered a human residence, considered broadly. Positive examples include Moble Homes, Single Family Homes, Apartment Buildings, Cars, Garages, Campgrounds, etc.

Pre-Pregnancy and Pregnancy
type: Class
subclass of: SIO_000417
definition: The time period that begins three months prior to conception and ends at the birth of a child.

Infrared Multiphoton Dissociation (IRMPD)
type: Class
subclass of: TandemMassSpectrometry

Lunch
type: Class
type: NodeShape
subclass of: Meal
comment: A midday meal sometimes also called dinner.

Uses Perenteryl
type: Class
type: QualityValue
subclass of: Uses Probiotic Supplement
subclass of: Restriction
  some values from: Perenteryl
  on property: SIO_000139
notation: 622

Strongly Agree Neighborhood Is Safe Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Neighborhood Is Safe Response
notation: 474

School Breakfast
type: Class
type: NodeShape
subclass of: Breakfast
subclass of: Restriction
  some values from: school
  on property: SIO_000061
comment: Breakfast meal prepared by, and served at school.

Unknown if Any Household Members Currently Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Household Member
notation: 553

active eosinophilic esophagitis
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of more than 25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: active eosinophilic esophagitis
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

Second
type: Class
subclass of: Thing

Agree Neighborhood Is Safe Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Neighborhood Is Safe Response
notation: 472

School Lunch
type: Class
type: NodeShape
subclass of: Lunch
subclass of: Restriction
  some values from: school
  on property: SIO_000061
comment: Lunch meal prepared by, and served at school.

allergen
type: Class
subclass of: Thing

NFGS Blinded Population Group
type: Class
type: QualityVariable
type: NodeShape
subclass of: Population Group
comment: A class detailing the NICHD Fetal Growth Study blinded population groups; the class contains exactly nine subclasses, one for each of blinded sites at which subjects were onboarded to the study.

Fatty Acid
type: Class
subclass of: Targeted Analyte
notation: PFACID
definition: Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.

Interleukin-8
type: Class
subclass of: Biological Response
subclass of: Inflammatory Marker
notation: IL8

N-Acetyl-S-(2-cyanoethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: CYMA
editorial note: To Do: align with CHEBI.

eosinophilic esophagitis in remission
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of less than 15 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: eosinophilic esophagitis in remission
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

type 1 diabetes mellitus
type: Class
type: QualityValue
subclass of: diabetes mellitus
notation: 180

Very Poorly Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001294
notation: 295

Family history
type: Class
type: QualityVariable
subclass of: Medical History

sequence_attribute
type: Class
type: NodeShape
subclass of: SIO_000030

Anatalline
type: Class
type: NodeShape
subclass of: Tobacco Metabolite
notation: ATL

Cuban
type: Class
type: QualityValue
type: NodeShape
subclass of: Hispanic or Latino Ethnicity
comment: A person of Cuban culture or origin, regardless of race. (Source: NCI Thesaurus)
notation: 671

Preschool-age Children's Physical Activity Questionnaire Response
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Questionnaire Response
comment: A response to a questionnaire on perceptions of neighborhood safety for child outdoor activity

Menarche
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: GO_0008150
comment: Onset of menses. (Source: NCI Thesaurus)

Perfluoroheptanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFHPA

Exposed to Second Hand Smoke at Outdoor Public Place and Other Place
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
subclass of: Exposed to Second Hand Smoke in Other Area
notation: 551
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  intersection of: Exposed to Second Hand Smoke in Other Area
  equivalent class: Exposed to Second Hand Smoke at Outdoor Public Place and Other Place

Multiflora
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

Canned Food Product
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: metal container
  on property: SIO_000128
equivalent class: Class

Preschool Child Behavior Checklist
type: Class
subclass of: Neurocognitive Assessment
definition: Child Behavior Checklist for ages 1 ½ through 5

N-Acetyl-S-(2-Carbxyethyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCCEM
editorial note: To Do: align with CHEBI.

Targeted Sequencing
type: Class
subclass of: Nucleic Acid Sequencing
definition: Nucleic acid sequencing that limits the scope of sequencing by filtering out portions of the nucleic acids that do not meet some criteria.

Other Hispanic or Latino(a)
type: Class
type: QualityValue
type: NodeShape
subclass of: Hispanic or Latino Ethnicity
comment: A person of Spanish culture or origin, but not Cuban, Mexican, Puerto Rican, South or Central American, regardless of race. (Source: NCI Thesaurus)
notation: 674

Eats School Lunch
type: Class
type: NodeShape
subclass of: Eating or Drinking
subclass of: Diet and Nutrition
subclass of: Restriction
  some values from: School Lunch
  on property: SIO_000230
comment: The act of eating a school prepared lunch.

Exposed to Second Hand Smoke at Other Parent's House, in Other Car, in Outdoor Public Place, at Relative's House, and in Other Area
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Other Parent's House
subclass of: Exposed to Second Hand Smoke in Other Car
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
subclass of: Exposed to Second Hand Smoke at Relative's House
subclass of: Exposed to Second Hand Smoke in Other Area
notation: 552
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Other Parent's House
  intersection of: Exposed to Second Hand Smoke in Other Car
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  intersection of: Exposed to Second Hand Smoke at Relative's House
  intersection of: Exposed to Second Hand Smoke in Other Area
  equivalent class: Exposed to Second Hand Smoke at Other Parent's House, in Other Car, in Outdoor Public Place, at Relative's House, and in Other Area

Neighborhood Is Safe Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the question "Is my child's neighborhood safe?"

Pregnancy Cohort Study
type: Class
subclass of: CohortStudy

N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: GAMA
editorial note: To Do: align with CHEBI.

Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
type: Class
subclass of: Inductively Coupled Plasma Mass Spectrometer
definition: A tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation.
was approved by: PER-Jim-McCusker

Benzene
type: Class
subclass of: Volatile Organic Compound
notation: BZ
definition: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

vascular malformation
type: Class
subclass of: Phenotypic abnormality

Silver
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Ag
definition: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.

Race or Ethnicity Combined
type: Class
type: QualityVariable
subclass of: Demographic
definition: Race or ethinicity as a combined concept.
equivalent class:
  union of: Ethnicity
  union of: Race
  equivalent class: Race or Ethnicity Combined

Biogaia
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

environmental exposure measurement
type: Class
type: QualityVariable
subclass of: Environmental Exposure

BPA Free Plastic Container
type: Class
type: NodeShape
subclass of: plastic container
subclass of: Class
  complement of: Restriction
    some values from: Bisphenol A
    on property: SIO_000369
comment: A plastic container that does not contain BPA (Bisphenol A).
equivalent class: Class
  intersection of: plastic container
  intersection of: Class
    complement of: Restriction
      some values from: Bisphenol A
      on property: SIO_000369
  equivalent class: BPA Free Plastic Container

Hemolyzed (covers all three levels), lipemic, and icteric
type: Class
subclass of: SIO_001167

brain ischemia
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

N-Acetyl-S-(2, 2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DCVMA22
editorial note: To Do: align with CHEBI.

Antimony
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Sb
definition: ANTIMONY is a metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.

Breakfast
type: Class
type: NodeShape
subclass of: Meal
comment: The first meal of the day (usually in the morning).

I Often Felt Unable To Manage Things In My Life Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001291
subclass of: I Felt Unable To Manage Things In My Life Response
notation: 469

Exposed to Second Hand Smoke in Outdoor Public Place and at Friend's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
subclass of: Exposed to Second Hand Smoke at Friend's House
notation: 549
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  intersection of: Exposed to Second Hand Smoke at Friend's House
  equivalent class: Exposed to Second Hand Smoke in Outdoor Public Place and at Friend's House

Tetrachlorobisphenol A
type: Class
type: NodeShape
subclass of: Phenol
notation: TECBPA2266

Biolactus
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

Exposed to Second Hand Smoke in Other Area
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 550

2, 5-Dichlorophenol
type: Class
subclass of: phenol
notation: DCP25
definition: PHYSICAL DESCRIPTION: Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 µg/L at 68-72°F; 33 µg/L at 86°F. Taste threshold 0.5 µg/L. (NTP, 1992)

Uses BPA Free Plastic Containers for Food Or Beverage Storage
type: Class
type: QualityValue
type: NodeShape
subclass of: Uses Plastic Containers for Food Or Beverage Storage
subclass of: Restriction
  some values from: BPA Free Plastic Container
  on property: SIO_000230
comment: The act of using BPA free plastic containers to store food or beverages.
notation: 594

Hemolyzed (covers all three levels) and lipemic
type: Class
subclass of: SIO_001167

N-Acetyl-S-(2, 4-dimethylphenyl)-L-cysteine + N-Acetyl-S-(2, 5-dimethylphenyl)-L-cysteine + N-Acetyl-S-(3, 4-dimethylphenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DPMA
editorial note: To Do: align with CHEBI.

Targeted Analyte
type: Class
subclass of: StudyIndicator
subclass of: Analyte
definition: A targeted analyte is one that has been selected by the CHEAR program as a prioritized analyte for CHEAR lab hubs to measure and has been carried over to HHEAR.
was approved by: PER-Jeanette-Stingone

Cesium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Cs
definition: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.

Budesonide/formoterol (Symbicort)
type: Class
subclass of: Asthma Controller Medication

Meal
type: Class
type: NodeShape
subclass of: Activity
comment: Any of the occasions for eating food that occur by custom or habit at more or less fixed times.

I Always Felt Unable To Manage Things In My Life Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001292
subclass of: I Felt Unable To Manage Things In My Life Response
notation: 467

No Sickle Cell Anemia
type: Class
type: QualityValue
subclass of: Health Outcome
notation: 138

Born Sixth Or Later
type: Class
type: QualityValue
subclass of: Ordinal Position
subclass of: Birth Order
notation: 241
definition: The sixth or later born child

Consumes Food Or Beverage Reheated in Plastic
type: Class
type: QualityValue
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Food Or Beverage Product Reheated in a Plastic Container
  on property: SIO_000230
comment: The act of consuming food (or beverages) that have been reheated in a plastic container.
notation: 565

Retinopathy
type: Class
type: QualityValue
subclass of: Phenotype
notation: 129
definition: Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.

N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA1
editorial note: To Do: align with CHEBI.

enzyme unit
type: SIO_000074
notation: enzyme unit

Exposed to Second Hand Smoke in Other Car, at Relative's House, and at Friend's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Other Car
subclass of: Exposed to Second Hand Smoke at Relative's House
subclass of: Exposed to Second Hand Smoke at Friend's House
notation: 547
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Other Car
  intersection of: Exposed to Second Hand Smoke at Relative's House
  intersection of: Exposed to Second Hand Smoke at Friend's House
  equivalent class: Exposed to Second Hand Smoke in Other Car, at Relative's House, and at Friend's House

Bio-flora
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

First or Second Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
definition: The time period from pregnancy week 1 through 28 and includes conception.

Dibenzyl phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DBZP

Score
type: Class
subclass of: SIO_000075

Perfluorobutanesulfonic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFBS

Uses Plastic Containers for Food Or Beverage Storage
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Activity
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000230
comment: The act of using plastic containers to store food or beverages.

High Performance Liquid Chromatography
type: Class
subclass of: Chromatography

N-Acetyl-S-(1-phenyl-2-hydroxyethyl-L-cysteine + N-Acetyl-S-(2-phenyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: PHEMA
editorial note: To Do: align with CHEBI.

Trimethylarsine oxide
type: Class
subclass of: Arsenic Species
notation: TMAO

Catheterization
type: Class
subclass of: SIO_001024

Intellectual disability
type: Class
type: NodeShape
subclass of: Neurodevelopmental abnormality
subclass of: Developmental delay or intellectual disability
comment: Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70. This term should be used for children at least five years old. For younger children, consider the term Global developmental delay (HP:0001263).

Exposed to Second Hand Smoke in Outdoor Public Place and at Relative's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
subclass of: Exposed to Second Hand Smoke at Relative's House
notation: 548
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  intersection of: Exposed to Second Hand Smoke at Relative's House
  equivalent class: Exposed to Second Hand Smoke in Outdoor Public Place and at Relative's House

Tetrabromobisphenol A
type: Class
type: NodeShape
subclass of: Phenol
notation: TBBPA3355

Lactil
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

I Sometimes Felt Unable To Manage Things In My Life Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Unable To Manage Things In My Life Response
notation: 471

Cognitive Task
type: Class
subclass of: Neurocognitive Assessment

Biospecimen Collection
type: Class
type: NodeShape
subclass of: Sample Collection
subclass of: Restriction
  some values from: Biospecimen
  on property: RO_0004009
comment: An event in which a biospecimen is collected in order to be measured or analyzed

Cis-Chlordane
type: Class
subclass of: Organochlorine Pesticide
notation: CCHL

microgram per cubic meter
type: SIO_000074
notation: µg/m3

Interleukin-10
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL10
definition: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Leukocyte
type: Class
subclass of: Blood Component
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.

CASI Controller Treatment Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

diethyldithiophosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DEDP
editorial note: To Do: align with CHEBI.

Refractometer
type: Class
subclass of: PhysicalInstrument
definition: A laboratory or field device for the measurement of an index of refraction (refractometry). The index of refraction is calculated from Snell's law while for mixtures, the index of refraction can be calculated from the composition of the material using several mixing rules such as the Gladstone–Dale relation and Lorentz–Lorenz equation.
was approved by: PER-Jim-McCusker

adrenic acid
type: Class
subclass of: Fatty Acid
notation: C224N6

Gestational Age
type: Class
type: QuantityVariable
subclass of: Birth Outcome
subclass of: Age
definition: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization
was approved by: PER-Jeanette-Stingone

Adiponectin
type: Class
type: NodeShape
subclass of: Nutrient
notation: ADIPO

Stool Sample Collection
type: Class
type: NodeShape
subclass of: Biospecimen Collection
subclass of: Restriction
  some values from: Stool Sample
  on property: RO_0004009
comment: An event in which a stool sample is collected in order to be measured or analyzed

Annual Maximum Concentration
type: Class
type: QuantityVariable
subclass of: SIO_001114
subclass of: Concentration

diethylphosphate
type: Class
subclass of: Dialkyl Phosphate Pesticide Metabolite
notation: DEP
editorial note: To Do: align with CHEBI.

Annual Income $5,001 to $10,000
type: Class
type: QualityValue
subclass of: Annual Income $14,999 or Less
subclass of: Annual Income $5,001 to $15,000
notation: 204

Trans-Chlordane
type: Class
subclass of: Organochlorine Pesticide
notation: TCHL

California
type: QualityValue
notation: 185

watt-hour
type: SIO_000074
notation: Wh

Bis(2-methylphenyl) hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DOCP

Red blood cells present
type: Class
subclass of: SIO_001167

all-cis-icosa-8, 11, 14-trienoic acid
type: Class
subclass of: Fatty Acid
notation: C203N6
definition: An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.

Z-Score For Fixed Age and Sex
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Z-Score
subclass of: Restriction
  some values from: Age
  on property: RO_0000079
subclass of: Restriction
  some values from: Biological Sex
  on property: RO_0000079
comment: A Z-score computation from a population which all share the same age range and sex assignment

urine
type: Class
subclass of: Bodily Fluid
definition: Excretion that is the output of a kidney [database_cross_reference: http://en.wikipedia.org/wiki/Urine][database_cross_reference: https://github.com/geneontology/go-ontology/issues/11025]

Aligent 8800 Triple Quadrupole ICP-MS
type: Class
subclass of: Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
was approved by: PER-Jim-McCusker

CASI Lung Function Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

magnetic flux density unit
type: SIO_000074
notation: MFDU

Annual Mean Concentration
type: Class
type: QualityVariable
subclass of: Mean Concentration

Benzophenone
type: Class
subclass of: Phenol

Reproductive Health
type: Class
subclass of: StudyIndicator
definition: Reproductive Health Indicator Class
was approved by: PER-Jeanette-Stingone

Z-Score For Fixed Height and Sex
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Z-Score
subclass of: Restriction
  some values from: Height
  on property: RO_0000079
subclass of: Restriction
  some values from: Biological Sex
  on property: RO_0000079
comment: A Z-score computation from a population which all share the same height range and sex assignment

weber
type: SIO_000074
notation: Wb

Vaginal Birth
type: Class
type: QualityValue
subclass of: birthing
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
notation: 24
definition: Had a birthing occur via the vagina.
editorial note: Again, can we add a delivery class

Adulthood Period
type: Class
subclass of: From Birth
definition: Time period that begins after adolesence and continues until death

CASI Nighttime Asthma Symptoms Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

stroke
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

Replicate Number
type: Class
subclass of: SampleIndicator
definition: Replicate Number

proton pump inhibitor agent therapy
type: Class
type: NodeShape
subclass of: Pharmacotherapy

(7Z, 10Z, 13Z, 16Z, 19Z)-docosapentaenoic acid
type: Class
subclass of: Fatty Acid
notation: C225N3
definition: The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.

One Month Prior to Baseline
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Baseline
  on property: intervalMeets
comment: A time interval that begins one month prior to a study baseline and ends at the beginning of the study baseline.

Local Streets Have Usable Footpaths Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "There are useable footpaths on most of the streets in my local area."

Fluticasone/salmeterol DPI (Advair Diskus)
type: Class
subclass of: Asthma Controller Medication

Adult
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
subclass of: Life Stage
notation: 3
definition: Refers to a person above a threshold age.
was approved by: PER-Jeanette-Stingone

Tissue
type: Class
subclass of: Biospecimen
subclass of: UBERON_0000479

volt-hour
type: SIO_000074
notation: Vh

Air Pollutant
type: Class
type: QualityVariable
subclass of: Environmental Exposure

Preschool Child Behavior Checklist Externalizing Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of preschool CBCL that assesses externalizing behaviors

CASI Daytime Asthma Symptoms Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

Tin
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Sn
definition: TIN is a trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.

cloxacillin
type: Class
type: NodeShape
subclass of: CHEBI_24431
comment: A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.

Exposed to Probiotics
type: Class
type: QualityValue
type: NodeShape
subclass of: exposure
subclass of: Restriction
  some values from: Probiotic
  on property: SIO_000139
comment: Exposure to probiotics, either through directly ingesting them or through other means
notation: 642

Agilent 1100 HPLC
type: Class
subclass of: High-Performance Liquid Chromatography
was approved by: PER-Jim-McCusker

CASI Exacerbation Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

tesla
type: SIO_000074
notation: Tesla

Preschool Child Behavior Checklist Internalizing Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of preschool CBCL that assesses internalizing behaviors

Some College or Technical School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
subclass of: Education
subclass of: Class
  union of: Some College
  union of: Some Technical School
notation: 203
equivalent class: Class
  union of: Some College
  union of: Some Technical School
  equivalent class: Some College or Technical School

Laboratory Biomarker Analysis
type: Class
type: NodeShape
subclass of: SIO_000999

Reheating Food or Beverage in a Plastic Container
type: Class
type: NodeShape
subclass of: food reheating
subclass of: Restriction
  some values from: Class
    intersection of: food product
    intersection of: Restriction
      some values from: plastic container
      on property: SIO_000128
  on property: SIO_000230
comment: Reheating food (including beverages) in a plastic container; the food may have been placed in the plastic container for the purposes of reheating, or it may have been packaged in plastic as a single product unit.

Disagree Neighborhood Is Safe Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Neighborhood Is Safe Response
notation: 473

N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA2
editorial note: To Do: align with CHEBI.

Mexico
type: QualityValue
notation: 183

mild eosinophilic esophagitis
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is mild when a biopsy of the esophagus reveals a count of 15-25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: mild eosinophilic esophagitis
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

Not Well Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001295
notation: 296

Perfluorodecanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFDA

Quantity of sample insufficient for repeat analysis
type: Class
subclass of: SIO_001167

Eats School Breakfast
type: Class
type: NodeShape
subclass of: Eating or Drinking
subclass of: Diet and Nutrition
subclass of: Restriction
  some values from: School Breakfast
  on property: SIO_000230
comment: The act of eating a school prepared breakfast.

Direct Measurement
type: Class
type: NodeShape
subclass of: Measurement
comment: A direct measurement is taken when one explicitly measures the desired characteristic or quantity of the object in question. This in comparison to an imputed, or indirect measurement where the measurement value is determined by measuring some other characteristic or quantity and applying a scale or algorithm to infer an estimated value of the desired quantity.

One Month Prior to Followup 2
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 2
  on property: intervalMeets
comment: A time interval that begins one month prior to a study's second follow-up and ends at the beginning of the study's second follow-up.

monoethyl phthalate (DEP)
type: Class
subclass of: Phthalate
notation: MEP

Strongly Disagree Neighborhood Is Safe Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Neighborhood Is Safe Response
notation: 475

Cell
type: Class
subclass of: Biospecimen

N-Acetyl-S-(2-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMA2
editorial note: To Do: align with CHEBI.

Active Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 2
definition: The quality of actively smoking.
editorial note: How is this different from "smoker'?

Prescription Medication and Dietary Supplements
type: Class
subclass of: StudyIndicator
definition: Prescription Medication and Dietary Supplements are forms of medical treatment.
was approved by: PER-Jeanette-Stingone

Well Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001297
notation: 297

Interleukin-27 subunit alpha
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL27

Sandwich ELISA
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)
definition: Sandwich ELISAs involve attachment of a capture antibody to a solid phase support. Samples containing known or unknown antigen are then added in a matrix or buffer that will minimize attachment to the solid phase. An enzyme-labeled antibody is then added for detection.

South Central Clinic
type: Class
type: QualityValue
subclass of: Population Group
notation: 273

Expressive Language Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03173
  on property: wasDerivedFrom

gestational diabetes
type: Class
type: QualityValue
subclass of: DOID_0081062
notation: 179

Eclampsia or Severe Pre-eclampsia
type: Class
type: QualityValue
type: NodeShape
subclass of: pre-eclampsia
subclass of: Class
  union of: eclampsia
  union of: DOID_13129
notation: 578
equivalent class: Class
  union of: eclampsia
  union of: DOID_13129
  equivalent class: Eclampsia or Severe Pre-eclampsia

watt per square meter
type: SIO_000074
notation: W/m2

Bismuth
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Bi
definition: BISMUTH is a metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.

milligram
type: SIO_000074
notation: mg

Anemia
type: Class
type: QualityValue
subclass of: Phenotype
notation: 128
definition: A reduction in erythrocytes volume or hemoglobin concentration.

UBERON_0036255
deprecated: true

Visual Reception Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03171
  on property: wasDerivedFrom

White Hispanic
type: Class
type: QualityValue
subclass of: Hispanic or Latino Ethnicity
subclass of: White
notation: 145
definition: White and Hispanic

Mean Body Weight
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Body Weight Quality

3, 4-Dihydroxy benzoic acid
type: Class
subclass of: phenol
notation: DHB34

gram
type: SIO_000074
notation: g

Superimposed Pre-eclampsia
type: Class
type: NodeShape
subclass of: pre-eclampsia
comment: Superimposed preeclampsia refers to women with chronic arterial hypertension (primary or secondary) who develop preeclampsia (PE). Source: Guedes-Martins L. Superimposed Preeclampsia. Adv Exp Med Biol. 2017;956:409-417. doi: 10.1007/5584_2016_82. PMID: 27722963.

Religion
type: Class
type: QualityVariable
subclass of: Demographic
definition: Religious Belief

Communication Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Communication Domain
  on property: wasDerivedFrom

USC Obstetrics-Gynecology
type: Class
type: QualityValue
subclass of: Population Group
notation: 271

Interstitial collagenase
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MMP1

Quality Control
type: Class
subclass of: Analyte
definition: The value contains quality control data

4-(tert-Butoxycarbonyl)benzoic acid
type: Class
type: NodeShape
subclass of: Phthalate
notation: MTBTP

brominated flame retardant
type: Class
type: NodeShape
subclass of: flame retardant
comment: Any organobromine compound that is used as a flame retardant. These chemicals are widely incorporated as additives in consumer products such as electronics, vehicles, polyurethane foams etc, to make them less flammable. (Source: CHEBI)
notation: PBFR

nanogram
type: SIO_000074
notation: ng

p-Xylene*
type: Class
subclass of: Volatile Organic Compound
notation: PXY
definition: P-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. Freezing point is 56°F. (USCG, 1999)

Route Of Delivery
type: Class
type: QualityVariable
subclass of: Delivery Characteristics

extracorporeal membrane oxygenation
type: Class
subclass of: SIO_001024
subclass of: ventilator supporting therapy

Replicate
type: Class
subclass of: Analyte
definition: The value contains data for a repeat of the study sample

Community Recruit
type: Class
type: QualityValue
subclass of: Population Group
notation: 272

Receptive Language Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03174
  on property: wasDerivedFrom

bronchial disease
type: Class
subclass of: Disease

food product
type: Class
type: NodeShape
subclass of: SIO_010363

einstein per square meter per second
type: SIO_000074
notation: einstein/sm2

Aspergillus
type: Class
subclass of: Thing

microgram
type: SIO_000074
notation: µg

lung disease
type: Class
subclass of: Disease

Mexican
type: Class
type: QualityValue
type: NodeShape
subclass of: Hispanic or Latino Ethnicity
comment: Denotes a person from or of Mexico. (Source: NCI Thesaurus)
notation: 670

3-methipurc acd, 4-methipurc acd(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC34M
editorial note: To Do: align with CHEBI.

Quadrapole Time-of-Flight Liquid Chromotography-Mass Spectrometry
type: Class
subclass of: Liquid Chromotography-Mass Spectrometery

Childhood
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
subclass of: Life Stage
notation: 11
definition: A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.
was approved by: PER-Jeanette-Stingone

Lithium
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Li
definition: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.

LAC + USC Med Center
type: Class
type: QualityValue
subclass of: Population Group
notation: 269

Socialization Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Socialization Domain
  on property: wasDerivedFrom

femtogram
type: SIO_000074
notation: fg

vegetative amoebae
type: Class
type: NodeShape
subclass of: SIO_010376

First Year of the Common Era
type: NamedIndividual

3-phenoxybenzoic acid
type: Class
subclass of: Universal Pesticide Metabolite in Urine
notation: PBA
editorial note: To Do: align with CHEBI.

Puerto Rican
type: Class
type: QualityValue
type: NodeShape
subclass of: Hispanic or Latino Ethnicity
comment: A person of Puerto Rican culture or origin, regardless of race. (Source: NCI Thesaurus)
notation: 672

Reichert AR200 Handheld Digital Refractometer
type: Class
subclass of: Refractometer
definition: Lightweight digital refractometer designed for the food, beverage, agricultural, industrial-fluid, chemical, petrochemical, pharmaceutical, medical, and plastic industries.
was approved by: PER-Jim-McCusker

Motor Skills Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Motor Skills Domain
  on property: wasDerivedFrom

Room
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 249

Eisner Health
type: Class
type: QualityValue
subclass of: Population Group
notation: 270

picogram
type: SIO_000074
notation: pg

watt per steradian per square meter
type: SIO_000074
notation: W/sr/m2

Theophylline
type: Class
subclass of: Asthma Controller Medication

Multiple Hispanic
type: Class
type: QualityValue
type: NodeShape
subclass of: Hispanic or Latino Ethnicity
comment: A person living in the United States of Mexican, Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans. (Source: NCI Thesaurus)
notation: 673

PCB138
type: Class
subclass of: Polychlorobiphenyl
notation: PCB138

3, 5, 6-trichloro-2-pyridinol
type: Class
subclass of: Universal Pesticide Metabolite in Urine
notation: TCP
editorial note: To Do: align with CHEBI.

very-low-density lipoprotein cholesterol
type: Class
type: NodeShape
subclass of: cholesterol
comment: Cholesterol esters and free cholesterol which are contained in or bound to very low density lipoproteins (VLDL).

Pregnancy Complication
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
notation: 75

microsecond
type: SIO_000074
notation: µs

All Los Angeles RCs plus Orange, San Diego, Tri-counties, and Inland
type: Class
type: QualityValue
subclass of: Population Group
notation: 340

Monopropyl Phthalate
type: Class
type: NodeShape
subclass of: Phthalate
notation: MPRP

gigabyte
type: SIO_000074
notation: GB

Atopy
type: Class
subclass of: Health Outcome
notation: 361

3-Methylhippuric acid + 4-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
notation: MHA34
editorial note: To Do: align with CHEBI.

Preterm Birth
type: Class
type: QualityValue
subclass of: Birth Outcome
notation: 88
definition: Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.
was approved by: PER-Jim-McCusker
equivalent class: Class
  equivalent class: Preterm Birth
  complement of: Term Birth
disjoint with: Term Birth

millisecond
type: SIO_000074
notation: ms

wheezing or tightness in the chest or cough
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Phenotypic abnormality
equivalent class: Class
  union of: Chest tightness
  union of: Cough
  union of: Wheezing
  equivalent class: wheezing or tightness in the chest or cough

mono-pentyl phthalate
type: Class
subclass of: Phthalate
notation: mPeP

Daily Living Skills Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Daily Living Skills Domain
  on property: wasDerivedFrom

degree Celsius
type: SIO_000074
notation: C

Eczema
type: Class
type: QualityValue
subclass of: Inflammatory abnormality of the skin
comment: Eczema has several forms including atopic dermatitis, contact dermatitis, dyshidrotic eczema, nummular eczema, seborrheic dermatitis, and stasis dermatitis. Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding.
notation: 425

zeaxanthin
type: Class
type: NodeShape
subclass of: Nutrient
notation: ZEA

Reactive Airway Disease
type: Class
type: QualityValue
subclass of: Non-Neoplastic Lung Disorder
notation: 186
definition: Coughing, wheezing, or shortness of breath that is triggered by allergens, infection, or other irritants. [def-source: NCI]

gigabasepair
type: SIO_000074
notation: Gb

Nicotine
type: Class
subclass of: Tobacco Metabolite
notation: NIC
definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

juvenile rheumatoid arthritis
type: Class
subclass of: Disease

Flunisolide HFA (Aerospan)
type: Class
subclass of: Asthma Controller Medication

Ethnicity
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000475
subclass of: Race or Ethnicity Combined
was approved by: PER-Jeanette-Stingone

high-density lipoprotein cholesterol
type: Class
type: NodeShape
subclass of: cholesterol
comment: Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL).

Chest Tube Placement
type: Class
subclass of: Medical History
subclass of: SIO_001024
subclass of: Restriction
  some values from: Chest Tube
  on property: SIO_000139

Duration of Hospital Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Healthcare Facility Admission
subclass of: Restriction
  some values from: Hospital Admission
  on property: SIO_000215
comment: The length of time a patient is admitted into a hospital

Tellurium
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Te
definition: Tellurium. An element that is a member of the chalcogen family. TELLURIUM has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.

Maternal Prenatal Stage
type: Class
type: NodeShape
subclass of: Life Stage
comment: The stage in the life of a mother during which she is pregnant. (Source: NCI Thesaurus)

Perfluoroakyl and Polyfluoroalkyl Substance
type: Class
subclass of: Targeted Analyte
notation: SPFAS

Residential Yard
type: Class
type: NodeShape
subclass of: domestic garden
comment: A subclass of domestic garden; a residential yard is an area attached or adjacent to a single family or multi-family house where domestic leisure activities typically occur.

Non-spontaneous Term Birth
type: Class
type: NodeShape
subclass of: Term Birth
subclass of: Non-spontaneous Birth
subclass of: Class
  intersection of: Term Birth
  intersection of: Non-spontaneous Birth
comment: The birth of a child that occurs at term and as the result of a medical intervention
equivalent class: Class
  intersection of: Term Birth
  intersection of: Non-spontaneous Birth
  equivalent class: Non-spontaneous Term Birth

Annual Income $25,000 to $29,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $25,000 to $34,999
notation: 592

Dibutyl phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
comment: Dibutyl phosphate is a pale-amber odorless liquid. Mp: -13 °C, bp: 135-138 °C. Density: 1.06 g cm-3. Moderately soluble in water (18 g / L at 20 °C). (Source: Pubchem)
notation: DBUP

Age
type: Class
type: QuantityVariable
subclass of: Demographic

catheterization associated UTI
type: Class
subclass of: hospital-acquired infection
subclass of: CAUTI or CLABSI or VAP
subclass of: Restriction
  some values from: Catheterization
  on property: SIO_001157
subclass of: urinary tract infection

injury
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 406

low-density lipoprotein cholesterol
type: Class
type: NodeShape
subclass of: cholesterol
comment: Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL).

Duration of Pediatric ICU Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Healthcare Facility Admission
subclass of: Restriction
  some values from: Pediatric ICU Admission
  on property: SIO_000215
comment: The length of time a patient is admitted into a pediatric intensive care unit

mono-isobutyl phthalate (DiBP)
type: Class
subclass of: Phthalate
notation: MiBP

Immunocompromised
type: Class
type: QualityValue
subclass of: immune response
notation: 374

Parous
type: Class
type: QualityValue
subclass of: Parity
notation: 73

4-nitrophenol
type: Class
subclass of: Universal Pesticide Metabolite in Urine
notation: PNP

SCD Genotype
type: Class
subclass of: Genotype

Private Residential Yard
type: Class
type: NodeShape
subclass of: Residential Yard
comment: A back yard for a residential house that is not shared among multiple houses

Quotient
type: Class
subclass of: SIO_000075

Very turbid
type: Class
subclass of: SIO_001167

Uses Antibiotics
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: CHEBI_33281
  on property: SIO_000139
notation: 379
definition: Had a form of treatment which uses antibiotics.
disjoint with: Does Not Use Antibiotics

Pediatric ICU Admission
type: Class
type: NodeShape
subclass of: ICU Admission
subclass of: Restriction
  some values from: Pediatric Intensive Care Unit
  on property: SIO_000061
comment: The admission into a pediatric ICU unit.

Nulliparous
type: Class
type: QualityValue
subclass of: Parity
notation: 62

count per molar second
type: SIO_000074
notation: 1/Ms

Registeries
type: Class
type: NodeShape
subclass of: SIO_001052
comment: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers. (Source: Medical Subject Headings Ontology)

Interleukin-33
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL33

8-iso Prostaglandin F2 alpha
type: Class
subclass of: Oxidative Stress Marker
notation: F2A8IP

Disagree Local Parks Are Too Dangerous For My Child
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Local Parks Are Too Dangerous For My Child
notation: 501

Non-spontaneous Birth
type: Class
type: NodeShape
subclass of: Birth Outcome
comment: The birth of a child that does not occur spontaneously; the birth may be initiated by or aided by some medical intervention.
equivalent class: Class
  equivalent class: Non-spontaneous Birth
  complement of: Spontaneous Labor and Birth

Owns Home
type: Class
type: QualityValue
subclass of: Home Ownership
notation: 147
definition: This person owns the home they live in.

Human Dwelling
type: Class
type: QualityVariable
subclass of: Human Dwelling

Duration of Healthcare Facility Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: PATO_0001309
subclass of: SIO_000070
subclass of: Restriction
  some values from: Healthcare Facility Admission
  on property: SIO_000215
comment: The duration of time a patient is admitted into a healthcare facility

Race
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000475
subclass of: Race or Ethnicity Combined
was approved by: PER-Jeanette-Stingone

Value less than LOD
type: Class
subclass of: SIO_001167

ICU Admission Requiring Tracheostomy
type: Class
type: QualityValue
subclass of: ICU Admission By Tracheostomy Status
subclass of: Restriction
  some values from: tracheostomy
  on property: SIO_000250
comment: An ICU Admission of a patient that requires a tracheostomy immediately upon admission.
notation: 377
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: tracheostomy
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Tracheostomy

Other Material Finish
type: Class
type: QualityValue
subclass of: Floor Type
notation: 70
definition: Flooring is made from another unspecified material.
was approved by: PER-Jeanette-Stingone

2,3,4,3',4'-Pentachlorobiphenyl
type: Class
type: NodeShape
subclass of: Polychlorobiphenyl
notation: PCB105

Metalloproteinase inhibitor 2
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: TIMP2

count per nanomolar second
type: SIO_000074
notation: 1/nMs

Spontaneous Term Birth
type: Class
type: NodeShape
subclass of: Term Birth
subclass of: Spontaneous Labor and Birth
subclass of: Class
  intersection of: Term Birth
  intersection of: Spontaneous Labor and Birth
comment: The birth of a child that occurs at term and without medical intervention
equivalent class: Class
  intersection of: Term Birth
  intersection of: Spontaneous Labor and Birth
  equivalent class: Spontaneous Term Birth

Strongly Disagree Local Parks Are Too Dangerous For My Child
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Local Parks Are Too Dangerous For My Child
notation: 503

Abnormality of the respiratory system
type: Class
type: QualityVariable
subclass of: Health Outcome

Asthma Controller Use
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Asthma Controller Medication Prescription
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: Asthma Controller Medication
  on property: SIO_000230
definition: A subclass of medical intervention that characterizes a patient's experience with using an asthma controller medication. Subclasses detail the level to which a patient has used such a medication to control their asthma symptoms, from never used to always uses.
equivalent class:
  union of: Has taken asthma control medications
  union of: Never takes asthma control medications
  equivalent class: Asthma Controller Use

Hospital Admission By Admission Source
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class is used to differentiate between admissions that originate from the ER department of the study hospital versus those that do not.

asphyxia
type: Class
subclass of: Phenotypic abnormality
subclass of: Drowning or Asphyxia or Hanging

Interleukin-31
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL31

count per nanomolar
type: SIO_000074
notation: 1/nM

Strongly Agree Local Parks Are Too Dangerous For My Child
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Local Parks Are Too Dangerous For My Child
notation: 502

New Onset Postpartum Hypertension
type: Class
type: QualityValue
type: NodeShape
subclass of: postpartum hypertension
notation: 581

1-hydroxynaphthalene
type: Class
subclass of: polycyclic hydrocarbon
notation: NAP1

Uses Muscle Relaxants
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: muscle relaxant
  on property: SIO_000139
notation: 688
definition: Had a form of treatment which uses muscle relaxants.

Upper Respiratory Tract Infection
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: infection

Hospital Admission Not From Study Emergency Department
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Admission Source
comment: An admission into a hospital where a clinical study is being conducted, and the subject was not previously in the study hospital's emergency department.
notation: 436
disjoint with: Hospital Admission From Study Emergency Department

Non-smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 59
definition: Doesn't smoke cigarettes.

Agree Local Parks Are Too Dangerous For My Child
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Local Parks Are Too Dangerous For My Child
notation: 500

nanosecond
type: SIO_000074
notation: ns

Indicated Birth
type: Class
type: QualityValue
type: NodeShape
subclass of: Non-spontaneous Birth
comment: A birth in which medical intervention is necessitated by the medical condition of the mother or fetus.
notation: 586

Mean Height
type: Class
type: QuantityVariable
subclass of: Height
subclass of: SIO_001109

Non-White Hispanic
type: Class
type: QualityValue
subclass of: Non-White
subclass of: Hispanic or Latino Ethnicity
notation: 146
definition: Non-White and Hispanic

State-Trait Anxiety Inventory
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: An instrument for measuring anxiety. It is designed to differentiate between temporary "state anxiety" and general, long-standing "trait anxiety". (Copyright Mind Garden, Inc.) (Source: NCI Thesaurus)

cortisol
type: Class
type: NodeShape
subclass of: Psychosocial Stress Marker
notation: CORTL

Required Home Medical Technology Prior to Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Prior Home Medical Technology Use
subclass of: Restriction
  some values from: Home Medical Technology
  on property: SIO_000249
comment: Denotes hospital admissions in which the patient required the use of home medical technology prior to admission.
notation: 433
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Restriction
    some values from: Home Medical Technology
    on property: SIO_000249
  equivalent class: Required Home Medical Technology Prior to Hospital Admission
disjoint with: Did Not Require Home Medical Technology Prior to Hospital Admission

foot candle
type: SIO_000074
notation: ft-c

picometer
type: SIO_000074
notation: pm

Superimposed, severe, or mild preeclampsia
type: Class
type: QualityValue
type: NodeShape
subclass of: pre-eclampsia
subclass of: Class
  union of: Superimposed Pre-eclampsia
  union of: DOID_13129
  union of: DOID_10590
notation: 579
equivalent class: Class
  union of: Superimposed Pre-eclampsia
  union of: DOID_13129
  union of: DOID_10590
  equivalent class: Superimposed, severe, or mild preeclampsia

Allergen
type: Class
subclass of: Thing

vasopressor agent therapy
type: Class
type: QualityVariable
subclass of: Pharmacotherapy

Asthma Controller Medication
type: Class
subclass of: SIO_010039
definition: A class of pharmeceutical drugs that are used to prevent or manage the onset of acute asthma before an attack occurs.

Did Not Require Home Medical Technology Prior to Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Prior Home Medical Technology Use
subclass of: Class
  complement of: Restriction
    some values from: Home Medical Technology
    on property: SIO_000249
comment: Denotes hospital admissions in which the patient did not require the use of home medical technology prior to admission.
notation: 434
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Class
    complement of: Restriction
      some values from: Home Medical Technology
      on property: SIO_000249
  equivalent class: Did Not Require Home Medical Technology Prior to Hospital Admission
disjoint with: Required Home Medical Technology Prior to Hospital Admission

Oxybenzone
type: Class
subclass of: phenols
notation: OXB
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.

Research or Clinical Assessment Tool
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Assessment
comment: Any evaluation or assessment tool used to ascertain a patient's condition or diagnosis. [Definition Source: NCI]

count per molar
type: SIO_000074
notation: 1/M

New Onset Antepartum Hypertension
type: Class
type: QualityValue
type: NodeShape
subclass of: antepartum hypertension
notation: 580

Local Parks Are Too Dangerous For My Child
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "There are dangers (e.g., dogs or undesirable people) in the local park(s) so I avoid taking my child there."

Gold
type: Class
subclass of: Metal
notation: Au
definition: GOLD is a yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

Kaiser Permanente Insurance
type: Class
type: QualityValue
type: NodeShape
subclass of: Private Insurance
notation: 668
disjoint with: Private Insurance Other Than Kaiser Permanente

Oxygen Treatment
type: Class
subclass of: SIO_001398
subclass of: Medical History
subclass of: Home Medical Technology
subclass of: Restriction
  some values from: SIO_011007
  on property: SIO_000139
comment: A medical intervention in which a patient is treated with oxygen.

DNA
type: Class
subclass of: Macromolecule

4-Hydroxybenzoic acid
type: Class
subclass of: phenol
notation: HB4

psychiatric disorder
type: Class
subclass of: Comorbidity Disease

Non-Hispanic Ethnicity
type: Class
type: QualityValue
subclass of: Ethnicity
notation: 58
definition: Non-Hispanic Ethnicity
was approved by: PER-Jeanette-Stingone

A Sample has a Pairing
type: Class
subclass of: SIO_001049
definition: Refers to having paired samples.
was approved by: PER-Jeanette-Stingone
editorial note: This actually should be a process. What should we do?

Urine grossly hematuric
type: Class
subclass of: SIO_001167

Eats Fried Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03310717
  on property: SIO_000369
notation: 229
definition: The attribute of eating fried fish.

Childhood Followup 8
type: Class
subclass of: Study Followup 8
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
definition: A point in a study that occurs after the seventh follow-up point in the study and occurs during the study subject's childhood period.

Duration of Domicile in United States
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Demographic
subclass of: PATO_0001309
comment: The length of time a person has lived in the United States

Islet Autoimmunity
type: Class
type: QualityValue
type: NodeShape
subclass of: DOID_0060005
comment: Persistent Islet Autoimmunity (or any IA) was defined as confirmed positive insulin autoantibodies (IAAs), GAD antibody (GADA), specifically to isoform GAD65, or insulinoma antigen-2 autoantibody, which were analyzed by radiobinding assays (25,26) on at least two consecutive study visits.
notation: 643

2-hydroxyfluorene
type: Class
subclass of: polycyclic hydrocarbon
notation: FLUO2

megabasepair
type: SIO_000074
notation: Mb

imidacloprid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. Source: ChEBI
notation: IMI

thousand parts per microgram
type: SIO_000074
notation: x103 µL

Unusually high
type: Class
subclass of: SIO_001167

Eats Shell Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03411433
  on property: SIO_000369
notation: 230
definition: The attribute of eating shell fish.

Fenton Weighted Z-Score
type: Class
type: QuantityVariable
subclass of: Z-Score
subclass of: SIO_001245
subclass of: Birth Outcome
subclass of: Class
  intersection of: SIO_001245
  intersection of: Restriction
    some values from: Birth Weight
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: Fenton Preterm Growth Chart
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: Gestational Age at Birth
    on property: wasDerivedFrom
definition: Derived from Birth Weight, Gestational Age, and Child Sex
was approved by: PER-Jeanette-Stingone

ICU Discharge On Oxygen
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000250
subclass of: ICU Discharge By Oxygen Use
comment: An event in which a patient is discharged from an intensive care unit and is given oxygen treatment.
notation: 372
equivalent class: Class
  intersection of: ICU Discharge
  intersection of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
  equivalent class: ICU Discharge On Oxygen
disjoint with: ICU Discharge Not On Oxygen

Strongly Disagree Local Shops Are Walkable From Home
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Local Shops Are Walkable From Home
notation: 499

Propyl paraben
type: Class
subclass of: Paraben
notation: PrPB
definition: Propylparaben is a Standardized Chemical Allergen. The physiologic effect of propylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of propylparaben is Allergens.

Arsenocholine
type: Class
subclass of: Arsenic Species
notation: AsC

substitution
type: Class
type: NodeShape
subclass of: sequence_alteration
comment: Any change in genomic DNA caused by a single event.

Microwave Oven Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of machines in the home used to heat up food using microwaves.
was approved by: PER-Jeanette-Stingone
editorial note: Putting a note here, but it applies to all of the appliances. These are used to calculate the SES Index that was reported within one of the pilots. So, there needs to be some connection between these terms.

chronic obstructive pulmonary disease
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 382

Acculturation
type: Class
subclass of: StudyIndicator
definition: Acculturation explains the process of cultural change and psychological change that results following meeting between cultures. This metaclass contains all classes that measure this process.
was approved by: PER-Jeanette-Stingone

Value above LOD but below LLOQ
type: Class
subclass of: SIO_001167

Eats Fresh Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03315446
  on property: SIO_000369
notation: 227
definition: The attribute of eating fresh fish.

Probiotic
type: Class
type: NodeShape
subclass of: Dietary Supplement
comment: A live microorganism used as a dietary supplement to help with digestion and normal bowel function. It may also help keep the gastrointestinal (GI) tract healthy. A bacterium found in yogurt called Lactobacillus acidophilus, is the most common probiotic. (Source: NCI Thesaurus)

Number of Adults in Household
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Members in Household

Hospital Discharge On Oxygen
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000250
subclass of: Hospital Discharge By Oxygen Use
comment: An event in which a patient is discharged from a hospital and is given oxygen treatment.
notation: 370
equivalent class: Class
  intersection of: Hospital Discharge
  intersection of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
  equivalent class: Hospital Discharge On Oxygen
disjoint with: Hospital Discharge Not On Oxygen

Abdomen
type: Class
subclass of: SIO_010046

Neighbor
type: Class
type: QualityValue
subclass of: Demographic
subclass of: SIO_000016
subclass of: SIO_000287
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: SIO_000485
notation: 355
definition: A person living near or next door to another person.

Abnormal hemoglobin variant observed
type: Class
subclass of: SIO_001167

Valid measurement, results repeated and confirmed (0, 33)
type: Class
subclass of: SIO_001167

spinal injury
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Eats Canned Fish
type: Class
type: QualityValue
subclass of: Eats Canned Food
subclass of: Restriction
  some values from: FOODON_03302764
  on property: SIO_000369
notation: 228
definition: The attribute of eating canned fish.

dinotefuran
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: DINF

Number of Children in Household
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Members in Household

Childhood Followup 7
type: Class
subclass of: Study Followup 7
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
definition: A point in a study that occurs after the sixth follow-up point in the study and occurs during the study subject's childhood period.

ICU Admission Not Requiring Mechanical Ventilation
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Mechanical Ventilation Status
subclass of: Class
  complement of: Restriction
    some values from: invasive mechanical ventilation
    on property: SIO_000250
notation: 438
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: invasive mechanical ventilation
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Mechanical Ventilation
disjoint with: ICU Admission Requiring Mechanical Ventilation

Hospital Discharge
type: Class
type: QualityVariable
subclass of: Healthcare Access
subclass of: Medical History
subclass of: Medical Discharge
subclass of: Restriction
  some values from: Hospital Admission
  on property: SIO_000249
comment: An event in which a person is discharged from a hospital.

Torn, perforated screen
type: Class
subclass of: SIO_001167

pre-eclampsia
type: Class
type: QualityValue
subclass of: artery disease
notation: 177

Volatile Organic Compound
type: Class
subclass of: Targeted Analyte
notation: VOCs

Malarial Retinopathy
type: Class
type: QualityValue
subclass of: Retinopathy
notation: 130
definition: Retinopathy due to malaria.

dehydroepiandrosterone sulfate
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

Advance Directive
type: Class
type: QualityVariable
subclass of: Medical History
subclass of: SIO_000148

Beryllium
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Be
definition: Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.

Annual Income $35,000 to $49,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $30,000 to $49,999
subclass of: Annual Income $30,001 to $50,000
notation: 666

Disagree Local Shops Are Walkable From Home
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Local Shops Are Walkable From Home
notation: 497

ICU Discharge
type: Class
type: QualityVariable
subclass of: Healthcare Access
subclass of: Medical History
subclass of: Restriction
  some values from: ICU Admission
  on property: SIO_000249
subclass of: Medical Discharge
comment: An event in which a person is discharged from an intensive care unit.

Hospital Admission By Prior Home Medical Technology Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; differentiates hospital admissions by whether or not the patient required home medical technology use prior to admission.

Copper
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Cu
definition: COPPER is a heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Torn bag (Mitest intact, capped)
type: Class
subclass of: SIO_001167

all-cis-docosa-4, 7, 10, 13, 16, 19-hexaenoic acid
type: Class
subclass of: Fatty Acid
notation: C226N3
definition: A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.

Mercury Species
type: Class
subclass of: Targeted Analyte

Zinc
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Zn
definition: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Annual Income $75,000 to $149,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income More Than $70,001
notation: 667

Nervous System
type: Class
subclass of: SIO_010003
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior

Cognitive Entity
type: Class
subclass of: Neurocognitive Assessment

Smoking Status - Asked During Pregnancy
type: Class
type: QualityVariable
type: NodeShape
subclass of: Smoking Status

Healthcare Facility Admission
type: Class
subclass of: Activity
subclass of: Restriction
  some values from: Healthcare Facility
  on property: SIO_000061
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000132
comment: An event in which a patient is admitted into a healthcare facility.

Methyl Paraben
type: Class
subclass of: Paraben
notation: MePB
definition: Methylparaben is a Standardized Chemical Allergen. The physiologic effect of methylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of methylparaben is Allergens.

ICU Admission By Mechanical Ventilation Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a invasive mechanical ventilation (dialysis, nitric oxide ventilation, or ECMO) during their ICU admission versus when they do not.

Diet
type: Class
type: QualityVariable
subclass of: Diet and Nutrition
definition: The customary allowance of food and drink taken by a person or an animal from day to day, particularly one especially planned to meet specific requirements of the individual, including or excluding certain items of food; a prescribed course of eating and drinking in which the amount and kind of food, as well as the times at which it is to be taken, are regulated for therapeutic purposes or selected with reference to a particular state of health.

linoleic acid
type: Class
subclass of: Fatty Acid
notation: C182N6
definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.

picomoles per milliliter
type: SIO_000074
notation: pmol/ml

Unusual color
type: Class
subclass of: SIO_001167

2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoic acid
type: Class
type: NodeShape
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
comment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid is a perfluorinated compound that is 2-propoxypentanoic acid in which all 11 of the hydrogens attached to carbon atoms have been replaced by fluorine atoms. Used as an alternative to perfluorooctanoic acid in the fluoropolymer industry for years, its widespread environmental distribution, high bioaccumulation capability, and human exposure have caused great concern, particularly as its potential toxicity and health risk is still largely unknown. It is a monocarboxylic acid, a perfluorinated compound and an ether. (Source: Pubchem)
notation: GENX

2-(6-Hydroxy-2-propylheptoxy)carbonylbenzoic acid
type: Class
type: NodeShape
subclass of: Phthalate
notation: MPHHP

Liquid Chromatography–Mass Spectrometer
type: Class
subclass of: Liquid Chromatography Instrument
subclass of: Mass Spectrometer
definition: An analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin.
was approved by: PER-Jim-McCusker

Strongly Agree Local Shops Are Walkable From Home
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Local Shops Are Walkable From Home
notation: 498

Agree Local Shops Are Walkable From Home
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Local Shops Are Walkable From Home
notation: 496

Smoking Status - Asked After Pregnancy
type: Class
type: QualityVariable
type: NodeShape
subclass of: Smoking Status

Medical Discharge
type: Class
subclass of: Activity
comment: An event in which a person is discharged from a medical facility.

ICU Admission Requiring Mechanical Ventilation
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Mechanical Ventilation Status
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000250
notation: 437
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: invasive mechanical ventilation
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Mechanical Ventilation
disjoint with: ICU Admission Not Requiring Mechanical Ventilation

Turbid
type: Class
subclass of: SIO_001167

Macromolecule
type: Class
subclass of: Biomolecule
definition: A very large molecule, such as protein, commonly created by polymerization of smaller subunits (monomers). They are typically composed of thousands of atoms or more. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, carbohydrates and polyphenols) and large non-polymeric molecules (such as lipids and macrocycles).

Recruited In Sweden
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q34
comment: A population group of study participants that were recruited in Sweden
notation: 602

Mercapturic acid of benzene
type: Class
subclass of: Volatile Organic Compound
notation: SPMA

Perfume Use
type: Class
type: QualityValue
subclass of: Personal Product Use
notation: 74
was approved by: PER-Jeanette-Stingone

tetradecanoic acid
type: Class
subclass of: Fatty Acid
notation: C140
definition: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.

angstrom
type: SIO_000074
notation: Ang

microcurie per milliliter
type: SIO_000074
notation: µcurie/ml

East Bay, San Andreas, and Golden Gate
type: Class
type: QualityValue
subclass of: Population Group
notation: 338

isoprostane
type: Class
subclass of: Thing

4, 4'-(1, 4-Phenylenediisopropylidene)bisphenol
type: Class
subclass of: Phenol
notation: BPP

African American
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 8
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American".
was approved by: PER-Jeanette-Stingone

Mercapturic acids of acrolein and crotonaldehyde
type: Class
subclass of: polycyclic hydrocarbon
notation: AMA

2-thoxothazlidne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCTTC
editorial note: To Do: align with CHEBI.

Polymerase Chain Reaction
type: Class
subclass of: SIO_001007

nanometer
type: SIO_000074
notation: nm

Valley Mt, Central Valley, and Kern
type: Class
type: QualityValue
subclass of: Population Group
notation: 339

Anthropometry
type: Class
subclass of: StudyIndicator
definition: Attributes pertaining to the scientific study of the measurements and proportions of the human body.
was approved by: PER-Jeanette-Stingone

curie per liter
type: SIO_000074
notation: curie/l

tebuconazole
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops. Source:ChEBI
notation: TBZ

Recruited In Finland
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q33
comment: A population group of study participants that were recruited in Finland
notation: 600

Life Stage
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Physical And Mental Assessment
comment: A designation assigned to a particular period during a life cycle, generally defined by chronological parameters. (Source: NCI Thesaurus)

High-Performance Liquid Chromatography-Mass Spectrometry
type: Class
subclass of: High-Performance Liquid Chromatography
subclass of: Mass Spectrometer
subclass of: Liquid Chromatography–Mass Spectrometer
definition: Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin. Therefore, LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries.
was approved by: PER-Jim-McCusker

2-4 Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 232
definition: A residential building that contains between two and four apartments, town houses, condos, or other single family dwelling spaces.

2-Thioxothiazolidine-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: TTCA
editorial note: To Do: align with CHEBI.

Interleukin-25
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL17EIL25

Bis(2-butoxyethyl) hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: BBOEP

Lead
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Pb
definition: LEAD is a soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)

Recruited In Germany
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q183
comment: A population group of study participants that were recruited in Germany
notation: 601

5-10 Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 233
definition: A residential building that contains between five and ten apartments, town houses, condos, or other single family dwelling spaces.

2-amnothiazolne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCATC
editorial note: To Do: align with CHEBI.

Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Tandem Mass Spectrometer
subclass of: Liquid Chromatography–Mass Spectrometer
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

Nucleic Acid Sequencing
type: Class
subclass of: SIO_001007

2,4-Dichlorophenoxyacetic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: 2,4-dichlorophenoxyacetic acid is an odorless white to tan solid. Sinks in water. (USCG, 1999) 2,4-Dichlorophenoxyacetic acid (2,4-D) does not occur naturally in the environment. 2,4-D is the active ingredient in many products used in the United States and throughout the world as an herbicide to kill weeds on land and in the water. There are nine forms of 2,4-D that can be used as an herbicide and it is typically sold as a powder or in a liquid form. 2,4-D is a chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines. It has a role as a synthetic auxin, a defoliant, an agrochemical, an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor, an environmental contaminant and a phenoxy herbicide. It is a chlorophenoxyacetic acid and a dichlorobenzene. It is a conjugate acid of a (2,4-dichlorophenoxy)acetate. Source: Pubchem
notation: D24

Cough
type: Class
subclass of: wheezing or tightness in the chest or cough

Emergency Medical Services Facility
type: Class
subclass of: Healthcare Facility

Recruited In Georgia or Florida
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Class
  union of: Restriction
    on property: SIO_000668
    has value: Q1428
  union of: Restriction
    on property: SIO_000668
    has value: Q812
comment: A population group of study participants that were recruited in either Georgia or Florida
notation: 598

Z-Score For Fixed Gestational Age and Sex
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Z-Score
subclass of: Restriction
  some values from: Biological Sex
  on property: RO_0000079
subclass of: Restriction
  some values from: Gestational Age
  on property: RO_0000079
comment: A Z-score computation from a population which all share the same gestational age range and sex assignment

centiMorgan
type: SIO_000074
notation: cM

Gas Chromatographer-Tandem Mass Spectrometer
type: Class
subclass of: Gas Chromatographer–Mass Spectrometer
subclass of: Tandem Mass Spectrometer
definition: MS/MS is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

times per week
type: SIO_000074
type: SIO_000794
notation: times/week

2-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
notation: MHA2
editorial note: To Do: align with CHEBI.

Analysis Mode
type: Class
type: QualityVariable
subclass of: SampleIndicator
definition: Analysis Mode

Value greater than ULOQ
type: Class
subclass of: SIO_001167

beta-cryptoxanthin
type: Class
type: NodeShape
subclass of: Nutrient
comment: A carotenol that exhibits antioxidant activity. It has been isolated from fruits such as papaya and oranges. (Source: ChEBI)
notation: CRYP

immune response
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: SIO_000475

Clinical Observations Severity
type: Class
subclass of: Thing

Observational Cohort Study
type: Class
type: NodeShape
subclass of: SIO_001066

Recruited In Washington State
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q1223
comment: A population group of study participants that were recruited in Washington State
notation: 599

Tris(2-chloroethyl) phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: TCEP

Multi Residence Building
type: Class
type: QualityValue
subclass of: Human Dwelling
subclass of: Residential Building
notation: 231
definition: A residential building that contains more than one apartment, town house, condo, or other single family dwelling space.

Graduated From High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 32
definition: The quality of having graduated from High School
was approved by: PER-Jeanette-Stingone

2-Methylhippuric acid (ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC2MH
editorial note: To Do: align with CHEBI.

Alcohol, Tobacco, and Illicit Drug Use
type: Class
subclass of: StudyIndicator
definition: Alcohol, Tobacco, and Illicit Drug Use Indicator Class
was approved by: PER-Jeanette-Stingone

Value below LLOQ, no LOD provided
type: Class
subclass of: SIO_001167

Fluticasone propionate DPI (Flovent Diskus)
type: Class
subclass of: Asthma Controller Medication

thiamethoxam
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. Source: ChEBI
notation: THX

2,4,5-Trichlorophenoxyacetic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: 2,4,5-trichlorophenoxyacetic acid is a light tan solid (melting point 153 °C). Insoluble in water. Contact may irritate the skin. (2,4,5-trichlorophenoxy)acetic acid is a chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines. It has a role as a defoliant, a synthetic auxin and a phenoxy herbicide. It is a chlorophenoxyacetic acid and a trichlorobenzene. It is a conjugate acid of a (2,4,5-trichlorophenoxy)acetate. An herbicide with strong irritant properties. Use of this compound on rice fields, orchards, sugarcane, rangeland, and other noncrop sites was terminated by the EPA in 1985. (From Merck Index, 11th ed) Source: Pubchem
notation: T245

school
type: Class
type: NodeShape
subclass of: Organization
comment: An educational institution.

Multiracial
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 54
definition: Having ancestors of several or various races.
was approved by: PER-Jeanette-Stingone
editorial note: Not part of current prov for Race. Should we remove this concept?

Type 1 Diabetes and Islet Autoimmunity
type: Class
type: QualityValue
type: NodeShape
subclass of: type 1 diabetes mellitus
subclass of: Islet Autoimmunity
subclass of: Class
  intersection of: type 1 diabetes mellitus
  intersection of: Islet Autoimmunity
comment: The condition of having both Type 1 Diabetes Mellitus and Islet Autoimmunity disease
notation: 644
equivalent class: Class
  intersection of: type 1 diabetes mellitus
  intersection of: Islet Autoimmunity
  equivalent class: Type 1 Diabetes and Islet Autoimmunity

antimalarial
type: Class
subclass of: drug

Private Insurance Other Than Kaiser Permanente
type: Class
type: QualityValue
type: NodeShape
subclass of: Private Insurance
notation: 669
equivalent class: Class
  intersection of: Private Insurance
  intersection of: Class
    complement of: Kaiser Permanente Insurance
  equivalent class: Private Insurance Other Than Kaiser Permanente
disjoint with: Kaiser Permanente Insurance

Parity
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Pregnancy Characteristic
definition: The number of time that a viviparous organism has given birth
was approved by: PER-Jeanette-Stingone

Attribute
type: Class
subclass of: ScienceIndicator

Increased Body Weight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 72
definition: BMI > 25

kilobasepair
type: SIO_000074
notation: kbp

Forceps-Assisted Birth
type: Class
type: QualityValue
subclass of: Vaginal Birth
notation: 25
definition: A vaginal birth with the assistance of forceps to extract the baby.

Oily Fish
type: Class
subclass of: fish
definition: Oily fish are fish that contain at least 2% fat by weight. (Oily Fish. (n.d.) Segen's Medical Dictionary. (2011))

Analyzed at a later date than rest of samples on worksheet (not a repeat)
type: Class
subclass of: SIO_001167

Children's Depression Inventory (Short Version) Score
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Score

Recruited In Colorado
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q1261
comment: A population group of study participants that were recruited in Colorado
notation: 695

centiRay
type: SIO_000074
notation: cR

Sustained Physical Activity
type: Class
type: QualityVariable
subclass of: Physical Activity
definition: Physical activity that is at least 30 minutes in duration.

Foster
type: Class
subclass of: Non-Biological Relative
definition: Fosterage, the practice of a family bringing up a child not their own, differs from adoption in that the child's parents, not the foster-parents, remain the acknowledged parents. In many modern western societies foster care can be organized by the state to care for children with troubled family backgrounds, usually on a temporary basis. In many pre-modern societies fosterage was a form of patronage, whereby influential families cemented political relationships by bringing up each other's children, similar to arranged marriages, also based on dynastic or alliance calculations.

Analyte
type: Class
subclass of: SIO_010004

Questionnaire Administration
type: Class
type: NodeShape
subclass of: SIO_001052

PCB118
type: Class
subclass of: Polychlorobiphenyl
notation: PCB118

Intensive Care Unit
type: Class
type: QualityValue
subclass of: Destination
subclass of: Healthcare Facility
notation: 168
definition: A health care facility unit that provides intensive care to critically ill patients and patients with complex medical problems who require constant monitoring or special therapy.

Triclocarban
type: Class
subclass of: phenol
notation: TCC
definition: Triclocarban is a triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition.

Daughter
type: Class
subclass of: Child
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
definition: The female offspring in relation to her parents.

Annual Income $75,000 to $99,999
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $149,999
notation: 421

Pregnancy Month 6
type: Class
subclass of: SIO_000417
definition: The sixth month of pregnancy

Annual Income $75,000 to $84,999
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 262

parts per hundred
type: SIO_000074
notation: pph

Annual Income $65,000 to $74,999
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 263

Public or No Insurance
type: Class
type: QualityValue
subclass of: Insurance
notation: 335
equivalent class: Class
  union of: Public Insurance
  union of: No Insurance / Self-funded
  equivalent class: Public or No Insurance

Father
type: Class
type: QualityValue
subclass of: Parent
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
notation: 188
definition: The male parent of a child. Besides the paternal bonds of a father to his children, the father may have a parental legal and social relationship with the child that carries with it certain rights and obligations. An adoptive father is a male who has become the child's parent through the legal process of adoption. A biological father is the male genetic contributor to the creation of the baby, through sexual intercourse or sperm donation. A biological father may have legal obligations to a child not raised by him, such as an obligation of monetary support. A putative father is a man whose biological relationship to a child is alleged but has not been established. A stepfather is a male who is the husband of a child's mother and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child.
was approved by: PER-Jeanette-Stingone

hematologic disease
type: Class
type: QualityValue
subclass of: Disease
notation: 404

antepartum hypertension
type: Class
type: QualityValue
type: NodeShape
subclass of: hypertension
notation: 691

3-hydroxyfluorene
type: Class
subclass of: polycyclic hydrocarbon
notation: FLUO3

Process
type: Class
subclass of: ScienceIndicator

pyrimethanil
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine. Source: ChEBI
notation: PYRM

2, 4, 5, 6-Tetrachlorophenol
type: Class
subclass of: phenol
notation: TeCP2456
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)

Annual Income $40,000 to $49,999
type: Class
type: QualityValue
subclass of: Annual Income $35,000 to $49,999
notation: 419

Average Folic Acid Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses Folic Acid Supplement

Annual Income More Than $95,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $70,001
notation: 260

year
type: SIO_000074
notation: y

Triclosan
type: Class
subclass of: phenol
notation: TCS
definition: Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.

parts per million
type: SIO_000074
notation: ppm

beverage food product
type: Class
type: NodeShape
subclass of: food product
comment: A liquid prepared for consumption, or a product that can be combined with water or milk to make one.

Tungsten
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: W
definition: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. TUNGSTEN is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.

2-Aminothiazoline-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: ATCA
editorial note: To Do: align with CHEBI.

Hemoglobin Genotype SS
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
notation: 346

Average B6 Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses B6 Supplement

FLOPO 0000089
type: Class
subclass of: SIO_010056

Annual Income $85,000 to $94,999
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 261

Annual Income $50,000 to $74,999
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 420

Transfer
type: Class
type: QualityValue
subclass of: Destination
notation: 172
definition: The act of conveying or transporting from one place to another.

parts per thousand
type: SIO_000074
notation: ppth

month
type: SIO_000074
notation: m

3-(Diethylcarbamoyl)benzoic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: DCBA

Descendant
type: Class
subclass of: Relative
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Ancestor
    intersection of: SIO_000485
definition: The child of a human, or any grandchild, great-grandchild, and so on.
was approved by: PER-Jeanette-Stingone

2, 3', 4, 4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE66
editorial note: To Do: align with CHEBI.

immune system disease
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 405

micromole
type: SIO_000074
notation: µmol

nanograms per liter
type: SIO_000074
notation: ng/L

Annual Income $20,000 to $29,999
type: Class
type: QualityValue
subclass of: Annual Income $15,000 to $29,999
subclass of: Annual Income $15,001 to $30,000
notation: 417

Uses B6 Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: B6 Vitamin Supplement
  on property: SIO_000139
notation: 334

microampere
type: SIO_000074
notation: µA

behavioral phenotype
type: Class
subclass of: SIO_010056

2, 4, 4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE28
editorial note: To Do: align with CHEBI.

Annual Income $30,000 to $39,999
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $49,999
notation: 418

Never exposed to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure measurement
notation: 259

First
type: Class
subclass of: Thing

Car
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 248

Average Iron Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses Iron Supplement

milliampere
type: SIO_000074
notation: mA

Shannon diversity index
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: community species diversity

Childhood Followup 6
type: Class
subclass of: Study Followup 6
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
definition: A point in a study that occurs after the fifth follow-up point in the study and occurs during the study subject's childhood period.

2, 2', 4, 4', 6-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE100
editorial note: To Do: align with CHEBI.

Benzo[a]pyrene tetraol
type: Class
subclass of: polycyclic hydrocarbon
notation: BAPT

Annual Income $5,000 to $9,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $14,999 or Less
notation: 415

Uses Folic Acid Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: Folic Acid Vitamin Supplement
  on property: SIO_000139
notation: 333

picogram per milliliter
type: SIO_000074
notation: pg/mL

Tris(2-butoxyethyl) phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: TBOEP

colony forming unit
type: SIO_000074
notation: cfu

N,N-diethyl-3-(hydroxymethyl)benzamide
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: DHMB

Home
type: Class
type: QualityValue
subclass of: Destination
notation: 167
definition: A person's place of residence.

2-[(2-Hydroxy-2-methylpropoxy)carbonyl]benzoate
type: Class
type: NodeShape
subclass of: Phthalate
notation: MHIBP

Birth
type: Class
subclass of: SIO_000417
subclass of: Beginning
subclass of: From Birth
subclass of: Restriction
  some values from: Pregnancy
  on property: intervalMetBy
definition: The ending of a pregnancy by one or more babies leaving a woman's uterus by vagina passage or c-section.
was approved by: PER-Jeanette-Stingone

2, 2', 4, 4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE47
editorial note: To Do: align with CHEBI.

B6 Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: vitamin B6
  on property: SIO_000369

1-hydroxypyrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PYR1

Annual Income $10,000 to $19,999
type: Class
type: QualityValue
subclass of: Annual Income $24,999 or Less
notation: 416

Non-Neoplastic Lung Disorder
type: Class
subclass of: SIO_000475

eosinophilic esophagitis
type: Class
subclass of: esophageal disease

SIO_000751
type: QualityValue
notation: 133

Education
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Socioeconomic Status
subclass of: SIO_000026
definition: The act or process of imparting or acquiring knowledge.
was approved by: PER-Jeanette-Stingone

2, 4'-DDT
type: Class
subclass of: Organochlorine Pesticide
notation: OPDDT

Relative Time
type: Class
subclass of: SIO_000391
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Process
definition: A time in relation to an event

ICU Admission By Re-admission Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: ICU Admission
comment: A subclass of ICU Admission; this class is used to distinguish between admissions of patients for the first time versus when a patient is readmitted to the ICU after previously being discharged.

ICU Admission
type: Class
subclass of: Healthcare Facility Admission
subclass of: Restriction
  some values from: Intensive Care Unit
  on property: SIO_000061
comment: The event of admitting some patient into the ICU.

Thallium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Tl
definition: THALLIUM is a heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.

Step Father
type: Class
type: QualityValue
type: NodeShape
subclass of: Father
subclass of: Step Parent
comment: A male that is related to a child or children through marriage to their biological parent. (Source: NCI Thesaurus)
notation: 657

Infinium Methylation EPIC BeadChip Assay
type: Class
subclass of: Microarray Assay
subclass of: Methylation Assay

Cigarettes Per Day Measurement - Asked During Pregnancy
type: Class
type: QuantityVariable
type: NodeShape
subclass of: cigarettes per day measurement

Beats per Minute
type: Class
type: SIO_000074
type: NodeShape
subclass of: counts per minute
comment: The number of heartbeats measured per minute time. [Definition Source: NCI]

Strongly Disagree Crime Makes It Unsafe To Walk In Daytime
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Crime Makes It Unsafe To Walk In Daytime
notation: 495

Interleukin-1 beta
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL1B
definition: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Analysis
type: Class
subclass of: Analyte
definition: The value contains concentrations from the study sample

ICU Readmission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: ICU Discharge
  on property: SIO_000249
subclass of: ICU Admission By Re-admission Status
comment: The event of re-admitting some patient into an ICU after they had previously been discharged.
notation: 373
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: ICU Discharge
    on property: SIO_000249
  equivalent class: ICU Readmission
disjoint with: ICU First Admission

ICU First Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Re-admission Status
subclass of: Class
  complement of: Restriction
    some values from: ICU Discharge
    on property: SIO_000249
comment: This class denotes the first time a patient is admitted to an ICU.
notation: 432
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: ICU Discharge
      on property: SIO_000249
  equivalent class: ICU First Admission
disjoint with: ICU Readmission

Hexachlorobenzene
type: Class
subclass of: Organochlorine Pesticide
notation: HCB

Breast Feeding
type: Class
type: QualityValue
type: NodeShape
subclass of: Feeding Method
comment: The nursing of an infant at the mother's breast. [Definition Source: NCI]
notation: 677

Insurance Type
type: Class
type: QualityVariable
subclass of: Insurance
definition: Insurance Type

FEV1/FVC Ratio
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Departure
type: Class
type: QualityValue
subclass of: Destination
notation: 174
definition: The act of leaving a destination.

Local Shops Are Walkable From Home
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "The local shop(s) are within easy walking distance of my home."

Cigarettes Per Day Measurement - Asked After Pregnancy
type: Class
type: QuantityVariable
type: NodeShape
subclass of: cigarettes per day measurement

hypertension
type: Class
type: QualityValue
subclass of: artery disease
notation: 178

From Birth
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: birthing
definition: A time in relation to a birth

Annual Income $15,000 to $24,999
type: Class
type: QualityValue
subclass of: Annual Income $15,000 to $29,999
notation: 268

Mobile Home
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 247

ICU Admission Not Requiring Blood Transfusion
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Blood Transfusion Status
subclass of: Class
  complement of: Restriction
    some values from: blood transfusion
    on property: SIO_000250
comment: An ICU Admission of a patient that does not require a blood transfusion upon admission.
notation: 431
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: blood transfusion
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Blood Transfusion
disjoint with: ICU Admission Requiring Blood Transfusion

1,1-Bis(4-hydroxyphenyl)cyclohexane
type: Class
subclass of: Phenol
notation: BPZ

Agree Crime Makes It Unsafe To Walk In Daytime
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Crime Makes It Unsafe To Walk In Daytime
notation: 492

Not Frequently Exposed to Second Hand Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Frequency
subclass of: Has Been Exposed to Second Hand Smoke
notation: 569

From Conception
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
definition: A time in relation to a conception

Hospital Readmission
type: Class
subclass of: Hospital Admission
subclass of: Restriction
  some values from: Hospital Discharge
  on property: SIO_000249
comment: The event of re-admitting some patient into a hospital after they had previously been discharged.

Hospital Admission By Admission Type
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class is used to differentiate the reasons for the hospital admission, Medical, Surgical, or Trauma.

ingestion
type: Class
subclass of: SIO_000475

Hospital Readmissions
type: Class
subclass of: SIO_000794
subclass of: Hospital Utilization
definition: An episode when a patient who had been discharged from a hospital is admitted again within a specified time interval.

microeinstein per square meter per second
type: SIO_000074
notation: µeinstein/sm2

Entity
type: Class
subclass of: ScienceIndicator

Disagree Crime Makes It Unsafe To Walk In Daytime
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Crime Makes It Unsafe To Walk In Daytime
notation: 493

Second Hand Smoke Exposure by Indicator Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
comment: A class to identify if a person has been exposed to second hand smoke or has not been exposed to second hand smoke during an implicit time period

bis(1-Chloropropan-2-yl) hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: BCPP

Birth Weight
type: Class
type: QuantityVariable
subclass of: Thing
equivalent class: Class
  intersection of: SIO_000279
  intersection of: Restriction
    on property: SIO_000793
    all values from: Birth
  equivalent class: Birth Weight

Annual Income $35,000 to $44,999
type: Class
type: QualityValue
subclass of: Annual Income $35,000 to $49,999
notation: 266

ICU Admission By Blood Transfusion Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a blood transfusion during their ICU admission versus when they do not.

mass percentage
type: SIO_000074
notation: w/w

Milk Collection Time Point
type: Class
type: NodeShape
subclass of: SIO_000417
comment: A time point after the birth of a child when a mother collects breast milk for analysis.

picosecond
type: SIO_000074
notation: ps

Annual Income $25,000 to $34,999
type: Class
type: QualityValue
subclass of: Annual Income $20,001 to $40,000
subclass of: Annual Income $25,000 to $49,999
notation: 267

Experimental Group
type: Class
type: QualityValue
subclass of: Population Group
notation: 201
definition: A study population that receives the intervention that is the focus of the study.

Beginning
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: SIO_000300
  has value: 1
definition: A time relative to the beginning of an event

Environmental Material
type: Class
subclass of: SIO_010412

ICU Admission Requiring Blood Transfusion
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Blood Transfusion Status
subclass of: Restriction
  some values from: blood transfusion
  on property: SIO_000250
comment: An ICU Admission of a patient that requires a blood transfusion upon admission.
notation: 430
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: blood transfusion
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Blood Transfusion
disjoint with: ICU Admission Not Requiring Blood Transfusion

Measurement
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment

Strongly Agree Crime Makes It Unsafe To Walk In Daytime
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Crime Makes It Unsafe To Walk In Daytime
notation: 494

Less than 11th Grade
type: Class
type: NodeShape
subclass of: High School or Less
comment: The status of completing less than the 11th grade of school

watt per steradian
type: SIO_000074
notation: W/sr

Bis(2-chloroethyl) phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: BCETP

room
type: Class
subclass of: Thing

Alta, Far Northern, and Redwood Coast
type: Class
type: QualityValue
subclass of: Population Group
notation: 336

Mother
type: Class
type: QualityValue
subclass of: Parent
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
notation: 189
definition: A mother is the female parent of a child. Mothers are women who inhabit or perform the role of bearing some relation to their children, who may or may not be their biological offspring. Thus, dependent on the context, women can be considered mothers by virtue of having given birth, by raising their child(ren), supplying their ovum for fertilisation, or some combination thereof. Such conditions provide a way of delineating the concept of motherhood, or the state of being a mother. Women who meet the third and first categories usually fall under the terms 'birth mother' or 'biological mother', regardless of whether the individual in question goes on to parent their child. Accordingly, a woman who meets only the second condition may be considered an adoptive mother, and those who meet only the third a surrogacy mother. The above concepts defining the role of mother are neither exhaustive nor universal, as any definition of 'mother' may differ based on how social, cultural, and religious roles are defined.
was approved by: PER-Jeanette-Stingone

Annual Income $55,000 to $64,999
type: Class
type: QualityValue
subclass of: Annual Income $50,001 to $75,000
subclass of: Annual Income $50,000 to $74,999
notation: 264

sequence_collection
type: Class
type: NodeShape
subclass of: SIO_000030

hour
type: SIO_000074
notation: h

Medical Device
type: Class
type: NodeShape
subclass of: PhysicalInstrument
comment: Any physical object that is useful for prevention, diagnosis, monitoring, or treatment of disease or other conditions. [Definition Source: NCI]

volume percentage
type: SIO_000074
notation: %(v/v)

Difference of Weights
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Weight
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Weight
  on property: SIO_000008
comment: The arithmetic difference of two weights

North Bay
type: Class
type: QualityValue
subclass of: Population Group
notation: 337

Annual Income $45,000 to $54,999
type: Class
type: QualityValue
subclass of: Annual Income $40,001 to $70,000
notation: 265

Son
type: Class
subclass of: Child
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
definition: A son is a male offspring; a boy or man in relation to his parents.

mass volume percentage
type: SIO_000074
notation: (w/v)

minute
type: SIO_000074
notation: min

Duration of Breast Feeding
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Diet and Nutrition
subclass of: PATO_0001309
subclass of: Restriction
  some values from: Breast Feeding
  on property: SIO_000215
comment: The length of time a mother has spent breastfeeding a child

4, 4'-DDE
type: Class
subclass of: Organochlorine Pesticide
notation: PPDDE

hexadecanoic acid
type: Class
subclass of: Fatty Acid
notation: C160
definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Invalid Allergy Test
type: Class
type: QualityValue
subclass of: Invalid Test
subclass of: Allergy Test
notation: 358
equivalent class: Class
  intersection of: Invalid Test
  intersection of: Allergy Test
  equivalent class: Invalid Allergy Test

Crime Makes It Unsafe To Walk In Daytime
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "The level of crime in my neighborhood makes it unsafe to go on walks with my child during the day."

deciliter
type: SIO_000074
notation: dl

Gas Chromatographer–Mass Spectrometer
type: Class
subclass of: Gas Chromatography Instrument
subclass of: Mass Spectrometer
definition: Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification. Like liquid chromatography–mass spectrometry, it allows analysis and detection even of tiny amounts of a substance.
was approved by: PER-Jim-McCusker

micrograms per deciliter
type: SIO_000074
notation: µg/dl

Small clot present
type: Class
subclass of: SIO_001167

Annual Income $14,999 or Less
type: Class
type: QualityValue
subclass of: Annual Income $24,999 or Less
notation: 219

Destination
type: Class
type: QualityVariable
subclass of: Healthcare Access
notation: Dest
definition: A place to which one is traveling or to which something is sent.

Eosinophil Percentage
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Consumed beverages containing probiotics 1 or 2 days per week
type: Class
type: QualityValue
type: NodeShape
subclass of: Probiotic Beverage Consumption Frequency
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 1
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 2
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: days per week
notation: 650

Haptoglobin
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: HAPTOGLOBIN

Consumed beverages containing probiotics 3 or 4 days per week
type: Class
type: QualityValue
type: NodeShape
subclass of: Probiotic Beverage Consumption Frequency
subclass of: Restriction
  on property: SIO_000221
  has value: days per week
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 3
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 4
  on property: SIO_000216
notation: 651

admission diagnosis
type: Class
subclass of: Health Outcome
subclass of: Restriction
  some values from: Admission
  on property: SIO_000687
subclass of: SIO_001331
comment: A medical diagnosis that occurs at admission to a hospital or other medical care provider.

gram per deciliter
type: SIO_000074
notation: g/dl

Allergy
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 279

HPLC with Fluorescence Level Detector
type: Class
subclass of: High-Performance Liquid Chromatography
definition: HPLC paired with a Fluorescence Level Detector. Fluorescence spectroscopy (also known as fluorometry or spectrofluorometry) is a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light. A complementary technique is absorption spectroscopy. In the special case of single molecule fluorescence spectroscopy, intensity fluctuations from the emitted light are measured from either single fluorophores, or pairs of fluorophores.

Slightly hemolyzed
type: Class
subclass of: SIO_001167

Annual Income $15,000 to $29,999
type: Class
type: QualityValue
subclass of: Household Income
notation: 220

Hospital Admission
type: Class
subclass of: Hospitalization
subclass of: Healthcare Facility Admission
subclass of: Restriction
  some values from: Hospital
  on property: SIO_000061
comment: The event of admitting some patient into a hospital.

Recruited At Northwestern University
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q309350
comment: A population group of study participants that were recruited at Northwestern University
notation: 573

Disagree Safe To Walk With Child In Neighborhood Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Disagree
subclass of: Safe To Walk With Child In Neighborhood Response
notation: 489

Invalid Test
type: Class
subclass of: Test
disjoint with: Valid Test

ICU Admission Not Requiring Tracheostomy
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Tracheostomy Status
subclass of: Class
  complement of: Restriction
    some values from: tracheostomy
    on property: SIO_000250
comment: An ICU Admission of a patient that does not require a tracheostomy immediately upon admission.
notation: 429
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: tracheostomy
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Tracheostomy

plastic container
type: Class
type: NodeShape
subclass of: OBI_0000967
comment: Corresponds to FSTA Thesaurus Packaging 2.2.1 Plastic container.

Z-Score
type: Class
subclass of: Anthropometry
definition: A z-score (also known as z-value, standard score, or normal score) is a measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value.

microunits per milliliter
type: SIO_000074
notation: µU/mL

Fast Food Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Eats Fast Food
  on property: SIO_000215
definition: Frequency of Fast Food Consumption.
was approved by: PER-Jeanette-Stingone

Specimen analyzed in singlicate for an assay that requires duplicates
type: Class
subclass of: SIO_001167

Estimated Body Fat Percentage
type: Class
type: QuantityVariable
type: NodeShape
subclass of: SIO_001413
subclass of: Imputed Measurement
subclass of: Restriction
  some values from: CMO_0000302
  on property: SIO_000283
comment: An estimated measure of body fat percentage

Valid Allergy Test
type: Class
type: QualityValue
subclass of: Valid Test
subclass of: Allergy Test
notation: 359
equivalent class: Class
  intersection of: Valid Test
  intersection of: Allergy Test
  equivalent class: Valid Allergy Test

Strongly Disagree Safe To Walk With Child In Neighborhood Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Safe To Walk With Child In Neighborhood Response
notation: 491

ICU Admission By Tracheostomy Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a tracheostomy upon ICU admission versus when they do not.

Fresh Vegetable Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Eats Fresh Vegetables
  on property: SIO_000215
definition: Frequency of Fresh Vegetable Consumption.
was approved by: PER-Jeanette-Stingone

micrograms per meter cubed
type: SIO_000074
notation: µg/m3

Socioeconomic Status
type: Class
subclass of: StudyIndicator
definition: Socioeconomic Status Indicator Class
was approved by: PER-Jeanette-Stingone

Drug, Food, Chemical or Biomedical Material
type: Class
type: NodeShape
subclass of: Thing
comment: An organic or inorganic substance, element, isotope, food or other materials derived from microorganism, plant, or animal sources. They can be used for the prevention, diagnosis, treatment or research of disease states, for industrial purposes, or for the promotion or maintenance of organism viability or health. (Source: NCI Thesaurus)

nitenpyram
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group. Source: ChEBI
notation: NIT

English Language
type: Class
type: QualityValue
subclass of: Acculturation
notation: 243
definition: The English Language

Age at Formula Introduction
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Age
subclass of: Diet and Nutrition
comment: The age at which an infant is first given artificial formula instead of breast milk

Strongly Agree Safe To Walk With Child In Neighborhood Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Agree
subclass of: Safe To Walk With Child In Neighborhood Response
notation: 490

School Breakfast Consumption Frequency
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Eats School Breakfast
  on property: SIO_000215
comment: A measure of the number of times in a given time interval that a person eats breakfast provided at school

Allergy Test
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: Allergy
  on property: SIO_000563

24 Hours Prior to Baseline
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Baseline
  on property: SIO_000668
subclass of: Restriction
  some values from: Study Baseline
  on property: intervalMeets

Element
type: Class
subclass of: Targeted Analyte

Invasive Mechanical Ventilator Assisted Respiration
type: Class
type: NodeShape
subclass of: respiration
subclass of: artificial respiration
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000139
comment: Respiration that requires assistance from an invasive mechanical respirator.
disjoint with: Ventilator Free Respiration

School Lunch Consumption Frequency
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Eats School Lunch
  on property: SIO_000215
comment: A measure of the number of times in a given time interval that a person eats lunch provided at school

Agree Safe To Walk With Child In Neighborhood Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Agree
subclass of: Safe To Walk With Child In Neighborhood Response
notation: 488

Valid Test
type: Class
subclass of: Test
disjoint with: Invalid Test

Ordinal Position
type: Class
subclass of: Thing

Ever Smoked
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 136
definition: The quality of having smoking in the past.
was approved by: PER-Jeanette-Stingone

Control Group
type: Class
type: QualityValue
subclass of: Population Group
notation: 200
definition: A group used as a standard of comparison in a control experiment.

72 kDa type IV collagenase
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MMP2

census
type: Class
type: NodeShape
subclass of: SIO_001052
comment: acquiring and recording information about the members of a given population (Source: Wikidata.org)

Probiotic Beverage Consumption Frequency
type: Class
type: QualityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
subclass of: Restriction
  some values from: Drinks Probiotic Beverage
  on property: SIO_000215
definition: Frequency of Probiotic Beverage Consumption.

Drug Other Than Antimalarial Use
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: drug other than antimalarial
  on property: SIO_000230
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291

Number of Members in Household
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Demographic
subclass of: SIO_000794
subclass of: Restriction
  some values from: Household
  on property: SIO_000215
comment: The number of people living in a household

Sleep Characterisitic
type: Class
subclass of: StudyIndicator
definition: Sleep Characterisitics Indicator Class
was approved by: PER-Jeanette-Stingone

2-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN2

DVD Player Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of devices in the home that play DVDs.
was approved by: PER-Jeanette-Stingone

Waist
type: Class
subclass of: SIO_010046
definition: The waist is the part of the abdomen between the rib cage and hips. On people with slim bodies, the waist is the narrowest part of the torso.

Strongly Disagree Street Traffic Makes It Dangerous To Walk Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Strongly Disagree
subclass of: Street Traffic Makes It Dangerous To Walk Response
notation: 487

Spouse or Significant Other and Adult Child Living In Household Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Spouse or Significant Other Living In Household Currently Smokes
subclass of: Adult Child Living In Household Currently Smokes
notation: 563
equivalent class: Class
  intersection of: Spouse or Significant Other Living In Household Currently Smokes
  intersection of: Adult Child Living In Household Currently Smokes
  equivalent class: Spouse or Significant Other and Adult Child Living In Household Currently Smokes

Ozone
type: Class
subclass of: Environmental Exposure

phenol
type: Class
subclass of: phenols

Spouse or Significant Other and Adult Child and Child Under 18 and Other Adults Living In Household Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Spouse or Significant Other Living In Household Currently Smokes
subclass of: Child Under 18 Living In Household Currently Smokes
subclass of: Adult Child Living In Household Currently Smokes
subclass of: Other Adults Living In Household Currently Smoke
notation: 564
equivalent class: Class
  intersection of: Spouse or Significant Other Living In Household Currently Smokes
  intersection of: Child Under 18 Living In Household Currently Smokes
  intersection of: Adult Child Living In Household Currently Smokes
  intersection of: Other Adults Living In Household Currently Smoke
  equivalent class: Spouse or Significant Other and Adult Child and Child Under 18 and Other Adults Living In Household Currently Smokes

Childhood Followup 3
type: Class
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Childhood Period
subclass of: Study Followup 3
definition: A point in a study that occurs after the second follow-up point in the study and occurs during the study subject's childhood period.

Some College Up To And Including Bachelors Degree
type: Class
type: QualityValue
type: NodeShape
subclass of: Higher Education
notation: 593

Short sample; sample probe picked up incomplete volume first time
type: Class
subclass of: SIO_001167

Diet Treatment Medical Therapy
type: Class
type: QualityValue
subclass of: Medical Therapy Procedure
notation: 26
definition: Diet Treatment is a form of Medical Therapy.
was approved by: PER-Jeanette-Stingone

Test
type: Class
subclass of: AnalyticalMethod

Triphenyl phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: TPHP

Safe To Walk With Child In Neighborhood Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Preschool-age Children's Physical Activity Questionnaire Response
comment: A response to the questionnaire statement "There are sufficient traffic lights or pedestrian crossings to make it safe to walk with my child around my neighborhood."

Childhood Followup 4
type: Class
subclass of: Study Followup 4
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
definition: A point in a study that occurs after the third follow-up point in the study and occurs during the study subject's childhood period.

Eats Fish Sticks
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03311701
  on property: SIO_000369
notation: 225
definition: The attribute of eating fish sticks.

Adopted
type: Class
subclass of: Non-Biological Relative
definition: Adoption is a process whereby a person assumes the parenting of another, usually a child, from that person's biological or legal parent or parents, and, in so doing, permanently transfers all rights and responsibilities, along with filiation, from the biological parent or parents.

2, 2', 4, 4', 5, 6'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE154
editorial note: To Do: align with CHEBI.

Diabetic Ketoacidosis
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 391

Study Emergency Department
type: Class
type: NodeShape
subclass of: Emergency Medical Services Facility
subclass of: Study Location
comment: An emergency department in a hospital at which a study is being conducted

monooxoisononyl phthalate (DiNP)
type: Class
subclass of: Phthalate
notation: MONP

2, 4, 6-Trichlorophenol
type: Class
subclass of: phenol
notation: TCP246
definition: 2 4 6-Trichlorophenol is a synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2, 4, 6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2, 4, 6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05)

Childhood Followup 5
type: Class
subclass of: Study Followup 5
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
definition: A point in a study that occurs after the fourth follow-up point in the study and occurs during the study subject's childhood period.

Ancestor
type: Class
subclass of: Relative
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Descendant
    intersection of: SIO_000485
definition: An ancestor or forebear is a parent or (recursively) the parent of an ancestor (i.e., a grandparent, great-grandparent, great-great-grandparent, and so forth). Ancestor is "any person from whom one is descended. In law the person from whom an estate has been inherited."
was approved by: PER-Jeanette-Stingone

Protein Family
type: Class
type: NodeShape
subclass of: Protein
comment: Collection of proteins that are evolutionarily related. This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP)

Eats Oily Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Oily Fish
  on property: SIO_000369
notation: 226
definition: The attribute of eating oily fish.

clothianidin
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. Source: ChEBI
notation: CLO

2, 2', 4, 4', 5-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE99
editorial note: To Do: align with CHEBI.

Annual Income $4,999 or Less
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $5,000 or Less
notation: 414

terabyte
type: SIO_000074
notation: TB

milligram per deciliter
type: SIO_000074
notation: mg/dl

Do Not Resuscitate Order
type: Class
type: QualityValue
subclass of: Advance Directive
notation: 365

mono-2-ethyl-5-hydroxyhexyl terephthalate (DEHTP)
type: Class
subclass of: Phthalate
notation: MEHHTP

Other Unrelated Female
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_000016
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
comment: A female that has a role as a caregiver for a subject but is not related to the subject.
notation: 664

Spanish Language
type: Class
type: QualityValue
subclass of: Acculturation
notation: 244
definition: The Spanish Language

Intensity Composite Score
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Composite Score
comment: A score that is the composite, summation, or aggregation of multiple measurements of intensity

muscle relaxant
type: Class
subclass of: drug

Eating or Drinking
type: Class
type: QualityVariable
subclass of: Diet Quantity
subclass of: nutrition intake
definition: The act of eating or drinking some food or beverage.

urinary tract infection
type: Class
subclass of: SIO_000475

2, 2', 4, 4', 5, 5'-Hexabromobiphenyl
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: PBB153
editorial note: To Do: align with CHEBI.

3-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: BCP3

Biological Sex
type: Class
type: QualityVariable
subclass of: Demographic

Neptunium
type: Class
subclass of: Metal
notation: Np
definition: Neptunium. A radioactive element of the actinide metals family. NEPTUNIUM has the atomic symbol Np, atomic number 93, and atomic weight 237.

pneumonia
type: Class
type: QualityValue
subclass of: lung disease
notation: 195

Operating Room
type: Class
type: QualityValue
subclass of: Destination
notation: 171
definition: A room in a health care facility equipped for the performance of surgical operations and procedures.

Childhood Followup 3
type: Class
subclass of: Study Followup 3
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
definition: A point in a study that occurs after the second follow-up point in the study and occurs during the study subject's childhood period.

Other Unrelated Male
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_000016
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
comment: A male that has a role as a caregiver for a subject but is not related to the subject.
notation: 665

sequence_feature
type: Class
subclass of: SIO_000030

Early Childhood
type: Class
type: NodeShape
subclass of: Childhood
subclass of: Life Stage
comment: A human life stage that begins at two years of age and continues until five complete years of age. [Definition Source: NCI][attribution: NICHD]

3-hydroxychrysene
type: Class
subclass of: polycyclic hydrocarbon
notation: CHRY3

Eats Rice
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03301641
  on property: SIO_000369
notation: 224
definition: The attribute of eating rice.

2, 2', 4, 4', 5, 5'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE153
editorial note: To Do: align with CHEBI.

cells per milliliter
type: SIO_000074
notation: cells per ml

Hospital Admission From Study Emergency Department
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Admission Source
comment: An admission from an emergency department into a hospital where a clinical study is being conducted, and the subject admitted is participating in the study.
notation: 435
disjoint with: Hospital Admission Not From Study Emergency Department

Middle Childhood
type: Class
type: NodeShape
subclass of: Childhood
subclass of: Life Stage
comment: A human life stage that begins at six years of age and continues until eleven complete years of age. [Definition Source: NCI][attribution: NICHD]

Plutonium
type: Class
subclass of: Metal
notation: Pu
definition: Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.

Malaria
type: Class
type: QualityValue
subclass of: Disease
notation: 121
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

parasites per microgram
type: SIO_000074
notation: parasites/µL

Other Female Relative
type: Class
type: QualityValue
type: NodeShape
subclass of: Relative
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
comment: A female relative that is not a mother, aunt, cousin, or grandmother.
notation: 662

Recruited At University Of Utah
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q168515
comment: A population group of study participants that were recruited at University of Utah
notation: 597

Annual Income More Than $100,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $95,000
notation: 223

atrazine
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group. Source: ChEBI
notation: ATZ

1-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: BCP1

Omalizumab (Xolair)
type: Class
subclass of: Asthma Controller Medication

millimole per liter
type: SIO_000074
notation: mmol/L

Specimen analyzed with less than usual dilution
type: Class
subclass of: SIO_001167

Polychlorobiphenyl
type: Class
subclass of: Targeted Analyte
notation: SPCB

Frequency Composite Score
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Composite Score
comment: A score that is the composite, summation, or aggregation of multiple frequency measurements

Edinburgh Postnatal Depression Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: A 10-item, self-rating questionnaire designed to screen postpartum women for indications of depression. (Source: NCI Thesaurus)

Other Male Relative
type: Class
type: QualityValue
type: NodeShape
subclass of: Relative
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
comment: A male relative that is not a father, uncle, cousin, or grandfather.
notation: 663

katal per liter
type: SIO_000074
notation: kat/l

2-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: BCP2

Difference of Weight-to-Length Z-Scores from 0 to 6 Months
type: Class
type: QuantityVariable
subclass of: Difference of Z-Scores
definition: The arithmetic difference between the weight-to-length Z-scores for a child taken at birth and at six months.

milligram per gram
type: SIO_000074
notation: mg/g

Specimen analyzed with less than normal quantity
type: Class
subclass of: SIO_001167

katal per cubic meter
type: SIO_000074
notation: kat/m3

Consumed beverages containing probiotics 5 or 6 days per week
type: Class
type: QualityValue
type: NodeShape
subclass of: Probiotic Beverage Consumption Frequency
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 5
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 6
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: days per week
notation: 652

Recruited At University Of California, Irvine
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q868421
comment: A population group of study participants that were recruited at University of California, Irvine
notation: 697

thiacloprid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen. Source: ChEBI
notation: THI

Measurement
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment

Health Maintenance Organization Insurance
type: Class
type: QualityValue
subclass of: Insurance
notation: 49

milliliter per liter
type: SIO_000074
notation: ml/l

Annual Income $30,000 to $49,999
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $60,000
notation: 221

mono-2-ethyl-5- carboxypentyl terephthalate (DEHTP)
type: Class
subclass of: Phthalate
notation: MECPTP

Surface-Induced Dissociation (SID)
type: Class
subclass of: TandemMassSpectrometry

Body Mass Index
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Anthropometry
subclass of: Class
  intersection of: Restriction
    some values from: Height
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: SIO_000279
    on property: wasDerivedFrom
definition: A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length
was approved by: PER-Jeanette-Stingone
editorial note: Should we note that this is derived from height and weight? JS: I think so

Recruited At University Of Pennsylvania
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
subclass of: Restriction
  on property: SIO_000668
  has value: Q49117
comment: A population group of study participants that were recruited at University of Pennsylvania
notation: 698

Consumed beverages containing probiotics all days of the week
type: Class
type: QualityValue
type: NodeShape
subclass of: Probiotic Beverage Consumption Frequency
subclass of: Restriction
  on property: SIO_000221
  has value: days per week
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 7
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 7
  on property: SIO_000216
notation: 653

Nornicotine
type: Class
subclass of: Tobacco Metabolite
notation: NORN

milliliter per cubic meter
type: SIO_000074
notation: ml/m3

1-hydroxybenz[a]anthacene
type: Class
subclass of: polycyclic hydrocarbon
notation: BAA1
editorial note: Only found in one journal article, no where else. Maybe mis-spelled?

Annual Income $50,000 to $99,999
type: Class
type: QualityValue
subclass of: Household Income
notation: 222

million parts per microgram
type: SIO_000074
notation: x106 µL

Study Baseline
type: Class
subclass of: SIO_000417
definition: Point in study set to initial point.

rs2292239
type: Class
type: NodeShape
subclass of: SNP

Autism Spectrum Disorder related condition
type: Class
type: QualityValue
subclass of: Developmental Disorder of Mental Health
notation: 150
definition: Quality refers to children who do not meet DSM criteria for ASD but have scores on ADOS and Mullens that suggest related outcome. All potential options seems to fall under this class from the Autism Ontology

experimentally modified cell in vitro
type: Class
subclass of: Cell

mono benzyl phthalate (BzBP)
type: Class
subclass of: Phthalate
notation: MBZP

FEF 25-75 Percent Predicted Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FEF 25-75 value divided by the expected or predicted FEF 25-75 value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPHE
editorial note: To Do: align with CHEBI.

Uncle
type: Class
type: QualityValue
subclass of: Relative
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
notation: 192
definition: The brother of your father or mother or the husband of your aunt.

Spontaneous Labor and Birth
type: Class
type: QualityValue
type: NodeShape
subclass of: Birth Outcome
comment: Initiation of labor without the use of pharmacological and/or mechanical interventions, resulting in a non-operative vaginal birth. (reVITALize) [Definition Source: NCI][attribution: NICHD]
notation: 609

Raw Score
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Score

Duration of Steroid Treatment
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Steroid Treatment
  on property: SIO_000215
comment: The length of time a patient is receiving steroids as a medical treatment

1-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN1

siemens
type: SIO_000074
notation: 1/AV

total calorie intake rate
type: Class
subclass of: CMO_0002248
comment: The entire number of calories consumed by an organism per unit time, regardless of source.

Tanner Scale For Breast Development (Assigned By Child's Mother)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: A rating of the Tanner Scale for Breast Development as assigned by the child's mother

cardiovascular system disease
type: Class
subclass of: Comorbidity Disease

Grandfather
type: Class
type: QualityValue
subclass of: Ancestor
notation: 682
definition: The father of your father or mother.

Duration of Chest Tube Placement
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: Chest Tube Placement
  on property: SIO_000215
comment: The length of time a patient has a chest tube placed in their chest cavity as a medical procedure

N-acel-S-(1, 2-dichlorovinl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC1DC
editorial note: To Do: align with CHEBI.

Functional Status Score
type: Class
subclass of: Score
comment: Functional Status Score (FSS) includes six domains with a scale from 1-5 with one being normal and 5 being very severely dysfunctional. A change would represent a new morbidity for the patient after ICU admission.1 (normal) to 6 (severely dysfunctional). FSS Score Reference: Pollack, M et al. The functional status score (FSS): a new pediatric outcome measure. Pediatrics, 2009. 124(1):18-28.

o-Xylene
type: Class
subclass of: Volatile Organic Compound
notation: OXY
definition: O-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)

Tanner Scale For Genital Development (Assigned By Child's Mother)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: A rating of the Tanner Scale for Genital Development as assigned by the child's mother

Triethyl phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
comment: Triethyl phosphate appears as a colorless, corrosive liquid. Combustible. Slowly dissolves in water and sinks in water. Severely irritates skin, eyes and mucous membranes. (Source: Pubchem)
notation: TEP

mono-n-butylphthalate (BzBP, DnBP)
type: Class
subclass of: Phthalate
notation: MnBP

N-ac-S-(2-carbmo-2-hydxel)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCGAM
editorial note: To Do: align with CHEBI.

Grandmother
type: Class
type: QualityValue
subclass of: Ancestor
notation: 190
definition: The mother of your father or mother.

FVC Percent Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FVC value divided by the expected or predicted FVC value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Tobacco Related Exposure
type: Class
subclass of: Thing

Duration of Invasive Mechanical Ventilation
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000215

electronvolt
type: SIO_000074
notation: eV

curie
type: SIO_000074
notation: Ci

Aunt
type: Class
type: QualityValue
subclass of: Relative
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
notation: 191
definition: The sister of your father or mother or the wife of your uncle.

FEV1 Percent Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FEV1 value divided by the expected or predicted FEV1 value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB3
editorial note: To Do: align with CHEBI.

Monocyclohexyl phthalate
type: Class
subclass of: Phthalate
notation: MCHP

Duration of Ventilator Free Respiration
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: PATO_0001309
subclass of: Restriction
  some values from: Ventilator Free Respiration
  on property: SIO_000215
comment: The length of time a patient is able to breathe without aid of mechanical ventilation.

Tanner Breast Development Stage I
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: no glandular tissue: areola follows the skin contours of the chest (prepubertal) (typically age 10 and younger) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 573

becquerel
type: SIO_000074
notation: Bq

watt per meter kelvin
type: SIO_000074
notation: W/mK

High-Performance Liquid Chromatography
type: Class
subclass of: Liquid Chromatography Instrument
definition: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out the column.
was approved by: PER-Jim-McCusker

First Void Urination
type: Class
type: QualityValue
subclass of: Urination
notation: 356

Spirometry Outcomes Did Not Meet Guidelines
type: Class
type: QualityValue
subclass of: Spirometry Outcome
subclass of: Restriction
  some values from: SIO_001310
  on property: SIO_000217
notation: 281

Daily Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 157

volt per meter
type: SIO_000074
notation: V/m

Interleukin-6
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL6
definition: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

chronic kidney disease
type: Class
subclass of: Comorbidity Disease

Sputum
type: Class
subclass of: Bodily Fluid
definition: Matter ejected from the lungs, bronchi, and trachea, through the mouth. [database_cross_reference: Dorlands_Medical_Dictionary:MerckSource]

Significant Other
type: Class
type: QualityValue
type: NodeShape
subclass of: Marital Status
comment: A gender-neutral term for a person's partner in an intimate or romantic relationship without disclosing or presuming marital status or sexual orientation. [Definition Source: NCI]
notation: 451

Has taken asthma control medications
type: Class
type: QualityValue
subclass of: Asthma Controller Use
notation: 282
disjoint with: Never takes asthma control medications

4-(Ethoxycarbonyl)benzoic acid
type: Class
type: NodeShape
subclass of: Phthalate
notation: METP

Occasional Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 158

First Void Urine
type: Class
type: QualityValue
subclass of: urine
subclass of: Restriction
  some values from: First Void Urination
  on property: SIO_000312
notation: 357

N-Acetyl-S-(trichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: TCVMA
editorial note: To Do: align with CHEBI.

electric field strength unit
type: SIO_000074
notation: Efs

Gray
type: SIO_000074
notation: Gy

esophageal disease
type: Class
subclass of: Disease

saliva
type: Class
subclass of: Bodily Fluid
definition: A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions. [database_cross_reference: http://en.wikipedia.org/wiki/Saliva][database_cross_reference: GO:0046541]

3-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN3

blood plasma
type: Class
subclass of: Blood Component
definition: The liquid component of blood, in which erythrocytes are suspended. [database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Mono-n-octyl phthalate
type: Class
subclass of: Phthalate
notation: MOP

infection
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: SIO_000475

Floor Type
type: Class
type: QualityVariable
subclass of: Housing Characteristic
subclass of: SIO_000004
definition: Type of material that makes up the floor.
was approved by: PER-Jeanette-Stingone

millisievert
type: SIO_000074
notation: mSv

Annual Income $30,000 to $60,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 349

Occasional E-Cigarette Use
type: Class
type: QualityValue
subclass of: E-Cigarette Use
notation: 155

Spirometry Outcome
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Respiratory System Findings Original Result
subclass of: Restriction
  some values from: NCIT C85397
  on property: SIO_001157

sievert
type: SIO_000074
notation: Sv

Cyclohexane-1,2-dicarboxylic acid mono carboxyisooctyl ester (DINCH)
type: Class
subclass of: Phthalate
notation: MCOCH

Perfluorononanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFNA

carotid artery intima media thickness
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: SIO_000043
comment: quantification of the thickness of tunica intima and tunica media, the innermost two layers of the wall of the carotid artery, usually by carotid ultrasound

Gravida
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Pregnancy Characteristic
definition: Pregnancy Count, regardless of whether pregnancy was carried to Term.
was approved by: PER-Jeanette-Stingone

Annual Income More Than $60,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 350

Daily E-Cigarette Use
type: Class
type: QualityValue
subclass of: E-Cigarette Use
notation: 156

Spirometry Outcomes Met Guidelines
type: Class
type: QualityValue
subclass of: Spirometry Outcome
subclass of: Restriction
  some values from: SIO_001312
  on property: SIO_000217
notation: 280

absorbance unit
type: SIO_000074
notation: AU

roentgen
type: SIO_000074
notation: Roentgen

Abnormality of the musculoskeletal system
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 386

1, 2-Dichloroethane
type: Class
subclass of: Volatile Organic Compound
notation: DE12
definition: Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)

Sodium perfluorodecanesulfonate
type: Class
type: NodeShape
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFDS

Tanner Genital Development Stage II
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: testicular volume between 1.6 and 6 ml; skin on scrotum thins, reddens and enlarges; penis length unchanged (9–11) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 581

DERP1 Dust Mite Allergen
type: Class
subclass of: Allergen

Functional Status Total Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Functional Status Score

Demographic
type: Class
subclass of: StudyIndicator
definition: Demographics are quantifiable characteristics of a given population.
was approved by: PER-Jeanette-Stingone
editorial note: SDD-2016-1431-P01_SG_Dictionary_SDD_v1.xlsx

Drug History
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 14

kilogram per square meter
type: SIO_000074
notation: kg/m2

Perfluorooctanoic acid (sum of branched isomers)
type: Class
type: NodeShape
subclass of: Perfluorooctanoic acid
notation: SBPFOA

Strongly Disagree
type: Class
type: NodeShape
subclass of: Disagree
comment: Intensely at odds. [Definition Source: NCI]

Functional Status Total Score 3 or Above
type: Class
type: QualityValue
subclass of: Functional Status Total Score
notation: 368

DERF1 Dust Mite Allergen
type: Class
subclass of: Allergen

Dental Fillings
type: Class
type: QualityValue
subclass of: Oral Health
notation: 13

neural cell
type: Class
subclass of: Cell

rs4948088
type: Class
type: NodeShape
subclass of: SNP

candela per square meter
type: SIO_000074
notation: cd/m2

Number of A minor alleles for rs689
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs689
  on property: SIO_000215

Perfluorooctanesulfonic acid (linear isomer only)
type: Class
type: NodeShape
subclass of: Perfluorooctanesulfonic acid
notation: NPFOS

Strongly Agree
type: Class
type: NodeShape
subclass of: Agree
comment: Intense concurrence. [Definition Source: NCI]

Non-Biological Relative
type: Class
subclass of: Relative
definition: People that are considered relatives but are not related by blood. This includes relatives by marriage, adoption, or fosterage.

Functional Status Feeding Score
type: Class
subclass of: Functional Status Score

Annual Income $24,999 or Less
type: Class
type: QualityValue
subclass of: Household Income
notation: 444

Mouse Allergen
type: Class
subclass of: Allergen

Developmental Quality
type: Class
type: QualityVariable
subclass of: SIO_000475
definition: Refers to which stage of development a person is in.
was approved by: PER-Jeanette-Stingone

Gas Chromatography Instrument
type: Class
subclass of: Chromatography Instrument
definition: Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.
was approved by: PER-Jim-McCusker

blood monocyte count
type: Class
subclass of: SIO_000794

gram per mole
type: SIO_000074
notation: g/mol

MMM Intervention Group
type: Class
type: NodeShape
subclass of: Population Group
comment: A group or cohort who are included in a multi-component, multi-level, multi-setting intervention

Tanner Breast Development Stage V
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: breast reaches final adult size; areola returns to contour of the surrounding breast, with a projecting central papilla. (15+) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 569

cyprodinil
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A member of the class of aminopyrimidine that is N-phenylpyrimidin-2-amine carrying additional cyclopropyl and methyl substituents at positions 4 and 6 respectively. A broad spectrum fungicide used to control a range of pathogens including Tapesia yallundae, Botrytis spp., Alternaria spp. and Rhynchospium secalis. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds as well as most aquatic organisms and earthworms, but it is not considered toxic to honeybees. Source: ChEBI
notation: CYP

Functional Status Respiratory Status Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Functional Status Score

Bedroom Dust
type: Class
subclass of: Allergen
subclass of: dust

Annual Income $25,000 to $49,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Household Income
notation: 445

septic shock
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Detectable
type: Class
subclass of: SIO_001167

Fibrinogen Assay (Clauss method)
type: Class
subclass of: SIO_001007

kilogram per mole
type: SIO_000074
notation: kg/mol

9-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN9

Blood Eosinophil Count
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

phenols
type: Class
type: NodeShape
subclass of: Phenol

Perfluorooctanoic acid (linear isomer only)
type: Class
type: NodeShape
subclass of: Perfluorooctanoic acid
notation: NPFOA

Tanner Genital Development Stage I
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: testicular volume less than 1.5 ml; small penis (prepubertal; typically age 9 and younger) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 580

No Formal Education
type: Class
type: QualityValue
subclass of: Education
notation: 57
definition: Has not been educated in a formal setting.
was approved by: PER-Jeanette-Stingone

Dog Allergen
type: Class
subclass of: Allergen

Functional Status Communication Score
type: Class
subclass of: Functional Status Score

Does Not Use Antibiotics During Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Antibiotic Use
subclass of: Class
  complement of: Restriction
    some values from: Uses Antibiotics
    on property: SIO_000325
comment: This class indicates when a patient does not antibiotics during a hospital admission. The patient may have used antibiotics prior to hospital admission or after discharge.
notation: 442
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Class
    complement of: Restriction
      some values from: Uses Antibiotics
      on property: SIO_000325
  equivalent class: Does Not Use Antibiotics During Hospital Admission
disjoint with: Uses Antibiotics During Hospital Admission

Occupation
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000016
subclass of: Socioeconomic Status
definition: An individual attribute that is the usual or principal work or business of an individual.
was approved by: PER-Jeanette-Stingone

birthing
type: Class
subclass of: Birth Outcome

Tanner Breast Development Stage III
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: breast begins to become more elevated, and extends beyond the borders of the areola, which continues to widen but remains in contour with surrounding breast (11.5–13) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 571

Employment not in Medical Field
type: Class
type: QualityValue
type: NodeShape
subclass of: Employment
comment: The status of being employed but not in a medical field
notation: 448
disjoint with: Employment in Medical Field

propiconazole
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds. Source: ChEBI
notation: PRPCN

No Insurance / Self-funded
type: Class
type: QualityValue
subclass of: Private Insurance or Self Pay
subclass of: Public or No Insurance
notation: 89

Functional Status Motor Functioning Score
type: Class
subclass of: Functional Status Score

Cat Allergen
type: Class
subclass of: Allergen

blood lymphocyte count
type: Class
subclass of: SIO_000794

cubic meter per mole
type: SIO_000074
notation: m3/mol

Disagree
type: Class
type: NodeShape
subclass of: Agreement Answer
comment: To be at odds. [Definition Source: NCI]

Tanner Breast Development Stage IV
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: increased breast sizing and elevation; areola and papilla form a secondary mound projecting from the contour of the surrounding breast (13–15) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 568

N-acetyl-S-(2-cyanoethyl)-L-cyst(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCCYM
editorial note: To Do: align with CHEBI.

Annual Income $5,000 or Less
type: Class
type: QualityValue
subclass of: Annual Income $14,999 or Less
notation: 159
definition: Personal or family annual income at or below $5,000

Competitive-inhibition enzyme-linked immunosorbent assay
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)

Functional Status Mental Status Score
type: Class
subclass of: Functional Status Score

Uses Antibiotics During Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Antibiotic Use
subclass of: Restriction
  some values from: Uses Antibiotics
  on property: SIO_000325
comment: This class indicates when a patient is using antibiotics during a hospital admission. The use of the antibiotics may precede the hospital admission, extend beyond hospital discharge, or occur wholly within the hospital admission.
notation: 441
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Restriction
    some values from: Uses Antibiotics
    on property: SIO_000325
  equivalent class: Uses Antibiotics During Hospital Admission
disjoint with: Does Not Use Antibiotics During Hospital Admission

Admission
type: Class
subclass of: Thing

Biological Mother
type: Class
type: QualityValue
type: NodeShape
subclass of: Mother
subclass of: Biological Parent
comment: A female who contributes to the genetic makeup of her offspring from the fertilization of her ovum. (Source: NCI Thesaurus)
notation: 654

Tanner Scale For Male Pubic Hair Development (Assigned By Child's Mother)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: A rating of the Tanner Scale for Male Pubic Hair Development as assigned by the child's mother

Agree
type: Class
type: NodeShape
subclass of: Agreement Answer
comment: To concur. [Definition Source: NCI]

Annual Income $5,001 to $15,000
type: Class
type: QualityValue
subclass of: Annual Income $24,999 or Less
notation: 160
definition: Personal or family annual income bwtween $5,001 and $15,000

health status
type: Class
subclass of: Thing

Nicotine (total)
type: Class
subclass of: Tobacco Metabolite
notation: NICT
editorial note: To Do: align with CHEBI.

hospital-acquired infection
type: Class
subclass of: infection

Common Era
type: Class
subclass of: Relative Time
definition: Common era time measurements are referenced against (in relation to) the beginning of the common era, 1 CE (or 1 AD).
equivalent class: Restriction
  on property: inRelationTo
  has value: First Year of the Common Era
  equivalent class: Common Era

Functional Status Sensory Functioning Score
type: Class
subclass of: Functional Status Score

Hospital Admission By Antibiotic Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class differentiates between when a patient uses antibiotics at any time during a hospital admission versus when they do not.

Other Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 325

Tanner Breast Development Stage II
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Breast Development
comment: breast bud forms, with small area of surrounding glandular tissue; areola begins to widen (10–11.5) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 570

Birth Order
type: Class
type: QualityVariable
subclass of: Birth Outcome

A minor allele for rs10517086
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs10517086
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs10517086
    on property: SIO_000272
  equivalent class: A minor allele for rs10517086

Annual Income $10,000 to $14,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $14,999 or Less
subclass of: Annual Income $5,001 to $15,000
subclass of: Annual Income $10,000 to $19,999
notation: 517

Female Caregiver
type: Class
type: NodeShape
subclass of: Caregiver
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
comment: A caregiver that identifies as female

2-Chlorophenol
type: Class
subclass of: phenol
notation: MCP2
definition: 2-chlorophenol is a colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g / cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).

Native Hawaiian or Other Pacific Islander
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 55
definition: A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands.
was approved by: PER-Jeanette-Stingone

Education Grade 3
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 115
definition: Finished grade 3

Competitive Immunoassay
type: Class
subclass of: Immunoassay

Education Grade
type: Class
type: QualityVariable
subclass of: Education
definition: The highest grade of education achieved
was approved by: PER-Jeanette-Stingone

Colorimetric Assay
type: Class
subclass of: SIO_001007

Questionnaire
subclass of: Restriction
  some values from: SIO_000085
  on property: SIO_000059
subclass of: Restriction
  on property: SIO_000059
  min qualified cardinality: 1
  on class: SIO_000085
subclass of: Restriction
  some values from: Questionnaire Response
  on property: SIO_000059
subclass of: Restriction
  on property: SIO_000059
  min qualified cardinality: 1
  on class: Questionnaire Response

Trans-generational
type: Class
type: NodeShape
subclass of: Life Stage

Annual Income $15,000 to $19,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $15,000 to $24,999
notation: 518

A minor allele for rs4948088
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs4948088
  on property: SIO_000272
subclass of: Restriction
  some values from: rs4948088
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs4948088
    on property: SIO_000272
  equivalent class: A minor allele for rs4948088
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs4948088
    on property: SIO_000272
  equivalent class: A minor allele for rs4948088

Female Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 324

Color Object Association Test
type: Class
subclass of: Neurocognitive Assessment
definition: a reliable and a valid measure of declarative memory for healthy children ages 18-36 months, living in a disadvantaged community

Cold Vapor Atomic Fluorescence Spectroscopy Instrument
type: Class
subclass of: Atomic Fluorescence Spectroscopy Instrument
definition: Used in the measurement of trace amounts of volatile heavy metals such as mercury, cold vapour AFS makes use of the unique characteristic of mercury that allows vapour measurement at room temperature.
was approved by: PER-Jim-McCusker

Education Grade 5
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 117
definition: Finished grade 5

Elective Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 19
definition: A caesarian section that was chosen by the mother but was not medically necessary.

Interleukin-2
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL2

blood c-reactive protein level by high sensitivity measurement
type: Class
type: NodeShape
subclass of: CMO_0003160
subclass of: Restriction
  some values from: High Sensitivity C-Reactive Protein Measurement
  on property: SIO_001157

Alternaria Allergen
type: Class
subclass of: Allergen
subclass of: Alternaria

Electronic Health Records
type: Class
type: NodeShape
subclass of: SIO_001027
comment: Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online CONSUMER HEALTH INFORMATION that is relevant to the health conditions and treatments related to a specific patient. (Source: Medical Subject Headings Ontology)

Master's Degree
type: Class
type: QualityValue
subclass of: Completed Graduate School
notation: 143
definition: The Master's Degree is an award that requires the successful completion of a program of study of at least the full-time equivalent of 1 but not more than two academic years of work beyond the bachelor's degree.

Sneeze
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.

Education Grade 1
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 113
definition: Finished grade 1

Cyclomicrons present
type: Class
subclass of: SIO_001167

flonicamid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A pyridinecarboxamide that is nicotinamide substituted by a trifluoromethyl group at position 4 and a cyanomethyl group at the carbamoyl nitrogen atom. Source: ChEBI
notation: FLNC

Completed Graduate School
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Postgraduate
comment: Completed graduate school
notation: 504

A minor allele for rs2476601
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs2476601
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs2476601
    on property: SIO_000272
  equivalent class: A minor allele for rs2476601

square meter
type: SIO_000074
notation: m2

Male Caregiver
type: Class
type: NodeShape
subclass of: Caregiver
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
comment: A caregiver that identifies as male

C minor allele for rs2816316
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs2816316
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs2816316
    on property: SIO_000272
  equivalent class: C minor allele for rs2816316

Cockroach Allergen
type: Class
subclass of: Allergen

Hair
type: Class
subclass of: Tissue
definition: A filament, mostly protein, that grows from follicles found in the dermis[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Hair]

Interleukin-13
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL13

Conceiving
type: Class
subclass of: SIO_000587
comment: to become pregnant with a child.

Education Grade 2
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 114
definition: Finished grade 2

cigarettes per day measurement
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 152

Other Caregiver
type: Class
type: NodeShape
subclass of: Caregiver
comment: An alternate or additional caregiver for a dependent person

platelet count
type: Class
subclass of: SIO_000794

ventilator supporting therapy
type: Class
type: QualityValue
subclass of: SIO_001398
comment: Medical procedures that support life systems when a patient is receiving invasive ventilation treatments.
notation: 383

Endotoxin Allergen
type: Class
subclass of: Allergen
subclass of: Endotoxin

folic acid
type: Class
subclass of: CHEBI_24431

Benzyl paraben
type: Class
subclass of: Paraben
notation: BzPB
definition: Benzylparaben is a Standardized Chemical Allergen. The physiologic effect of benzylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of benzylparaben is Allergens.

Sample Collection
type: Class
subclass of: SIO_000417
subclass of: Activity
subclass of: Restriction
  some values from: SIO_001050
  on property: RO_0004009
comment: An event in which some sample is collected for measurement or analysis
definition: Collection Date of Sample
was approved by: PER-Jeanette-Stingone

Atomic Emission Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

cancer
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 381

square millimeter
type: SIO_000074
notation: mm2

A minor allele for rs689
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs689
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs689
    on property: SIO_000272
  equivalent class: A minor allele for rs689

Universal Pesticide Metabolite in Urine
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: UPEST2

Aspergillus Allergen
type: Class
subclass of: Allergen
subclass of: Aspergillus

Chromatography Instrument
type: Class
subclass of: PhysicalInstrument
definition: Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate. The separation is based on differential partitioning between the mobile and stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation.
was approved by: PER-Jim-McCusker

Atomic Absorption Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

minor polymorphic allele
type: Class
type: NodeShape
subclass of: polymorphic allele
comment: A polymorphic allele that is not present at the highest frequency among all fixed variants at the locus (i.e. not the major polymorphic allele at a given location).

Conception
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Beginning
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
definition: When a sperm fertilizes an egg
was approved by: PER-Jeanette-Stingone

white blood cell count
type: Class
subclass of: SIO_000794

square centimeter
type: SIO_000074
notation: cm2

Mammary Gland Tissue
type: Class
type: NodeShape
subclass of: Tissue
subclass of: Restriction
  some values from: UBERON_0000310
  on property: SIO_000068
comment: The glandular tissue of the breast. In females, it is composed of numerous lobules with alveolar ducts and alveoli. In males, it is composed of rudimentary glands. (Source: NCI Thesaurus)

Organochlorine Pesticide
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: SOC

G minor allele for rs231775
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs231775
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs231775
    on property: SIO_000272
  equivalent class: G minor allele for rs231775

Tanner Scale For Pubic Hair Development
type: Class
type: NodeShape
subclass of: Tanner Scale

Medical Related Hospital Admission
type: Class
type: QualityValue
subclass of: Hospital Admission By Admission Type
notation: 375

Blinded Season 4 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 301

all-cis-5, 8, 11, 14, 17-icosapentaenoic acid
type: Class
subclass of: Fatty Acid
notation: C205N3
definition: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.

Interleukin-12 subunit alpha
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL12P70

Collision-Induced Dissociation (CID)
type: Class
subclass of: TandemMassSpectrometry

major polymorphic allele
type: Class
type: NodeShape
subclass of: polymorphic allele
comment: A polymorphic allele that is present at the highest frequency relative to other polymorphic variants at the same genomic location.

Biospecimen
type: Class
subclass of: SIO_010412
definition: A biological laboratory specimen held by a biorepository for research. Such a specimen would be taken by sampling so as to be representative of any other specimen taken from the source of the specimen. When biological specimens are stored, ideally they remain equivalent to freshly-collected specimens for the purposes of research.

native cell
type: Class
subclass of: Cell

gram per cubic centimeter
type: SIO_000074
notation: g/cm3

Organophosphorus Flame Retardant
type: Class
type: NodeShape
subclass of: flame retardant
notation: UOPFR

GO_0016265
deprecated: true

Nitric Oxide Ventilation
type: Class
subclass of: Restriction
  some values from: Nitric Oxide
  on property: SIO_000139
subclass of: ventilator supporting therapy
subclass of: artificial respiration
comment: The administration of nitric oxide gas via artificial ventilation mechanisms.

Allergen
type: Class
subclass of: Environmental Exposure
subclass of: Allergen
subclass of: allergen

polymorphic allele
type: Class
type: NodeShape
subclass of: allele
comment: An allele that is fixed in a population at some stable level, typically > 1%. Polymorphic alleles reside at loci where more than one version exists at some significant frequency in a population. (source: PMID: 25741868 ACMG Guidelines)

College Graduate
type: Class
type: QualityValue
subclass of: Higher Education
subclass of: College Graduate or Higher
notation: 12
definition: The quality of having graduated from College
was approved by: PER-Jeanette-Stingone

respiration
type: Class
subclass of: Process

Before
type: Class
subclass of: Relative Time
definition: A negative index of a time measurement in relation to a reference event. A conventional time measurement can be generated from a before time measurement by duplicating the measurement, reversing the sign of the value, and removing the "Before" class.

kilogram per cubic meter
type: SIO_000074
notation: kg/m3

red blood cell count
type: Class
subclass of: SIO_000794

Oxidative Stress Marker
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: OXID

4, 4'-DDT
type: Class
subclass of: Organochlorine Pesticide
notation: PPDDT

disease of metabolism
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 403

Second or Third Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
definition: The time period from pregnancy week 13 through 40.

SNP
type: Class
type: NodeShape
subclass of: SNV
comment: SNPs are single base pair positions in genomic DNA at which different sequence alternatives exist in normal individuals in some population(s), wherein the least frequent variant has an abundance of 1% or greater.

Mandelic acid
type: Class
subclass of: Volatile Organic Compound
notation: MA
editorial note: To Do: align with CHEBI.

Did Not Consume Alcohol
type: Class
type: QualityValue
subclass of: Alcohol Use
notation: 53

Hemoglobin Genotype AA
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
subclass of: Class
  some values from: SCDO_0004139
  on property: SCDO_1000222
notation: 348
disjoint with: Class
  some values from: SCDO_0000514
  on property: SCDO_1000222
  disjoint with: Hemoglobin Genotype AA
disjoint with: Class
  on property: RO_0003303
  disjoint with: Hemoglobin Genotype AA
  some valuesfrom: NCIT C131682
IAO_0000115: A genotype whereby both HBB alleles produce hemoglobin beta chains for normal adult hemoglobin. Individuals with this genotype are not carriers of the sickle cell trait.
has exact synonym: Hemoglobin Genotype AA
has exact synonym: Haemoglobin Genotype AA
has exact synonym: AA Genotype
has exact synonym: AA Hemoglobin Genotype
has exact synonym: Hemoglobin A Genotype

Asthma Induced Night Sleeplessness
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Sleep disturbance
subclass of: behavioral response to pain
subclass of: Restriction
  some values from: wheezing or tightness in the chest or cough
  on property: SIO_001157

Aluminum
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Al
definition: ALUMINUM is a metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

air
type: Class
subclass of: Thing

Sickle Cell Anemia
type: Class
type: QualityValue
subclass of: Disease
notation: 122
definition: A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

Neurodevelopmental delay
type: Class
type: NodeShape
subclass of: Neurodevelopmental abnormality
subclass of: Developmental delay or intellectual disability

Mandelic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMAD
editorial note: To Do: align with CHEBI.

Diet Quantity
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Diet and Nutrition
definition: A quantity relating to diet and nutrition.
was approved by: PER-Jeanette-Stingone
editorial note: What differentiated diet from nutrition? That is why is this needed since we have the DietAndNutrition Class

times per two weeks
type: SIO_000074
type: SIO_000794
notation: times / two weeks

units per square meter
type: SIO_000074
notation: U/m^2

Population Group
type: Class
type: QualityVariable
subclass of: StudyIndicator
definition: A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender)

No Household Members Currently Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Household Member
comment: No one in the household living in your household currently smoke cigarettes, cigars or pipes.
notation: 524
disjoint with: Some Household Member Currently Smokes

spinal disease
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Pregnancy
type: Class
subclass of: SIO_000417
subclass of: Pregnancy Characteristic
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
subclass of: Restriction
  some values from: Pre-Pregnancy
  on property: intervalMetBy
subclass of: Maternal Prenatal Stage
definition: The time during which one or more offspring develops inside a woman.
was approved by: PER-Jeanette-Stingone

High School or Less
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School to Some College
notation: 33
definition: Education Level of High School or Less
was approved by: PER-Jeanette-Stingone

Consumed Alcohol
type: Class
type: QualityValue
subclass of: Alcohol Use
notation: 52

drug other than antimalarial
type: Class
subclass of: drug
subclass of: Class
  intersection of: drug
  intersection of: Class
    complement of: Antimalarial
definition: Any drug other than an antimalarial drug

Gadolinium
type: Class
subclass of: Metal
notation: Gd
definition: Gadolinium. An element of the rare earth family of metals. GADOLINIUM has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.

Apartment
type: Class
type: QualityValue
subclass of: Living Quarters
notation: 196

Sepsis
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Spouse or Significant Other Living In Household Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Household Member Currently Smokes
comment: The spouse or significant other living in a household currently smoke cigarettes, cigars or pipes
notation: 525

Higher Education
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
notation: 31
definition: College or university education beyond the successful completion of high school or grammar school, or the attainment of an approved equivalent
was approved by: PER-Jeanette-Stingone

Date of Birth
type: Class
type: QuantityVariable
subclass of: Demographic
subclass of: SIO_000417
definition: Date of day on which a person was born.
was approved by: PER-Jeanette-Stingone

Received Drug Therapy
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: drug
  on property: SIO_000230
notation: 360

Asthma Induced Reduced Play Or Activity
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: behavioral response to pain
subclass of: Lack of spontaneous play
subclass of: Restriction
  some values from: wheezing or tightness in the chest or cough
  on property: SIO_001157

Urination
type: Class
type: QualityVariable
subclass of: Biological Response
subclass of: Targeted Analyte

Neurodevelopmental abnormality
type: Class
type: NodeShape
subclass of: Abnormal nervous system physiology
comment: A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period.

Pre-gestational Diabetes
type: Class
type: QualityValue
type: NodeShape
subclass of: DOID_0081062
comment: Diabetes diagnosed before current pregnancy. (Source: reVITALize)
notation: 693

endocrine system disease
type: Class
subclass of: Comorbidity Disease

G minor allele for rs12708716
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs12708716
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs12708716
    on property: SIO_000272
  equivalent class: G minor allele for rs12708716

Annual Income More Than $65,000
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income More Than $60,000
notation: 521

Finished Elementary School
type: Class
type: QualityValue
subclass of: Finished Elementary Grade 4
notation: 15
definition: Finished Elementary School
was approved by: PER-Jim-McCusker

Eats Fresh Vegetables
type: Class
type: QualityValue
subclass of: Eating or Drinking
notation: 29
definition: Whether or not Fresh Vegetables are consumed.
was approved by: PER-Jeanette-Stingone

Body Weight Quality
type: Class
subclass of: Anthropometry
subclass of: SIO_000005
definition: A categorization of body mass relative to the height, as defined using Body Mass Index.

10^9 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^9 cells / µL

Iodine
type: Class
subclass of: Element
subclass of: Trace Element in Urine
notation: I
definition: Iodine is a nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

postpartum hypertension
type: Class
type: NodeShape
subclass of: hypertension

microgram per liter
type: SIO_000074
notation: µg/L

Perfluorohexane-1-sulphonic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFHxS

Some Household Member Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Household Member
comment: Someone living in the household currently smoke cigarettes, cigars or pipes.
notation: 523
disjoint with: No Household Members Currently Smoke

Trunk
type: Class
subclass of: SIO_010046
definition: Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.

dust
type: Class
subclass of: Thing

Normal Weight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Underweight/Normal
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 61
definition: Adult normal weight is defined as having a BMI between 18.5 and 25 kg/m^2; Child normal weight is defined as greater than or equal to the 5th percentile but less than the 85th percentile for age, gender and height.

Gestational Age at Birth
type: Class
subclass of: Gestational Age
definition: Describes how far along a pregnancy is, usually measured in weeks, as measured at birth.
equivalent class: Class
  intersection of: Gestational Age
  intersection of: Restriction
    on property: SIO_000793
    all values from: Birth
  equivalent class: Gestational Age at Birth
deprecated: true

Car Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Cars in the Home
editorial note: Again, this isn't related to physical properties of housing. This is more closely related to Socioeconomic Status. Consider moving it.

6-chloronicotinic acid
type: Class
subclass of: Universal Pesticide Metabolite in Urine
notation: CINA6

parasites per microliter
type: SIO_000074
type: SIO_000794
notation: parasites / µL

Delivery Characteristics
type: Class
subclass of: StudyIndicator
definition: Attributes related to the delivery of a child.

C-reactive protein
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: CRP
definition: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Uranium
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: U
definition: Uranium. A radioactive element of the actinide series of metals. URANIUM has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.

Annual Income $20,000 to $24,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $20,000 to $29,999
subclass of: Annual Income $24,999 or Less
notation: 519

Fluticasone/vilanterol (Breo Ellipta)
type: Class
subclass of: Asthma Controller Medication

A minor allele for rs2292239
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs2292239
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs2292239
    on property: SIO_000272
  equivalent class: A minor allele for rs2292239

Education Grade 6
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 118
definition: Finished grade 6

Eats Fast Food
type: Class
type: QualityValue
subclass of: Eating or Drinking
notation: 16
definition: Whether or not fast food is consumed.
was approved by: PER-Jeanette-Stingone

Annual Income $45,000 to $64,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $40,001 to $70,000
notation: 520

A minor allele for rs3184504
type: Class
type: NodeShape
subclass of: minor polymorphic allele
subclass of: Restriction
  some values from: rs3184504
  on property: SIO_000272
equivalent class: Class
  intersection of: minor polymorphic allele
  intersection of: Restriction
    some values from: rs3184504
    on property: SIO_000272
  equivalent class: A minor allele for rs3184504

First Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
subclass of: Restriction
  some values from: Pregnancy
  on property: intervalStarts
definition: From pregnancy week 1 through 12 and includes conception. Conception is when the sperm fertilizes the egg. The fertilized egg then travels down the fallopian tube and attaches to the inside of the uterus, where it begins to form the embryo and placenta. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus).
was approved by: PER-Jeanette-Stingone

Education Grade 7
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 119
definition: Finished grade 7

Bodily Fluid
type: Class
subclass of: Biospecimen
definition: Liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not.

acetamiprid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group. Source: ChEBI
notation: ACE

cannabinoid
type: Class
subclass of: CHEBI_24431

ADOS calibrated severity score
type: Class
type: QuantityVariable
subclass of: CAO_01168
definition: Calibrated severity score on the Total Standardized Autism Diagnostic Observation Schedule (ADOS).

Used to take asthma control medications but no longer
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Used to take but no longer
  on property: SIO_000217
notation: 276

Duration of Central Venous Cannula Insertion
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: central venous cannula insertion
  on property: SIO_000215
comment: The length of time a patient undergoes a central venous cannula insertion procedure

second
type: SIO_000074
notation: s

Airborne Particulate Matter
type: Class
type: QualityVariable
subclass of: Air Pollutant

nanogray
type: SIO_000074
notation: nGy

Annual Income $100,000 to $149,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $100,000 to $199,999
notation: 595

Neurologic
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 396

Cis-Nonachlor
type: Class
subclass of: Organochlorine Pesticide
notation: CNON

Takes asthma control medications some days but not others
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Takes some days but not others
  on property: SIO_000217
notation: 277

diabetes mellitus
type: Class
type: QualityValue
subclass of: Disease
notation: 342

Dead
type: Class
type: QualityValue
subclass of: Destination
notation: 173
definition: The cessation of life.

Prenatal Vitamin Use
type: Class
type: QualityValue
subclass of: nutrition intake
notation: 694
definition: Prenatal vitamins are supplements that contain daily vitamins and minerals needed by mothers before and during pregnancy.

Duration of Noninvasive Positive-Pressure Ventilation
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: noninvasive positve-pressure ventilation
  on property: SIO_000215
comment: The length of time a patient undergoes noninvasive positive-pressure ventilation

milligray
type: SIO_000074
notation: mGy

nanogram per milliliter
type: SIO_000074
notation: ng/ml

blood serum
type: Class
subclass of: Blood Component
definition: Liquid derived from blood plasma that has clotting factors removed. [database_cross_reference: http://en.wikipedia.org/wiki/Serum_(blood)][database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Residential Building With A Yard
type: Class
type: NodeShape
subclass of: Residential Building
subclass of: Restriction
  some values from: Residential Yard
  on property: SIO_000028
comment: A residential building that has an attached yard or garden where domestic leisure activities occur.
equivalent class: Class
  intersection of: Residential Building
  intersection of: Restriction
    some values from: Residential Yard
    on property: SIO_000028
  equivalent class: Residential Building With A Yard
disjoint with: Residential Building Without A Yard

Annual Income $150,000 to $199,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $100,000 to $199,999
subclass of: Annual Income More Than $125,000
notation: 596

Bisulfite Pyrosequencing
type: Class
subclass of: Nucleic Acid Sequencing

Never takes asthma control medications
type: Class
type: QualityValue
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Never takes
  on property: SIO_000217
notation: 274
disjoint with: Has taken asthma control medications

Pentachlorophenol
type: Class
subclass of: phenol
notation: PCP
definition: An insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor and has been used as such as an experimental tool.

Non-White
type: Class
type: QualityValue
subclass of: Race
notation: 149
definition: A race other than white.

Educational Status
type: Class
type: QualityVariable
subclass of: SIO_001326
subclass of: Educational Status
subclass of: Education

millicurie
type: SIO_000074
notation: mCi

Annual Income $50,000 to $59,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $50,000 to $74,999
notation: 593

kelvin
type: SIO_000074
notation: K

Third
type: Class
subclass of: Thing

Systemic Inflammatory Response Syndrome
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Interleukin-21
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL21

10^6 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^6 cells / µL

Only takes asthma control medications with symptoms
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Only takes with symptoms
  on property: SIO_000217
notation: 275

Social Affect + Restricted and Repetitive Behavior Total
type: Class
type: QuantityVariable
subclass of: CAO_01168
definition: Total Standardized Autism Diagnostic Observation Schedule (ADOS) score.

Chromium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Cr
definition: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002, 1985), chromium and some of its compounds have been listed as known carcinogens.

Annual Income $60,000 to $74,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $50,000 to $74,999
notation: 594

nanosievert
type: SIO_000074
notation: nSv

ampere
type: SIO_000074
notation: A

Ciclesonide HFA (Alvesco)
type: Class
subclass of: Asthma Controller Medication

percentile
type: SIO_000074
notation: %

Residential Building
type: Class
type: QualityValue
type: QualityVariable
subclass of: Housing Characteristic
notation: 154

Used Only Anti Malarials or No Medications
type: Class
type: QualityValue
subclass of: Prescription Medication and Dietary Supplements
subclass of: Drug Other Than Antimalarial Use
notation: 139

Lower Respiratory Tract Infection
type: Class
type: QualityValue
subclass of: infection
notation: 384

Received Antimalarial Therapy
type: Class
type: QualityValue
subclass of: Antimalarial Use
subclass of: Received Drug Therapy
subclass of: Restriction
  some values from: Antimalarial
  on property: SIO_000230
notation: 344

Crowdsourcing
type: Class
type: NodeShape
subclass of: SIO_001052
comment: Results of data collected from Crowdsource collection. Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects. Source: Medical Subject Headings Ontology

SO_0000000
deprecated: true

Home Ownership
type: Class
type: QuantityVariable
subclass of: Demographic
definition: Who owns the home they live in.

Takes some days but not others
type: Class
subclass of: SIO_001290

candela
type: SIO_000074
notation: cd

disintegrations per minute
type: SIO_000074
notation: dpm

Cromolyn
type: Class
subclass of: Asthma Controller Medication

Sleep disturbance
type: Class
subclass of: SIO_000475

tetraconazole
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A racemate comprising equal amounts of (R)- and (S)-tetraconazole. A fungicide used to control a range of fungal infections including powdery mildew, rusts, bunt, loose smut and scab. Source: ChEBI
notation: TETZ

Biomolecule
type: Class
subclass of: Biospecimen
definition: A biospecimen that is composed of molecular entities.

Received Drug Therapy Other Than Antimalarials
type: Class
type: QualityValue
subclass of: Drug Other Than Antimalarial Use
subclass of: Received Drug Therapy
subclass of: Restriction
  some values from: drug other than antimalarial
  on property: SIO_000230
notation: 345

Takes every day
type: Class
subclass of: SIO_001292

neurological dysfunction
type: Class
subclass of: Comorbidity Disease

Renter
type: Class
type: QualityValue
subclass of: Home Ownership
notation: 148
definition: This person rents the home they live in.

microcurie
type: SIO_000074
notation: µCi

mole
type: SIO_000074
notation: mol

milliunits per milliliter
type: SIO_000074
notation: mU/ml

Dimethylarsinic Acid
type: Class
subclass of: Arsenic Species
notation: DMA

Inflammatory abnormality of the skin
type: Class
type: NodeShape
subclass of: Health Outcome
subclass of: DOID 37
comment: The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.

Perfluorooctanesulfonamide
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFOSA

2,3,4,5-Tetrabromobenzoic acid
type: Class
type: NodeShape
subclass of: brominated flame retardant
comment: 2,3,4,5-Tetrabromobenzoic acid is a member of benzoic acids and an organohalogen compound. (Source: Pubchem)
notation: TBBA

type 2 diabetes mellitus
type: Class
type: QualityValue
subclass of: diabetes mellitus
notation: 181

Cotinine (total)
type: Class
subclass of: Tobacco Metabolite
notation: COTT
editorial note: To Do: align with CHEBI.

Tobacco Smoke Exposure
type: Class
type: QualityValue
subclass of: Environmental Exposure
notation: 98

Only takes with symptoms
type: Class
subclass of: SIO_001290

Interleukin-5
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL5

micrometer
type: SIO_000074
notation: µm

Vineland Testing
type: Class
subclass of: Childhood Followup
subclass of: Restriction
  some values from: Class
    intersection of: Childhood Period
  on property: SIO_000668
definition: The time period when the Vineland early childhood development testing is administered to a subject.

Screening Test
type: Class
subclass of: Test

millimeter
type: SIO_000074
notation: mm

Interleukin-4
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL4

polycyclic hydrocarbon
type: Class
subclass of: Targeted Analyte
notation: UPAH

tetracosanoic acid
type: Class
subclass of: Fatty Acid
notation: C240
definition: A C24 straight-chain saturated fatty acid.

Cousin
type: Class
type: QualityValue
subclass of: Relative
subclass of: SIO_000287
notation: 354
definition: A person belonging to the same extended family.

Tri-Cell DMA-80 Direct Mercury Analyzer
type: Class
subclass of: Direct Mercury Analyzer
definition: The DMA-80 is based on the principles of sample thermal decomposition, mercury amalgamation and atomic absorption detection. The DMA-80 has been used to develop the US EPA method 7473 (Mercury in solids and solutions by thermal decomposition, amalgamation, and atomic absorption spectrophotometry). It is furthermore compliant with ASTM method D-6722-01 (Total mercury in coal and coal combustion residues) and ASTM method D-7623-10 (Total mercury in crude oil).
was approved by: PER-Jim-McCusker

Mullens Testing
type: Class
subclass of: Childhood Followup
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Childhood Period
definition: The time period when the Mullens early childhood development testing is administered to a subject.

Used to take but no longer
type: Class
subclass of: SIO_001288

counts per minute
type: SIO_000074
notation: cpm

centimeter
type: SIO_000074
notation: cm

Agreement Answer
type: Class
type: NodeShape
subclass of: SIO_000965
comment: A response about an individual's agreement about something. [Definition Source: NCI]

Ethyl paraben
type: Class
subclass of: Paraben
notation: EtPB
definition: Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of ethylparaben is Allergens.

liver disease
type: Class
subclass of: Comorbidity Disease

Trauma Related Hospital Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: injury
  on property: SIO_001157
subclass of: Hospital Admission By Admission Type
notation: 378

Blinded Season 2 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 299

Duration of Muscle Relaxant Use
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Muscle Relaxants
  on property: SIO_000215
comment: The length of time a patient is taking muscle relaxants as a medical intervention

Absorbance Reader
type: Class
subclass of: Microplate Reader
definition: Absorbance readers are used for assays such as ELISA assays, protein and nucleic acid quantification or enzyme activity assays. A light source illuminates the sample using a specific wavelength (selected by an optical filter, or a monochromator), and a light detector located on the other side of the well measures how much of the initial (100%) light is transmitted through the sample: the amount of transmitted light will typically be related to the concentration of the molecule of interest.
was approved by: PER-Jim-McCusker

days per week
type: Class
type: NodeShape
subclass of: UO_0000280

Ruthenium
type: Class
subclass of: Metal
notation: Ru
definition: RUTHENIUM is a hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.

milliliter
type: SIO_000074
notation: ml

Late Adulthood
type: Class
type: NodeShape
subclass of: Adult
comment: The life stage that begins when a person is 65 years old

Tanner Scale For Breast Development
type: Class
type: NodeShape
subclass of: Tanner Scale

Tanner Scale For Genital Development
type: Class
type: NodeShape
subclass of: Tanner Scale

Blinded Season 3 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 300

Surgery Related Hospital Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: surgical procedure
  on property: SIO_000243
subclass of: Hospital Admission By Admission Type
notation: 376

Duration of Antibiotic Use
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Antibiotics
  on property: SIO_000215
comment: The length of time a patient receives antibiotic treatment as a medical intervention

valid measurement
type: Class
type: QualityValue
subclass of: SIO_001167
subclass of: Measurement
notation: 351

5-iso Prostaglandin F2 alpha-VI
type: Class
subclass of: Oxidative Stress Marker
notation: F2AVI

Diagnosis Group
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Health Outcome

cubic centimeter
type: SIO_000074
notation: cm3

Percentile For Fixed Age and Sex
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Anthropometry
subclass of: percentile
subclass of: SIO_001415
subclass of: Restriction
  some values from: Age
  on property: RO_0000079
subclass of: Restriction
  some values from: Biological Sex
  on property: RO_0000079
comment: A percentile computation from a population which all share the same age range and sex assignment

smoking behavior
type: Class
type: NodeShape
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: GO_0007610

Cerebrospinal fluid
type: Class
subclass of: SIO_010046
definition: A clear, colorless fluid that is found in the brain and spinal cord.

Specific Gravity
type: Class
type: QuantityVariable
subclass of: SIO_001018
subclass of: Urinary Dilution Factor
notation: SG
definition: Specific gravity is the ratio of the density of a substance to the density of a reference substance; equivalently, it is the ratio of the mass of a substance to the mass of a reference substance for the same given volume. Apparent specific gravity is the ratio of the weight of a volume of the substance to the weight of an equal volume of the reference substance. The reference substance is nearly always water at its densest (4°C) for liquids; for gases it is air at room temperature (21°C). Nonetheless, the temperature and pressure must be specified for both the sample and the reference. Pressure is nearly always 1 atm (101.325 kPa). Temperatures for both sample and reference vary from industry to industry.
editorial note: Why is this here? Maybe it belongs in another list

Duration of Medical Intervention
type: Class
type: NodeShape
subclass of: PATO_0001309
subclass of: Restriction
  some values from: SIO_001398
  on property: SIO_000215
comment: The length of time a patient receives some form of medical intervention

symptom
type: Class
subclass of: SIO_010056

Hospital ER Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Hospital Emergency Room
  on property: SIO_000061
subclass of: Hospital Admission
comment: This class denotes an ER admission that results in a hospital admission as well.
notation: 371

Childhood Cohort Study
type: Class
subclass of: CohortStudy

Asthma Related Hospitalization
type: Class
type: QuantityVariable
subclass of: Healthcare Access
subclass of: Hospitalization
subclass of: Restriction
  some values from: asthma
  on property: SIO_000635

Assisted Reproductive Therapy
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
notation: 7

Dioxybenzone
type: Class
subclass of: Phenol
notation: BP8

Biological Father
type: Class
type: QualityValue
type: NodeShape
subclass of: Father
subclass of: Biological Parent
comment: A male who contributes to the genetic makeup of his offspring through the fertilization of an ovum by his sperm. (Source: NCI Thesaurus)
notation: 655

erythromycin A
type: Class
type: NodeShape
subclass of: CHEBI_24431
comment: An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.

Krieger Racism Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: Instrument conceptualized as measuring self-report experiences of racial discrimination; Combines questions from multiple instruments including the Experiences of Discrimination questionnaire, Williams’ Major and Everyday Discrimination measures, a five-item social desirability scale and additional items on worries, global experiences and formal complaints of discrimination. Source: Krieger N, Smith K, Naishadham D, Hartman C, Barbeau EM. Experiences of discrimination: validity and reliability of a self-report measure for population health research on racism and health. Soc Sci Med. 2005 Oct;61(7):1576-96. doi: 10.1016/j.socscimed.2005.03.006. Epub 2005 Apr 21. PMID: 16005789.

Residential Building With A Large Yard
type: Class
type: QualityValue
type: NodeShape
subclass of: Residential Building With A Yard
subclass of: Restriction
  some values from: Large Residential Yard
  on property: SIO_000028
comment: A residential building with a medium yard attached or adjacent to it
notation: 582
equivalent class: Class
  intersection of: Residential Building
  intersection of: Restriction
    some values from: Large Residential Yard
    on property: SIO_000028
  equivalent class: Residential Building With A Large Yard

Clinical Encounter
type: Class
subclass of: Thing

Hospital Emergency Room
type: Class
subclass of: Restriction
  some values from: Hospital
  on property: SIO_000061
subclass of: Emergency Medical Services Facility

Duration of Oxygen Treatment
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000215
comment: The length of time a patient is receiving oxygen treatment as a medical intervention

Blinded Season 1 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 298

Adolescence
type: Class
type: NodeShape
subclass of: Childhood
subclass of: Life Stage
comment: A human life stage that begins at twelve years of age and continues until twenty-one complete years of age, generally marked by the beginning of puberty and lasting to the beginning of adulthood.

Alcohol Use
type: Class
type: QualityValue
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 83
definition: Uses Alcohol

2-(((6-Oxo-2-propylheptyl)oxy)carbonyl)benzoic Acid
type: Class
type: NodeShape
subclass of: Phthalate
notation: MPOHP

central nervous system infection
type: Class
type: QualityValue
subclass of: infection
notation: 402

liter
type: SIO_000074
notation: L

Preschool-age Children's Physical Activity Questionnaire
type: Class
type: NodeShape
subclass of: Questionnaire
subclass of: Restriction
  some values from: Preschool-age Children's Physical Activity Questionnaire Response
  on property: SIO_000059
comment: The Preschool-age Children's Physical Activity Questionnaire (Pre-PAQ) was designed to measure activity of preschool-age children in the home environment in population studies. Reference: The validity and reliability of a home environment preschool-age physical activity questionnaire (Pre-PAQ) Genevieve M Dwyer, Louise L Hardy, Jennifer K Peat & Louise A Baur International Journal of Behavioral Nutrition and Physical Activity volume 8, Article number: 86 (2011) https://ijbnpa.biomedcentral.com/articles/10.1186/1479-5868-8-86

Gestational Age From 20 to 28 Weeks
type: Class
type: QualityValue
type: NodeShape
subclass of: Gestational Age
comment: The gestational age range of a fetus beginning at the start of week 20 and ending immediately before the beginning of week 28
notation: 700

E-Cigarette Use
type: Class
type: QualityVariable
subclass of: Active Smoker

Hemoglobin
type: Class
subclass of: Protein
definition: The iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae), as well as the tissues of some invertebrates. Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism.
was approved by: PER-Jim-McCusker

Pediatric Intensive Care Unit
type: Class
type: QualityValue
subclass of: Intensive Care Unit
notation: 689

Hospital Discharge By Oxygen Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Hospital Discharge
comment: A subclass of ICU Discharge; this class differentiates between whether or not a patient is discharged from a hospital on oxygen.

Residential Building With A Small Yard
type: Class
type: QualityValue
type: NodeShape
subclass of: Residential Building With A Yard
subclass of: Restriction
  some values from: Small Residential Yard
  on property: SIO_000028
comment: A residential building with a small yard attached or adjacent to it
notation: 585
equivalent class: Class
  intersection of: Residential Building
  intersection of: Restriction
    some values from: Small Residential Yard
    on property: SIO_000028
  equivalent class: Residential Building With A Small Yard

millimetres of mercury
type: SIO_000074
notation: mmHg

Multidimensional Scale of Perceived Social Support
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: Source: Zimet, G. D., Dahlem, N. W., Zimet, S. G., & Farley, G. K. (1988). The multidimensional scale of perceived social support. Journal of personality assessment, 52(1), 30-41.

E-Cigarette Puffs Per Day
type: SIO_000074

Diagnostic Procedure
type: Class
type: NodeShape
subclass of: SIO_001024
comment: Any procedure or test to diagnose a disease or disorder. A specific test or series of steps done to help diagnose a disease or condition. Mammograms and colonscopies (sp) are examples of diagnostic procedures. (Source: NCI Thesaurus)
equivalent class: SIO_001022

Matched Pair of Subjects
type: Class
subclass of: SIO_000616
definition: A set of 2 subjects which result from a pairing process which assigns subject to a set based on a pairing rule/criteria

penicillin
type: Class
type: NodeShape
subclass of: CHEBI_24431
comment: Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.

microbiome richness
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: community species diversity
comment: Microbiome richness is the total number of bacterial species in a microbiome.

Hospital Discharge Not On Oxygen
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Discharge By Oxygen Use
subclass of: Class
  complement of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
comment: An event in which a patient is discharged from a hospital and is not given oxygen treatment.
notation: 440
equivalent class: Class
  intersection of: Hospital Discharge
  intersection of: Class
    complement of: Restriction
      some values from: Oxygen Treatment
      on property: SIO_000250
  equivalent class: Hospital Discharge Not On Oxygen
disjoint with: Hospital Discharge On Oxygen

Stool Sample
type: Class
type: NodeShape
subclass of: Biospecimen
comment: A fecal biospecimen. (Source: NCI Thesaurus)

microliters per minute
type: SIO_000074
notation: µL/min

Residential Building With A Medium Yard
type: Class
type: QualityValue
type: NodeShape
subclass of: Residential Building With A Yard
subclass of: Restriction
  some values from: Medium Residential Yard
  on property: SIO_000028
comment: A residential building with a medium yard attached or adjacent to it
notation: 586
equivalent class: Class
  intersection of: Residential Building
  intersection of: Restriction
    some values from: Medium Residential Yard
    on property: SIO_000028
  equivalent class: Residential Building With A Medium Yard

Pregnancy Experience Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: “The Pregnancy Experience Scale measures daily stressors women may experience during pregnancy (DiPietro et al., 2004). The brief version of the scale (PES-Brief) contains 20 items representing the most frequently endorsed hassles and uplifts from the 41-item original scale (DiPietro, Christensen, & Costigan, 2008). Each item is rated on a 4-point Likert scale with values of 0 to 3. The items are combined into a set of six scores: frequency of hassles,frequency of uplifts, intensity of hassles, intensity of uplifts, hassle:uplift frequency ratio, andhassle:uplift intensity ratio. DiPietro, Christensen, & Costigan (2008) reported that the hassleand uplift scales demonstrated acceptable internal consistency reliability with Cronbach’s alphasof 0.83 and 0.82, respectively. Test-retest reliability of the scales ranged from 0.63 to 0.73. ThePES-Brief scores were significantly correlated with the STAI, Center for Epidemiologic Studies-Depression scale (CES-D; Radloff, 1977), and the World Health Organization five-item wellbeingindex (WHO-5), supporting the convergent validity of the scale.” Source: DiPietro JA, Christensen AL, & Costigan KA (2008). The pregnancy experience scale-brief version. JPsychosom Obstet Gynaecol, 29(4), 262-267.

White
type: Class
subclass of: Thing

Takes asthma control medications every day
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Takes every day
  on property: SIO_000217
notation: 278

Age Equivalent
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Score
definition: Age Equivalent is the individual's ability; skill, knowledge, or measurement expressed as the age at which most individuals reach the same level (age norm). The Age Norm is the average score of a particular test completed by children of a given chronological age.

ICU Discharge By Oxygen Use
type: Class
type: NodeShape
subclass of: ICU Discharge
comment: A subclass of ICU Discharge; this class differentiates between whether or not a patient is discharged from the ICU on oxygen.

Bisphenol B
type: Class
subclass of: Phenol
notation: BPB

cis-vaccenic acid
type: Class
subclass of: Fatty Acid
notation: C181N7
definition: The cis isomer of vaccenic acid.

microgray
type: SIO_000074
notation: µGy

microgram per milliliter
type: SIO_000074
notation: µg/ml

One Month Prior to Followup
type: Class
type: NodeShape
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup
  on property: intervalMeets
comment: A time interval that begins one month prior to a study follow-up and ends at the beginning of the study follow-up.

Residential Building Without A Yard
type: Class
type: QualityValue
type: NodeShape
subclass of: Class
  complement of: Restriction
    some values from: Residential Yard
    on property: SIO_000028
subclass of: Residential Building Without A Private Yard
comment: A residential building that does not have a yard attached or adjacent to it
notation: 588
equivalent class: Class
  intersection of: Residential Building
  intersection of: Class
    complement of: Restriction
      some values from: Residential Yard
      on property: SIO_000028
  equivalent class: Residential Building Without A Yard
disjoint with: Residential Building With A Yard

Obese
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 63

Alternaria
type: Class
subclass of: Thing

2-hydroxychrysene
type: Class
subclass of: polycyclic hydrocarbon
notation: CHRY2

Metalloproteinase inhibitor 1
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: TIMP1

Mean Concentration
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Concentration
definition: The mean aggregate of multiple concentration measurements of a single substance within a compound substance.

Ventilator Free Respiration
type: Class
subclass of: respiration
comment: Resipration that is not aided by a mechanical ventilator.
equivalent class: Class
  intersection of: respiration
  intersection of: Class
    complement of: Restriction
      some values from: invasive mechanical ventilation
      on property: SIO_001157
  equivalent class: Ventilator Free Respiration
disjoint with: Invasive Mechanical Ventilator Assisted Respiration

ICU Discharge Not On Oxygen
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Discharge By Oxygen Use
subclass of: Class
  complement of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
comment: An event in which a patient is discharged from an intensive care unit and is not given oxygen treatment.
notation: 439
equivalent class: Class
  intersection of: ICU Discharge
  intersection of: Class
    complement of: Restriction
      some values from: Oxygen Treatment
      on property: SIO_000250
  equivalent class: ICU Discharge Not On Oxygen
disjoint with: ICU Discharge On Oxygen

4-Chlorophenol
type: Class
subclass of: phenol
notation: MCP4
definition: P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.

milligram per liter
type: SIO_000074
notation: mg/L

Nicotine-N-oxide
type: Class
subclass of: Tobacco Metabolite
notation: NICO

Residential Building Without A Private Yard
type: Class
type: QualityValue
type: NodeShape
subclass of: Residential Building
subclass of: Class
  complement of: Restriction
    some values from: Private Residential Yard
    on property: SIO_000028
comment: A residential building that has an attached or adjacent yard that is not private
notation: 589
equivalent class: Class
  intersection of: Residential Building
  intersection of: Class
    complement of: Restriction
      some values from: Private Residential Yard
      on property: SIO_000028
  equivalent class: Residential Building Without A Private Yard

Connor Davidson Resilience Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: "Resilience may be viewed as a measure of stress coping ability and, as such, could be an important target of treatment in anxiety, depression, and stress reactions. We describe a new rating scale to assess resilience. The Connor-Davidson Resilience scale (CD-RISC) comprises of 25 items, each rated on a 5-point scale (0–4), with higher scores reflecting greater resilience." Source: DEVELOPMENT OF A NEW RESILIENCE SCALE: THE CONNOR-DAVIDSON RESILIENCE SCALE (CD-RISC) Kathryn M. Connor, M.D., and Jonathan R.T. Davidson, M.D.

Roentgen equivalent man
type: SIO_000074
notation: rem

Population Based Selection Criterion
type: Class
type: NodeShape
subclass of: OBI_0001755

Some Technical School
type: Class
type: QualityValue
type: NodeShape
subclass of: Some College or Technical School
comment: Has attended some, but has not completed, technical school
notation: 604

Overweight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 71

formazin nephelometric unit
type: SIO_000074
notation: FNU

Chief Complaint
type: Class
type: QualityVariable
subclass of: Health Outcome

Molybdenum
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Mo
definition: MOLYBDENUM is a metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)

Biological Response
type: Class
subclass of: StudyIndicator
definition: Indicator of biological response to environmental exposure
editorial note: abolic_SDD_v1.xlsx

asthma
type: Class
type: QualityValue
subclass of: bronchial disease
subclass of: Comorbidity Disease
notation: 193

thawed and clotted
type: Class
subclass of: SIO_001167

PCB180
type: Class
subclass of: Polychlorobiphenyl
notation: PCB180

cubic centimeter per mole
type: SIO_000074
notation: cm3/mol

Occupation Category 3
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 3=machine operators and semi-skilled workers
notation: 510

Interleukin-17A
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL17A

Technical School Graduate
type: Class
type: QualityValue
type: NodeShape
subclass of: Technical School
comment: A graduate of a technical school
notation: 605

Occupation Category 4
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 4=smaller business owners (<$25,000), skilled manual laborers, craftsmen, tenant farmers
notation: 511

Clinic Based Selection Criterion
type: Class
type: NodeShape
subclass of: OBI_0001755

metal container
type: Class
type: NodeShape
subclass of: OBI_0000967

Below LOD, results repeated and confirmed (37, 33)
type: Class
subclass of: SIO_001167

Preschool
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education Grade
notation: 112
definition: Finished preschool

quantity of sample insufficient for analysis
type: Class
subclass of: SIO_001167

Difference of POPC Scores
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Pediatric Overall Performance Category
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Pediatric Overall Performance Category
  on property: SIO_000008
comment: The arithemetic difference of two Pediatric Overall Performance Category scores.

Annulled
type: Class
type: QualityValue
subclass of: Never Married
notation: 43
definition: A marital status in which a voidable marriage is legally declared null and void, as though it never existed. Specific grounds for annullment vary within the presiding jurisdiction, whether geographic or religious.

Public Insurance
type: Class
type: QualityValue
subclass of: Public or No Insurance
notation: 79

Birth Outcome
type: Class
subclass of: StudyIndicator
definition: Birth Outcomes Indicator Class
was approved by: PER-Jeanette-Stingone

thawed, hemolyzed (covers all three levels) and exposed to light
type: Class
subclass of: SIO_001167

turns per second
type: SIO_000074
notation: 1/s

Experimental/RCT Study
type: Class
type: NodeShape
subclass of: SIO_001066

Post-Birth 28 Days Or More
type: Class
type: NodeShape
subclass of: SIO_000417
comment: A time interval that begins at the beginning of the 28th day after birth

Occupation Based Selection Criterion
type: Class
type: NodeShape
subclass of: OBI_0001755

Transplantation
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 401

Benzophenone-1
type: Class
subclass of: Benzophenone
notation: BP1

Interlocutory Marital Status
type: Class
type: QualityValue
subclass of: Marital Status
notation: 44
definition: The condition existing when an order or judgement is considered temporary until either a specified period of time has passed or specific information is provided to assist in rendering a permanent decision.

Birth Cohort Study
type: Class
subclass of: CohortStudy

thawed and hemolyzed (covers all three levels)
type: Class
subclass of: SIO_001167

PCB153
type: Class
subclass of: Polychlorobiphenyl
notation: PCB153

Uses Probiotic Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: Probiotic
  on property: SIO_000139
subclass of: Exposed to Probiotics
notation: 603
disjoint with: Does Not Use Probiotic Supplements

kilogram meter per second
type: SIO_000074
notation: kg.m/s

Large Residential Yard
type: Class
type: NodeShape
subclass of: Residential Yard

Pediatric Overall Performance Category
type: Class
subclass of: Physical And Mental Assessment
comment: Reference: POPC/PCPC Reference: Fiser HD, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit. Critical Care Medicine 2000. 28(4):1173-1179.

2, 2', 4, 4'-tetrahydroxybenzophenone
type: Class
subclass of: Phenol
notation: BP2

Atomic Fluorescence Spectroscopy Instrument
type: Class
subclass of: PhysicalInstrument
definition: a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light.
was approved by: PER-Jim-McCusker

did not precipitate
type: Class
subclass of: SIO_001167

Nickel
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Ni
definition: NICKEL is a trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.

Private Insurance or Self Pay
type: Class
type: QualityValue
subclass of: Insurance
notation: 51

meter per second
type: SIO_000074
notation: m/s

Observational Case Only Study
type: Class
type: NodeShape
subclass of: SIO_001066

Difference of PCPC Scores
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Pediatric Cerebral Performance Category
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Pediatric Cerebral Performance Category
  on property: SIO_000008
comment: The arithemetic difference of two Pediatric Cerebral Performance Category scores.

2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
type: Class
type: NodeShape
subclass of: Phenol
notation: BP6

Protein
type: Class
subclass of: Biological Response

Visit
type: Class
subclass of: SIO_000417
definition: The time interval of an encounter between a study subject and a study administrator.

Proton Pump Inhibitor Treatment
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor
  on property: SIO_000139
subclass of: proton pump inhibitor agent therapy
notation: 27
definition: Proton Pump Inhibitor Treatment as a form of medical therapy.
editorial note: UPDATE: Yes, add the prescription medication, either as an indicator or as a class under Medical Therapy. Whichever works for the ontology. Why isn't this listed under prescription medication? How do you differentiate between medical therapy and prescription medication?

cubic meter per kilogram
type: SIO_000074
notation: m3/kg

Post-Birth Up To 27 Days
type: Class
type: NodeShape
subclass of: SIO_000417
comment: A time period that begins immediately after birth and ends at the end of the 27th day after birth

Observational Cross-Sectional Study
type: Class
type: NodeShape
subclass of: SIO_001066

Small Residential Yard
type: Class
type: NodeShape
subclass of: Residential Yard

CAUTI or CLABSI or VAP
type: Class
type: QualityValue
subclass of: hospital-acquired infection
notation: 362
equivalent class: Class
  union of: catheterization associated UTI
  union of: Central Line Infection
  union of: ventilator-associated pneumonia
  equivalent class: CAUTI or CLABSI or VAP

Duration of Medical Procedure
type: Class
type: NodeShape
subclass of: Medical History
subclass of: PATO_0001309
subclass of: Restriction
  some values from: SIO_001024
  on property: SIO_000215
comment: The length of time a patient undergoes a medical procedure

Behavior Rating Inventory of Executive Function - Preschool Version
type: Class
subclass of: Neurocognitive Assessment
definition: Standardized rating scale designed to specifically measure the range of executive function in preschool-aged children

eosinophils per high-power field
type: Class
subclass of: SIO_000794
comment: A histological count of the eosinophils in a high-power microscopic field of view, or 0.158 mm^2 (x400).

Peripheral Blood Mononuclear Cell
type: Class
subclass of: Cell
definition: Any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.

Digestive System Disorder
type: Class
type: QualityValue
subclass of: Disease
notation: 392

cubic meter
type: SIO_000074
notation: m3

Observational Case-Control Study
type: Class
type: NodeShape
subclass of: SIO_001066

Duration of Vasopressor Agent Therapy
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: vasopressor agent therapy
  on property: SIO_000215
comment: The length of time a patient undergoes vasopressor agent therapy

Medium Residential Yard
type: Class
type: NodeShape
subclass of: Residential Yard

Pediatric Cerebral Performance Category
type: Class
subclass of: Physical And Mental Assessment
comment: Reference: POPC/PCPC Reference: Fiser HD, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit. Critical Care Medicine 2000. 28(4):1173-1179.

Atomic Spectroscopy
type: Class
subclass of: Spectroscopy

rs2816316
type: Class
type: NodeShape
subclass of: SNP

enzyme-linked immunosorbent assay (ELISA)
type: Class
subclass of: Immunoassay
definition: ELISA is an immunoassay that uses antibodies and color change to identify a substance (Wikipedia)

4-Fluoro-3-phenoxybenzoic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: FPBA

Previous Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 78
definition: The quality of having smoked in the past.

Pharmacotherapy
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: Medical Therapy Procedure

hematocrit
type: Class
subclass of: SIO_001018

Observational Case-Cohort Study
type: Class
type: NodeShape
subclass of: SIO_001066

spinal cord
type: Class
subclass of: SIO_000004

Education Grade 8
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Middle School
comment: Finished Grade 8
notation: 505

Phenotype
type: Class
subclass of: Health Outcome

Eats Canned Food
type: Class
type: QualityValue
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Canned Food Product
  on property: SIO_000230
comment: The act of eating food that has been packaged in a metal container.
notation: 9
was approved by: PER-Jeanette-Stingone

Ultra Performance Liquid Chromatography - Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
subclass of: Ultra High Performance Liquid Chromatography Instrument
was approved by: PER-Jim-McCusker

Tandem Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: Tandem mass spectrometry, also known as MS/MS or MS2, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. In a tandem mass spectrometer, ions are formed in the ion source and separated by mass-to-charge ratio in the first stage of mass spectrometry (MS1). Ions of a particular mass-to-charge ratio (precursor ions) are selected and fragment ions (product ions) are created by collision-induced dissociation, ion-molecule reaction, photodissociation, or other process. The resulting ions are then separated and detected in a second stage of mass spectrometry (MS2).
was approved by: PER-Jim-McCusker

Fluticasone/salmeterol HFA(Advair HFA)
type: Class
subclass of: Asthma Controller Medication

Month Prior and First Month of Pregnancy
type: Class
subclass of: SIO_000417
definition: The time period beginning at the beginning of the month prior to conception and ending at the end of the first month of pregnancy

hours per day
type: Class
type: NodeShape
subclass of: UO_0000280

Vital Statistics
type: Class
type: NodeShape
subclass of: SIO_000088
comment: Government records of live births, fetal deaths, marriages, divorces, and deaths that occur within that jurisdiction. (Source: NCI Thesaurus)

Object
type: Class
subclass of: ScienceIndicator

beta-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Pesticide
notation: BHCH

Esophagus
type: Class
subclass of: SIO_010003

Childhood Period
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Childhood
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: birthing
definition: The age span ranging from birth to adolescence

Education Grade 9
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Middle School
comment: Finished Grade 9
notation: 506

Term Birth
type: Class
type: QualityValue
subclass of: Birth Outcome
notation: 97
disjoint with: Preterm Birth

Bisphenol AF
type: Class
subclass of: Phenol
notation: BPAF

Early Concerns or High Risk for Autism
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 343

microsievert
type: SIO_000074
notation: µSv

N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-2,6-dihydro-1,3,5-oxadiazin-4-yl]nitramide
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: NDMT

Never takes
type: Class
subclass of: SIO_001289

Blood Component
type: Class
subclass of: Bodily Fluid
definition: A derivable component of whole blood.

Female Cousin
type: Class
type: QualityValue
type: NodeShape
subclass of: Cousin
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
comment: A female child of one's aunt or uncle. (Source: NCI Thesaurus)
notation: 660

alpha-carotene
type: Class
type: NodeShape
subclass of: Nutrient
notation: ACAR

Respiratory System Findings Original Result
type: Class
subclass of: Thing

Occupation Category 9
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 9=higher executive, proprietor of large businesses, major professional
notation: 516

Trade School Graduate or Some College
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
subclass of: Class
  union of: Some College
  union of: Trade School Graduate
comment: Someone who graduated from trade school or attended some college
notation: 646
equivalent class: Class
  union of: Some College
  union of: Trade School Graduate
  equivalent class: Trade School Graduate or Some College

Step
type: Class
subclass of: Non-Biological Relative
definition: A stepfamily is a family where at least one parent has children that are not genetically related to the other spouse or partner. Either one parent may have children from a previous relationship. Children in a stepfamily may live with one biological parent, or they may live with each biological parent for a period of time. In addition, visitation rights mean that children in stepfamilies often have contact with both biological parents, even if they permanently live with only one. A child is referred to as the stepchild, stepdaughter or stepson of their biological parent's new spouse, and that person as the stepparent, stepfather or stepmother of the child. A stepfather is the husband of one's mother, and not one's biological father. A stepmother is the wife of one's father, and not one's biological mother. A step-grandmother is the wife of one's grandfather, and not one's biological grandmother. A step-grandfather is the husband of one's grandmother, and not one's biological grandfather. Similarly, a stepbrother is the son of a stepparent who one is not biologically related to. A stepsister is the daughter of a stepparent to whom one is not biologically related. A step-grandson is the son of a stepson or stepdaughter who one is not biologically related to. A step-granddaughter is the daughter of a stepson or stepdaughter who one is not biologically related. A parent's spouse of the same sex may also count as a stepparent.

Benzophenone-3
type: Class
subclass of: phenol
notation: BP3
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
editorial note: Duplicate of OXB?

SpectraMax Plus 384 Microplate Reader
type: Class
subclass of: Microplate Reader
definition: Get absorbance measurements from 190 to 1000 nm quickly for samples in test tubes, cuvettes, and 96- or 384-well microplates. The SpectraMax® Plus 384 Microplate Reader gives you walk-up convenience for both standard spectrophotometer and microplate reader applications on the same instrument. Monochromator wavelength selection saves you the time and trouble of ever having to change out filters. Typical applications for this powerful reader include DNA and RNA quantification, enzyme kinetic assays, and ELISA based assays. When your project is ready for high throughput, take advantage of StakMax® automated microplate handling compatibility for full robotic integration.
was approved by: PER-Jim-McCusker

kilogram
type: SIO_000074
notation: kg

Fine Motor Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03172
  on property: wasDerivedFrom

scoliosis
type: Class
subclass of: SIO_010056
subclass of: Scoliosis or Spinal Surgery

6-hydroxychrysene
type: Class
subclass of: polycyclic hydrocarbon
notation: CHRY6

Less Than Grade 7
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Middle School
comment: Completed less than Grade 7
notation: 507

Technical Post Junior College
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
subclass of: Technical School
notation: 93
definition: Attended a Technical Post Junior College
was approved by: PER-Jeanette-Stingone

Biological Relative
type: Class
subclass of: Relative
definition: Being from the same biological kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person.

Subject
type: Class
subclass of: SIO_000016
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Study
definition: A living individual about whom a research investigator (whether a professional or a student) obtains data through 1) intervention or interaction with the individual, or 2) identifiable private information
was approved by: PER-Jeanette-Stingone

meter
type: SIO_000074
notation: m

Early Learning Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_01393
  on property: wasDerivedFrom

Platinum
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Pt
definition: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) PLATINUM is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".

gamma-tocopherol
type: Class
type: NodeShape
subclass of: Nutrient
notation: GTOC

Abnormal nervous system physiology
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 352

Occupation Category 7
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 7=smaller business owners, farm owners, managers, minor professionals
notation: 514

2-isopropyl-6-methyl-4-pyrimidinone
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A pyrimidone that is pyrimidin-4(1H)-one substituted by a methyl group at position 6 and an isopropyl group at position 2. It is a metabolite of diazinon. (Source: CHEBI)
notation: IMPY

Trade School Graduate
type: Class
type: QualityValue
type: NodeShape
subclass of: Trade School Graduate or Some College
comment: Graduated from a trade school
notation: 608
disjoint with: Some Trade School

Some High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 87
definition: Education Level of Some High School
was approved by: PER-Jeanette-Stingone

Adolescent Period
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: birthing
subclass of: Adolescence
definition: The age span ranging from adolescence to adulthood

Broken Mitest
type: Class
subclass of: SIO_001167

fish
type: Class
subclass of: Thing

College Graduate or Higher
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
comment: A graduate of a college or university, or of a higher graduate degree
notation: 645

Occupation Category 8
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 8=administrators, lesser professionals, proprietor of medium-sized business
notation: 515

Some Middle School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 90
definition: Attended Some Middle School
was approved by: PER-Jeanette-Stingone

Advanced Graduate Degree
type: Class
type: QualityValue
subclass of: Education
notation: 4
definition: Having earned a pos-baccalaureate degree

Shotgun Lipidomics
type: Class
subclass of: Electrospray Ionization Mass Spectrometry

Blackbody Infrared Radiative Dissociation (BIRD)
type: Class
subclass of: TandemMassSpectrometry

School Based Selection Criterion
type: Class
type: NodeShape
subclass of: OBI_0001755

Occupation Category 5
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 5=clerical and sales workers, small farm and business owners (business valued at $25,000-50,000)
notation: 512

Some Trade School
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
comment: Has attended some trade school, but has not graduated from trade school
notation: 606
disjoint with: Trade School Graduate

SIO_010048
type: QualityValue
notation: 111

cells per microliter
type: SIO_000074
notation: cp/µl

4-(methlynitrosamino)-1-(3-pyridyl)-1-butanol
type: Class
subclass of: Tobacco Metabolite
notation: NNAL
editorial note: To Do: align with CHEBI.

Sibling
type: Class
type: QualityValue
subclass of: Relative
subclass of: SIO_000287
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Sibling
    intersection of: SIO_000485
notation: 353
definition: One of two or more individuals having one or both parents in common. A male sibling is a brother, and a female sibling is a sister. In most societies throughout the world, siblings often grow up together, thereby facilitating the development of strong emotional bonds. The emotional bond between siblings is often complicated and is influenced by factors such as parental treatment, birth order, personality, and personal experiences outside the family. However, there are cases where siblings grow up in separate homes, in different environments.
was approved by: PER-Jeanette-Stingone

Nitrogen Dioxide
type: Class
subclass of: Environmental Exposure

Occupation Category 6
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 6=technicians, semi-professionals, small business owners (business valued at $50,000-70,000)
notation: 513

Completed Primary School and Some Trade School
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Trade School
comment: Has completed primary school and has attended some trade school, but has not graduated
notation: 607

Post-Menopause
type: Class
type: NodeShape
subclass of: Life Stage
subclass of: Restriction
  some values from: Menopause
  on property: intervalMetBy
comment: The time period that begins after the onset of menopause

Some Elementary School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 86
definition: Attended Some Elementary School
was approved by: PER-Jeanette-Stingone

Active Non-Tobacco Smoker
type: Class
type: QualityValue
subclass of: Active Smoker
notation: 1
definition: Active Non-Tobacco Smoker

Male Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 323

Cellular debris present
type: Class
subclass of: SIO_001167

Phenol, 2,6-dichloro-4-[1-(3-chloro-4-hydroxyphenyl)-1-methylethyl]-
type: Class
type: NodeShape
subclass of: Phenol
notation: TCBPA335

Underweight/Normal
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 100

Underweight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Underweight/Normal
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 99
definition: BMI < 18.5

Drowning
type: Class
subclass of: Activity
subclass of: Drowning or Asphyxia or Hanging
comment: Drowning is a type of suffocation induced by the submersion or immersion of the mouth and nose in a liquid. ... An incident of drowning can also cause further complications for victims due to low body temperature, aspiration of vomit, or acute respiratory distress syndrome (respiratory failure from lung inflammation). (Source: https://en.wikipedia.org/wiki/Drowning)

I Never Felt Problems Kept Piling Up Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001289
subclass of: I Felt Problems Kept Piling Up Response
notation: 458

Bisphenol A diglycidyl ether
type: Class
type: NodeShape
subclass of: Phenol
notation: BADGE

times per two months
type: SIO_000074
type: SIO_000794
notation: times / two months

Interferon lambda-2
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL28A

Bisphenol A
type: Class
subclass of: phenol
notation: BPA
definition: 4, 4'-isopropylidenediphenol is a white to light brown flakes or powder. Has a weak medicine odor. Sinks in water. (USCG, 1999)

dots per inch
type: SIO_000074
notation: dpi

Tanner Male Pubic Hair Development Stage V
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: hair extends to medial surface of the thighs (15+) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 572

Magnesium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
notation: Mg
definition: An element with atomic symbol Mg, atomic number 12, and atomic weight 24.3. Magnesium is an alkaline earth metal and is important to bone structure in human physiology.

feces
type: Class
subclass of: Biospecimen
definition: Portion of semisolid bodily waste discharged through the anus[MW, modified] [database_cross_reference: http://en.wikipedia.org/wiki/Feces][database_cross_reference: http://www.merriam-webster.com/dictionary/feces]

Unknown Education Level
type: Class
type: QualityValue
subclass of: Education
notation: 101
definition: Level of Education is not known
was approved by: PER-Jeanette-Stingone

Hanging
type: Class
subclass of: Activity
subclass of: Drowning or Asphyxia or Hanging
comment: Hanging is the suspension of a person by a noose or ligature around the neck. ... Hanging is a common method of suicide in which a person applies a ligature to the neck and brings about unconsciousness and then death by suspension or partial suspension. (Source: https://en.wikipedia.org/wiki/Hanging).

8,12-iso-Isoprostane-F2 alpha-VI
type: Class
subclass of: isoprostane
subclass of: Oxidative Stress Marker
notation: F2A12I
definition: An Isoprostane with the CAS # 1445349-99-4

I Rarely Felt Problems Kept Piling Up Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Problems Kept Piling Up Response
notation: 460

millimolal
type: SIO_000074
notation: mmol/kg

parasite count
type: Class
subclass of: Concentration

Four Factor Index of Social Status Questionnaire
type: Class
type: NodeShape
subclass of: Questionnaire
comment: Four Factor Index of Social Status by August B. Hollingshead Reference: https://sociology.yale.edu/sites/default/files/files/yjs_fall_2011.pdf

Cobalt
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Co
definition: COBALT is a trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.

renal dialysis
type: Class
subclass of: SIO_001024
subclass of: ventilator supporting therapy
subclass of: Home Medical Technology

mono-isononyl phthalate
type: Class
subclass of: Phthalate
notation: mINP

Third Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
subclass of: Restriction
  some values from: Second Trimester
  on property: intervalMetBy
subclass of: Restriction
  some values from: Pregnancy
  on property: intervalFinishes
definition: From 29 weeks through 40 weeks.
was approved by: PER-Jeanette-Stingone

Tobacco Cessation Intervention Group
type: Class
type: QualityValue
subclass of: Experimental Group
notation: 202
definition: A group receiving a tobacco cessation intervention that is being tested in a study.

Cardiovascular disease - congenital
type: Class
type: QualityValue
subclass of: arteriosclerotic cardiovascular disease
notation: 389

I Never Felt Stressed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Never Feels Stressed
subclass of: I Felt Stressed Response
notation: 453

Bis(2-ethylhexyl) hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: BEHP

pixels per inch
type: SIO_000074
notation: p/in

Tanner Male Pubic Hair Development Stage III
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: hair becomes more coarse and curly, and begins to extend laterally (11.5–13) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 678

Limit of Quantitation
type: Class
subclass of: Concentration
definition: The Limit of Quantitation is the lowest concentration at which the analyte can not only be reliably detected but at which some predefined goals for bias and imprecision are met. The LoQ may be equivalent to the LoD or it could be at a much higher concentration. (Source: Limit of Blank, Limit of Detection and Limit of Quantitation, David A Armbruster and Terry Pry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556583/)

I Felt Problems Kept Piling Up Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: PROMIS Psychological Stress Experiences Response
comment: A response to the PROMIS questionnaire question "I felt that my problems kept piling up."

Total nicotine
type: Class
subclass of: Tobacco Metabolite
notation: TNIC
editorial note: Duplicate of NIC?

Congenital anomaly or chromosomal defect
type: Class
type: QualityValue
subclass of: Disease
notation: 390
equivalent class: Class
  union of: chromosomal aberration
  union of: Congenital Abnormality
  equivalent class: Congenital anomaly or chromosomal defect

micron pixel
type: SIO_000074
notation: µm pixel

placenta
type: Class
subclass of: Tissue
subclass of: Pregnancy Sample
definition: Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. [database_cross_reference: http://en.wikipedia.org/wiki/Placenta][database_cross_reference: http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm]

Tanner Male Pubic Hair Development Stage IV
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: adult-like hair quality, extending across pubis but sparing medial thighs (13–15) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 679

Summer
type: Class
type: QualityValue
subclass of: Season
notation: 212

Number of Minor Alleles for SNP
type: Class
type: NodeShape
subclass of: SIO_000794
subclass of: Medical History
comment: The measured count of a specific minor allele for a single nucleotide polymorphism of a gene variant

Stress
type: Class
type: QualityValue
subclass of: Stress Frequency
notation: 92
definition: Whether or not a person gets stressed.
was approved by: PER-Jeanette-Stingone

Birthplace
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Location
definition: The place where a person was born.

Childhood Asthma Control Test Score
type: Class
type: QuantityVariable
subclass of: Score
definition: The Childhood Asthma Control Test is a standardized rating scale developed by Nathan et al in 2004, which is used to identify patients from 4 to 11 years old with poorly controlled asthma. This questionnaire contains seven items, four to be answered with the child patient and three to be answered by the child patient's guardian and the score is computed by summing the responses to the seven items. The CACT Score range is from 0 to 27, where a higher number indicates a better level of asthma control.

I Sometimes Felt Stressed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Sometimes Feels Stressed
subclass of: I Felt Stressed Response
notation: 456

base pair
type: SIO_000074
notation: bp

Antimalarial
type: Class
type: QualityValue
subclass of: Medication
notation: 120
definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

Tanner Male Pubic Hair Development Stage I
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: no pubic hair at all (prepubertal) (typically age 10 and younger) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 576

Pregnancy Characteristic
type: Class
subclass of: StudyIndicator
definition: Pregnancy Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

SIO_000784
type: QualityValue
notation: 109

amoxicillin
type: Class
type: NodeShape
subclass of: CHEBI_24431
comment: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.

Fall
type: Class
type: QualityValue
subclass of: Season
notation: 213

Granulocyte-macrophage colony-stimulating factor
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: GMCSF

Non-ecigarette user
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 199
definition: Doesn't use e-cigarettes.

Imputed Measurement
type: Class
type: NodeShape
subclass of: Measurement
comment: An imputed, or inferred measurement one where an assumed value given to an item when the actual value is not known or available. The value may be determined by applying a standard scale or algorithm to other measurements that can be used to estimate the true value of the measurement.

2,4,4',5-Tetrachlorobiphenyl
type: Class
type: NodeShape
subclass of: Polychlorobiphenyl
notation: PCB74

Dietary Supplement
type: Class
type: NodeShape
subclass of: Drug, Food, Chemical or Biomedical Material
comment: Oral preparations containing dietary ingredient(s) intended to supplement the diet. Dietary ingredients include vitamins, minerals, herbs, amino acids, extracts and metabolites. (Source: NCI Thesaurus)

Technical School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
subclass of: Associate's Degree or Technical Degree
notation: 96
definition: Attended a Technical School.
was approved by: PER-Jeanette-Stingone

Cardiovascular disease - acquired
type: Class
type: QualityValue
subclass of: arteriosclerotic cardiovascular disease
notation: 388

I Rarely Felt Stressed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Rarely Feels Stressed
subclass of: I Felt Stressed Response
notation: 455

mass-to-charge ratio
type: SIO_000074
notation: Th

Tanner Male Pubic Hair Development Stage II
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Male Pubic Hair Development
comment: small amount of long, downy hair with slight pigmentation at the base of the penis and scrotum (10–11.5) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 574

pixels per millimeter
type: SIO_000074
notation: p/mm

Predominantly fibrous material
type: Class
subclass of: SIO_001167

pascal
type: SIO_000074
notation: Pa

9-hydroxyfluorene
type: Class
subclass of: polycyclic hydrocarbon
notation: FLUO9

food reheating
type: Class
type: NodeShape
subclass of: food transformation process
comment: A process to bring an already fully cooked product to serving temperature.

Winter
type: Class
type: QualityValue
subclass of: Season
notation: 210

PCB101
type: Class
subclass of: Polychlorobiphenyl
notation: PCB101

Mirex
type: Class
subclass of: Organochlorine Pesticide
notation: MIREX

Asian and White
type: Class
type: QualityValue
type: NodeShape
subclass of: Asian
subclass of: White
subclass of: Multiracial
comment: A multiracial race category indicating that a subject identifies as both Asian and White
notation: 640

endotoxin unit per cubic meter
type: SIO_000074
notation: EU/m3

Second Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
subclass of: Restriction
  some values from: First Trimester
  on property: intervalMetBy
subclass of: Restriction
  some values from: Pregnancy
  on property: intervalDuring
definition: From week 13 through 28. Around the middle of the second trimester, movement of the fetus may be felt. At 28 weeks, more than 90% of babies can survive outside of the uterus if provided with high-quality medical care.
was approved by: PER-Jeanette-Stingone

mono-methyl phthalate
type: Class
subclass of: Phthalate
notation: mMP

Study Followup
type: Class
subclass of: SIO_000417
definition: A point in a study where data is gathered after the initial baseline.

mebibyte
type: SIO_000074
notation: MiB

I Always Felt Stressed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Always Feels Stressed
subclass of: I Felt Stressed Response
notation: 690

Fever
type: Class
type: QualityValue
subclass of: Phenotype
notation: 123
definition: Elevated body temperature due to failed thermoregulation.

Spring
type: Class
type: QualityValue
subclass of: Season
notation: 211

Black and White
type: Class
type: QualityValue
type: NodeShape
subclass of: African American
subclass of: White
subclass of: Multiracial
comment: A multiracial race category indicating that a subject identifies as both Black (African American) and White
notation: 641

Asthma Control Test Score
type: Class
type: QuantityVariable
subclass of: Score
definition: The Asthma Control Test is a standardized rating scale developed by Nathan et al in 2004, which is used to identify patients 12 years or older with poorly controlled asthma. This questionnaire contains five items and the score is computed by summing the responses to the five items. The ACT Score range is from 0 to 25, where a higher number indicates a better level of asthma control.

Birth Year
type: Class
type: QualityValue
subclass of: SIO_000428
notation: 198
definition: The year in which a person was born.

I Often Felt Stressed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: Often Feels Stressed
subclass of: I Felt Stressed Response
notation: 454

Spontaneous Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 22
definition: Had a spontaneous caesarian section
was approved by: PER-Jeanette-Stingone

Household Income
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Socioeconomic Status
definition: A demographic parameter indicating the amount of earnings made by a family.
was approved by: PER-Jeanette-Stingone

joule
type: SIO_000074
notation: J

kibibyte
type: SIO_000074
notation: KiB

Tanner Female Pubic Hair Development Stage V
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: hair extends to medial surface of the thighs (15+) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 575

Born Fourth
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Fourth
notation: 239
definition: The fourth born child

Overweight BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 29.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 25.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter
notation: 685

Tanner Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Research or Clinical Assessment Tool
comment: A scale of physical development in children, adolescents and adults based on external primary and secondary sex characteristics, such as the size of the breasts, genitalia, and development of pubic hair. [Definition Source: NCI][attribution: Tanner JM. Growth at adolescence. 2d ed. Oxford: Blackwell, 1962]

4, 4'-(1-phenylethylidene)bisphenol
type: Class
subclass of: Phenol
notation: BPAP

Healthcare Access
type: Class
subclass of: StudyIndicator
definition: Healthcare Access

Central Line Infection
type: Class
subclass of: hospital-acquired infection
subclass of: Restriction
  some values from: central venous cannula insertion
  on property: SIO_001157
subclass of: CAUTI or CLABSI or VAP

Polybrominated Diphenyl Ether
type: Class
subclass of: brominated flame retardant

Exposed to Second Hand Smoke in Primary Caregiver's Car, in Other Car, in Relative's House, and in Outdoor Public Space
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Primary Caregiver's Car
subclass of: Exposed to Second Hand Smoke in Other Car
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
subclass of: Exposed to Second Hand Smoke at Relative's House
notation: 545
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Primary Caregiver's Car
  intersection of: Exposed to Second Hand Smoke in Other Car
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  intersection of: Exposed to Second Hand Smoke at Relative's House
  equivalent class: Exposed to Second Hand Smoke in Primary Caregiver's Car, in Other Car, in Relative's House, and in Outdoor Public Space

degree Fahrenheit
type: SIO_000074
notation: F

molar
type: SIO_000074
notation: M

Thiacloprid amide
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
notation: TA

Vivera
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

Obese BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 29.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter
notation: 687

Born Fifth
type: Class
type: QualityValue
subclass of: Fifth
subclass of: Birth Order
notation: 240
definition: The fifth born child

1-hydroxychrysene
type: Class
subclass of: polycyclic hydrocarbon
notation: CHRY1

HUC sample having discrepancy between fluorometer results and semi quantative Albustix test results
type: Class
subclass of: SIO_001167

leukotriene E4
type: Class
subclass of: Biological Response
subclass of: Inflammatory Marker
notation: LTE4

Vintix
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

Exposed to Second Hand Smoke in Other Car and at Relative's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke in Other Car
subclass of: Exposed to Second Hand Smoke at Relative's House
notation: 546
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke in Other Car
  intersection of: Exposed to Second Hand Smoke at Relative's House
  equivalent class: Exposed to Second Hand Smoke in Other Car and at Relative's House

Non-White Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-White
subclass of: Non-Hispanic Ethnicity
notation: 326

Born Second
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Second
notation: 237
definition: The second born child

Neurological Vascular Malformation
type: Class
type: QualityValue
subclass of: vascular malformation
subclass of: Neurologic
comment: Vascular malformations within the central nervous system
notation: 411
editorial note: Additional research I did suggests this CNS vascular malformations includes AVMs, capillary telangiectasias, cavernous malformations, dural arteriovenous fistulas, venous malformations.

Hemolyzed (covers all three levels) and debris present
type: Class
subclass of: SIO_001167

Budesonide nebulized (Pulmicort)
type: Class
subclass of: Asthma Controller Medication

liter per kilogram
type: SIO_000074
notation: l/kg

micromolar
type: SIO_000074
notation: µM

Number of A minor alleles for rs2476601 genotyped on the Illumina Immunochip
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of A minor alleles for rs2476601

Healthy BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 25.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 0.0
  on property: SIO_000216
notation: 686

Born Third
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Third
notation: 238
definition: The third born child

Hemolyzed (covers all three levels) and contaminated
type: Class
subclass of: SIO_001167

2, 3, 4, 6-Tetrachlorophenol
type: Class
subclass of: phenol
notation: TeCP2346
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)

millimolar
type: SIO_000074
notation: mM

Perenteryl
type: Class
type: NodeShape
subclass of: Probiotic
comment: A name brand probiotic supplement

Tumor necrosis factor
label: TNF-alpha
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: TNFA
definition: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

Toxin Ingestion
type: Class
subclass of: Drug or Toxin Ingestion
subclass of: ingestion
subclass of: Restriction
  some values from: toxin
  on property: SIO_000139

Garage
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 235
definition: A building, or part of a building primarily used for housing a motor vehicle or vehicles.

Gas Chromatography
type: Class
subclass of: Chromatography

Post-Birth 1 Minute
type: Class
subclass of: SIO_000417
definition: One minute after birth of a child

Polygamous
type: Class
type: QualityValue
subclass of: Marital Status
notation: 45
definition: A type of living arrangement or mating system in which at least one member of a relationship has more than one mate.

picomolar
type: SIO_000074
notation: pM

microliter per kilogram
type: SIO_000074
notation: µl/kg

Fluticasone propionate HFA (Flovent HFA)
type: Class
subclass of: Asthma Controller Medication

Occupation Category 2
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 2=unskilled workers
notation: 509

Diisobutyl hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DIBP

Lymphotoxin-alpha
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: TNFB

Drug or Toxin Ingestion
type: Class
type: QualityValue
subclass of: ingestion
notation: 394
equivalent class: Class
  union of: Drug Ingestion
  union of: Toxin Ingestion
  equivalent class: Drug or Toxin Ingestion

Post-Birth 5 Minutes
type: Class
subclass of: SIO_000417
definition: Five minutes after birth of a child

malonaldehyde
type: Class
type: NodeShape
subclass of: Oxidative Stress Marker
comment: A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form. (Source: ChEBI)
notation: OSMDA

Born First
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: First
notation: 236
definition: The first born child

Paraben
type: Class
subclass of: Phenol

nanomolar
type: SIO_000074
notation: nM

milliliter per kilogram
type: SIO_000074
notation: ml/kg

Number of A minor alleles for rs2476601 genotyped by the TEDDY HLA Lab
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of A minor alleles for rs2476601

Unplanned Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 23
definition: Had an unplanned caesarian section.
was approved by: PER-Jeanette-Stingone

Butyl paraben
type: Class
subclass of: Paraben
notation: BuPB
definition: Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of butylparaben is Allergens.

Seasonal Population Group
type: Class
type: QualityVariable
subclass of: Population Group
definition: A Population Group organized by which season of the year the subjects were tested or studied.

Greater than 99th percentile
type: Class
subclass of: SIO_001167

Drowning or Asphyxia or Hanging
type: Class
type: QualityValue
subclass of: Activity
notation: 393
equivalent class: Class
  union of: Drowning
  union of: Hanging
  union of: asphyxia
  equivalent class: Drowning or Asphyxia or Hanging

I Sometimes Felt Problems Kept Piling Up Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Problems Kept Piling Up Response
notation: 461

Doctorate Degree
type: Class
type: QualityValue
subclass of: Completed Graduate School
notation: 144
definition: The Doctor's Degree is the highest award a student can earn for graduate study. The doctor's degree classification includes such degrees in any field.

mono-hexyl phthalate
type: Class
subclass of: Phthalate
notation: mHxP

molal
type: SIO_000074
notation: mol/kg

Ethylbenzene
type: Class
subclass of: Volatile Organic Compound
notation: EB
definition: Ethylbenzene is mainly used in the manufacture of styrene. Acute (short-term) exposure to ethylbenzene in humans results in respiratory effects, such as throat irritation and chest constriction, irritation of the eyes, and neurological effects such as dizziness. Chronic (long-term) exposure to ethylbenzene by inhalation in humans has shown conflicting results regarding its effects on the blood. Animal studies have reported effects on the blood, liver, and kidneys from chronic inhalation exposure to ethylbenzene. Limited information is available on the carcinogenic effects of ethylbenzene in humans. In a study by the National Toxicology Program (NTP), exposure to ethylbenzene by inhalation resulted in an increased incidence of kidney and testicular tumors in rats, and lung and liver tumors in mice. EPA has classified ethylbenzene as a Group D, not classifiable as to human carcinogenicity.

Four Factor Index of Social Status Questionnaire Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: Demographic
subclass of: Socioeconomic Status
subclass of: Questionnaire Response

I Often Felt Problems Kept Piling Up Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001291
subclass of: I Felt Problems Kept Piling Up Response
notation: 459

lutein
type: Class
type: NodeShape
subclass of: Nutrient
notation: LUT

Gravimetric Analysis Instrument
type: Class
subclass of: PhysicalInstrument
definition: Gravimetric analysis describes a set of methods used in analytical chemistry for the quantitative determination of an analyte (the ion being analyzed) based on its mass. The principle behind this type of analysis is that once an ion's mass has been determined as a unique compound, that known measurement can then be used to determine the same analyte's mass in a mixture, as long as the relative quantities of the other constituents are known.
was approved by: PER-Jim-McCusker

Tetrachloroethene
type: Class
subclass of: Volatile Organic Compound
notation: TCE
definition: TETRACHLOROETHYLENE is a chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.

4-hydroxychrysene
type: Class
subclass of: polycyclic hydrocarbon
notation: CHRY4

Drug Ingestion
type: Class
subclass of: Drug or Toxin Ingestion
subclass of: ingestion
subclass of: Restriction
  some values from: drug
  on property: SIO_000139

Pregnancy Month 1
type: Class
subclass of: SIO_000417
definition: The first month of pregnancy

11 or More Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 234
definition: A residential building that contains eleven or more apartments, town houses, condos, or other single family dwelling spaces.

phthalic acid
type: Class
subclass of: Phthalate
notation: PA
definition: PHYSICAL DESCRIPTION: White crystals or fine white powder. (NTP, 1992)

Occupation Category 1
type: Class
type: QualityValue
type: NodeShape
subclass of: Occupation
subclass of: Four Factor Index of Social Status Questionnaire Response
comment: 1=farm laborers, menial service workers, students, housewives, (dependent on welfare, no regular occupation),
notation: 508

Sneezing, Runny Nose, or Congestion
type: Class
type: NodeShape
subclass of: SIO_010056
notation: 428
equivalent class: Class
  union of: Sneeze
  union of: Rhinorrhea
  union of: Nasal congestion
  equivalent class: Sneezing, Runny Nose, or Congestion

Exposed to Second Hand Smoke at Home and in Other Car
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Home
subclass of: Exposed to Second Hand Smoke in Other Car
notation: 541
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Home
  intersection of: Exposed to Second Hand Smoke in Other Car
  equivalent class: Exposed to Second Hand Smoke at Home and in Other Car

DR3*0501/0201*DR9*030X/0303
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 613

I Rarely Felt Overwhelmed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Overwhelmed Response
notation: 465

Mono-3-hydroxybutyl phthalate
type: Class
type: NodeShape
subclass of: Phthalate
comment: Synonyms: Mono-3-hydroxybutyl phthalate SCHEMBL4078490 DTXSID601027746 Phthalic acid 1-(3-hydroxybutyl) ester

SIO_010058
type: QualityValue
notation: 131

N-Ace-S-(dimethylphenyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCDPM
editorial note: To Do: align with CHEBI.

Non-Spontaneous Preterm Birth
type: Class
type: QualityValue
subclass of: Preterm Birth
subclass of: Non-spontaneous Birth
subclass of: Class
  intersection of: Preterm Birth
  intersection of: Non-spontaneous Birth
notation: 60
equivalent class: Class
  intersection of: Preterm Birth
  intersection of: Non-spontaneous Birth
  equivalent class: Non-Spontaneous Preterm Birth

Head
type: Class
subclass of: SIO_010046

I Sometimes Felt Overwhelmed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Overwhelmed Response
notation: 466

Food Product Packaged in Plastic
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000128
equivalent class: Class
equivalent class: Class
  intersection of: food product
  intersection of: Restriction
    some values from: plastic container
    on property: SIO_000128
  equivalent class: Food Product Packaged in Plastic

Exposed to Second Hand Smoke at Home and in Outdoor Public Place
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Home
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
notation: 542
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Home
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  equivalent class: Exposed to Second Hand Smoke at Home and in Outdoor Public Place

SIO_010059
type: QualityValue
notation: 132

N-Acel-S-(2, 2-Dichlorvinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC2DC
editorial note: To Do: align with CHEBI.

Other GI Disease
type: Class
type: QualityValue
subclass of: SIO_010299
subclass of: Health Outcome
notation: 69
editorial note: This is a temp concept that needs addressing

Freeze/Thaw Cycles Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
definition: Number of Freeze/Thaw cycles.
was approved by: PER-Jeanette-Stingone

alpha-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Pesticide
notation: AHCH

Styrene
type: Class
subclass of: Volatile Organic Compound
notation: STY
definition: STYRENE is a colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.

oleic acid
type: Class
subclass of: Fatty Acid
notation: C181N9
definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.

Domestic Partnership
type: Class
type: QualityValue
subclass of: Unmarried
notation: 42
definition: Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered.

DR4*030X/0302*DR9*030X/0303
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 621

Exposed to Second Hand Smoke at Daycare
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 539

SIO_001068
type: QualityValue
notation: 135

Mean Circumference
type: Class
type: NodeShape
subclass of: SIO_001109
subclass of: Circumference
comment: The mean value obtained from several measurements of an object's circumference

Nicotelline
type: Class
type: NodeShape
subclass of: Tobacco Metabolite
notation: NICTL

Step Parent
type: Class
type: NodeShape
subclass of: Step
subclass of: Parent
comment: A non-biological parent through current or prior marriage to the subject's biological or legal parent. (Source: NCI Thesaurus)

N-Ace-S-(3-Hydroxypropyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHPM
editorial note: To Do: align with CHEBI.

I Felt Overwhelmed Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: PROMIS Psychological Stress Experiences Response
comment: A response to the PROMIS questionnaire question "I felt overwhelmed."

I Never Felt Overwhelmed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001289
subclass of: I Felt Overwhelmed Response
notation: 463

Exposed to Second Hand Smoke at Home and in Primary Caregiver's Car
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Home
subclass of: Exposed to Second Hand Smoke in Primary Caregiver's Car
notation: 540
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Home
  intersection of: Exposed to Second Hand Smoke in Primary Caregiver's Car
  equivalent class: Exposed to Second Hand Smoke at Home and in Primary Caregiver's Car

DR3*0501/0201*DR3*0501/0201
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 612

T-Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Score
definition: A method for converting an individual score into a standard form. While similar to a z-score, t-score is used when the conversion is made without knowledge of the population standard deviation and mean.

Developmental delay or intellectual disability
type: Class
type: QualityValue
subclass of: Neurodevelopmental abnormality
notation: 427
equivalent class: Class
  union of: Intellectual disability
  union of: Neurodevelopmental delay
  equivalent class: Developmental delay or intellectual disability

N-Ace-S-(N-methlcarbamoyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCAMC
editorial note: To Do: align with CHEBI.

Multiplex real-time PCR
type: Class
subclass of: Polymerase Chain Reaction

Height
type: Class
type: QuantityVariable
subclass of: Anthropometry
definition: Height
was approved by: PER-Jeanette-Stingone

Behavioral Experimental Paradigm
type: Class
subclass of: Neurocognitive Assessment

Biological Parent
type: Class
type: NodeShape
subclass of: Parent
subclass of: Biological Relative
comment: The male who supplied the sperm or the female who supplied the egg which resulted in one's conception. (Source: NCI Thesaurus)

Cohort Group 3
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
comment: Cohort group 3 for the "Sex-Specific Omics Profiles Related to Toxicant Exposures in Children" study conducted by Wei Perng, University of Michigan School of Public Health
notation: 704

cerebral infarction
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

Annual Income $100,000 to $199,999
type: Class
type: QualityValue
subclass of: Annual Income More Than $95,000
notation: 422

Failed positive control
type: Class
subclass of: SIO_001167

No Anti Malarial Use
type: Class
type: QualityValue
subclass of: Antimalarial Use
subclass of: Prescription Medication and Dietary Supplements
notation: 140

N-Ace-S-(2-carbamoylethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCAAM
editorial note: To Do: align with CHEBI.

Exposed to Second Hand Smoke at Relative's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 537

cyclic peptide
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).

DR4*030X/0302*DR13*0102/0604
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 615

Pathogen Transmission
type: Class
subclass of: Process

DR4*030X/0302*DR4*030X/0304
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 619

Annual Income More Than $200,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $125,000
notation: 423

Failed negative control
type: Class
subclass of: SIO_001167

Neurocognitive Assessment
type: Class
subclass of: Physical And Mental Assessment

N-Ace-S-(2-hydroxypropyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHP2
editorial note: To Do: align with CHEBI.

Interleukin-15
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL15

Retinol
type: Class
type: NodeShape
subclass of: Nutrient
notation: VITA

I Always Felt Problems Kept Piling Up Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001292
subclass of: I Felt Problems Kept Piling Up Response
notation: 457

Exposed to Second Hand Smoke at Friend's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 538

Mean Concentration Range > 1000 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 1000.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 322

SIO_010052
type: QualityValue
notation: 110

microbial phenotype
type: Class
subclass of: SIO_010056

Fibrin present
type: Class
subclass of: SIO_001167

Clinical Measurement
type: Class
subclass of: Physical And Mental Assessment
definition: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

DR4*030X/0302*DR8*0401/0402
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 620

Exposed to Second Hand Smoke in Other Car
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 535

Cohort Group 2A
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
comment: Cohort group 2A for the "Sex-Specific Omics Profiles Related to Toxicant Exposures in Children" study conducted by Wei Perng, University of Michigan School of Public Health
notation: 702
notation: 703

10^3 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^3 cells / µL

drug
type: Class
subclass of: Thing

Forced Expiratory Flow at 25-75 Percent
type: Class
type: QualityVariable
subclass of: CMO_0000094

Fenton Preterm Growth Chart
type: Class
subclass of: SIO_000442
definition: A growth chart adusted for gestational age

Cohort Group 2B
type: Class
type: NodeShape
subclass of: Population Group
comment: Cohort group 2B for the "Sex-Specific Omics Profiles Related to Toxicant Exposures in Children" study conducted by Wei Perng, University of Michigan School of Public Health

Exposed to Second Hand Smoke in Outdoor Public Place
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 536

DR4*030X/0302*DR1*0101/0501
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 614

8-hydroxy-2'-deoxyguanosine
type: Class
subclass of: Biological Response
subclass of: Biomolecule
subclass of: Oxidative Stress Marker
notation: OS8OHDG
definition: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Inpatient Encounter
type: Class
type: QualityValue
subclass of: Destination
notation: 169
definition: A patient encounter where a patient is admitted to a hospital or equivalent facility.

Maternal Antibody
type: Class
type: NodeShape
subclass of: SIO_010465
comment: Maternal antibodies are transferred from mother to child and protect neonates and infants during the time of maturation of their immune system. The vast majority of maternal antibodies are of the IgG isotype. Source: Niewiesk S. Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies. Front Immunol. 2014 Sep 16;5:446. doi: 10.3389/fimmu.2014.00446. PMID: 25278941; PMCID: PMC4165321.

Wheezing
type: Class
type: QualityValue
subclass of: wheezing or tightness in the chest or cough
notation: 597

Spontaneous Preterm Birth
type: Class
type: QualityValue
subclass of: Preterm Birth
subclass of: Spontaneous Labor and Birth
subclass of: Class
  intersection of: Preterm Birth
  intersection of: Spontaneous Labor and Birth
notation: 91
equivalent class: Class
  intersection of: Preterm Birth
  intersection of: Spontaneous Labor and Birth
  equivalent class: Spontaneous Preterm Birth

Childhood Baseline
type: Class
subclass of: Study Baseline
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
definition: A point in a study set to the initial point which occurs during the study subject's childhood period.

microgram per gram
type: SIO_000074
notation: µg/g

picoliter
type: SIO_000074
notation: pl

Personal Product Use
type: Class
subclass of: StudyIndicator
definition: Personal Product Use Indicator Class
was approved by: PER-Jeanette-Stingone

Bis(4-methylphenyl) hydrogen phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DPCP

Medication
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
notation: 142
definition: A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.

Exposure to Maternal Antibodies
type: Class
type: QualityValue
type: NodeShape
subclass of: exposure
subclass of: Restriction
  some values from: Maternal Antibody
  on property: SIO_000139
comment: Exposure to maternal antibodies
notation: 639

Childhood Followup
type: Class
subclass of: Study Followup
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
subclass of: Restriction
  some values from: Childhood Baseline
  on property: intervalAfter
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
definition: A point in a study that occurs after the initial baseline of the study and occurs during the study subject's childhood period.

picogram per cubic meter
type: SIO_000074
notation: pg/m3

Repeat Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 21
definition: Had Repeat Caesarian Section

nanoliter
type: SIO_000074
notation: nl

megabyte
type: SIO_000074
notation: MB

Partial match
type: Class
subclass of: SIO_001167

EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor
type: Class
type: NodeShape
subclass of: drug

Study Followup 7
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 6
  on property: intervalAfter
definition: A point in a study where data is gathered after the sixth study followup.

I Rarely Felt Unable To Manage Things In My Life Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001290
subclass of: I Felt Unable To Manage Things In My Life Response
notation: 470

Socioeconomic Status Index
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Socioeconomic Status
definition: A measure of SES.
editorial note: This is a specific index, derived from other variables. So, it should somehow be connected to this variables. Also, we may want to be more specific about the type of index that it is. Perhaps there should be a general SESIndex and then subclasses of specific measures?

hertz
type: SIO_000074
notation: Hz

rs231775
type: Class
type: NodeShape
subclass of: SNP

Monthly Income $3,751 to $4,166
type: Class
type: QualityValue
subclass of: Household Income
notation: 293

Caregiver
type: Class
subclass of: Demographic
subclass of: SIO_000016
definition: a paid or unpaid and without formal training member of a person's social network who helps them with activities of daily living. Caregiving is most commonly used to address impairments related to old age, disability, a disease, or a mental disorder.

Physical And Mental Assessment
type: Class
subclass of: StudyIndicator
definition: Physical and Mental Assessments Indicator Class
was approved by: PER-Jeanette-Stingone

Study Followup 8
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 7
  on property: intervalAfter
definition: A point in a study where data is gathered after the seventh study followup.

Teenager
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
notation: 137
definition: An individual between the ages of 13 and 19.
was approved by: PER-Jeanette-Stingone

Solid-Phase Sandwich ELISA
type: Class
subclass of: Sandwich ELISA
was approved by: PER-Jim-McCusker

4-hydroxyphenanthrene
type: Class
subclass of: polycyclic hydrocarbon
notation: PHEN4

Monthly Income More Than $4,166
type: Class
type: QualityValue
subclass of: Household Income
notation: 294

Some Postgraduate
type: Class
type: QualityValue
subclass of: Higher Education
subclass of: Restriction
  some values from: NCIT C92860
  on property: SIO_000230
notation: 187
definition: Has begun postgraduate (masters, doctorate, etcl) and may or may not have matriculated with a graduate degree.

femtoliter
type: SIO_000074
notation: fl

Physical Activity and Fitness
type: Class
subclass of: StudyIndicator
definition: Physical Activity and Fitness Indicator Class
was approved by: PER-Jeanette-Stingone

mono (5-carboxy-2-ethylpentyl) phthalate (DEHP)
type: Class
subclass of: Phthalate
notation: MECPP

Barium
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Ba
definition: BARIUM is an element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.

Study Followup 5
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 4
  on property: intervalAfter
definition: A point in a study where data is gathered after the fourth study followup.

I Felt Unable To Manage Things In My Life Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: PROMIS Psychological Stress Experiences Response
comment: A response to the PROMIS questionnaire question "I felt unable to manage things in my life."

N-Acetyl-S- (3-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMA
editorial note: To Do: align with CHEBI.

Room Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Rooms in the Home
was approved by: PER-Jeanette-Stingone

newton
type: SIO_000074
notation: Ntn

2, 4, 5-Trichlorophenol
type: Class
subclass of: phenol
notation: TCP245
definition: Exposure to 2, 4, 5-trichlorophenol may occur during its production or use as a pesticide. Acute (short-term) dermal exposure to 2, 4, 5-trichlorophenol may burn skin in humans. It also irritates the eyes, nose, pharynx, and lungs in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of 2, 4, 5-trichlorophenol in humans. In one study, slight degenerative changes were observed in the liver and kidneys of rats chronically exposed to 2, 4, 5-trichlorophenol in their diet. EPA has classified 2, 4, 5-trichlorophenol as a Group D, not classifiable as to human carcinogenicity. PHYSICAL DESCRIPTION: Colorless needles, gray flakes or off-white lumpy solid. Phenolic odor. Formerly used as a fungicide and bactericide.

Overloaded filter
type: Class
subclass of: SIO_001167

Monthly Income $2,918 to $3,333
type: Class
type: QualityValue
subclass of: Household Income
notation: 291

bronchiolitis
type: Class
type: QualityValue
subclass of: lung disease
notation: 194

adult respiratory distress syndrome
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 385

Matrix metalloproteinase-9
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MMP9

Food Or Beverage Product Reheated in a Plastic Container
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: Reheating Food or Beverage in a Plastic Container
  on property: SIO_000311
comment: Food (or beverage) that has been reheated inside a container made of plastic

Monomethylarsonic Acid
type: Class
subclass of: Arsenic Species
notation: Monomethylarsonic Acid

Study Followup 6
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 5
  on property: intervalAfter
definition: A point in a study where data is gathered after the fifth study followup.

I Never Felt Unable To Manage Things In My Life Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001289
subclass of: I Felt Unable To Manage Things In My Life Response
notation: 468

N-Acetyl-S-(1, 2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DCVMA12
editorial note: To Do: align with CHEBI.

SYNAPT G2-Si Mass Spectrometer
type: Class
subclass of: Hydrogen–Deuterium Exchange Mass Spectrometer
was approved by: PER-Jim-McCusker

Oral Health
type: Class
subclass of: StudyIndicator
definition: Oral Health Indicator Class
was approved by: PER-Jeanette-Stingone

Monthly Income $3,334 to $3,750
type: Class
type: QualityValue
subclass of: Household Income
notation: 292

I Often Felt Overwhelmed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001291
subclass of: I Felt Overwhelmed Response
notation: 464

Eats Food Packaged in Plastic
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Food Product Packaged in Plastic
  on property: SIO_000230
comment: The act of eating food that has been packaged in a plastic container.

Exposed to Second Hand Smoke at Other Parent's House, in Other Car, and in Outdoor Public Place
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Other Parent's House
subclass of: Exposed to Second Hand Smoke in Other Car
subclass of: Exposed to Second Hand Smoke in Outdoor Public Place
notation: 543
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Other Parent's House
  intersection of: Exposed to Second Hand Smoke in Other Car
  intersection of: Exposed to Second Hand Smoke in Outdoor Public Place
  equivalent class: Exposed to Second Hand Smoke at Other Parent's House, in Other Car, and in Outdoor Public Place

Perceived Stress Scale
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire
subclass of: Research or Clinical Assessment Tool
comment: A 10-item self-report questionnaire that measures a person's evaluation of the stressfulness of life situations in the past month. Each item is rated 0-4 on a 5-point Likert scale. (Cohen, et al, J Health Soc Behav, 24 (1983)) (Source: NCI Thesaurus)

N-Acetyl-S- (2-carboxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: CEMA
editorial note: To Do: align with CHEBI.

Pregnancy Sample
type: Class
subclass of: Biospecimen
definition: A sample that is taken at or near pregnancy or birth.

Parental Health and Family History
type: Class
subclass of: StudyIndicator
definition: Parental Health and Family History Indicator Class
was approved by: PER-Jeanette-Stingone

Beverage Packaged in Plastic
type: Class
type: NodeShape
subclass of: beverage
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000128
comment: A liquid beverage that is packaged in a plastic container
equivalent class: Class
  intersection of: beverage
  intersection of: Restriction
    some values from: plastic container
    on property: SIO_000128
  equivalent class: Beverage Packaged in Plastic

I Always Felt Overwhelmed Response
type: Class
type: QualityValue
type: NodeShape
subclass of: SIO_001292
subclass of: I Felt Overwhelmed Response
notation: 462

4-hydroxybenzophenone
type: Class
subclass of: Benzophenone
notation: OH4BP

Exposed to Second Hand Smoke at Other Parent's House and at Relative's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Exposed to Second Hand Smoke at Other Parent's House
subclass of: Exposed to Second Hand Smoke at Relative's House
notation: 544
equivalent class: Class
  intersection of: Exposed to Second Hand Smoke at Other Parent's House
  intersection of: Exposed to Second Hand Smoke at Relative's House
  equivalent class: Exposed to Second Hand Smoke at Other Parent's House and at Relative's House

N-Acetyl-S- (3, 4-dihydroxybutyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DHBMA
editorial note: To Do: align with CHEBI.

RNA Sequencing
type: Class
subclass of: Nucleic Acid Sequencing

Monthly Income $2,501 to $2,917
type: Class
type: QualityValue
subclass of: Household Income
notation: 290

Panel change
type: Class
subclass of: SIO_001167

Drinks Beverage Packaged in Plastic
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Beverage Packaged in Plastic
  on property: SIO_000230
comment: The act of drinking a beverage that has been packaged in a plastic container.

N-methyl Perfluorooctane sulfonamido acetic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: NMFOSAA

beta-carotene
type: Class
type: NodeShape
subclass of: Nutrient
comment: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid. (Source: ChEBI)
notation: BCAR

Metabolite
type: Class
subclass of: Analyte
definition: A substance formed in or necessary for metabolism

Mono(2-propyl-6-carboxyhexyl) phthalate
type: Class
type: NodeShape
subclass of: Phthalate
notation: MPCHP

PROMIS Pediatric Instrument Bank
type: Class
type: NodeShape
subclass of: Questionnaire
subclass of: Restriction
  some values from: PROMIS Questionnaire Response
  on property: SIO_000059

Pre-Pregnancy
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Conceiving
definition: The time before a pregnancy.
was approved by: PER-Jeanette-Stingone

Functional Status Respiratory Status Score Below 2
type: Class
type: QualityValue
subclass of: Functional Status Respiratory Status Score
notation: 367

Ethyl mercury (C2H5Hg+)
type: Class
subclass of: Mercury Species
notation: C2H5Hg

megavolt
type: SIO_000074
notation: MV

Tanner Scale For Male Pubic Hair Development
type: Class
type: NodeShape
subclass of: Tanner Scale For Pubic Hair Development

hemoglobin measurement
type: Class
subclass of: Concentration

White
type: Class
type: QualityValue
subclass of: Race
notation: 102
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
was approved by: PER-Jeanette-Stingone

Glucan
type: Class
subclass of: Environmental Exposure

Prenatal Nonsmoker
type: Class
type: QualityValue
subclass of: Non-smoker
notation: 76
definition: Could be a former smoker or a non-smoker, so neither should be encoded as the superclass.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?

Health Outcome
type: Class
subclass of: StudyIndicator

Comorbidity Disease
type: Class
type: QualityValue
subclass of: Disease
notation: 363

PROMIS Pediatric Psychological Stress Experiences
type: Class
type: NodeShape
subclass of: PROMIS Pediatric Instrument Bank

Interleukin-9
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL9

picovolt
type: SIO_000074
notation: pV

Tanner Scale For Female Pubic Hair Development
type: Class
type: NodeShape
subclass of: Tanner Scale For Pubic Hair Development

SNV
type: Class
type: NodeShape
subclass of: substitution
comment: SNVs are single base pair positions in genomic DNA at which different sequence alternatives exist.

3-Hydroxypropyl-1-methyl mercapturic acid + 3-Hydroxypropyl-2-methyl mercapturic acid + 3-Hydroxypropyl-3-methyl mercapturic acid
notation: HMPMA

Single-Family House
type: Class
type: QualityValue
subclass of: Residential Building
notation: 175
definition: A residential building designed to hold one family.

Study Followup 3
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 2
  on property: intervalAfter
definition: A point in a study where data is gathered after the second study followup.

Monthly Income $2,084 to $2,500
type: Class
type: QualityValue
subclass of: Household Income
notation: 289

Planned Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 18
definition: Planned caesarian section.
was approved by: PER-Jeanette-Stingone

Employment in Medical Field
type: Class
type: QualityValue
type: NodeShape
subclass of: Employment
subclass of: SIO_000712
comment: Employment in some medical field
notation: 449
equivalent class: Class
  intersection of: Employment
  intersection of: SIO_000712
  equivalent class: Employment in Medical Field
disjoint with: Employment not in Medical Field

Tanner Genital Development Stage IV
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: testicular volume between 12 and 20 ml; scrotum enlarges further and darkens; penis increases in length (12.5–14) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 684

Chest Tube
type: Class
type: NodeShape
subclass of: Medical Device
comment: A hollow tube that is inserted into the pleural space through a surgical incision in the chest wall. [Definition Source: NCI]

newton per meter
type: SIO_000074
notation: N/m

Femur
type: Class
subclass of: SIO_010046

Post-Pregnancy
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: birthing
subclass of: Restriction
  some values from: Birth
  on property: intervalMetBy
definition: The period after birth.
was approved by: PER-Jeanette-Stingone

Multi-Family House
type: Class
type: QualityValue
subclass of: Residential Building
notation: 176
definition: A residential building designed to hold more than one family.

Study Followup 4
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup 3
  on property: intervalAfter
definition: A point in a study where data is gathered after the third study followup.

Functional Status Respiratory Status Score 2 or Above
type: Class
type: QualityValue
subclass of: Functional Status Respiratory Status Score
notation: 366

High School to Some College
type: Class
type: QualityValue
type: NodeShape
subclass of: Educational Status
comment: High school to some college educational status
notation: 450

azoxystrobin
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture. Source: ChEBI
notation: AZO

katal
type: SIO_000074
notation: kat

Tanner Genital Development Stage V
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: testicular volume greater than 20 ml; adult scrotum and penis (14+) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 590

bone marrow proteoglycan proteolytic cleavage product
type: Class
type: NodeShape
subclass of: SIO_010363

Has Not Provided a Stool Sample
type: Class
type: QualityValue
type: NodeShape
subclass of: Measurement
comment: A subject has not provided a stool sample for analysis.
notation: 637
disjoint with: Has Provided a Stool Sample

Monthly Income $1,251 to $1,666
type: Class
type: QualityValue
subclass of: Household Income
notation: 287

Annual Income $90,001 to $120,000
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $149,999
notation: 165
definition: Personal or family annual income bwtween $90,001 and $120,000

Annual Income $100,000 to $124,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $100,000 to $199,999
notation: 446

Phenylglyoxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: PGA
editorial note: To Do: align with CHEBI.

radian
type: SIO_000074
notation: rad

Bis-(1,3-dichloro-2-propyl) phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: BDCPP

Platelet
type: Class
subclass of: Blood Component
definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

No preservative added
type: Class
subclass of: SIO_001167

Short Stay
type: Class
type: QualityValue
subclass of: Destination
notation: 170
definition: A patient encounter where the patient is admitted to a health care facility for a predetermined length of time, usually less than 24 hours. [def-source:

Oxychlordane
type: Class
type: NodeShape
subclass of: Organochlorine Pesticide
notation: OCHL

Trans-Nonachlor
type: Class
subclass of: Organochlorine Pesticide
notation: TNON

Study Followup 2
type: Class
subclass of: SIO_000417
subclass of: Restriction
  some values from: Study Followup
  on property: intervalAfter
definition: A point in a study where data is gathered after the first study followup.

Phenylglyoxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPHG
editorial note: To Do: align with CHEBI.

Monthly Income $1,667 to $2,083
type: Class
type: QualityValue
subclass of: Household Income
notation: 288

Annual Income More Than $120,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $100,000
notation: 166
definition: Personal or family annual income greater than $120,000

Annual Income More Than $125,000
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income More Than $120,000
notation: 447

dyne per cm
type: SIO_000074
notation: dyn/cm

Diphenyl Phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: DPHP

Tanner Genital Development Stage III
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Genital Development
comment: testicular volume between 6 and 12 ml; scrotum enlarges further; penis begins to lengthen (11–12.5) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 591

No Hct, Hct=40 assumed
type: Class
subclass of: SIO_001167

Total Breast Area
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: SIO_001407
subclass of: Restriction
  some values from: UBERON_0000310
  on property: SIO_000215
comment: The total surface area of a human breast

Medical Therapy Procedure
type: Class
type: QualityVariable
subclass of: Medical History
subclass of: SIO_001024
definition: Medical Therapy Procedure to aide in treatment.
was approved by: PER-Jeanette-Stingone

Annual Income $50,001 to $75,000
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 163
definition: Personal or family annual income bwtween $50,001 and $75,000

decibel
type: SIO_000074
notation: dB

Monthly Income $417 to $833
type: Class
type: QualityValue
subclass of: Household Income
notation: 285

steradian
type: SIO_000074
notation: sr

poise
type: SIO_000074
notation: Poise

Congenital Abnormality
type: Class
subclass of: Disease
subclass of: Congenital anomaly or chromosomal defect

Obvious coarse debris
type: Class
subclass of: SIO_001167

neuron
type: Class
subclass of: Cell

Healthcare Facility
type: Class
type: NodeShape
subclass of: Organization
comment: The buildings and organizations where healthcare services are provided.

Has Provided a Stool Sample
type: Class
type: QualityValue
type: NodeShape
subclass of: Measurement
comment: A subject has provided a stool sample for analysis
notation: 636
disjoint with: Has Not Provided a Stool Sample

Monthly Income $834 to $1,250
type: Class
type: QualityValue
subclass of: Household Income
notation: 286

Perfluroundecanoic acid
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFUNDA

Annual Income $75,001 to $90,000
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 164
definition: Personal or family annual income bwtween $75,001 and $90,000

Mometasone HFA (Asmanex HFA)
type: Class
subclass of: Asthma Controller Medication

octadecanoic acid
type: Class
subclass of: Fatty Acid
notation: C180
definition: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

pascal second
type: SIO_000074
notation: Pas

Cerebral Malaria
type: Class
type: QualityValue
subclass of: Malaria
notation: 126
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

Red Blood Cell
type: Class
subclass of: Blood Component
definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.

Not Current Student
type: Class
type: QualityValue
subclass of: Educational Status
notation: 141
definition: The state of an individual not currently engaged in educational activity as a pupil.

Adoptive Mother
type: Class
type: QualityValue
type: NodeShape
subclass of: Mother
subclass of: Adoptive Parent
comment: A female parent in the parent-child relationship established by a legal adoption proceeding. (Source: NCI Thesaurus)
notation: 658

Post Ventilation Childhood Followup 2
type: Class
subclass of: Childhood Followup 2
comment: A second follow-up evaluation that occurs after the subject has been removed from artificial ventilation.

Mean Concentration Range 200 - 500 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 500.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 200.0
  on property: SIO_000216
notation: 320

Environmental Exposure
type: Class
subclass of: StudyIndicator
definition: EnvironmentalExposure Indicator Class
was approved by: PER-Jeanette-Stingone
editorial note: may need to refine this name in order to clearly differentiate from environmental exposures measured within CHEAR. Perhaps ExternalEnvironmental Exposure. Ok for now but we may want to discuss.

Methylation Assay
type: Class
subclass of: SIO_001007
definition: An assay that measures the methylation levels of sections of a genome.

Tripropyl phosphate
type: Class
type: NodeShape
subclass of: Organophosphorus Flame Retardant
notation: TPP

arteriosclerotic cardiovascular disease
type: Class
subclass of: Disease

mono-(2-ethylhexyl) terephthalate
type: Class
subclass of: Phthalate
notation: MEHTP

cell in vitro
type: Class
subclass of: Cell

arsenate(3−)
type: Class
type: NodeShape
subclass of: Arsenic Species
notation: AsV

DR4*030X/0302*DR4*030X/0302
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 618

metribuzin
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A member of the class of 1,2,4-triazines that is 1,2,4-triazin-5(4H)-one substituted by an amino group at position 4, tert-butyl group at position 6 and a methylsulfanyl group at position 3. Source: ChEBI
notation: METB

Trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
type: Class
type: NodeShape
subclass of: 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
notation: TDCCA

Mean Concentration Range 500 - 1000 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 1000.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 500.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 321

Electrospray Ionization Mass Spectrometry
type: Class
subclass of: MassSpectrometry
definition: Mass spectrometry using ESI is called electrospray ionization mass spectrometry (ESI-MS) or, less commonly, electrospray mass spectrometry (ES-MS). ESI is a so-called 'soft ionization' technique, since there is very little fragmentation. This can be advantageous in the sense that the molecular ion (or more accurately a pseudo molecular ion) is always observed, however very little structural information can be gained from the simple mass spectrum obtained. This disadvantage can be overcome by coupling ESI with tandem mass spectrometry (ESI-MS/MS). Another important advantage of ESI is that solution-phase information can be retained into the gas-phase.
was approved by: PER-Jim-McCusker

Mental Health
type: Class
subclass of: Physical And Mental Assessment
definition: Mental Health Indicator
was approved by: PER-Jeanette-Stingone

sulfoxaflor
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A mixture of the four diastereoisomers arising from the two tetrahedral stereocentres of [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-λ6-sulfanylidene]cyanamide (the sulfur atom and the carbon attached to position 3 of the pyridine ring). [Both E- and Z-isomers involving the S=N double bond and the cyano group exist, but they interconvert rapidly at r.t.]. A nicotinic acetylcholine receptor agonist in insects, sulfoxaflor is used as an insecticide, particularly for the control of aphids. Source: ChEBI
notation: SUF

femtomolar
type: SIO_000074
notation: fM

Cohort Group 1
type: Class
type: QualityValue
type: NodeShape
subclass of: Population Group
comment: Cohort group 1 for the "Sex-Specific Omics Profiles Related to Toxicant Exposures in Children" study conducted by Wei Perng, University of Michigan School of Public Health
notation: 701

DR4*030X/0302*DR4*030X/020X
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 617

Home Medical Technology
type: Class
type: QualityValue
subclass of: SIO_001398
notation: 364

Mean Concentration Range 30 - 100 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 30.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 100.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 318

3, 4-Dihydroxy-benzoic acid methyl ester
type: Class
subclass of: phenol
notation: OHMeP

Exposure Monitoring Instrument
type: Class
subclass of: PhysicalInstrument
definition: A physical instrument that monitors the environment for chemical exposures.
was approved by: PER-Jim-McCusker

Microarray Assay
type: Class
subclass of: SIO_001007
definition: An assay that uses a microarray to perform measurements.

mole fraction
type: SIO_000074
notation: chi

Circumference
type: Class
type: QuantityVariable
subclass of: Anthropometry

Psychosocial Stress Marker
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: STRESS

Tanner Female Pubic Hair Development Stage IV
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: adult-like hair quality, extending across pubis but sparing medial thighs (13–15) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 680

Vitamin E
type: Class
type: NodeShape
subclass of: Nutrient
notation: ATOC

Mean Concentration Range 100 - 200 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 200.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 100.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 319

Adoptive Father
type: Class
type: QualityValue
type: NodeShape
subclass of: Father
subclass of: Adoptive Parent
comment: A male parent in the parent-child relationship established by a legal adoption proceeding. (Source: NCI Thesaurus)
notation: 659

Post Ventilation Childhood Followup
type: Class
subclass of: Childhood Followup
comment: A follow-up evaluation that occurs after the subject has been removed from artificial ventilation.

Monoisopropyl phthalate
type: Class
subclass of: Phthalate
notation: MiPP

Arsenobetaine
type: Class
subclass of: Arsenic Species
notation: AsB

Enzyme Immunoassay
type: Class
subclass of: Immunoassay

MicroPEM
type: Class
subclass of: Exposure Monitoring Instrument
definition: The MicroPEM device monitors individual exposures to very fine airborne particles—or particulate matter—at two sizes. PM10 has a diameter of less than 10 micrometers (PM10), which is approximately 1/30th the size of a human hair, and PM2.5, which at diameters of less than 2.5 micrometers, is even smaller.
was approved by: PER-Jim-McCusker

normal
type: SIO_000074
notation: Norm

Cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
type: Class
type: NodeShape
subclass of: 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
notation: CDCCA

DR4*030X/0302*DR3*0501/0201
type: Class
type: QualityValue
type: NodeShape
subclass of: HLA Complex
notation: 616

PROMIS Psychological Stress Experiences Response
type: Class
type: NodeShape
subclass of: PROMIS Questionnaire Response
comment: A response to a PROMIS Pediatric Psychological Stress Experiences question

Quit Smoking
type: Class
type: QualityValue
subclass of: Previous Smoker
notation: 82
definition: Quit Smoking Cigarettes

Inductively Coupled Plasma Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: A type of mass spectrometry which is capable of detecting metals and several non-metals at concentrations as low as one part in 10^15 (part per quadrillion, ppq) on non-interfered low-background isotopes. This is achieved by ionizing the sample with inductively coupled plasma and then using a mass spectrometer to separate and quantify those ions.
was approved by: PER-Jim-McCusker

Pediatric Risk of Mortality Score (PRISM III)
type: Class
subclass of: Physical And Mental Assessment
subclass of: Score
comment: "The PRISM III score has 17 physiologic variables subdivided into 26 ranges. The variables most predictive of mortality were minimum systolic blood pressure, abnormal pupillary reflexes, and stupor/coma. Other risk factors, including two acute and two chronic diagnoses, and four additional risk factors, were used in the final predictors." (See skos:editorialNote for reference)
editorial note: This concept is taken from PRISM III: an updated Pediatric Risk of Mortality score M M Pollack 1, K M Patel, U E Ruttimann PMID: 8706448 DOI: 10.1097/00003246-199605000-00004 https://pubmed.ncbi.nlm.nih.gov/8706448/

Mean Concentration Range 0 - 10 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 0.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 10.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 316

radian per second per second
type: SIO_000074
notation: alpha

Vitamin
type: Class
subclass of: Drug, Food, Chemical or Biomedical Material

Nutrient
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: NUTR

Tanner Female Pubic Hair Development Stage II
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: small amount of long, downy hair with slight pigmentation on the labia majora (10–11.5) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 583

chromosomal aberration
type: Class
subclass of: Disease
subclass of: Congenital anomaly or chromosomal defect

Home Ventilation
type: Class
subclass of: Home Medical Technology
subclass of: artificial respiration
subclass of: Restriction
  some values from: Home
  on property: SIO_000061

I Felt Stressed Response
type: Class
type: QualityVariable
type: NodeShape
subclass of: PROMIS Psychological Stress Experiences Response
comment: A response to the question "I felt stressed" in the PROMIS Questionnaire

Immunoturbidimetry
type: Class
subclass of: SIO_001007
definition: An analytical technique that uses light scattering, a physical phenomenon resulting from the interaction of light with particles in solution, to measure the concentration of particles. The photometric signal is generated by a decrease in light intensity as a direct consequence of increasing turbidity in the reaction well. Immunoturbidimetry uses the classical antigen-antibody reaction. The antigen-antibody complexes are particles which can be optically detected by an photometer.
was approved by: PER-Jim-McCusker

Season
type: Class
type: QualityValue
subclass of: SIO_000417
subclass of: Environmental Exposure
notation: 209

Mean Concentration Range 10 - 30 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 30.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 10.0
  on property: SIO_000216
notation: 317

Histidine-rich protein PFHRP-II
type: Class
subclass of: Protein

Phthalate
type: Class
subclass of: Targeted Analyte
notation: UPHTH

meter per second per second
type: SIO_000074
notation: m/s2

Nail
label: nail of manual digit
type: Class
subclass of: Tissue
definition: A nail that is part of a manual digit. [database_cross_reference: OBOL:automatic]

gamma-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Pesticide
notation: GHCH

Cyclohexane-1,2-dicarboxylic acid mono hydroxyisononyl ester (DINCH)
type: Class
subclass of: Phthalate
notation: MHNCH

Lipid in Blood
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: BLIPID

Tanner Female Pubic Hair Development Stage III
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: hair becomes more coarse and curly, and begins to extend laterally (11.5–13) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 584

(9Z)-hexadecenoic acid
type: Class
subclass of: Fatty Acid
notation: C161N7
definition: A hexadecenoic acid with a cis-double bond at position C-9.

Prenatal Smoker
type: Class
type: QualityValue
subclass of: Smoker
notation: 77
definition: The quality of having smoked while being pregnant.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?

Antibiotic Score
type: Class
subclass of: Score
subclass of: Prescription Medication and Dietary Supplements
comment: Antibiotic Score is the total coverage score that was based on whether the antibiotic included coverage against gram-positive bacteria, gram-negative bacteria and/or anaerobic bacteria. Coverage in each area was graded on a 3-point scale: 0 for no activity, 1 for narrow activity, and 2 for broad activity. For patients treated with multiple antibiotics simultaneously, the score for each antibiotic received on a given day was summed. Cumulative scores were summed across days.

5+ Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 315

Electron-Detachment Dissociation (EDD)
type: Class
subclass of: TandemMassSpectrometry

Liquid Chromatography Instrument
type: Class
subclass of: Chromatography Instrument
definition: A separation technique in which the mobile phase is a liquid. It can be carried out either in a column or a plane. Present day liquid chromatography that generally utilizes very small packing particles and a relatively high pressure is referred to as high performance liquid chromatography (HPLC).
was approved by: PER-Jim-McCusker

Questionnaire Response
type: Class
type: NodeShape
subclass of: SIO_000785
comment: A response to a question in a questionnaire

Protocatechuic acid ethyl ester
type: Class
subclass of: phenol
notation: OHEtP

Lymphocyte
type: Class
subclass of: Leukocyte
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

cholesterol
type: Class
type: NodeShape
subclass of: Lipid in Blood
notation: CHOL

Tanner Scale For Female Pubic Hair Development (Assigned By Child's Mother)
type: Class
type: QualityVariable
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: A rating of the Tanner Scale for Female Pubic Hair Development as assigned by the child's mother

nanovolt
type: SIO_000074
notation: nV

Private Insurance
type: Class
type: QualityValue
subclass of: Private Insurance or Self Pay
notation: 103

Corticosteroid Burst
type: Class
type: QuantityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: CHEBI_50858
  on property: SIO_000230

Known Food Allergies
type: Class
type: QualityVariable
subclass of: Health Outcome

Toluene
type: Class
subclass of: Volatile Organic Compound
notation: TOL
definition: Toluene is a widely used industrial solvent.

duration hospital admission to urine sample
type: Class
type: QuantityVariable
subclass of: SIO_000417
subclass of: Physical And Mental Assessment
subclass of: PATO_0001309

PROMIS Questionnaire Response
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Questionnaire Response
comment: A response to a question in the PROMIS questionnaire See also <http://purl.bioontology.org/ontology/LNC/LP102768-1>

Hospitalization
type: Class
type: QualityValue
subclass of: SIO_001024
subclass of: Hospital Utilization
notation: 104
definition: Admission to a hospital

radian per second
type: SIO_000074
notation: rad/s

rs689
type: Class
type: NodeShape
subclass of: SNP

Tanner Female Pubic Hair Development Stage I
type: Class
type: QualityValue
type: NodeShape
subclass of: Tanner Scale For Female Pubic Hair Development
comment: no pubic hair at all (prepubertal) (typically age 10 and younger) Source: Adolescent health care : a practical guide. Neinstein, Lawrence S., Neinstein, Lawrence S. (5th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008. ISBN 9780781792561. OCLC 148727849.
notation: 587

Focus Group
type: Class
type: NodeShape
subclass of: SIO_000620
comment: A small, usually diverse group of people whose response to something is studied to determine the response that can be expected from a larger population. It is used especially in market research and political analysis. (Source: NCI Thesaurus)

Spouse or Significant Other and Child Under 18 Living In Household Currently Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Spouse or Significant Other Living In Household Currently Smokes
subclass of: Child Under 18 Living In Household Currently Smokes
comment: Spouse/SO and Child under age 18 living in the household currently smoke cigarettes, cigars or pipes.
notation: 530
equivalent class: Class
  intersection of: Spouse or Significant Other Living In Household Currently Smokes
  intersection of: Child Under 18 Living In Household Currently Smokes
  equivalent class: Spouse or Significant Other and Child Under 18 Living In Household Currently Smoke

Number of A minor alleles for rs3184504
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs3184504
  on property: SIO_000215

N,N-diethyl-m-toluamide
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine
comment: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide. Source: ChEBI
notation: DEET

gamma-linolenic acid
type: Class
subclass of: Fatty Acid
notation: C183N6
definition: A C18, ω-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.

Phenotypic abnormality
type: Class
subclass of: SIO_000475

Parent
type: Class
subclass of: Ancestor
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Child
    intersection of: SIO_000485
definition: A parent is the caretaker of a child (where "child" refers to offspring, not necessarily age). A biological parent is a person whose gamete resulted in a child, a male through the sperm, and a female through the ovum. Parents are first-degree relatives and have 50% genetic meet. A female can also become a parent through surrogacy. Some parents may be adoptive parents, who nurture and raise an offspring, but are not actually biologically related to the child. Orphans without adoptive parents can be raised by their grandparents or other family members.
was approved by: PER-Jeanette-Stingone

Metabolite
type: Class
subclass of: Small Molecule
definition: The intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Electron Capture Dissociation (ECD)
type: Class
subclass of: TandemMassSpectrometry

Whole Blood
type: Class
subclass of: Bodily Fluid
definition: A fluid that is composed of blood plasma and erythrocytes. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Blood][database_cross_reference: https://github.com/obophenotype/uberon/issues/9][database_cross_reference: FMA:9670]

Creatinine
type: Class
subclass of: Urinary Dilution Factor
notation: CRE
definition: Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

Mometasone DPI (Asmanex)
type: Class
subclass of: Asthma Controller Medication

rs12708716
type: Class
type: NodeShape
subclass of: SNP

Has Been Exposed to Second Hand Smoke
type: Class
type: QualityValue
subclass of: Second Hand Smoke Exposure by Indicator Status
notation: 568

Number of G minor alleles for rs12708716
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: G minor allele for rs12708716
  on property: SIO_000215

2, 3, 4, 5-Tetrachlorophenol
type: Class
subclass of: phenol
notation: TeCP2345
definition: PHYSICAL DESCRIPTION: Needles (from petroleum ether, ligroin) or beige solid. (NTP, 1992)

Perfluorooctanesulfonate
type: Class
subclass of: Perfluoroakyl and Polyfluoroalkyl Substance
notation: PFDODA

Ultra-Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Tandem Mass Spectrometer
subclass of: Ultra Performance Liquid Chromatography - Mass Spectrometer
was approved by: PER-Jim-McCusker

Metal
type: Class
subclass of: Element
definition: For environmental purposes, HHEAR metals are metals and metalliods, as originally defined in CHEAR.

Household Appliance Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total number of appliances that can be found in the home.
was approved by: PER-Jeanette-Stingone

Early Childhood Vigilance Test
type: Class
subclass of: Neurocognitive Assessment
definition: a computer-based assessment of sustained attention during which the child is required to watch a screen where various animated stimuli disappear and reappear

2, 4-Dichlorophenol
type: Class
subclass of: phenol
notation: DCP24
definition: 2, 4-dichlorophenol is a colorless crystalline solid with a medicinal odor. Melting point 45°C. Sinks in water. Strong irritant to tissues; toxic by ingestion.

Urinary Dilution Factor
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: UDILUTE

Number of A minor alleles for rs4948088
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs4948088
  on property: SIO_000215

genomic feature
type: Class
type: NodeShape
subclass of: Thing
comment: A sequence feature (continuous extent of biological sequence) that is of genomic origin (i.e. carries sequence from the genome of a cell or organism)

Finished Elementary Grade 4
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Some Elementary School
notation: 116
definition: Finished grade 4

Maternal Weight Gain
type: Class
subclass of: Pregnancy Characteristic
subclass of: Difference of Weights
definition: The amount of weight gained during a pregnacy.
was approved by: PER-Jeanette-Stingone

Hospital
type: Class
subclass of: Healthcare Facility

ventilator-associated pneumonia
type: Class
subclass of: pneumonia
subclass of: hospital-acquired infection
subclass of: CAUTI or CLABSI or VAP

Other Adults Living In Household Currently Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Household Member Currently Smokes
comment: Other adults in the home living in the household currently smoke cigarettes, cigars or pipes.
notation: 528

Number of A minor alleles for rs2292239
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs2292239
  on property: SIO_000215
subclass of: Restriction
  some values from: A minor allele for rs2292239
  on property: SIO_000215

Inconsistent Class
type: Class
type: QualityValue
subclass of: Nothing
notation: 522
notation: 529

Genotype
type: Class
subclass of: Medical History

Inflammatory Marker
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: INFLAM

Chloroform
type: Class
subclass of: Volatile Organic Compound
notation: CFRM
definition: CHLOROFORM is a commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

Adoptive Parent
type: Class
type: NodeShape
subclass of: Parent
comment: A parent in the parent-child relationship established by a legal adoption proceeding. (Source: NCI Thesaurus)

Head of Household
label: Head Of Household
type: Class
subclass of: Demographic
subclass of: SIO_000016
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Household
definition: The Person is the head of Household
definition: Head of Household is a filing status for individual United States taxpayers. To use the Head of Household filing status, a taxpayer must: (1) Be unmarried or considered unmarried at the end of the year (2) Have paid more than half the cost of keeping up a home for the tax year (either one's own home or the home of a qualifying parent) (3) Usually have a qualifying person who lived with the head in the home for more than half of the tax year unless the qualifying person is a dependent parent.
was approved by: PER-Jeanette-Stingone

Mercapturic acids of 1, 3-butadiene
type: Class
subclass of: Tobacco Metabolite
notation: HEMA

Electron Transfer Dissociation (ETD)
type: Class
subclass of: TandemMassSpectrometry

nutrition intake
type: Class
type: QualityVariable
subclass of: Diet and Nutrition
definition: Nutrition intake is the process of taking in of nutrients, especially by eating or drinking, considered in relation to the body’s dietary needs.

3-Chlorophenol
type: Class
subclass of: phenol
notation: MCP3
definition: PHYSICAL DESCRIPTION: White crystals with an odor of phenol. Sinks in and slowly dissolves in water. (NTP, 1992)

Hispanic or Latino Ethnicity
type: Class
type: QualityValue
subclass of: Ethnicity
notation: 47
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term “Spanish origin” can also be used in addition to “Hispanic or Latino.”
was approved by: PER-Jeanette-Stingone

toxin
type: Class
subclass of: Thing

Cotinine
type: Class
subclass of: Tobacco Metabolite
notation: COT
definition: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.

1 or 2 Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 313

Anatabine
type: Class
subclass of: Tobacco Metabolite
notation: ANAT

United States of America
type: QualityValue
notation: 184

Difference
type: Class
subclass of: SIO_000052
definition: Variables derived from taking the difference of two other variables. For example, the first difference of a time series {yt} is defined as Dyt = yt - yt-1

rs2476601
type: Class
type: NodeShape
subclass of: SNP

Haircare Product Use
type: Class
type: QualityValue
subclass of: Personal Product Use
notation: 30
was approved by: PER-Jeanette-Stingone

Patella
type: Class
subclass of: SIO_010046
definition: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella.

Technical Post-Middle School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
subclass of: Technical School
notation: 94
definition: Attended a Technical Post-Middle School.
was approved by: PER-Jeanette-Stingone

Mercury
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Hg
definition: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.

Abrasion
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 387

micromolal
type: SIO_000074
notation: µmol/kg

Trace Element in Blood
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: BTE

Child Under 18 Living In Household Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Household Member Currently Smokes
comment: A child under age 18 living in the household currently smoke cigarettes, cigars or pipes.
notation: 526

Number of C minor alleles for rs2816316
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: C minor allele for rs2816316
  on property: SIO_000215

Trace Element in Urine
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: UTE

3 or 4 Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 314

3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
type: Class
type: NodeShape
subclass of: Universal Pesticide Metabolite in Urine

behavioral response to pain
type: Class
subclass of: SIO_000475

Diet and Nutrition
type: Class
subclass of: StudyIndicator
definition: Diet and Nutrition Indicator
was approved by: PER-Jeanette-Stingone

Gel Electrophoresis
type: Class
subclass of: SIO_001007
definition: Gel electrophoresis is a method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge.

m-Xylene*
type: Class
subclass of: Volatile Organic Compound
notation: MXY
definition: M-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)

Child
type: Class
subclass of: Descendant
subclass of: Restriction
  on property: SIO_000668
  all values from: Class
    intersection of: Restriction
      on property: SIO_000228
      all values from: Parent
    intersection of: SIO_000485
definition: A relationship with a parent (such as sons and daughters of any age).
was approved by: PER-Jeanette-Stingone

Adult Child Living In Household Currently Smokes
type: Class
type: QualityValue
type: NodeShape
subclass of: Some Household Member Currently Smokes
comment: An adult child living in the household currently smoke cigarettes, cigars or pipes
notation: 527

Number of A minor alleles for rs10517086
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs10517086
  on property: SIO_000215

Functional Status Total Score Below 3
type: Class
type: QualityValue
subclass of: Functional Status Total Score
notation: 369

Asthma Diagnosis Group
type: Class
type: QualityValue
subclass of: Diagnosis Group
notation: 312

2,3-dinor-8-iso Prostaglandin F2 alpha
type: Class
subclass of: Oxidative Stress Marker
notation: F2A23D

Direct Mercury Analyzer
type: Class
subclass of: PhysicalInstrument
definition: Direct mercury analysis incorporates the following sequence: thermal decomposition, catalytic conversion, amalgamation, and atomic absorption spectrophotometry. Controlled heating stages are implemented to first dry and then thermally decompose a sample introduced into a quartz tube. A continuous flow of oxygen carries the decomposition products through a hot catalyst bed where halogens, nitrogen, and sulfur oxides are trapped. All mercury species are reduced to Hg(0) and are then carried along with reaction gases to a gold amalgamator where the mercury is selectively trapped. All nonmercury vapors and decomposition products are flushed from the system by the continuous flow of gas. The amalgamator is subsequently heated and releases all trapped mercury to the single-beam, fixed-wavelength atomic absorption spectrophotometer. Absorbance is measured at 253.7 nm as a function of mercury content
was approved by: PER-Jim-McCusker

4-((Benzyloxy)carbonyl)benzoic acid
type: Class
type: NodeShape
subclass of: Phthalate
notation: MBZTP

Hydrogen–Deuterium Exchange Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: Hydrogen–deuterium exchange mass spectrometry can determine the overall deuterium content of molecules which have undergone H/D exchange. Because of the sample preparation required, it is typically considered to provide an accurate measurement of non-exchangeable hydrogen atoms only.
was approved by: PER-Jim-McCusker

Weight
type: Class
type: QuantityVariable
subclass of: Anthropometry
subclass of: SIO_000279
definition: The resulting Force from the interaction between a person's Mass and Gravity.
was approved by: PER-Jeanette-Stingone

picomolal
type: SIO_000074
notation: pmolal

Perfluorooctanesulfonic acid (sum of branched isomers)
type: Class
type: NodeShape
subclass of: Perfluorooctanesulfonic acid
notation: SBPFOS

Number of G minor alleles for rs231775
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: G minor allele for rs231775
  on property: SIO_000215

Bedroom
type: Class
subclass of: room
definition: A room in a human dwelling that is the primary location where one or more occupants sleep.

Dilution required
type: Class
subclass of: SIO_001167

Hospital Utilization
type: Class
subclass of: Healthcare Access
definition: Hospital Utilization
was approved by: PER-Jeanette-Stingone

Technical Post Primary School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
subclass of: Technical School
notation: 95
definition: Attended a Technical Post Primary School
was approved by: PER-Jeanette-Stingone

nanomolal
type: SIO_000074
notation: nmolal

Number of A minor alleles for rs2476601
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Number of Minor Alleles for SNP
subclass of: Restriction
  some values from: A minor allele for rs2476601
  on property: SIO_000215

Phenol
type: Class
type: NodeShape
subclass of: Targeted Analyte
notation: UPHENOL

Breast Fibroglandular Tissue Volume
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: SIO_000049
subclass of: Restriction
  some values from: Breast Fibroglandular Tissue
  on property: SIO_000215
comment: The volume of a human breast's fibroglandular tissue

Divorced
type: Class
type: QualityValue
subclass of: Unmarried
notation: 40
definition: Indicates a person whose marriage has been legally dissolved and has not remarried.

Long Range Polymerase Chain Reaction
type: Class
subclass of: Polymerase Chain Reaction
definition: Amplification of DNA lengths that cannot typically be amplified using routine PCR methods or reagents. For simple DNA templates, polymerases optimized for Long Range PCR can amplify up to 30 kb and beyond. For complex, genomic templates, 20 kb is a typical target.
was approved by: PER-Jim-McCusker

times per year
type: SIO_000074
type: SIO_000794
notation: times / year

Matrilysin
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MMP7

lux
type: SIO_000074
notation: lx

microvolt
type: SIO_000074
notation: µV

Annual Income $15,001 to $30,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 161
definition: Personal or family annual income bwtween $15,001 and $30,000

Moderately hemolyzed
type: Class
subclass of: SIO_001167

Stromelysin-2
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: MMP10

Manganese
type: Class
subclass of: Metal
subclass of: Trace Element in Blood
subclass of: Trace Element in Urine
notation: Mn
definition: MANGANESE is a trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

Titanium
type: Class
subclass of: Metal
subclass of: Trace Element in Urine
notation: Ti
definition: TITANIUM is a dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)

High Sensitivity C-Reactive Protein Measurement
type: Class
type: NodeShape
subclass of: Measuring
comment: The determination of the amount of C-reactive protein (CRP) present in a sample through the use of immunonephelometry, immunoturbidimetry, high-sensitivity enzyme-linked immunosorbent assay (ELISA) and/or resonant acoustic profiling (RAP). This test is optimized to measure lower concentrations of CRP than a conventional CRP test. (Source: NCI Thesaurus)

Percentage of Fibroglandular Volume
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: SIO_001413
subclass of: Restriction
  some values from: Total Breast Volume
  on property: STATO_0000259
subclass of: Restriction
  some values from: Breast Fibroglandular Tissue Volume
  on property: STATO_0000101
comment: The ratio of a breast's fibroglandular volume to its total breast tissue volume, expressed as a percentage

Separated
type: Class
type: QualityValue
subclass of: Married
notation: 41
definition: Indicates a person living apart from his/her spouse by legal arrangement.

Marital Status
type: Class
type: QualityVariable
subclass of: Demographic
definition: A person's current conjugal status.
was approved by: PER-Jeanette-Stingone

Retina
type: Class
subclass of: SIO_010003
definition: The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

kilovolt
type: SIO_000074
notation: kV

Monthly Income Less Than $416
type: Class
type: QualityValue
subclass of: Household Income
notation: 284

Annual Income $30,001 to $50,000
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $60,000
notation: 162
definition: Personal or family annual income bwtween $30,001 and $50,000

Mitest not capped
type: Class
subclass of: SIO_001167

millivolt
type: SIO_000074
notation: mV

watt
type: SIO_000074
notation: watt

Chest tightness
type: Class
subclass of: wheezing or tightness in the chest or cough

Finished Primary School
type: Class
type: QualityValue
type: NodeShape
subclass of: Finished Elementary School
comment: Has completed primary school education level
notation: 638

Never Married
type: Class
type: QualityValue
subclass of: Unmarried
notation: 38
definition: Indicates a person who has never been married or whose marriages have been annulled.

attention deficit hyperactivity disorder
type: QualityValue
notation: 424

N-Ace-S- (3, 4-Dihidxybutl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCDHB
editorial note: To Do: align with CHEBI.

Light Bulb Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Lightbulbs in the Home
was approved by: PER-Jeanette-Stingone

2, 3, 5, 6-Tetrachlorophenol
type: Class
subclass of: phenol
notation: TeCP2356
definition: PHYSICAL DESCRIPTION: Leaflets (from ligroin) or light beige powder. (NTP, 1992)

lumen
type: SIO_000074
notation: lm

Consumption Behavior
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use

Asthma Controller Medication Prescription
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
definition: A subclass of medical intervention that characterizes a patient's receipt of asthma controller medication by prescription. It does not indicate if a patient has or has not received such medication or a prescription for such medication. These distinctions are made in the subclasses of this class.

arsenite(3−)
type: Class
type: NodeShape
subclass of: Arsenic Species
notation: AsIII

Male Cousin
type: Class
type: QualityValue
type: NodeShape
subclass of: Cousin
subclass of: Restriction
  on property: SIO_000227
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
comment: A male child of one's aunt or uncle. (Source: NCI Thesaurus)
notation: 661

No FOL result; FOL = 8 ng/mL assumed
type: Class
subclass of: SIO_001167

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: AAMA

Interleukin-22
type: Class
subclass of: Protein
subclass of: Inflammatory Marker
notation: IL22

Total Breast Volume
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: SIO_000049
subclass of: Restriction
  some values from: Mammary Gland Tissue
  on property: SIO_000215
subclass of: Restriction
  some values from: UBERON_0000310
  on property: SIO_000215
comment: The total volume of a human breast

Widowed
type: Class
type: QualityValue
subclass of: Unmarried
notation: 39
definition: Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.

N-Ace-S-(2-Hydroxyethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHEM
editorial note: To Do: align with CHEBI.

Limit of Detection
type: Class
subclass of: Concentration
definition: The lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.

Has Received Asthma Controller Medication
type: Class
type: QualityValue
subclass of: Asthma Controller Medication Prescription
notation: 283

Neighborhood Characteristic
type: Class
subclass of: StudyIndicator
definition: Neighborhood Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

megakaryocyte-erythroid progenitor cell

Exposed to Second Hand Smoke at Other Parent's House
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 533

N-A-S-(3-hydrxprpl-1-metl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPMM
editorial note: To Do: align with CHEBI.

Quit Smoking Before Pregnancy
type: Class
type: QualityValue
subclass of: Quit Smoking
subclass of: Pregnancy Characteristic
subclass of: Prenatal Nonsmoker
notation: 81
definition: A Previous Smoker who Quit Smoking Before Pregnancy

Intelligence Quotient
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Physical And Mental Assessment
definition: A measure of intelligence
was approved by: PER-Jeanette-Stingone

Study Site
type: QualityVariable
definition: A facility in which study/protocol activities are conducted. [def-source: NCI]

Married
type: Class
type: QualityValue
subclass of: Marital Status
notation: 37
definition: Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.

Zafirlukast (Accolate)
type: Class
subclass of: Asthma Controller Medication

Exposed to Second Hand Smoke in Primary Caregiver's Car
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 534

micromole per liter
type: SIO_000074
notation: µmol/L

N-Ac-S-(2-Hydrxy-3-butnyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB2
editorial note: To Do: align with CHEBI.

Landfill Proximity
type: Class
type: QuantityVariable
subclass of: Environmental Exposure
subclass of: SIO_000041
definition: How close a household is to a landfill.
was approved by: PER-Jeanette-Stingone

Childhood Followup 2
type: Class
subclass of: Study Followup 2
subclass of: Restriction
  some values from: Childhood Period
  on property: intervalDuring
subclass of: Restriction
  on property: SIO_000668
  all values from: Childhood Period
definition: A point in a study that occurs after the initial follow-up point in the study and occurs during the study subject's childhood period.

Has Not Been Exposed to Second Hand Smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Indicator Status
notation: 531

Medical Leave
type: Class
type: QualityValue
subclass of: Occupation
notation: 246

Family History of Type 1 Diabetes Mellitus
type: Class
type: QualityValue
type: NodeShape
subclass of: Family history
subclass of: Restriction
  some values from: type 1 diabetes mellitus
  on property: SIO_000668
comment: Has family history of Type 1 Diabetes Mellitus
notation: 611

Breath

arachidonic acid
type: Class
subclass of: Fatty Acid
notation: C204N6
definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

Hydroxycotinine
label: Hydroxycotinine (total)
type: Class
subclass of: Tobacco Metabolite
notation: HCOTT
notation: HCOT

High Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Liquid Chromatography - Tandem Mass Spectrometer
subclass of: High-Performance Liquid Chromatography-Mass Spectrometry
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS (Tandem MS) is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

In Vitro Fertilization
type: Class
type: QualityValue
subclass of: Assisted Reproductive Therapy
notation: 50

Microplate Reader
type: Class
subclass of: PhysicalInstrument
definition: Instruments which are used to detect biological, chemical or physical events of samples in microtiter plates. They are widely used in research, drug discovery, bioassay validation, quality control and manufacturing processes in the pharmaceutical and biotechnological industry and academic organizations. Sample reactions can be assayed in 6-1536 well format microtiter plates. The most common microplate format used in academic research laboratories or clinical diagnostic laboratories is 96-well (8 by 12 matrix) with a typical reaction volume between 100 and 200 µL per well. Higher density microplates (384- or 1536-well microplates) are typically used for screening applications, when throughput (number of samples per day processed) and assay cost per sample become critical parameters, with a typical assay volume between 5 and 50 µL per well. Common detection modes for microplate assays are absorbance, fluorescence intensity, luminescence, time-resolved fluorescence, and fluorescence polarization.
was approved by: PER-Jim-McCusker

Hepatic failure
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 395

artery disease
type: Class
subclass of: Disease

Exposed to Second Hand Smoke at Home
type: Class
type: QualityValue
type: NodeShape
subclass of: Second Hand Smoke Exposure by Location
notation: 532

Quit Smoking After Pregnancy
type: Class
type: QualityValue
subclass of: Quit Smoking
subclass of: Prenatal Smoker
subclass of: Pregnancy Characteristic
notation: 80
definition: Quit Smoking After Pregnancy

N-A-S-(1-HydrxMet)-2-Prpn)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB1
editorial note: To Do: align with CHEBI.

Insurance
type: Class
type: QualityValue
type: QualityVariable
subclass of: Socioeconomic Status
subclass of: Healthcare Access
notation: 683

Medical History
type: Class
subclass of: StudyIndicator
definition: Medical History Indicator Class
was approved by: PER-Jeanette-Stingone

Niobium
type: Class
subclass of: Metal
notation: Nb
definition: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)

Leptin
type: Class
subclass of: Protein
subclass of: Metabolite
subclass of: Nutrient
notation: LEPT
definition: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.

Datatype
intersection of: Datatype
  with restrictions:
    min exclusive: 25.0
  on datatype: float
intersection of: Datatype
  with restrictions:
    max exclusive: 29.9
  on datatype: float

rest: nil
first:
  max exclusive: 25

rest: nil
first:
  min exclusive: 18.5

Restriction
on property: SIO_000300
all values from: Datatype
  with restrictions:
    min inclusive: 15
  on datatype: integer

min exclusive: 25.0

rest:
  rest: nil
  first: Datatype
    with restrictions:
      max exclusive: 25.0
    on datatype: float
first: Datatype
  on datatype: float

Datatype
with restrictions:
  min exclusive: 25
on datatype: integer

min exclusive: 29.9

Restriction
on property: SIO_000300
all values from: Datatype
  with restrictions:
    max exclusive: 15
  on datatype: integer

rest: nil
first:
  max exclusive: 25.0

Datatype
with restrictions:
  max exclusive: 18.5
on datatype: float