Class ID,Preferred Label,Synonyms,Definitions,Obsolete,CUI,Semantic Types,Parents,causesAdverseEvent,hasContriversialAssociationWith,hasFinding,hasLocation,http://data.bioontology.org/metadata/prefixIRI,http://example.org/irAEs.owl#ChineseLabel,http://example.org/irAEs.owl#CTCAE_Grade,http://example.org/irAEs.owl#Definition,http://example.org/irAEs.owl#FactorType,http://example.org/irAEs.owl#hasDiagnosis,http://example.org/irAEs.owl#hasSeverityGrade,http://example.org/irAEs.owl#isAlsoSee,http://example.org/irAEs.owl#isCausedBy,http://example.org/irAEs.owl#isTreatedWith,http://example.org/irAEs.owl#managedBy,http://example.org/irAEs.owl#reference,http://example.org/irAEs.owl#Synonyms,http://example.org/irAEs.owl#Toxicity_Management,http://example.org/irAEs.owl#URL,isAssoicatedWith,isBiomarkerOf,isProtectiveFactorFor,isRiskFactorFor
http://example.org/irAEs.owl#Eye_and_Orbit_Tumours,Eye and Orbit Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,Eye_and_Orbit_Tumours,眼及眼眶肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#anti-scl-70,Anti-scl-70 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,anti-scl-70,抗scl-70抗体,,An anti-nuclear autoantibody that recognizes a 70 kDa fragment of DNA topoisomerase 1. It is associated with scleroderma.,,,,,,,,SNOMED_CT:259928007|LOINC:LP39721-3,Topoisomerase 1 Antibody|Antibody to SCL-70|Anti-Topoisomerase 1|Anti-Topoisomerase 1 Antibody,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C122770,,,,
http://example.org/irAEs.owl#Mg,Serum Magnesium,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,Mg,血清镁离子,,A quantitative measurement of the amount of magnesium present in a sample of serum.,,,,,,,,SNOMED_CT:63571001|LOINC:LP14343-5,Serum Mg Measurement,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61035,,,,
http://example.org/irAEs.owl#MRI-1,Magnetic Resonance Imaging,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies5,,,,,MRI-1,核磁共振成像,,"Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.",,,,,,,,SNOMED_CT:113091000|LOINC:LP206574-8,Magnetic resonance|MR|MRI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16809,,,,
http://example.org/irAEs.owl#Serum_Calcium,Serum Calcium,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,,,,,Serum_Calcium,血清钙离子,,A quantitative measurement of the amount of calcium present in a sample of serum.,,,,,,,,LOINC:86915-6|SNOMED_CT:271240001,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61020,,,,
http://example.org/irAEs.owl#Serum_Calcium1,Serum Calcium,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,Serum_Calcium1,血清钙离子,,A quantitative measurement of the amount of calcium present in a sample of serum.,,,,,,,,LOINC:86915-6|SNOMED_CT:271240001,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61020,,,,
http://example.org/irAEs.owl#Endoscopic_Examinations,Endoscopic Examinations,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests8,,,,,Endoscopic_Examinations,内窥镜检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Endoscopic_Examinations2,Endoscopic Examinations,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,,,,,Endoscopic_Examinations2,内窥镜检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Endoscopic_Examinations1,Endoscopic Examinations,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests,,,,,Endoscopic_Examinations1,内窥镜检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Oncologic_and_Treatment_Data,Oncologic Data,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,Oncologic_and_Treatment_Data,肿瘤数据,,,,,,,,,,,,,,,,,
"http://example.org/irAEs.owl#Creatine_Kinase_MB,_CK-MB",Creatine Kinase MB,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_CK-MB,肌酸激酶同工酶,,An isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type.,,,,,,,,LOINC:LP15513-2|SNOMED_CT:12016004,Creatine Phosphokinase-MB|MB Creatine Kinase|CK-MB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C122778,,,,
"http://example.org/irAEs.owl#Creatine_Kinase_MB,_CK-MB2",Creatine Kinase MB,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding2,,,,,_CK-MB2,肌酸激酶同工酶,,An isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type.,,,,,,,,LOINC:LP15513-2|SNOMED_CT:12016004,Creatine Phosphokinase-MB|MB Creatine Kinase|CK-MB|CPK-MB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C122778,,,,
http://example.org/irAEs.owl#PTPN11（rs143894582）C/CA,Protein Tyrosine Phosphatase Non-Receptor Type 11,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,CA,蛋白酪氨酸磷酸酶非受体型 11,,"This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene transcription.",Risk Factor,,,,,,,NCBI Gene ID: 5781,Protein Tyrosine Phosphatase Non-Receptor Type 11 Gene|PTPN11,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26337,,,,
http://example.org/irAEs.owl#acute_lymphoblastic_leukemia,Acute Lymphoblastic Leukemia,,,FALSE,,,http://example.org/irAEs.owl#acute_leukemias,,,,,acute_lymphoblastic_leukemia,急性淋巴细胞白血病,,"Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.",,,,,,,,MedDRA:10000845|ICD-11:2B33.3,Lymphoblastic Leukemia|Common precursor B ALL|Precursor Cell Lymphoblastic Leukemia|Precursor Lymphoblasic Leukemia|ALL - Acute Lymphocytic Leukemia|ALL|c-ALL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3167,,,,
http://example.org/irAEs.owl#pruritus,Pruritus,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,pruritus,瘙痒,"A disorder characterized by an intense itching sensation.

Grade 1:Mild or localized; topical intervention indicated.
Grade 2:Widespread and intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity.
Grade 3:Widespread and constant; systemic corticosteroid or immunosuppressive therapy indicated; limiting sleep or self-care ADL or severe impact on age-appropriate normal daily activity.
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C58006",An intense itching sensation.,,,,,,,,MedDRA:10037087|ICD-11:ME65.1,Itching Sensation|Itch|Itching,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3344,,,,
http://webprotege.stanford.edu/RCnliyyHrycjsiM31UdpA3J,PI3K-Akt Signaling Pathway,,,FALSE,,,http://example.org/irAEs.owl#Pathway,,,,,RCnliyyHrycjsiM31UdpA3J,PI3K-Akt 信号通路,,"The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.",,,,,,,,KEGG ID:map04151,,,https://www.kegg.jp/entry/map04151,,,,
http://example.org/irAEs.owl#Reticulocyte_Count,Reticulocyte Count,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Hematology_3,,,,,Reticulocyte_Count,网织红细胞计数,,The determination of the number of reticulocytes in a blood sample.,,,,,,,,SNOMED_CT:45995003|LOINC:LP16487-8,Reticulocytes|RETI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C51947,,,,
http://example.org/irAEs.owl#胶质瘤,Glioma,,,FALSE,,,http://example.org/irAEs.owl#神经系统,,,,,胶质瘤,胶质瘤,,"A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas.",,,,,,,,ICD-11:2A00.0|MedDRA:10018338,Tumor of Neuroglia|Glial Neoplasm|Neuroglial Neoplasm|Neoplasm of Neuroglia|Neuroglial Tumor|glial tumor,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3059,,,,
http://example.org/irAEs.owl#Functional_and_Subjective_Tests,Eye Function Test,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies2,,,,,Functional_and_Subjective_Tests,眼部功能测试,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Digestive_System,Digestive System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Digestive_System,消化系统,,"The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas.",,,,,,,,UBERON:0001007|SOC:10017947.0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12378,,,,
http://example.org/irAEs.owl#Laboratory_Tests4,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests13,,,,,Laboratory_Tests4,实验室检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Anti-ku_Antibody,Anti-Ku Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti-ku_Antibody,抗Ku抗体,,"The Ku (p70/p80) autoantigen, a heterodimer consisting of 70 kDa (p70) and 80 kDa (p80) protein subunits, is one of a group of DNA-associated autoantigens identified as targets of autoantibodies produced by patients with SLE and related disorders (PubMed).",Risk Factor,,,,,,,SNOMED_CT:259924009|LOINC:LP38765-1,anti-p70/p80 antibody|Ku Ab,,https://pubmed.ncbi.nlm.nih.gov/1626075/,,,,
http://example.org/irAEs.owl#anti-NP1L4,Anti-Proteolipid Protein 1 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,anti-NP1L4,抗蛋白脂蛋白 1 抗体,,"Proteolipid protein (PLP), a transmembrane protein expressed only in the central nervous system (CNS), is a candidate target autoantigen for autoimmune-mediated demyelination (PubMed).",Risk Factor,,,,,,,,Anti-PLP1,,https://pubmed.ncbi.nlm.nih.gov/9357441/,,,,
http://example.org/irAEs.owl#Skin_and_Subcutaneous_Tissue,Skin and Subcutaneous Tissue,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Skin_and_Subcutaneous_Tissue,皮肤和皮下组织,,"A tissue sample that contains the epidermis, dermis, and subcutaneous adipose tissue.",,,,,,,,UBERON:0002097,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C92441,,,,
http://example.org/irAEs.owl#女性,Female Reproductive System,,,FALSE,,,http://example.org/irAEs.owl#Disease1,,,,,女性,女性生殖系统,,"The collection of organs and tissues, including the ovaries, genital tract, and breasts, that have several functions, including sexual maturation, pregnancy, and childbirth.",,,,,,,,UBERON:0000474,"Genital System, Female|Gynecologic Body System|Body System, Gynecologic|Female Reproductive Body System|Female Genital Tract|Gynecologic Organ System|Body System, Reproductive, Female|Female Reproductive Organ System",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12402,,,,
http://example.org/irAEs.owl#Histopathological_Examination-1,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination,,,,,Histopathological_Examination-1,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Disease_7,Disease,,,FALSE,,,http://example.org/irAEs.owl#Endocrine_System,,,,,Disease_7,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Arterial_Blood_Gas_ABG,Arterial Blood Gas,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies,,,,,Arterial_Blood_Gas_ABG,动脉血气分析,,A measurement of blood gas levels done for diagnostic purposes.,,,,,,,,LOINC: 24336-0|SNOMED_CT: 60170009,Diagnostic Blood Gas Testing|Blood Gases|ABG|BG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C217391,,,,
http://example.org/irAEs.owl#Sarcoid_like_Reaction,Sarcoidosis,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Sarcoid_like_Reaction,结节病,,"An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin. Cardiac involvement is also possible.",,,,,,,,MedDRA:10039490|ICD-11: 4B20,Sarcoid-like Reaction|Sarcoidosis NOS|Sarcoid,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34995,,,,
http://example.org/irAEs.owl#Others_7,Large cell lung cancer,,,FALSE,,,http://example.org/irAEs.owl#NSCLC,,,,,Others_7,肺大细胞癌,,"An undifferentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular, squamous, or neuroendocrine differentiation.",,,,,,,,ICD-11: 2C25.3|MedDRA:10023774,Large Cell Carcinoma of the Lung|Anaplastic Lung Carcinoma|Large Cell Undifferentiated Lung Carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4450,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_8,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests,,,,,Clinical_Chemistry_8,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#多形性癌,Sarcomatoid Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer,,,,,多形性癌,肺肉瘤样癌,,A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present.,,,,,,,,ICD-11:2C25.Y|MedDRA:10081400,Spindle Cell Carcinoma|Pseudosarcomatous carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27004,,,,
http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,Genetic Mutation Status,,,FALSE,,,http://example.org/irAEs.owl#Oncologic_and_Treatment_Data,,,,,Tumor_Mutational_Burden_TMB,基因突变状态,,The total number of genomic alterations found in the cells of a cancer.,,,,,,,,,Sequence Alteration|DNA Alteration|DNA Sequence Alteration,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18093,,,,
http://example.org/irAEs.owl#Hematology_Birmarher,Hematology Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Biomarker,,,,,Hematology_Birmarher,血液生物标志物,,,,,,,,,,,,,,,,,
"http://example.org/irAEs.owl#Troponin_T_Cardiac_Muscle,_cTnT2",Troponin T Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,,,,,_cTnT2,心肌肌钙蛋白 T,,"Troponin T, cardiac muscle (298 aa, ~36 kDa) is encoded by the human TNNT2 gene. This protein plays a role in cardiac muscle contraction.",,,,,,,,SNOMED_CT:102684000|LOINC:LP17145-1,"Troponin T, Cardiac Muscle|Cardiac Muscle Troponin T|TnTc|cTnT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104220,,,,
"http://example.org/irAEs.owl#Troponin_T_Cardiac_Muscle,_cTnT1",Troponin T Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test2,,,,,_cTnT1,心肌肌钙蛋白 T,,"Troponin T, cardiac muscle (298 aa, ~36 kDa) is encoded by the human TNNT2 gene. This protein plays a role in cardiac muscle contraction.",,,,,,,,SNOMED_CT:102684000|LOINC:LP17145-1,"Troponin T, Cardiac Muscle|Cardiac Muscle Troponin T|TnTc|cTnT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104220,,,,
http://example.org/irAEs.owl#Blood_and_Lymphatic_system,Blood,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Blood_and_Lymphatic_system,血液系统,,"A liquid tissue; its major function is to transport oxygen throughout the body. It also supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection. Several hormones also travel in the blood.",,,,,,,,UBERON:0000178|SOC:10005329.0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12434,,,,
http://example.org/irAEs.owl#HLA-DPB1,Human Leukocyte Antigen DPB1:02,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,HLA-DPB1,人类白细胞抗原DPB1:02,,"HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.",Risk Factor,,,,,,,LOINC:LP99667-5|NCBI Gene ID: 3115,DPB1|HLA-DP|HLA-DP1B|HLA-DPB|HLA-DPB1,,https://www.ncbi.nlm.nih.gov/gene/3115,,,,
http://example.org/irAEs.owl#Visual_Evoked_Potentials_VEP,Sweep Visual Evoked Potentials,,,FALSE,,,http://example.org/irAEs.owl#Electrophysiological_Studies_3,,,,,Visual_Evoked_Potentials_VEP,扫频视觉诱发电位,,"A technique that measures an evoked potential caused by a visual stimulus and recorded by an electroencephalogram, used for those individuals who are unable to provide a verbal response to questions, including infants, toddlers, and other non verbal individuals.",,,,,,,,SNOMED:63107007|LOINC:LP190653-8,Sweep Visual Evoked Potential|VEP - visual evoked potential|Visual evoked potential study|Evoked potentials visual|visual evoked potential (VEP) test|Sweep VEP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C191332,,,,
http://example.org/irAEs.owl#Bullous_Dermatitis,Bullous Dermatitis,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Bullous_Dermatitis,大疱性皮炎,"A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid.

Grade 1: Asymptomatic; blisters covering <10% BSA
Grade 2: Blisters covering 10-30% BSA; painful blisters; limiting instrumental ADL
Grade 3: Blisters covering >30% BSA; limiting self care ADL
Grade 4: Blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143346",Inflammation of the skin characterized by the presence of bullae which are filled with fluid.,,,,,,,,ICD-11:EB41.0|MedDRA:10006556,Bullous disorder|Dermatitis bullous|bullous dermatoses|Dermatosis bullous|bullous; disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35149,,,,
"http://example.org/irAEs.owl#Electrocardiography,_ECG6",Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_10,,,,,_ECG6,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
http://example.org/irAEs.owl#Antimicrobial_Susceptibility_Testing_AST,Antimicrobial Susceptibility Testing,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test3,,,,,Antimicrobial_Susceptibility_Testing_AST,抗菌药物敏感性试验,,A proprietary system that determines which antimicrobial agents a microorganism is susceptible to and the concentration of antimicrobial agent needed to arrest infection.,,,,,,,,LOINC:LP7755-4|SNOMED_CT:14788002,Sensititer system test|Sensititre Antimicrobial Susceptibility Testing|AST|Sensititre,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220141,,,,
http://example.org/irAEs.owl#Triglycerides_TG,Triglycerides,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,Triglycerides_TG,甘油三酯,,Fats composed of three fatty acid chains linked to a glycerol molecule.,,,,,,,,SNOMED_CT:85600001|LOINC:LP15275-8,TG - Triglyceride|Triacylglycerol|TG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C906,,,,
http://example.org/irAEs.owl#前列腺,Prostate,,,FALSE,,,http://example.org/irAEs.owl#男性,,,,,前列腺,前列腺,,"The walnut shaped accessory sex gland of the male reproductive system. It is located in the pelvis just below the bladder, surrounding the prostatic part of the urethra. The prostate gland secretes a fluid which is part of the semen.",,,,,,,,UBERON:0002367,"male prostate|Genital System, Male, Prostate|Prostate Gland",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12410,,,,
http://example.org/irAEs.owl#前列腺炎,Granulomatous Prostatitis,,,FALSE,,,http://example.org/irAEs.owl#前列腺,,,,,前列腺炎,肉芽肿性前列腺炎,,"An infectious or non-infectious inflammatory process that affects the prostate gland. Infectious causative agents include bacteria, parasites, fungi, and viruses. It is characterized by the formation of granulomas in the prostatic tissue.",,,,,,,,ICD-11:GA91.Y|MedDRA:10057092,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26789,,,,
http://example.org/irAEs.owl#ACTH,Adrenocorticotropic hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,ACTH,促肾上腺皮质激素,,"Corticotropin (39 aa, ~5 kDa) is encoded by the human POMC gene. This protein plays a role in the stimulation of cortisol secretion by the adrenal gland.",,,,,,,,LOINC:LP32529-7|SNOMED_CT:40789008,ACTH - Adrenocorticotrophic hormone|Corticotropin|ATCH|CCTROP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2282,,,,
http://example.org/irAEs.owl#Notch,Notch Signaling Pathway,,,FALSE,,,http://example.org/irAEs.owl#Pathway,,,,,Notch,Notch 信号通路,,"The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.[KEGG]",Risk Factor,,,,,,,KEGG ID:map04330,,,https://www.kegg.jp/entry/map04330,,,,
http://example.org/irAEs.owl#胃腺癌,Gastric Adenocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,胃腺癌,胃腺癌,,"An adenocarcinoma that arises from the stomach glandular epithelium. Microscopically, two important histologic types are recognized: the diffuse and intestinal types. It usually affects older individuals and is strongly associated with Helicobacter pylori infection. The majority of patients present with advanced disease due to lack of early symptoms, and the overall prognosis is poor.",,,,,,,,ICD-11:2B72.0|MedDRA:10001150,Adenocarcinoma|Adenocarcinoma of Stomach|STAD,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4004,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Test,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests2,,,,,Clinical_Chemistry_Test,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Test-,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_11,,,,,Clinical_Chemistry_Test-,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Test2,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_3,,,,,Clinical_Chemistry_Test2,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#乳腺肿瘤,Breast Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,乳腺肿瘤,乳腺肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Granulomatosis_with_polyangiitis,Granulomatosis with Polyangiitis,,,FALSE,,,http://example.org/irAEs.owl#Disease_12,,,,,Granulomatosis_with_polyangiitis,肉芽肿性多血管炎,,"A rare, autoimmune, systemic medium and small size vasculitis. It is characterized by the formation of necrotizing granulomas in the respiratory tract, necrotizing angiitis, and glomerulonephritis.",,,,,,,,MedDRA:10072579|ICD-11:4A44.A1,Wegener Granulomatosis|Wegener's Granulomatosis|GPA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3444,,,,
http://example.org/irAEs.owl#TTE,Transthoracic Echocardiography,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies4,,,,,TTE,经胸超声心动图,,A non-invasive cardiac ultrasound performed by placing the transducer on the chest.,,,,,,,,SNOMED_CT:433236007,TRANSTHORACIC ECHOCARDIOGRAPHY|TTE,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C80404,,,,
http://example.org/irAEs.owl#Chronic_lymphocytic_leukemia,Chronic Lymphocytic Leukemia,,,FALSE,,,http://example.org/irAEs.owl#acute_leukemias,,,,,Chronic_lymphocytic_leukemia,慢性淋巴细胞白血病,,"The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy.",,,,,,,,MedDRA:10008976|ICD-11:2A82.0,B Cell Chronic Lymphocytic Leukemia|Chronic B-Cell Lymphocytic Leukemia|Hematopoeitic - Chronic Lymphocytic Leukemia (CLL)|B cell CLL|BCLL|CLL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3163,,,,
http://example.org/irAEs.owl#Stevens_Johnson_Sydrome_SJS_Immune_related_Toxic_Epidermal_Necrolysis_TEN,Stevens-Johnson Sydrome / Immune-related Toxic Epidermal Necrolysis,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Stevens_Johnson_Sydrome_SJS_Immune_related_Toxic_Epidermal_Necrolysis_TEN,史蒂文斯-约翰逊综合征/免疫相关性中毒性表皮坏死松解症,"A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.

Grade 3: Skin sloughing covering <10% BSA
Grade 4: Skin sloughing covering >=10% BSA; life-threatening consequences
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143859https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143859","A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma).",,,,,,,,ICD-11:EB13.2|MedDRA:10044223,Erythema exsudativum multiforme|Bullous erythema multiforme|Erythema exudativum multiforme|Erythema multiforme exudativum|SJS/TEN|TEN,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C79484,,,,
http://example.org/irAEs.owl#Medulla_Spinalis,Medulla Spinalis,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Medulla_Spinalis,脊髓,,"Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal.",,,,,,,,UBERON:0002240,Spinal Cord,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12464,,,,
http://example.org/irAEs.owl#Chronic_Pleuritis,Pleuritis,,,FALSE,,,http://example.org/irAEs.owl#Pleura,,,,,Chronic_Pleuritis,胸膜炎,,Inflammation of the pleura. It is usually caused by infections. Chest pain while breathing or coughing is the presenting symptom.,,,,,,,,MedDRA:10035624|ICD-11:MD31,Pleuritides|Inflammation of pleura|Pleurisy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26860,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Test-2,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests1,,,,,Clinical_Microbiology_Test-2,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Reticulocyte_Count1,Recticulocyte Count,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Reticulocyte_Count1,网织红细胞计数,,The determination of the number of reticulocytes in a blood sample.,"Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Cerebrospinal_Fluid_Examination,Cerebrospinal Fluid Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_10,,,,,Cerebrospinal_Fluid_Examination,脑脊液检查,,A laboratory analysis of a sample of cerebrospinal fluid.,,,,,,,,SNOMED:167699000,CSF Analysis|Cerebrospinal Fluid Analysis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C173272,,,,
http://example.org/irAEs.owl#Cerebrospinal_Fluid_Examination2,Cerebrospinal Fluid Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_6,,,,,Cerebrospinal_Fluid_Examination2,脑脊液检查,,A laboratory analysis of a sample of cerebrospinal fluid.,,,,,,,,SNOMED:167699000,CSF Analysis|Cerebrospinal Fluid Analysis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C173272,,,,
http://example.org/irAEs.owl#Musculoskeletal_System_and_Connective_Tissue,Musculoskeletal System and Connective Tissue,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Musculoskeletal_System_and_Connective_Tissue,肌肉骨骼系统和结缔组织,,"Musculoskeletal System: The system of muscles, tendons, ligaments, bones, joints and associated tissues that move the body and maintain its form.
Connective Tissue: The supporting or framework tissue of the animal body, formed of fibrous and ground substance with more or less numerous cells of various kinds; it is derived from the mesenchyme, and this in turn from the mesoderm; the varieties of connective tissue are: areolar or loose; adipose; dense, regular or irregular, white fibrous; elastic; mucous; and lymphoid tissue; cartilage; and bone; the blood and lymph may be regarded as connective tissues the ground substance of which is a liquid.",,,,,,,,"SOC:10028395.0|UBERON:0002204
UBERON:002384",,,"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12754
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12374",,,,
http://example.org/irAEs.owl#Hypothyroidism,Hypothyroidism,,,FALSE,,,http://example.org/irAEs.owl#Thyroid,,,,,Hypothyroidism,甲状腺功能减退症,"A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; thyroid replacement initiated; increase in current thyroid replacement therapy; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe symptoms; hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143576",Abnormally low levels of thyroid hormone.,,,,,,,,MedDRA:10021114|ICD-11:5A00,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26800,,,,
http://example.org/irAEs.owl#Family_Medical_History,Family Medical History,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,Family_Medical_History,家族病史,,A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions.,,,,,,,,,"Epidemiology, Family Medical History|family history|Family History of",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17726,,,,
http://example.org/irAEs.owl#神经系统,Central Nervous System Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,神经系统,中枢神系统肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#C-MET,"MET Proto-Oncogene, Receptor Tyrosine Kinase",,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,C-MET,MET 原癌基因，受体酪氨酸激酶,,"This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.",,,,,,,,NCBI Gene ID:4233,ONCOGENE MET|hepatocyte growth factor receptor|HGFR|MET|RCCP2,,https://www.ncbi.nlm.nih.gov/gene/4233,,,,
http://example.org/irAEs.owl#Peripheral_Ulcerative_Keratitis,Keratitis,,,FALSE,,,http://example.org/irAEs.owl#Cornea,,,,,Peripheral_Ulcerative_Keratitis,角膜炎,"A disorder characterized by inflammation to the cornea of the eye.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)
Grade 3: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); corneal ulcer; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Perforation; best corrected visual acuity of 20/200 or worse in the affected eye
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55847",Inflammation of the cornea.,,,,,,,,MedDRA:10023332|ICD-11:9A7Z,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26805,,,,
http://example.org/irAEs.owl#DRB3,Human Leukocyte Antigen DRB3*01:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,DRB3,人类白细胞抗原DRB3*01:01,,"Major histocompatibility complex, class II, DR beta 3, also known as HLA-DRB3, is a human gene.",Risk Factor,,,,,,,NCBI Gene ID:3125|LOINC:LP36467-6,"Major Histocompatibility Complex, Class II, DR Beta 3 Gene|HLA-DRB3",,https://www.ncbi.nlm.nih.gov/gene/3125,,,,
http://example.org/irAEs.owl#Adrenal_Insufficiency_AI,Adrenal Insufficiency,,,FALSE,,,http://example.org/irAEs.owl#Adrenal_Gland,,,,,Adrenal_Insufficiency_AI,肾上腺功能不全,"A disorder characterized by the adrenal cortex not producing enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Moderate symptoms; medical intervention indicated
Grade 3: Severe symptoms; hospitalization indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55748","An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).",,,,,,,,MedDRA:10001367|ICD-11:5A74,Adrenal Cortical Hypofunction|Adrenocortical Insufficiency|Hypocortisolemia|Adrenal Cortical Insufficiency|AI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26691,,,,
http://example.org/irAEs.owl#Hepatobiliary_System,Hepatobiliary System,,,FALSE,,,http://example.org/irAEs.owl#Disease,,,,,Hepatobiliary_System,肝胆系统,,"The liver, gallbladder, and associated ducts, considered collectively.",,,,,,,,UBERON:0002423,hepatobiliary,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C43612,,,,
http://example.org/irAEs.owl#linbaguan,Lymphatic Vessel,,,FALSE,,,http://example.org/irAEs.owl#Disease_12,,,,,linbaguan,淋巴管,,A tubule that carries lymph throughout the body.,,,,,,,,SNOMED_CT:279089004|UBERON:0001473,"lymph vessel|VESSEL, LYMPHATIC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C33038,,,,
http://example.org/irAEs.owl#5,EOCG 5,,,FALSE,,,http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,,,,,irAEs.owl#5,东部肿瘤协作组 5分,,Dead.,Risk Factor,,,,,,,,ECOG Performance Status 5,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105728,,,,
http://example.org/irAEs.owl#50,≥50%,,,FALSE,,,http://example.org/irAEs.owl#Proportion_of_PD_L1_positive_cellsTPSCPS,,,,,irAEs.owl#50,,,,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Oral,Oral,,,FALSE,,,http://example.org/irAEs.owl#Disease,,,,,Oral,口腔,,"Of, or relating to, or affecting, or for use in the mouth.",,,,,,,,UBERON:0000165,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25311,,,,
http://example.org/irAEs.owl#ARP,Reticulocyte Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,ARP,网织红细胞计数,,The determination of the number of reticulocytes in a blood sample.,"Below Baseline, Risk Factor",,,,,,,SNOMED_CT:45995003|LOINC:LP16487-8,"Reticulocyte Number|Numbers, Reticulocyte|Count, Reticulocyte|reticulocyte count percentage|Test;reticulocyte count",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C51947,,,,
http://example.org/irAEs.owl#T_Stage,T Category,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Stage,,,,,T_Stage,T 分期,,"One criteria of the TNM staging system. T refers to the extent of tumor involvement at the primary site (T, followed by a number indicating size and depth of invasion).",Risk Factor,,,,,,,,T Classification|T Stage,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25728,,,,
http://example.org/irAEs.owl#抗生素治疗,History of Antibiotic Treatment,,,FALSE,,,http://example.org/irAEs.owl#Treatment_history,,,,,抗生素治疗,抗生素治疗史,,,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Absolute_Neutrophil_Count,Absolute Neutrophil Count,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Absolute_Neutrophil_Count,绝对中性粒细胞计数,,"The real number of white blood cells (WBC) that are neutrophils. It is derived by multiplying the WBC count by the percent of neutrophils in the differential WBC count. The normal range for ANC is 1.5 to 8.0 (1,500 to 8,000/mm3).","Over Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Vit_B12,Vitamin B12,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_8,,,,,Vit_B12,维生素B12,,"An essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.",,,,,,,,SNOMED_CT:304111003|LOINC:LP15505-8,Cobalamin (1+)|B12 Vitamin|Vitamin B-12|Cobalamin|VIT B12,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C939,,,,
http://example.org/irAEs.owl#IL-35,Interleukin-35,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-35,白介素35,,A heterodimeric cytokine that is comprised of interleukin-12 subunit alpha and interleukin-27 subunit beta. This protein complex is reported to be secreted by regulatory T-cells and may suppress inflammation.,"Below Baseline, Risk Factor",,,,,,,,IL35|IL-35,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C131304,,,,
http://example.org/irAEs.owl#Uvea,Uvea,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Uvea,葡萄膜,,"The pigmented layer of the eyeball between the tough, white outer coat of the eye and the retina.",,,,,,,,UBERON:0001768,Tunica Vasculosa of Eyeball|uveal tract,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12811,,,,
http://example.org/irAEs.owl#Pure_Red_Cell_Aplsia,Pure Red Cell Aplsia,,,FALSE,,,http://example.org/irAEs.owl#Bone_Marrow,,,,,Pure_Red_Cell_Aplsia,纯红细胞再生障碍性贫血,,"A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia, and selective erythroid hypoplasia.",,,,,,,,MedDRA:10002965|ICD-11:3A61,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34974,,,,
http://example.org/irAEs.owl#acute_leukemias,Leukemia,,,FALSE,,,http://example.org/irAEs.owl#Hematological_Tumors,,,,,acute_leukemias,白血病,,"A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.",,,,,,,,ICD-11:2B33.4|MedDRA:10024329,"LEUKEMIA, MALIGNANT|Leukemia, Disease",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3161,,,,
http://example.org/irAEs.owl#‘reactive_cutaneous_capillary_endothelial_proliferation,Reactive Cutaneous Capillary Endothelial Proliferation,,,FALSE,,,http://example.org/irAEs.owl#Capillary,,,,,reactive_cutaneous_capillary_endothelial_proliferation,反应性皮肤毛细血管内皮增生,,,,,,,,,,,RCCEP,,,,,,
http://example.org/irAEs.owl#International_Normalized_Ratio_INR,International Normalized Ratio,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,International_Normalized_Ratio_INR,国际标准化比值,,"A system, commonly called the INR, established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index (ISI) for the particular thromboplastin reagent and instrument combination utilized to perform the test; the ratio of a patient's clotting time to the lab's mean reference value is normalized against the ISI. (from medterms.com and medicine.ucsf.edu)",,,,,,,,SNOMED_CT:165581004|LOINC:LP17102-2,"coagulation studies: INR|Ratios, International Normalized|Normalized Ratios, International|INR",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25352,,,,
http://example.org/irAEs.owl#White_Blood_Cell_WBC,White Blood Cell,,,FALSE,,,http://example.org/irAEs.owl#Disease_9,,,,,White_Blood_Cell_WBC,白细胞,,"Blood cells that are devoid of hemoglobin, capable of ameboid motion and phagocytosis, and act as the principal components of the immune system.",,,,,,,,UBERON:CL_0000738,White Blood Cells|LEUKOCYTE|Leukocyte|WBC|WBCs|White Cell,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12529,,,,
http://example.org/irAEs.owl#Inflammatory_Marker_Panel,Inflammtory Marker,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding4,,,,,Inflammatory_Marker_Panel,血液炎症标志物,,A substance detectable in the blood that can be used to assess levels of inflammation in the body.,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Aspartate_Aminotransferase_AST,Aspartate Transaminase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Aspartate_Aminotransferase_AST,天冬氨酸氨基转移酶,,A family of pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. Aspartate aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-aspartate to alpha-ketoglutarate forming oxaloacetate and L-glutamate.,Risk Factor,,,,,,,LOINC:LP15426-7|SNOMED_CT:26091008,Aspartate aminotransferase|AAT|ASAT|AST|AspAT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25202,,,,
http://example.org/irAEs.owl#4,ECOG 4,,,FALSE,,,http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,,,,,irAEs.owl#4,东部肿瘤协作组 4分,,Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair.,Risk Factor,,,,,,,,ECOG Performance Status 4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105727,,,,
http://example.org/irAEs.owl#Interleukin,Interleukin,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Interleukin,白细胞介素,,Interleukin is the generic name for a group of well-characterized cytokines that are produced by leukocytes and other cell types. They have a broad spectrum of functional activities that regulate the activities and capabilities of a wide variety of cell types. They are particularly important as members of the cytokine networks that regulate inflammatory and immune responses.,Risk Factor,,,,,,,LOINC:LP30867-3|SNOMED_CT:38476002,Interleukins|IL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20497,,,,
http://example.org/irAEs.owl#PRDM1,PR Domain Zinc Finger Protein 1,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,PRDM1,PR 结构域锌指蛋白 1,,This gene is involved in repression of transcription. It plays a role in the formation of pre-plasma memory B cells and immunoglobulin-secreting plasma cells.,,,,,,,,NCBI Gene ID: 639,PR/SET Domain 1 Gene|PRDM1 Gene|PRDM1,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C24692,,,,
http://example.org/irAEs.owl#Pancreas,Pancreas,,,FALSE,,,http://example.org/irAEs.owl#Disease,,,,,Pancreas,胰腺,,"An organ behind the lower part of the stomach that is the shape of a fish and about the size of a hand. It is a compound gland composed of both exocrine and endocrine tissues. The endocrine pancreas makes insulin so that the body can use glucose (sugar) for energy. The exocrine pancreas makes enzymes that help the body digest food. Spread all over the pancreas are areas called the Islets of Langerhans. The cells in these areas each have a special purpose. The alpha cells make glucagon, which raises the level of glucose in the blood; the beta cells make insulin; the delta cells make somatostatin. There are also PP cells and D1 cells, about which little is known.",,,,,,,,UBERON:0001264,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12393,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests,,,,,Clinical_Humoral_and_Pathological_Examination,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Brainstem,Brain Stem,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Brainstem,脑干,,"Three sections, the midbrain, pons and medulla oblongata, that are located at the base of the brain. The brain stem regulates the central nervous system, and is vital as a conduit for motor and sensory innervations.",,,,,,,,UBERON:0002298,Brainstem structure|Brainstem,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12441,,,,
http://example.org/irAEs.owl#Creatine_Kinase,Creatine Kinase,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Creatine_Kinase,肌酸激酶,,"An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.","Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Serum_Potassium,Serum Potassium,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,,,,,Serum_Potassium,血清钾离子,,A quantitative measurement of the amount of potassium present in a sample of serum.,,,,,,,,LOINC:108797-2|SNOMED_CT:312468003,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61030,,,,
http://example.org/irAEs.owl#Serum_Potassium1,Serum Potassium,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,Serum_Potassium1,血清钾离子,,A quantitative measurement of the amount of potassium present in a sample of serum.,,,,,,,,LOINC:108797-2|SNOMED_CT:312468003,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61030,,,,
http://example.org/irAEs.owl#Adrenocorticotropic_hormone,Adrenocortictropic Hormine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,,,,,Adrenocorticotropic_hormone,促肾上腺皮质激素,,"Corticotropin (39 aa, ~5 kDa) is encoded by the human POMC gene. This protein plays a role in the stimulation of cortisol secretion by the adrenal gland.",,,,,,,,LOINC:LP32529-7|SNOMED_CT:40789008,ACTH - Adrenocorticotrophic hormone|Corticotropin|ATCH|CCTROP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2282,,,,
http://example.org/irAEs.owl#Organ_specific_examination_items_10,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests12,,,,,Organ_specific_examination_items_10,功能性检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Orbit,Orbit,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Orbit,眼眶,,"The bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa. Seven bones contribute to the structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, ethmoid, and palatine bones.",,,,,,,,UBERON:0004088,orbital region|Orbital Cavity|Ocular Orbit|Eye Socket,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12347,,,,
http://example.org/irAEs.owl#Repetitive_Nerve_Stimulation_RNS_2,Repetitive Nerve Stimulation,,,FALSE,,,http://example.org/irAEs.owl#Electrophysiological_Studies_3,,,,,Repetitive_Nerve_Stimulation_RNS_2,重复神经刺激,,"This panel contains the collection of terms that would be used to report the results of a repetitive nerve stimulation (RNS) study. The panel should be repeated for each nerve and muscle studied. RNS is used to evaluate neuromuscular transmission and is used to help diagnose conditions such as myasthenia gravis. Whereas in a typical motor nerve conduction study a single nerve stimulus is applied and the muscle response is recorded, in RNS, the nerve is stimulated multiple times and the corresponding muscle responses are measured along with the change in response over time. In patients without neuromuscular disease, the muscle response stays constant with repeated stimulation as well as with exercise. In patients with disease, there is typically a significant decrease in muscle response with repeated stimulation (LOINC).",,,,,,,,SNOMED_CT:252748005|LOINC:98706-5,RNS,,https://loinc.org/98706-5/,,,,
http://example.org/irAEs.owl#Conjunctival_Impression_Cytology,Impression Cytology,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_9,,,,,Conjunctival_Impression_Cytology,印迹细胞学检查,,"A non-invasive specimen collection technique where cellulose acetate filter paper is applied to a body surface (e.g., ocular surface) to collect superficial epithelial cells, which can be air-dried or fixed and then stained for histological, immunohistological, or molecular analysis.",,,,,,,,SNOMED_CT:168440009,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C179749,,,,
http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,Common Terminology Criteria for Adverse Events 6.0,,,FALSE,,,http://example.org/irAEs.owl#irAE-Treatment_Data,,,,,Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,不良事件通用术语标准6.0 版,,"A standard terminology developed to report adverse events occurring in cancer clinical trials. Common terminology criteria for adverse events (CTCAE) are used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTCAE contain a grading scale for each adverse event term representing the severity of the event.
The sixth version of the NCI Common Terminology Criteria for Adverse Events is a descriptive terminology which can be utilized for Adverse Event (AE) reporting. A grading (severity) scale is provided for each AE term.",,,,,,,,,CTCAE 6.0,,https://safetyprofiler-ctep.nci.nih.gov/safety-profiler/index.html|https://dctd.cancer.gov/research/ctep-trials/for-sites/adverse-events#ctcae|https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220612,,,,
http://example.org/irAEs.owl#Cytokine_Release_Syndrome_CRS,Cytokine Release Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Cytokine_Release_Syndrome_CRS,细胞因子释放综合征,"A disorder characterized by fever, tachypnea, headache, tachycardia, hypotension, rash, and/or hypoxia caused by the release of cytokines.

Grade 1: Fever with or without constitutional symptoms
Grade 2: Hypotension responding to fluids; hypoxia requiring low-flow nasal cannula or blow-by
Grade 3: Hypotension managed with one pressor; hypoxia requiring high-flow nasal cannula, facemask, nonrebreather mask, or Venturi mask
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143394","A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening.",,,,,,,,MedDRA:10052015,CRS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78251,,,,
http://example.org/irAEs.owl#Glucose_GLU,Glucose,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Glucose_GLU,葡萄糖,,"A simple sugar monosaccharide having two isoforms, alpha and beta, with a chemical structure of C6H12O6 that acts as an energy source for both plants and animals by reacting with oxygen, generating carbon dioxide and water, and releasing energy.",,,,,,,,SNOMED_CT:67079006|LOINC:LP14635-4,d-Glucose preparation|D-glucopyranose monohydrate preparation|D-Glucose|GLU|dextrose,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2831,,,,
http://example.org/irAEs.owl#Bone_Marrow,Bone Marrow,,,FALSE,,,http://example.org/irAEs.owl#Disease_9,,,,,Bone_Marrow,骨髓,,"The tissue occupying the spaces of bone. It consists of blood vessel sinuses and a network of hematopoietic cells which give rise to the red cells, white cells, and megakaryocytes.",,,,,,,,UBERON:0002371,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12431,,,,
http://example.org/irAEs.owl#Folic_acid,Folic Acid,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_8,,,,,Folic_acid,叶酸,,"A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production.",,,,,,,,LOINC:LP15575-1|SNOMED_CT:63718003,FA|Folacin|Vitamin B9,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C510,,,,
http://example.org/irAEs.owl#Transforming_Growth_Factor_beta_TGF_β,Transforming Growth Factor-beta,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Transforming_Growth_Factor_beta_TGF_β,转化生长因子-β,,"A family of structurally-related cytokines that bind to their cognate serine/threonine kinase receptors as homodimers or heterodimers linked by a single disulfide bond. These proteins play a role in embryonic development, hematopoiesis, tissue repair and extracellular matrix remodeling.",Candidate Factor,,,,,,,LOINC:LP429491-6|SNOMED_CT:708710005,Transforming Growth Factor-Beta Superfamily|Transforming Growth Factor-beta1|Bone-Derived Transforming Growth Factor; TGF B|TGF Beta|TGF-β,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20455,,,,
http://example.org/irAEs.owl#Disease_8,Disease,,,FALSE,,,http://example.org/irAEs.owl#Cardiac_Organ,,,,,Disease_8,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Alanine_Aminotransferase_ALT,Alanine Transaminase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Alanine_Aminotransferase_ALT,丙氨酸氨基转移酶,,"A family of pyridoxal phosphate-dependent enzymes involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Alanine aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-alanine to alpha-ketoglutarate forming pyruvate and L-glutamate.",,,,,,,,SNOMED_CT:56935002|LOINC:LP15333-5,Glutamic-Pyruvic Transaminase|Alanine Aminotransferase|L-alanine transaminase|ALAT|ALT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25293,,,,
http://example.org/irAEs.owl#HBV,Hepatitis B Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test,,,,,HBV,乙肝病毒,,Hepatitis B Virus (HBV) is the prototype of the Hepadnavirus Family. Included in the family are the Woodchuck Hepatitis Virus (WHV) and the Duck Hepatitis B Virus (DHBV) which provide animal models of infection. The HBV genome is a partially double stranded circular DNA. A viral reverse transcriptase is bound to the 5' extremity of the long strand.,,,,,,,,SNOMED_CT:81665004|LOINC:LP14306-2,HBV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14215,,,,
http://example.org/irAEs.owl#Sex,Sex,,,FALSE,,,http://example.org/irAEs.owl#Demographics,,,,,Sex,性别,,"An arbitrary categorization of individuals based on the assemblage of physical properties related to reproduction, and commonly associated with the designation of such categories as female and male. This designation is based on a combination of observable information from organ inventories, morphological assessments, hormone assessments, genetic testing, observed primary and secondary sex characteristics, menstrual status, and/or obstetric history. Current sex designation may or may not be the same as an individual's sex assigned or reported at birth.",Controversial Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C28421,,,,
http://example.org/irAEs.owl#Anti-ds_DNA_Antibody,Anti-ds DNA Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti-ds_DNA_Antibody,抗双链 DNA 抗体,,"A type of antinuclear antibody that specifically targets double stranded DNA; while these antibodies are sometimes detectable in multiple different autoimmune disorders, their presence is generally considered highly specific for systemic lupus erythematosus.",,,,,,,,LOINC:LP37936-9|SNOMED_CT:76731000,Anti-Double-Stranded DNA Antibody,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C114565,,,,
http://example.org/irAEs.owl#C5a,Complement component C5,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test3,,,,,C5a,补体C5,,"Complement C5 (1676 aa, ~188 kDa) is encoded by the human C5 gene. This protein is involved in complement-mediated immunity.",,,,,,,,SNOMED_CT:62699008|LOINC:LP16376-3,Complement C5|Prepro-C5,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C21539,,,,
http://example.org/irAEs.owl#Membranous_Nephropathy_MN,Membranous Nephropathy,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Membranous_Nephropathy_MN,膜性肾病,,"A slowly progressive inflammation of the glomeruli characterized by immune complex deposits at the glomerular basement membrane, resulting in a thickened membrane, and nephrotic syndrome.",,,,,,,,ICD-11:GB41|MedDRA:10027170,chronic nephritic syndrome with diffuse membranous glomerulonephritis|Membranous Glomerulonephritis|Membranous Glomerulonephropathy|MN,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34645,,,,
http://example.org/irAEs.owl#Prognostic_Nutritional_Index_PIN,Prognostic Nutritional Index,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,Prognostic_Nutritional_Index_PIN,预后营养指数,,The prognostic nutritional status was calculated on the basis of admission data as follows: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm(3)) (PubMed).,"＜40, Risk Factor",,,,,,,,PIN,,https://pubmed.ncbi.nlm.nih.gov/23884382/,,,,
http://example.org/irAEs.owl#Lactate_Dehydrogenase,Lactate Dehydrogenase,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Lactate_Dehydrogenase,乳酸脱氢酶,,"A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.","Over Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#SLCO1B1,Solute Carrier Organic Anion Transporter Family Member 1B1,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,SLCO1B1,溶质载体有机阴离子转运蛋白家族 1B1,,This gene is involved in sodium-independent uptake of numerous endogenous compounds in the liver.,,,,,,,,NCBI Gene ID: 10599,"Solute Carrier Organic Anion Transporter Family, Member 1B1 Gene|SLCO1B1 Gene|SLCO1B1",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106614,,,,
http://example.org/irAEs.owl#ANKRD44,Ankyrin Repeat Domain 44,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,ANKRD44,锚蛋白重复结构域蛋白 44,,"ANKRD44 (Ankyrin Repeat Domain 44) is a Protein Coding gene. Diseases associated with ANKRD44 include Neurodevelopmental Disorder With Hypotonia, Seizures, And Absent Language and Mitochondrial Complex I Deficiency, Nuclear Type 1.",,,,,,,,NCBI Gene ID: 91526,Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-B|Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat|ARSB|PP6-ARS-B|Subunit B|ANKRD44,,https://www.ncbi.nlm.nih.gov/gene/91526,,,,
http://example.org/irAEs.owl#AMH,Anti-Müllerian Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,,,,,AMH,抗苗勒管激素,,"Muellerian-inhibiting factor (560 aa, ~59 kDa) is encoded by the human AMH gene. This protein plays a role in the development of the male reproductive system.",,,,,,,,LOINC:90742-8|SNOMED_CT:53252001,Mullerian Inhibiting Factor|Müllerian Inhibiting Substance|Mullerian-Inhibiting Substance|Muellerian-Inhibiting Factor|MIS|AMH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C101737,,,,
http://example.org/irAEs.owl#IL-1bata,Interleukin-1 beta,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-1bata,白介素1β,,"Interleukin-1 beta (269 aa, ~31 kDa) is encoded by the human IL1B gene. This protein is involved in the macrophage-dependent inflammatory response.","Over Baseline, Risk Factor",,,,,,,,Catabolin|IL-1-b|IL-1B|IL-1β|IL1F2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20522,,,,
http://example.org/irAEs.owl#Amylase_AMY,Amylase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Amylase_AMY,淀粉酶,,Amylase is an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands.,,,,,,,,LOINC:LP15355-8|SNOMED_CT:387031005,AMY,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16284,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_2,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests10,,,,,Clinical_Humoral_and_Pathological_Examination_2,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Granulocyte_Macrophage_Colony_Stimulating_Factor_GM_CFS,Granulocyte-Macrophage Colony-Stimulating Factor,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Granulocyte_Macrophage_Colony_Stimulating_Factor_GM_CFS,粒细胞-巨噬细胞集落刺激因子,,"Granulocyte-macrophage colony-stimulating factor (144 aa, ~16 kDa) is encoded by the human CSF2 gene. This protein plays a role in the positive regulation of the growth and differentiation of cells in the granulocyte, macrophage, eosinophil and erythrocyte lineages.","Over Baseline, Risk Factor",,,,,,,LOINC:LP421049-0|SNOMED_CT:53681007,"Colony Stimulating Factor, Granulocyte-Macrophage|Colony Stimulating Factor 2|CSF|CSF2|GM-CFS|GMCSF",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20545,,,,
http://example.org/irAEs.owl#头颈部肿瘤,Head and Neck Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,头颈部肿瘤,头颈部肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#子宫,Uterus,,,FALSE,,,http://example.org/irAEs.owl#女性,,,,,子宫,子宫,,"A hollow, thick-walled, muscular organ located within the pelvic cavity of a woman. Within the uterus the fertilized egg implants and the fetus develops during pregnancy.",,,,,,,,UBERON:0000995,"Genital System, Female, Uterus|Uterine structure (body structure)|Uterine|Utero|Womb",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12405,,,,
http://example.org/irAEs.owl#Thrombin_Time_TT,Thrombin Time,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,Thrombin_Time_TT,凝血酶时间,,A measurement of the time it takes a plasma sample to clot after adding the active enzyme thrombin.,,,,,,,,LOINC:LP394068-3|SNOMED_CT:55323000,Thrombin Clotting Time|TCT|TT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C80365,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests12,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Non-anatomical/Sys,,,,,Diagnostic_and_Assessment_Tests12,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#D_dimer,D-dimer,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,D_dimer,D-二聚体,,"A unit of measure for the concentration of fibrin degradation products in a sample, calculated based upon the mass of D-dimers contained within that sample.",,,,,,,,LOINC:LP15987-8|LOINC:108010-0|SNOMED_CT:726530008,Fibrin D-dimer|DDU - D-dimer unit|D-dimer unit,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C161494,,,,
"http://example.org/irAEs.owl#Electromyography,_EMG",Electromyography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items,,,,,_EMG,肌电图,,"An assessment of skeletal muscle function and nerve control, obtained by recording and studying the intrinsic electrical properties of the muscles.",,,,,,,,LOINC:LP6246-5|SNOMED_CT:42803009,Harvey-Masland test|electromyogram|Electromyography Procedures|EMG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38056,,,,
"http://example.org/irAEs.owl#Electromyography,_EMG2",Electromyography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_4,,,,,_EMG2,肌电图,,"An assessment of skeletal muscle function and nerve control, obtained by recording and studying the intrinsic electrical properties of the muscles.",,,,,,,,LOINC:LP6246-5|SNOMED_CT:42803009,Harvey-Masland test|electromyogram|Electromyography Procedures|EMG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38056,,,,
http://example.org/irAEs.owl#Absolute_Neutrophil_Count_ANC,Absolute Neutrophil Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Absolute_Neutrophil_Count_ANC,绝对中性粒细胞计数,,"The real number of white blood cells (WBC) that are neutrophils. It is derived by multiplying the WBC count by the percent of neutrophils in the differential WBC count. The normal range for ANC is 1.5 to 8.0 (1,500 to 8,000/mm3).","Over Baseline, Risk Factor",,,,,,,LOINC:LP14267-6|SNOMED_CT:30630007,Absolute Neutrophil|Neutrophils|ANC|NEUT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C63321,,,,
"http://example.org/irAEs.owl#AchR_Autoantibody,_ACHR",AchR Autoantibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding3,,,,,_ACHR,乙酰胆碱受体自身抗体,,An autoantibody that recognizes acetylcholine receptor proteins.,,,,,,,,SNOMED_CT:103189000|LOINC:LP36947-7,Anti-AchR Autoantibody|Acetylcholine receptor Ab|Anti-Acetylcholine Receptor Autoantibody|AchR Autoantibody|ACRA - Acetylcholine receptor antibody|ACHR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C212207,,,,
http://example.org/irAEs.owl#淋巴管炎,Lymphangitis,,,FALSE,,,http://example.org/irAEs.owl#linbaguan,,,,,淋巴管炎,淋巴管炎,,Inflammation of the lymphatic vessels.,,,,,,,,MedDRA:10025226|ICD-11:BD91,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34790,,,,
http://example.org/irAEs.owl#Disease_10,Disease,,,FALSE,,,http://example.org/irAEs.owl#Eye,,,,,Disease_10,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Disease_13,Disease,,,FALSE,,,http://example.org/irAEs.owl#Non-anatomical/Sys,,,,,Disease_13,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Disease_12,Disease,,,FALSE,,,http://example.org/irAEs.owl#Vascular_and_Lymphatic_System,,,,,Disease_12,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Disease_11,Disease,,,FALSE,,,http://example.org/irAEs.owl#Immune_System,,,,,Disease_11,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Bells_Palsy,Bell's Palsy,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,Bells_Palsy,贝尔麻痹,,Partial or complete paralysis of the facial muscles of one side of a person's face. It is caused by damage to the seventh cranial nerve. It is usually temporary but it may recur.,,,,,,,,MedDRA:10004223|ICD-11:8B88.0,Facial Nerve Paralysis|Facial Paralysis|Cranial nerve palsy VII|Cranial Nerve VII Palsy|Facial Palsy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26769,,,,
http://example.org/irAEs.owl#动脉粥样硬化,Atherosclerosis,,,FALSE,,,http://example.org/irAEs.owl#Artery,,,,,动脉粥样硬化,动脉粥样硬化,,Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.,,,,,,,,MedDRA:10003601|ICD-11:BD40,Unspecified atherosclerosis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35768,,,,
http://example.org/irAEs.owl#SMAD3,SMAD Family Member 3,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,SMAD3,SMAD 家族成员 3,,This gene is involved in signal transduction and apoptosis. It also plays a role in the regulation of both steroid synthesis and T-cell response.,Risk Factor,,,,,,,NCBI Gene ID: 4088,Mothers Against Decapentaplegic Homolog 3 Gene|SMAD3 Gene|SMAD3,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18504,,,,
http://example.org/irAEs.owl#Thrombocyte,Thrombocyte,,,FALSE,,,http://example.org/irAEs.owl#Disease_9,,,,,Thrombocyte,血小板,,"An irregular, disc-shaped element in the blood that assists in blood clotting. Platelets are not blood cells, they are fragments of large bone marrow cells called megakaryocytes.",,,,,,,,UBERON:CL_0000233,Blood Platelet|Platelet,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12520,,,,
http://example.org/irAEs.owl#Narcolepsy（发作性睡病_/_嗜睡症标准名）_通用嗜睡：Hypersomnia_解剖定位,Narcolepsy,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,_嗜睡症标准名）_通用嗜睡：Hypersomnia_解剖定位,嗜睡症,,A sleep disorder characterized by a tendency for excessive sleepiness during the day which occurs even after adequate sleep in the nighttime. The persons who suffer from this condition experience fatigue and may fall asleep at inappropriate times during the day.,,,,,,,,MedDRA:10028713|ICD-11:MG42,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84489,,,,
http://example.org/irAEs.owl#卵巢鳞癌,Ovarian Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#卵巢癌,,,,,卵巢鳞癌,卵巢鳞状细胞癌,,A usually high grade squamous cell carcinoma that arises from the ovary and is not associated with a germ cell tumor. The prognosis is poor.,,,,,,,,,Ovarian Squamous Cell Cancer,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C40093,,,,
http://example.org/irAEs.owl#FSH,Follicle Stimulating Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,FSH,促卵泡激素,,"A heterodimeric glycoprotein hormone secreted by the gonadotropic cells of the anterior pituitary gland. This hormone is involved in gonadal development, growth, maturation and reproductive processes, including the regulation of spermatogenesis in males and follicular growth and ovulation in females.",,,,,,,,LOINC:LP14499-5|SNOMED_CT:768662008,Follitropin|Follicle-Stimulating Hormone|FSH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C181076,,,,
http://example.org/irAEs.owl#高血压,Hypertension,,,FALSE,,,http://example.org/irAEs.owl#Artery,,,,,高血压,高血压,"A disorder characterized by a pathological increase in blood pressure.

Grade 1: Adult: Systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP >= 120/80 even if < 95th percentile
Grade 2: Adult: Systolic BP 140-159 mm Hg or diastolic BP 90-99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130-139 or diastolic between 80-89 even if < 95th percentile
Grade 3: Adult: Systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; Pediatric and adolescent: Systolic and/or diastolic > 5 mmHg above the 99th percentile
Grade 4: Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55060",Blood pressure that is abnormally high.,,,,,,,,MedDRA:10020772|ICD-11:BA00,High blood pressure|Vascular hypertensive disorder|HTN,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3117,,,,
http://example.org/irAEs.owl#Concomitant_Medications,Concomitant Therapy,,,FALSE,,,http://example.org/irAEs.owl#Therapy_Method,,,,,Concomitant_Medications,联合用药治疗,,"Any pharmaceutical agent, other than the primary therapy, that is administered to or used by the subject prior to or during a specified time period.",Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C53630,,,,
http://example.org/irAEs.owl#Myasthenia,Myasthenia Gravis,,,FALSE,,,http://example.org/irAEs.owl#Neuromuscular_Junction_NMJ,,,,,Myasthenia,重症肌无力,"A disorder characterized by weakness and rapid fatigue of any of the skeletal muscles.

Grade 1: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2: Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143232",A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness. It is caused by the blockage of the acetylcholine receptors at the neuromuscular junction.,,,,,,,,ICD-11:8C60.0|MedDRA:10028417,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C60989,,,,
http://example.org/irAEs.owl#DQB10602,Human Leukocyte Antigen DQB1*06:02,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,DQB10602,人类白细胞抗原 DQB1*06:02,,"DQB1*0602 is commonly linked to DQA1*0102 to form 6.2 haplotype. DQ6.2 and is common from Central Asia into Western Europe, *0602 is also linked to DQA1*0103 in parts of Asia.",,,,,,,,LOINC:LP113969-2,,,https://loinc.org/LP113969-2,,,,
http://example.org/irAEs.owl#Absolute_Eosinophil_Count_AEC,Absolute Eosinophil Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Absolute_Eosinophil_Count_AEC,绝对嗜酸性粒细胞计数,,The total number of white blood cells that are eosinophils. It is calculated by multiplying the white blood cell count by the percent of eosinophils in the differential white blood cell count.,"Over Baseline, Risk Factor",,,,,,,LOINC:LP14539-8|SNOMED_CT:71960002,Total Eosinophil Count|AEC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C188680,,,,
http://example.org/irAEs.owl#HLA-A*02：01,Human Leukocyte Antigen A*02:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,：01,人类白细胞抗原A*02:01,,"HLA class I histocompatibility antigen, A-0201 alpha chain (365 aa, ~41 kDa) is encoded by the human HLA-A gene. This protein plays a role in the presentation of foreign antigens to the immune system.",Risk Factor,,,,,,,,"HLA Class I Histocompatibility Antigen, A-0201 Alpha Chain|Major Histocompatibility Complex, Class I, A0201 Antigen|HLA-A*02:01|HLA-A Histocompatibility Type Antigen 0201|HLA-A Class I Antigen 0201|MHC Class I Antigen A*0201",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C128306,,,,
http://example.org/irAEs.owl#Absolute_Lymphocytes_Count_ALC,Absolute Lymphocytes Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Absolute_Lymphocytes_Count_ALC,绝对淋巴细胞计数,,The number of lymphocytes found in a given volume of blood.,"Below Baseline, Risk Factor",,,,,,,SNOMED_CT:74765001|LOINC:LP14540-6,Absolute Blood Lymphocyte Count|ALC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113237,,,,
http://example.org/irAEs.owl#Insulin,Insulin,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,Insulin,胰岛素,,"Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.",,,,,,,,SNOMED_CT:67866001|LOINC:LP14676-8,INS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2271,,,,
http://example.org/irAEs.owl#Laboratory_Tests2,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests2,,,,,Laboratory_Tests2,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#M_Stage,M Category,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Stage,,,,,M_Stage,M 分期,,One criteria of the TNM staging system. M refers to the presence of metastasis.,Risk Factor,,,,,,,,M Classification|M Stage,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25727,,,,
http://example.org/irAEs.owl#HLA-DQB1*03：01突变,Human Leukocyte Antigen DQB1*03:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,：01突变,人类白细胞抗原DQB1*03:01,,"HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.",Risk Factor,,,,,,,LOINC:LP36436-1|NCBI Gene ID: 3119,"Major Histocompatibility Complex, Class II, DQ Beta 1 Gene|HLA-DQB1*03:01",,https://www.ncbi.nlm.nih.gov/gene/3119,,,,
http://example.org/irAEs.owl#High_Density_Lipoprotein_Cholesterol_HDL_C,High-Density Lipoprotein Cholesterol,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,High_Density_Lipoprotein_Cholesterol_HDL_C,高密度脂蛋白胆固醇,,"Cholesterol is an essential lipid present in all cells. Cholesterol is needed in order to construct hormones, metabolites, and Vitamin D. Cholesterol travels throughout the bloodstream with the aid of two lipoproteins: high-density lipoprotein (HDL) and low-density lipoprotein (LDL). LDL carries cholesterol from the liver to other parts of the body and HDL carries cholesterol from other parts of the body to the liver where it can be broken down. HDL is considered ""good cholesterol"" because it removes excess cholesterol from the blood and into the liver where it can be disposed of properly. A higher level of HDL can decrease the risk for heart disease and atherosclerosis. When observing the blood HDL levels, less than 40 mg/dL is too low (high risk for heart disease), 40-59 mg/dL is average, and 60 mg/dL or higher is optimal (low risk for heart disease) (LOINC).",,,,,,,,LOINC:LP15489-5|SNOMED_CT:102737005,HDL Cholesterol|High Density Lipoprotein Cholesterol Measurement|HDL Cholesterol Measurement|HDL|HDL-C,,https://loinc.org/LP15489-5,,,,
http://example.org/irAEs.owl#Hepatitis,Hepatitis,,,FALSE,,,http://example.org/irAEs.owl#Hepatobiliary_System,,,,,Hepatitis,肝炎,"A disorder characterized by inflammation of the liver.

Grade 2: Moderate symptoms; medical intervention indicated
Grade 3: Symptomatic liver dysfunction; compensated cirrhosis; hospitalization or prolongation of existing hospitalization indicated
Grade 4: Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221076","Inflammation of the liver; usually from a viral infection, but sometimes from toxic agents.",,,,,,,,MedDRA:10019717|ICD-11:DB97,"Inflammatory liver disease, unspecified",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3095,,,,
"http://example.org/irAEs.owl#Blood_Urea_Nitrogen,_BUN1",Blood Urea Nitrogen,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,_BUN1,血尿素氮,,The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.,,,,,,,,SNOMED_CT:95971004|LOINC:LP14492-0,urea nitrogen|BUN|Blood Urea,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1753,,,,
http://example.org/irAEs.owl#Pulse_Oximetry,Pulse Oximetry,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_10,,,,,Pulse_Oximetry,脉搏血氧饱和度测定法,,A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin.,,,,,,,,SNOMED_CT:252465000|LOINC:LP6469-3,Pulse oximetry technique|Transcutaneous pulse oximetry,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38085,,,,
http://example.org/irAEs.owl#Anti_Jo-1_Antibody,Anti-Jo Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti_Jo-1_Antibody,抗Jo-1抗体,,"An autoantibody that recognizes histidyl-tRNA synthetase, cytoplasmic protein.",,,,,,,,SNOMED_CT:45932003,"Anti-Histidine-tRNA Ligase, Cytoplasmic Antibody|Jo-1 Antigen Antibody|Anti-HisRS Autoantibody|Anti-Histidyl-tRNA Synthetase|Anti-HARS1",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C183519,,,,
http://example.org/irAEs.owl#History_of_Cardiovascular_Diseases,Cardiovascular History,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,History_of_Cardiovascular_Diseases,心血管疾病史,,A record of a patient's medical background regarding cardiovasular disease.,Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C66921,,,,
http://example.org/irAEs.owl#Optic_Nerve,Optic Nerve,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Optic_Nerve,视神经,,The second cranial nerve.,,,,,,,,UBERON:0000348,Second Cranial Nerve|OPTIC NERVE,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12761,,,,
http://example.org/irAEs.owl#Testosterone,Testosterone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,,,,,Testosterone,睾酮,,"A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. Testosterone may also be made in the laboratory and is used to treat certain medical conditions.",,,,,,,,LOINC:15432-8|SNOMED_CT:43688007,Delta4-androsten-17beta-ol-3-one|Trans-Testosterone|(17Beta)-17-hydroxyandrost-4-en-3-one,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2299,,,,
"http://example.org/irAEs.owl#Thyroid-Stimulating_Hormone,_TSH2",Thyroid-Stimulating Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,_TSH2,促甲状腺激素,,A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.,,,,,,,,SNOMED_CT:61167004|LOINC:LP14487-0,Thyrotropic Hormone|Thyrotropin|Thyreotrophic Hormone|Thyreotropin|TSH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2280,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_6,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests7,,,,,Clinical_Humoral_and_Pathological_Examination_6,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests10,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Skin_and_Subcutaneous_Tissue,,,,,Diagnostic_and_Assessment_Tests10,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#IL-10-1,Interleukin-10,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-10-1,白介素10,,"Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.",Controversial Factor,,,,,,,LOINC:LP21163-8|SNOMED_CT:11267006,T-Cell Growth Inhibitory Factor|Cytokine Synthesis Inhibitory Factor|CSIF|IL-10|TGIF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20512,,,,
http://example.org/irAEs.owl#肺动脉高压,Pulmonary Arterial Hypertension,,,FALSE,,,http://example.org/irAEs.owl#Artery,,,,,肺动脉高压,肺动脉高压,,Increased pressure within the pulmonary arterial circulation.,,,,,,,,MedDRA:10064911|ICD-11:BB01,PAH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C157552,,,,
http://example.org/irAEs.owl#Bronchoalveolar_lavage,Bronchoscopy and Bronchoalveolar Lavage,,,FALSE,,,http://example.org/irAEs.owl#Cytological_Examination2,,,,,Bronchoalveolar_lavage,支气管镜检查及支气管肺泡灌洗,,"A procedure in which cells are taken from the inside of the airways that lead to the lungs. A bronchoscope is inserted through the nose or mouth into the lungs. A mild salt solution is washed over the surface of the airways to collect cells, which are then looked at under a microscope. Bronchial washing is used to find infections. It may also help find cancer or changes in cells that may lead to cancer.",,,,,,,,SNOMED_CT:397397002,"Bronchoscopy with Bronchoalveolar Lavage
Bronchoscopy with cell washing
bronchoalveolar lavage",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38042,,,,
http://example.org/irAEs.owl#Concomitant_Medication_Category,Concomitant Medication Category,,,FALSE,,,http://example.org/irAEs.owl#Concomitant_Medications,,,,,Concomitant_Medication_Category,联合用药类别,,The variable assigned to a concomitant medication class.,,,,,,,,,CMCLAS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C83219,,,,
http://example.org/irAEs.owl#泌尿系统,Urinary and Male Genital Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,泌尿系统,泌尿系统及男性生殖器官肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Autoimmune_hemolytic_Anaemia_AIHA,Autoimmune Hemolytic Anaemia,,,FALSE,,,http://example.org/irAEs.owl#Red_Blood_Cell_RBC,,,,,Autoimmune_hemolytic_Anaemia_AIHA,自身免疫性溶血性贫血,"Anemia resulting from hemolysis.

Grade 1: <10% drop in Hgb from last assessment; intervention not indicated
Grade 2:<=2 units of PRBCs transfused per day
Grade 3: >2 units of PRBCs per day indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220801","An acquired anemia caused by destruction of the red blood cells by autoantibodies. Causes include autoimmune disorders, lymphoproliferative disorders, and infections.",,,,,,,,ICD-11:3A20|MedDRA:10003825,Immune hemolytic anemia drug-induced|AIHA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34378,,,,
http://example.org/irAEs.owl#肌少症,Sarcopenia,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,肌少症,肌少症,,A reduction in muscle mass and function that is associated with aging or disuse.,Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C186726,,,,
http://example.org/irAEs.owl#Ipilimumab,Ipilimumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_CTLA_4,,,,,Ipilimumab,伊匹木单抗,,"A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.",,,,,,,,DrugBank ID:DB06186,Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody|BMS 734016|MDX 010,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2654,,,,
http://example.org/irAEs.owl#Remitting_Seronegative_Symmetrical_Synovitis_with_Pitting_Edema_Syndrome_RS3PE,Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Joint_System,,,,,Remitting_Seronegative_Symmetrical_Synovitis_with_Pitting_Edema_Syndrome_RS3PE,血清阴性对称性滑膜炎伴凹陷性水肿综合征,,"The remitting seronegative symmetric synovitis with pitting edema (RS3PE) syndrome is a rare inflammatory rheumatic disease of older adults, which can also be paraneoplastic. The main symptom is a rapidly progressing symmetric edematous swelling of both hands, sometimes also both feet, accompanied by (teno-)synovitis (PubMed).",,,,,,,,MedDRA:10065253|ICD-11:FA27.Y,RS3PE syndrome|RS3PE,,"https://pubmed.ncbi.nlm.nih.gov/35904275/
https://pubmed.ncbi.nlm.nih.gov/40864242/",,,,
"http://example.org/irAEs.owl#Hepatitis_C_Virus,_HCV",Hepatitis C Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_5,,,,,_HCV,丙型肝炎病毒,,"A small, enveloped, positive sense single strand RNA virus in the family Flaviviridae. The genome consists of a single RNA molecule with a single open reading frame.",,,,,,,,SNOMED_CT:62944002|LOINC:LP14400-3,HCV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14312,,,,
http://example.org/irAEs.owl#Hemophagocytic_Lymphohistiocytosis,Secondary Hemophagocytic Lymphohistiocytosis,,,FALSE,,,http://example.org/irAEs.owl#Red_Blood_Cell_RBC,,,,,Hemophagocytic_Lymphohistiocytosis,继发性噬血细胞性淋巴组织细胞增生症,"A disorder characterized by the development of a pathological and biochemical hyperinflammatory syndrome characterized by fever, cytopenias, hyperferritinemia, coagulopathy, hypofibrinogenemia and/or transaminitis and is attributable to therapy.

Grade 1: Asymptomatic or mild symptoms; requiring clinical and/or diagnostic evaluation; intervention not indicated
Grade 2: Moderate symptoms; intervention indicated (e.g., immunosuppressive agents)
Grade 3: Severe or medically significant but not immediately life threatening; hospitalization or prolongation of existing hospitalization indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221078","A disorder characterized by the development of a pathological and biochemical hyperinflammatory syndrome characterized by fever, cytopenias, hyperferritinemia, coagulopathy, hypofibrinogenemia and/or transaminitis and is attributable to therapy.",,,,,,,,MedDRA:10081409|ICD-11:3B62.Z,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121184,,,,
"http://example.org/irAEs.owl#Thyroid-Stimulating_Hormone,_TSH",Thyroid-Stimulating Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_TSH,促甲状腺激素,,A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.,,,,,,,,SNOMED_CT:61167004|LOINC:LP14487-0,Thyrotropic Hormone|Thyrotropin|Thyreotrophic Hormone|Thyreotropin|TSH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2280,,,,
http://example.org/irAEs.owl#Organ_specific_examination_items_4,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests7,,,,,Organ_specific_examination_items_4,功能学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Organ_specific_examination_items_3,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,,,,,Organ_specific_examination_items_3,功能性检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Organ_specific_examination_items_9,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests11,,,,,Organ_specific_examination_items_9,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#PJP,Pneumocystis jirovecii,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test2,,,,,PJP,卡氏肺孢子菌,,A species of yeast-like fungus that is the causative organism of Pneumocystis pneumonia.,,,,,,,,LOINC:LP39441-8|SNOMED_CT:415122004,Pneumocystis carinii hominis|Pneumocystis carinii f. sp. hominis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C117361,,,,
http://example.org/irAEs.owl#Red_Blood_Cell_RBC,Red Blood Cell,,,FALSE,,,http://example.org/irAEs.owl#Disease_9,,,,,Red_Blood_Cell_RBC,红细胞,,An erythrocyte with a darker-than-normal red color due to increased hemoglobin concentration. It is seen with some types of anemia.,,,,,,,,UBERON:CL_0000232,Hyperchromic Red Blood Cell|Hyperchromia|Hyperchromic Erythrocyte|RBC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C206366,,,,
http://example.org/irAEs.owl#Avelumab,Avelumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_L1,,,,,Avelumab,阿维鲁单抗,,"A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human immunosuppressive ligand programmed death-ligand 1 (PD-L1) protein, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, avelumab binds to PD-L1 and prevents the interaction of PD-L1 with its receptor programmed cell death protein 1 (PD-1). This inhibits the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T-lymphocytes (CTLs) targeted to PD-L1-overexpressing tumor cells. In addition, avelumab induces an antibody-dependent cellular cytotoxic (ADCC) response against PD-L1-expressing tumor cells. PD-1, a cell surface receptor belonging to the immunoglobulin superfamily expressed on T-cells, negatively regulates T-cell activation and effector function when activated by its ligand, and plays an important role in tumor evasion from host immunity. PD-L1, a transmembrane protein, is overexpressed on a variety of tumor cell types and is associated with poor prognosis.",,,,,,,,Drug Bank ID: DB11945,MSB 0010718C|Bavencio,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C116870,,,,
http://example.org/irAEs.owl#卵巢癌,Ovarian Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#女性生殖系统及乳腺,,,,,卵巢癌,卵巢癌,,"An invasive carcinoma that arises from the surface ovarian epithelium. The vast majority of cases are adenocarcinomas. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms.",,,,,,,,ICD-11:2C73|MedDRA:10033131,Ovarian epithelial cancer|Epithelial Ovarian Cancer|Carcinoma of Ovary,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4908,,,,
http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,Organ-Specific irAEs,,,FALSE,,,http://example.org/irAEs.owl#immune_related_Adverse_Events_irAEs,,,,,AnatomicalSystemic_irAEs,器官特异性免疫相关不良事件,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Thrombotic_Thrombocytopenic_Purpura,Thrombotic Thrombocytopenic Purpura,,,FALSE,,,http://example.org/irAEs.owl#Thrombocyte,,,,,Thrombotic_Thrombocytopenic_Purpura,血栓性血小板减少性紫癜,"A disorder characterized by a deficiency of ADAMTS13 and the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.

Grade 3: Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)
Grade 4: Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143874","A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction.",,,,,,,,MedDRA:10043648|ICD-11:3B64.14,Moschowitz Disease|TTP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78797,,,,
http://example.org/irAEs.owl#Laboratory_Tests1,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests1,,,,,Laboratory_Tests1,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#CRTAM,Cytotoxic and Regulatory T-Cell Molecule,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,CRTAM,细胞毒性与调节性 T 细胞分子,,This gene is involved in immune function.,,,,,,,,NCBI Gene ID: 56253,Class-I MHC-Restricted T-Cell-Associated Molecule|CD355|CRTAM,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104172,,,,
http://example.org/irAEs.owl#Glomerular_Filtration_Rate_GFR_UPCR,Urine Protein/ Creatinine Ratio,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_11,,,,,Glomerular_Filtration_Rate_GFR_UPCR,尿蛋白与肌酐比值,,The determination of the ratio of total protein compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.,,,,,,,,LOINC: 34366-5|SNOMED_CT:313500004,UPCR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C79463,,,,
http://example.org/irAEs.owl#FGF2,Fibroblast Growth Factor‐2,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,FGF2,成纤维细胞生长因子2,,"Fibroblast growth factor 2 (288 aa, ~31 kDa) is encoded by the human FGF2 gene. This protein plays a role in the regulation of cell proliferation, angiogenesis, and limb and nervous system development.",Risk Factor,,,,,,,LOINC:LP428253-1,Heparin-Binding Growth Factor 2|Basic Fibroblast Growth Factor|Prostatropin|HBGF-2|bFGF|FGF2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20547,,,,
http://example.org/irAEs.owl#大B细胞淋巴瘤,Diffuse Large B Cell Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,大B细胞淋巴瘤,弥漫大B细胞淋巴瘤,,"A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell lymphoma.",,,,,,,,MedDRA:10012818|ICD-11:2A81,"Non-follicular (diffuse) lymphoma, unspecified, unspecified site|Diffuse Large B-Cell Lymphoma|DLBCL",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8851,,,,
http://example.org/irAEs.owl#Vanishing_Bile_Duct_Syndrome,Vanishing Bile Duct Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Hepatobiliary_System,,,,,Vanishing_Bile_Duct_Syndrome,胆管消失综合征,,A morphologic finding indicating reduction in the numbers of interlobular and septal bile ducts in the liver tissue.,,,,,,,,MedDRA:10054753,Ductopenia|VBDS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C111785,,,,
"http://example.org/irAEs.owl#Varicella_Zoster_Virus,_VZV","Varicella Zoster Virus, VZV",,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test1,,,,,_VZV,带状疱疹病毒,,"An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles.",,,,,,,,SNOMED_CT:19551004|LOINC:LP14853-3,human alphaherpesvirus 3|chickenpox virus|Human herpesvirus 3|HHV-3|VZ Viruses|VZV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71091,,,,
"http://example.org/irAEs.owl#Varicella_Zoster_Virus,_VZV1",Varicella Zoster Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding1,,,,,_VZV1,带状疱疹病毒,,"An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles.",,,,,,,,SNOMED_CT:19551004|LOINC:LP14853-3,human alphaherpesvirus 3|chickenpox virus|Human herpesvirus 3|HHV-3|VZ Viruses|VZV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71091,,,,
http://example.org/irAEs.owl#Red_blood_cell_distribution_width_RDW,Red blood cell distribution width,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Red_blood_cell_distribution_width_RDW,红细胞分布宽度,,"An index of the variation in the size of the red cells and can be used to detect subtle degress of anisocytosis. It is computed directly from the RBC histogram and is calculated as a standard statictical value, the coefficient of variation of the red cell volume ditribution (ratio of standard deviation and mean copuscular volume).",,,,,,,,SNOMED_CT:66842004|LOINC:LP393348-0,Erythrocyte Distribution Width Measurement|Erythrocytes Distribution Width|Red Cell Volume Distribution Width|RDW|RDW-CV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64800,,,,
http://example.org/irAEs.owl#Lung_Cancer,Lung Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#huxi,,,,,Lung_Cancer,肺癌,,"A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors.",,,,,,,,ICD-11:2C25.5|MedDRA:10025064,lung cancer|Cancer of Lung|Carcinoma of Lung,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4878,,,,
http://example.org/irAEs.owl#ALK,Anaplastic Lymphoma Kinase,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,ALK,间变性淋巴瘤激酶,,"This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[",,,,,,,,NCBI Gene ID:238,ALK,,https://www.ncbi.nlm.nih.gov/gene/238,,,,
"http://example.org/irAEs.owl#Adrenocorticotropic_hormone,_ATCH2",Adrenocorticotropic hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_ATCH2,促肾上腺皮质激素,,"Corticotropin (39 aa, ~5 kDa) is encoded by the human POMC gene. This protein plays a role in the stimulation of cortisol secretion by the adrenal gland.",,,,,,,,LOINC:LP32529-7|SNOMED_CT:40789008,ACTH - Adrenocorticotrophic hormone|Corticotropin|ATCH|CCTROP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2282,,,,
"http://example.org/irAEs.owl#Adrenocorticotropic_hormone,_ATCH1",Adrenocorticotropic hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test-,,,,,_ATCH1,促肾上腺皮质激素,,"Corticotropin (39 aa, ~5 kDa) is encoded by the human POMC gene. This protein plays a role in the stimulation of cortisol secretion by the adrenal gland.",,,,,,,,LOINC:LP32529-7|SNOMED_CT:40789008,ACTH - Adrenocorticotrophic hormone|Corticotropin|ATCH|CCTROP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2282,,,,
http://example.org/irAEs.owl#阴茎,Penis and Corpus Cavernosum,,,FALSE,,,http://example.org/irAEs.owl#男性,,,,,阴茎,阴茎和海绵体,,"The male organ of urination and copulation. (Penis)|One of two chambers along the shaft of the penis containing spongy erectile tissue, which, combined with the Corpus Spongiosum, fill with blood to create a penile erection. (Corpora Cavernosa)",,,,,,,,UBERON:0006609 (Corpus Cavernosum)|UBERON:0000989 (Penis),,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12409 (Penis)|https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C32382 (Corpus Cavernosm),,,,
http://example.org/irAEs.owl#阴道,Vagina,,,FALSE,,,http://example.org/irAEs.owl#女性,,,,,阴道,阴道,,"The female genital canal, extending from the uterus to the vulva.",,,,,,,,UBERON:0000996,"birth canal|Vaginal structure (body structure)|Genital System, Female, Vagina|Vagina, NOS|Vagina",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12407,,,,
http://example.org/irAEs.owl#Toripalimab,Toripalimab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Toripalimab,特瑞普利单抗,,"A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (programmed death-1; PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, toripalimab binds to PD-1 and inhibits the binding of PD-1 to its ligands, programmed cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the Ig superfamily that is expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity.",,,,,,,,Drug Bank ID: DB15043,Anti-PD-1 Monoclonal Antibody JS001|JS 001|Loqtorzi|TAB-001|Tuoyi,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C131334,,,,
http://example.org/irAEs.owl#Schirmers_Test,Schirmer's Tear Test,,,FALSE,,,http://example.org/irAEs.owl#Functional_and_Subjective_Tests,,,,,Schirmers_Test,施尔默泪液分泌试验,,A test used to determine the amount of tears collected on a filter paper strip in 5 minutes.,,,,,,,,LOINC:LP32270-8|SNOMED:164742009,Schirmer Test Wetting|SCHIRMER METHOD|Wetting,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C75526,,,,
http://example.org/irAEs.owl#Impact_Factors,Contributing Factors,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,Impact_Factors,影响因素,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#post-transplant_lymphoproliferative_disorder,Post-Transplant Lymphoproliferative Disorder,,,FALSE,,,http://example.org/irAEs.owl#Hematological_Tumors,,,,,post-transplant_lymphoproliferative_disorder,移植后淋巴增生性疾病,,"Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type.",,,,,,,,MedDRA:10051358|ICD-11:2B32,PTLD,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4727,,,,
http://example.org/irAEs.owl#1,ECOG 1,,,FALSE,,,http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,,,,,irAEs.owl#1,东部肿瘤协作组 1分,,"Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work.",Protective Factor,,,,,,,,ECOG Performance Status 1,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105723,,,,
http://example.org/irAEs.owl#Esophagitis,Esophagitis,,,FALSE,,,http://example.org/irAEs.owl#Gastrointestinal_Tract,,,,,Esophagitis,食管炎,"A disorder characterized by inflammation of the esophageal wall.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; altered eating/swallowing; oral supplements indicated
Grade 3: Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated
Grade 4: Life-threatening consequences; urgent operative intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C57797",An acute or chronic inflammatory process affecting the esophageal wall.,,,,,,,,ICD-11:DA24|MedDRA:10015461,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9224,,,,
http://example.org/irAEs.owl#Gastrointestinal_Tract,Gastrointestinal Tract,,,FALSE,,,http://example.org/irAEs.owl#Disease,,,,,Gastrointestinal_Tract,胃肠道,,"The upper gastrointestinal (GI) tract is comprised of mouth, pharynx, esophagus and stomach while the lower GI tract consists of intestines and anus. The primary function of the GI tract is to ingest, digest, absorb and ultimately excrete food stuff.",,,,,,,,UBERON:0001555,digestive tract|alimentary part of gastrointestinal system|Alimentary Canal,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34082,,,,
http://example.org/irAEs.owl#Ring_shaped_erythema_centrifugal_like_rash,Erythema Multiforme,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Ring_shaped_erythema_centrifugal_like_rash,多形性红斑,"A disorder characterized by target lesions (a pink-red ring around a pale center).

Grade 1: Not associated with skin tenderness
Grade 2: Associated with skin tenderness
Grade 3: Associated with oral or genital erosions
Grade 4: Associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143449","A hypersensitivity reaction characterized by the sudden appearance of symmetrical cutaneous and mucocutaneous macular or papular lesions which evolve into lesions with bright red borders (target lesions). The lesions usually appear in the hands, feet, extremities, and face. Symptoms include fever, malaise, sore throat, cough, vomiting, diarrhea, arthralgia, and myalgia. Causes include infections (most commonly herpes simplex virus), drugs (e.g., sulfonamides, anticonvulsants, and antibiotics), malignancies, and collagen vascular disorders.",,,,,,,,MedDRA:10015218|ICD-11:EB12. Z,EM - Erythema multiforme|multiforme; erythema,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3024,,,,
http://example.org/irAEs.owl#Disease_5,Disease,,,FALSE,,,http://example.org/irAEs.owl#Respiratory_thoracic_and_Mediastinal_System,,,,,Disease_5,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Optic_Neuritis,Optic Neuritis,,,FALSE,,,http://example.org/irAEs.owl#Optic_Nerve,,,,,Optic_Neuritis,视神经炎,"A disorder characterized by inflammation and demyelination of the optic nerve that causes acute, usually monocular, visual loss.

Grade 1: Asymptomatic or mild symptoms; only enhancement on MRI scan with no change in vision
Grade 2: Treatment indicated; best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline in the affected eye; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe or medically significant but not immediately sight-threatening; decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200) in the affected eye; oral steroids indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Sight-threatening consequences; urgent intervention indicated; best corrected visual acuity of 20/200 or worse in the affected eye: significant visual field loss; marked optic disc edema or enhancement on MRI scan; intravenous steroids indicated; blindness
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221099","A disorder characterized by inflammation of the optic nerve. Causes include autoimmune disorders, infections, toxins, drugs, and multiple sclerosis. It may manifest with acute loss of vision and pain.",,,,,,,,ICD-11:9C40.1|MedDRA:10030942,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84950,,,,
http://example.org/irAEs.owl#多形性肉瘤,Undifferentiated Pleomorphic Sarcoma,,,FALSE,,,http://example.org/irAEs.owl#软组织肿瘤,,,,,多形性肉瘤,未分化多形性肉瘤,,An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.,,,,,,,,MedDRA:10087873|ICD-11:XH73J4,"malignant fibrous cytoma|Malignant Fibroxanthoma|Malignant fibrous histiocytoma|Histiocytoma, Fibrous, Malignant|Storiform-Pleomorphic Fibrous Histiocytoma|Fibroxanthosarcoma|MFH|UPS",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4247,,,,
http://example.org/irAEs.owl#Disease_9,Disease,,,FALSE,,,http://example.org/irAEs.owl#Blood_and_Lymphatic_system,,,,,Disease_9,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#男性,Male Reproductive System,,,FALSE,,,http://example.org/irAEs.owl#Disease1,,,,,男性,男性生殖系统,,The sex organs of the male.,,,,,,,,UBERON:0000079,"Body System, Reproductive, Male|Male Reproductive Body System|Male Reproductive Tract|Penis and Other Genital|Male Genital Tract|Male Reproductive Organ System|Genital System, Male",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12722,,,,
http://example.org/irAEs.owl#HLA-DPA1*02：02,Human Leukocyte Antigen DPA1:03,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,：02,人类白细胞抗原DPA1:03,,"HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.",Risk Factor,,,,,,,NCBI Gene ID: 3113|LOINC:96645-7,DP(W4)HLA-DPA|DP(W3)|DPA1|HLA-DP1A|HLADP|HLASB|PLT1,,https://www.ncbi.nlm.nih.gov/gene/3113,,,,
http://example.org/irAEs.owl#肿瘤相关生物标志物,Tumor-Related Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Impact_Factors,,,,,肿瘤相关生物标志物,肿瘤相关生物标志物,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#唾液炎,Sialadenitis,,,FALSE,,,http://example.org/irAEs.owl#Oral,,,,,唾液炎,唾液腺炎,,An acute or chronic inflammatory process affecting a salivary gland. Signs and symptoms include pain and tenderness in the affected area.,,,,,,,,ICD-11:DA04.1|MedDRA:10040627,Sialoadenitis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26882,,,,
http://example.org/irAEs.owl#Pathway,Targeted Signaling Pathways,,,FALSE,,,http://example.org/irAEs.owl#Impact_Factors,,,,,Pathway,靶点信号转导通路,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Globulin_GLB,Globulin,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Globulin_GLB,球蛋白,,"A family of globular proteins found in blood that does not include albumin. These proteins are insoluble in water but solubility is increased in dilute salt solutions. Globulins are grouped into four categories (alpha 1, alpha 2, beta and gamma) based on differences in electrophoretic mobility.",,,,,,,,LOINC:LP14885-5|SNOMED_CT:81905004,Serum Globulin|GLB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17125,,,,
http://example.org/irAEs.owl#Joint_System,Joint System,,,FALSE,,,http://example.org/irAEs.owl#Disease_3,,,,,Joint_System,关节系统,,The connection point between two bones or skeletal elements. The joint may be fixed or movable.,,,,,,,,UBERON:0000982,skeletal joint|Articulation|Articular,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C13044,,,,
http://example.org/irAEs.owl#霍奇金淋巴瘤,Hodgkin Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#Hematological_Tumors,,,,,霍奇金淋巴瘤,霍奇金淋巴瘤,,"A lymphoma characterized by the presence of relatively few malignant cells called Reed-Sternberg cells and mononuclear Hodgkin cells that are admixed with nonneoplastic inflammatory cells. The malignant cells have a distinctive immunophenotype; they are positive for CD30 and CD15 and negative for CD3, CD20, and CD45.",,,,,,,,MedDRA:10020328|ICD-11:2B30,"Hodgkin's Lymphoma|Malignant lymphoma, Hodgkin|Hodgkin's Disease|Hodgkin disease, NOS|HL",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9357,,,,
http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests3,,,,,Morphological_and_Imaging_Tests,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#非霍奇金淋巴瘤,Non-Hodgkin Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#Hematological_Tumors,,,,,非霍奇金淋巴瘤,非霍奇金淋巴瘤,,"Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.",,,,,,,,ICD-11:2B33.5|MedDRA:10029547,Non-Hodgkin's Lymphoma|NHL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3211,,,,
http://example.org/irAEs.owl#Skeletal_System,Skeletal System,,,FALSE,,,http://example.org/irAEs.owl#Disease_3,,,,,Skeletal_System,骨骼系统,,"The collection of bones and tissues, including ligaments and cartilage, that compose the rigid internal framework of the human body, and which serves a multitude of functions, including structural support, movement, protection, production of blood cells, storage of ions, and endocrine regulation.",,,,,,,,UBERON:0001434,skeleton,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12788,,,,
http://example.org/irAEs.owl#IL-6-1,Interleukin-6,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-6-1,白介素6,,"Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells.","Over Baseline, Risk Factor",,,,,,,LOINC:LP16474-6|SNOMED_CT:30965005,Hepatocyte Stimulatory Factor|CTL Differentiation Factor|BSF-2|CDF|HGF|IFN Beta 2|IL-6,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20451,,,,
http://example.org/irAEs.owl#rs2910164,rs2910164,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs2910164,,,,Risk Factor,,,,,,,"Canonical SPDI:NC_000005.10:160485410:C:G|Gene:MIR146A , MIR3142HG",,,https://www.ncbi.nlm.nih.gov/snp/?term=rs2910164,,,,
http://example.org/irAEs.owl#Na,Serum Sodium,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,Na,血清钠离子,,A quantitative measurement of the amount of sodium present in a sample of serum.,,,,,,,,LOINC:LP15099-2|SNOMED_CT:104934005,Serum Sodium Ion Test|serum Na+,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61029,,,,
http://example.org/irAEs.owl#Total_Bilirubin_TBIL,Total Bilirubin,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Total_Bilirubin_TBIL,总胆红素,,"A dark orange, yellow pigment that is the product of the breakdown of iron in the blood; it is conjugated in the liver and excreted in the bile.",,,,,,,,LOINC:LP285100-6|SNOMED_CT:417572006,Total Bilirubin Level|BILI|Bilirubin|TBIL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C305,,,,
http://example.org/irAEs.owl#MPV,Mean Platelet Volume,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,MPV,平均血小板体积,,The determination of the average size of the platelets present in a blood sample.,"Below Baseline, Risk Factor",,,,,,,LOINC:LP183490-4|SNOMED_CT:75672003,MPV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C74730,,,,
http://example.org/irAEs.owl#Guillain_Barré_Syndrome_GBS,Guillain-Barré Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,Guillain_Barré_Syndrome_GBS,吉兰-巴雷综合征,"A disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.

Grade 1: Mild symptoms
Grade 2: Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4:  Life-threatening consequences; urgent intervention indicated; intubation
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143231","A rapidly progressive autoimmune disorder of the peripheral nervous system characterized by limb paresthesias, areflexia, and generalized muscle weakness or paralysis that often begins in the legs and spreads to the arms, torso, and face.",,,,,,,,MedDRA:0018767|ICD-11:8C01.0,Guillain-Barre Syndrome|GBS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C116345,,,,
http://webprotege.stanford.edu/R9SLYezUwf5WcAMq9ZGLDPV,Management,,,FALSE,,,http://example.org/irAEs.owl#irAE-Treatment_Data,,,,,R9SLYezUwf5WcAMq9ZGLDPV,管理方案,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Follicle_Stimulating_Hormone,Follicle Stimulating Hormine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,,,,,Follicle_Stimulating_Hormone,促卵泡激素,,"A heterodimeric glycoprotein hormone secreted by the gonadotropic cells of the anterior pituitary gland. This hormone is involved in gonadal development, growth, maturation and reproductive processes, including the regulation of spermatogenesis in males and follicular growth and ovulation in females.",,,,,,,,LOINC:LP14499-5|SNOMED_CT:768662008,Follitropin|Follicle-Stimulating Hormone|FSH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C181076,,,,
http://example.org/irAEs.owl#Aplastic_Anemia_AA,Aplastic Anemia,,,FALSE,,,http://example.org/irAEs.owl#Bone_Marrow,,,,,Aplastic_Anemia_AA,再生障碍性贫血,"A disorder characterized by the inability of the bone marrow to make enough new blood cells.

Grade 2: Use of growth factor indicated; transfusion indicated
Grade 3: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220794","Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors.",,,,,,,,ICD-11:3A70|MedDRA:10002969,AA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2870,,,,
http://example.org/irAEs.owl#anti-GBM,Glomerular Basement Membrane Autoantigens,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_4,,,,,anti-GBM,肾小球基底膜自身抗原,,A group of autoimmune substances found in the glomerular basement membrane that may be comprised of (but not limited to) the alpha 3 chain of type IV collagen. They are commonly associated with autoimmune disease Goodpasture syndrome.,,,,,,,,LOINC:LP38249-6|SNOMED_CT:11353004,GBM Autoantigens,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C209569,,,,
http://example.org/irAEs.owl#Focal_Segmental_Glomerulosclerosis_FSGS,Focal Segmental Glomerulosclerosis,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Focal_Segmental_Glomerulosclerosis_FSGS,局灶节段性肾小球硬化,,"A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.",,,,,,,,ICD-11:MF8Y|MedDRA:10067757,Focal glomerulosclerosis|Focal and segmental glomerular sclerosis|Focal glomerular sclerosis|Focal & segmental glomerulosclerosis|FSGS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C37308,,,,
http://example.org/irAEs.owl#Absolute_Lymphocytes_Count,Absolute Lymphocytes Count,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Absolute_Lymphocytes_Count,绝对淋巴细胞计数,,The number of lymphocytes found in a given volume of blood.,"Below Baseline, Risk Factor",,,,,,,,,,,,,,
"http://example.org/irAEs.owl#Human_Immunodeficiency_Virus,_HIV1",Human Immunodeficiency Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test1,,,,,_HIV1,人类免疫缺陷病毒,,"The virus isolated and recognized as the etiologic agent of AIDS. HIV-1 is classified as a lentivirus, a subtype of retroviruses.",,,,,,,,LOINC:LP17126-1|SNOMED_CT:19030005,HIV|Virus-HIV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14219,,,,
"http://example.org/irAEs.owl#Human_Immunodeficiency_Virus,_HIV2",Human Immunodeficiency Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding1,,,,,_HIV2,人类免疫缺陷病毒,,"The virus isolated and recognized as the etiologic agent of AIDS. HIV-1 is classified as a lentivirus, a subtype of retroviruses.",,,,,,,,LOINC:LP17126-1|SNOMED_CT:19030005,HIV|Virus-HIV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14219,,,,
"http://example.org/irAEs.owl#Human_Immunodeficiency_Virus,_HIV3",Human Immunodeficiency Virus,,,FALSE,,,http://example.org/irAEs.owl#Viral_Serology_7,,,,,_HIV3,人类免疫缺陷病毒,,"The virus isolated and recognized as the etiologic agent of AIDS. HIV-1 is classified as a lentivirus, a subtype of retroviruses.",Risk Factor,,,,,,,LOINC:LP17126-1|SNOMED_CT:19030005,HIV|Virus-HIV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14219,,,,
http://example.org/irAEs.owl#Optical_Coherence_Tomography_OCT,Optical Coherence Tomography,,,FALSE,,,http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,,,,,Optical_Coherence_Tomography_OCT,光学相干断层扫描,,"Optical Coherence Tomography (OCT) combines the principles of ultrasound with the imaging performance of a microscope. OCT uses infrared light waves that reflect off the internal microstructure within the biological tissues. The frequencies and bandwidths of infrared light are orders of magnitude higher than medical ultrasound signals, resulting in greatly increased image resolution, 8-25 times greater than any existing modality. In addition to providing high-level resolutions for the evaluation of microanatomic structures OCT is also able to provide information regarding tissue composition.",,,,,,,,LOINC:LP97036-5|SNOMED:392010000,"Doppler OCT|Tomography, OCT|OCT - Optical coherence tomography|OCT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20828,,,,
http://example.org/irAEs.owl#心力衰竭,Heart Failure,,,FALSE,,,http://example.org/irAEs.owl#Myocardium,,,,,心力衰竭,心力衰竭,"A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.

Grade1: Mild symptoms; no initiation or intensification of treatment.
Grade2: Outpatient initiation or intensification of treatment.
Grade3: Hospitalization indicated.
Grade4: Requiring inotropic support, mechanical circulatory support, or consideration of cardiac transplantation.
Grade5: Death.
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143529","Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction.",,,,,,,,ICD-11:BD1Y|MedDRA:10019279,Cardiac Failure|HF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C50577,,,,
http://example.org/irAEs.owl#Skin,Skin,,,FALSE,,,http://example.org/irAEs.owl#Disease_2,,,,,Skin,皮肤,,"An organ that constitutes the external surface of the body. It consists of the epidermis, dermis, and skin appendages.",,,,,,,,UBERON:0001003,entire skin|Integument|human skin|skin organ,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12470,,,,
http://example.org/irAEs.owl#Grade_4,Grade 4,,,FALSE,,,http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,,,,,Grade_4,4 级,,Life-threatening consequences; urgent intervention indicated.,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#DA,Diseased Appetite,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,DA,食欲不振,,Anorexia is a pathological lack or loss of appetite (ICD-11).,,,,,,,,ICD-11:MG 43.7|MedDRA:10061428,Decrease in appetite|Loss of appetite|Reduced appetite|Poor appetite|Hyporexia,,https://icd.who.int/browse/2025-01/mms/en#2137507044,,,,
"http://example.org/irAEs.owl#Troponin_I,_Cardiac_Muscle",Troponin I Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding,,,,,_Cardiac_Muscle,心肌肌钙蛋白 I,,"Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells",,,,,,,,LOINC:LP14890-5|SNOMED_CT:116886006,Cardiac Troponin I|Troponin I.cardiac|TNNI3|cTnI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104226,,,,
http://example.org/irAEs.owl#Procalcitonin_PCT,Procalcitonin,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,Procalcitonin_PCT,降钙素原,,"Procalcitonin (116 aa, ~13 kDa) is encoded by the human CALCA gene. This protein plays a role in sepsis.",,,,,,,,SNOMED_CT:418752001|LOINC:LP31682-5,PCT|Pro-CALCA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C173465,,,,
http://example.org/irAEs.owl#CMV,Herpes Simplex Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding2,,,,,CMV,单纯疱疹病毒,,Any viral organism that can be classified as a Human herpes simplex virus type. This is a non-taxonomic term used to describe the Human herpes simplex virus type 1 or type 2.,,,,,,,,SNOMED_CT:19965007|LOINC:LP14821-0,Human Herpes Simplex Virus|HSV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C214771,,,,
http://example.org/irAEs.owl#CD47,Anti-CD47 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,CD47,,抗CD47抗体,Any monoclonal antibody that targets the CD47 antigen.,"Over Basline, Risk Factor",,,,,,,SNOMED_CT:63621008|LOINC:17161-1,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C159583,,,,
http://example.org/irAEs.owl#Lymphocyte_Count,Lymphocyte Count,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Lymphocyte_Count,淋巴细胞计数,,The determination of the number of lymphocytes in a blood sample.,"Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Anti-La_Antibody,Anti-La Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti-La_Antibody,抗La抗体,,An antinuclear antibody directed against a 47 kDa RNA-binding protein in the nucleus. They can be associated with Sjogren syndrome and system lupus erythematosus. Maternal anti-La antibody positivity can be associated with neonatal lupus.,,,,,,,,SNOMED_CT:31960007|LOINC:LP39754-4,Anti La antibody|Sjogren's Anti-SS-B autoantibody|Anti-SSB/La Antibody|Anti SS-B antibody,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121323,,,,
http://example.org/irAEs.owl#Chemistry_History,Chemotherapy History,,,FALSE,,,http://example.org/irAEs.owl#Treatment_history,,,,,Chemistry_History,化学治疗史,,,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,Eastern Cooperative Oncology Group Performance Status,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,东部肿瘤协作组体能状态,,A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient.,,,,,,,,,ECOG Performance Status|ecog_performance_status|ECOG PS|ECOG Score,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105721,,,,
http://example.org/irAEs.owl#Cytotoxic_T_cell_count,Cytotoxic T Cell Count,,,FALSE,,,http://example.org/irAEs.owl#T_lymphocyte_subset_analysis_2,,,,,Cytotoxic_T_cell_count,细胞毒性 T 细胞计数,,The determination of the amount of cytotoxic T-lymphocyte present in a sample.,"Over Baseline, Risk Factor",,,,,,,LOINC:73809-6|SNOMED_CT:420638008,Cytotoxic T-Lymphocyte Analysis|CD8 cells Count|CTL Analysis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C181186,,,,
http://example.org/irAEs.owl#Sicca_Syndrome,Sicca Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Sicca_Syndrome,干燥综合征,,"A constellation of symptoms that include abnormal dryness of the mouth, eyes and other mucous membranes. The condition is seen in patients with Sjogren syndrome, sarcoidosis, amyloidosis, and deficiencies of vitamins A and C.",,,,,,,,MedDRA:10040633|ICD-11:4A43.2,"Sicca syndrome, unspecified|Dacryosialoadenopathy syndrome|SICCA|SS",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70647,,,,
http://example.org/irAEs.owl#CD274,Cluster of Differentiation 274,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,CD274,分化簇 274,,This gene is involved in T cell activation and proliferation.,,,,,,,,NCBI Gene ID: 29126,CD274 Molecule Gene|PD-L1|CD274,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C96022,,,,
http://example.org/irAEs.owl#Acute_Tubular_Injury_ATI,Acute Tubular Injury,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Acute_Tubular_Injury_ATI,急性肾小管损伤,,Damage to the renal tubules.,,,,,,,,MedDRA:10092560|ICD-11:GB54,Tubular Damage|Renal tubular damage|ATI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C185689,,,,
http://example.org/irAEs.owl#Electroencephalogram_EEG,Electroencephalogram,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_4,,,,,Electroencephalogram_EEG,脑电图,,"The neurophysiologic exploration of the electrical activity of the brain by the application of electrodes to the scalp. The resulting traces are known as an electroencephalogram (EEG). This test is used to assess brain damage, epilepsy and other problems.",,,,,,,,LOINC:LP6239-0|SNOMED_CT:54550000,Electroencephalography|EEG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38054,,,,
http://example.org/irAEs.owl#irAE-Treatment_Data,Immune Checkpoint Inhibitor-Related Toxicity Management,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,irAE-Treatment_Data,免疫检查点抑制剂毒性管理,,,,,,,,,,"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)
Version 1.2026",,,https://nccn.medlive.cn/guide/detail/970,,,,
http://example.org/irAEs.owl#Choroid,Choroid,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Choroid,脉络膜,,A blood vessel-containing membrane of the eye that lies between the retina and the sclera.,,,,,,,,UBERON:0001776,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12344,,,,
http://example.org/irAEs.owl#盆腔,Pelvic Cavity,,,FALSE,,,http://example.org/irAEs.owl#女性,,,,,盆腔,盆腔,,"The bony, basin-shaped structure formed by the hipbones and the base of the backbone supporting the lower limbs in humans.",,,,,,,,UBERON:0008203,Pelvic Region|lesser pelvis|true pelvis|Pelvis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12767,,,,
http://example.org/irAEs.owl#Retinal_Disease,Retinal Disease,,,FALSE,,,http://example.org/irAEs.owl#Retina,,,,,Retinal_Disease,视网膜疾病,,A non-neoplastic or neoplastic disorder that affects the retina.,,,,,,,,MedDRA:10038853|ICD-11:9B71,"Retinal disease, NOS|Retinal disorder|Noninflammatory retina disease|Retinal Disorder|Retinopathy|Unspecified retinal disorder",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26875,,,,
http://example.org/irAEs.owl#Autonomic_neuropathy,Autonomic Neuropathy,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,Autonomic_neuropathy,自主神经病变,,"An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities.",,,,,,,,ICD-11:8E4A.1|MedDRA:10061666,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27033,,,,
http://example.org/irAEs.owl#0_1,0-1%,,,FALSE,,,http://example.org/irAEs.owl#Proportion_of_PD_L1_positive_cellsTPSCPS,,,,,_1,,,,Candidate Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Total_Cholesterol_TC,Total Cholesterol,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,Total_Cholesterol_TC,总胆固醇,,A quantitative measurement of the total amount of cholesterol present in a sample of serum.,,,,,,,,SNOMED_CT:390956002|LOINC:LP18020-5,TC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61032,,,,
http://example.org/irAEs.owl#Vein,Vein,,,FALSE,,,http://example.org/irAEs.owl#Disease_12,,,,,Vein,静脉,,A blood vessel that carries blood toward the heart.,,,,,,,,UBERON:0004582,venous tree organ part,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12814,,,,
http://example.org/irAEs.owl#Histopathological_Examination,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_3,,,,,Histopathological_Examination,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Histopathological_Examination4,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_11,,,,,Histopathological_Examination4,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Histopathological_Examination-,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_10,,,,,Histopathological_Examination-,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C147493,,,,
http://example.org/irAEs.owl#Histopathological_Examination1,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_4,,,,,Histopathological_Examination1,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Histopathological_Examination2,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_5,,,,,Histopathological_Examination2,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,"Histopathology
Histopathologic Study
Histopathological",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Histopathological_Examination3,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_2,,,,,Histopathological_Examination3,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Coagulation_Tests_4,Coagulation Tests,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_12,,,,,Coagulation_Tests_4,凝血试验,,"Techniques used to study blood coagulation times, activities, or defects.",,,,,,,,SNOMED_CT:3116009|LOINC:LP6186-3,Coagulation Study|Clotting screening,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62662,,,,
http://example.org/irAEs.owl#BNP,B-type Natriuretic Peptide,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding,,,,,BNP,B型利钠肽,,"Natriuretic peptides B (134 aa, ~15 kDa) is encoded by the human NPPB gene. This protein is involved in the maintenance of cardiac homeostasis.",,,,,,,,LOINC:LP28609-3|SNOMED_CT:407059007,ProB-Type Natriuretic Peptide|Gamma-Brain Natriuretic Peptide|Natriuretic Peptides B|BNP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C88522,,,,
http://example.org/irAEs.owl#primary_mediastinal_B_cell_lymphoma,Primary Mediastinal Large B-Cell Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,primary_mediastinal_B_cell_lymphoma,原发性纵隔大B细胞淋巴瘤,,"A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good.",,,,,,,,MedDRA:10036710|ICD-11:2A81.0,Thymic large B-cell lymphoma|Mediastinal large B-cell lymphoma|B-Cell Diffuse Large Cell Lymphoma of the Mediastinum|Mediastinal Diffuse Large Cell Lymphoma with Sclerosis|Mediastinal (thymic) large B-cell lymphoma|PMBCL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9280,,,,
http://example.org/irAEs.owl#Inflammatory_Arthritis,Inflammatory Arthritis,,,FALSE,,,http://example.org/irAEs.owl#Joint_System,,,,,Inflammatory_Arthritis,炎性关节炎,,"Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).",,,,,,,,MedDRA:10081014|ICD-11:FA27,"Arthritis, unspecified|JOINT INFLAMMATION",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C119022,,,,
http://example.org/irAEs.owl#默克尔细胞癌,Merkel Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#皮肤和附属器,,,,,默克尔细胞癌,梅克尔细胞癌,,"A rare aggressive neuroendocrine carcinoma that usually arises from the skin. Rarely, it arises from extracutaneous sites, including the oral cavity, salivary glands, breast, vulva, and vaginal wall. The tumor is composed of small round cells with scanty cytoplasm. Merkel cell polyomavirus is implicated in the majority of cases.",,,,,,,,MedDRA:10064025|ICD-11:2C34,Merkel cell tumor|Merkel Cell Carcer,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9231,,,,
http://example.org/irAEs.owl#Neuromuscular_Junction_NMJ,Neuromuscular Junction,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Neuromuscular_Junction_NMJ,神经肌肉接头,,"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential (UBERON).
The synapse between a neuron and a muscle (MeSH).",,,,,,,,UBERON:GO_0031594,junction neuromuscular|Myoneural junction|NMJ,,https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0031594,,,,
http://example.org/irAEs.owl#anti-CCP,Anti-cyclic Citrullinated Peptide Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,anti-CCP,抗环状胍氨酸多肽抗体,,An autoantibody directed against peptides or proteins whose arginine residues have been enzymatically converted to citrulline. It is often associated with rheumatoid arthritis.,,,,,,,,SNOMED_CT:408200008|LOINC:42898-7,Anti-Perinuclear Factor Antibody|Anti-CCP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121326,,,,
http://example.org/irAEs.owl#SCLC,Small Cell Lung Cancer,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer,,,,,SCLC,小细胞肺癌,,A highly aggressive carcinoma with neuroendocrine differentiation that arises from the lung. It is characterized by the presence of malignant small cells and more than 10 mitoses per 2 mm2. Necrosis is frequently seen. Metastatic disease is usually present at the time of diagnosis.,,,,,,,,ICD-11:2C25.1|MedDRA:10041067,Lung Small Cell Carcinoma|Small Cell Carcinoma of the Lung|SCLC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4917,,,,
http://example.org/irAEs.owl#Life_Style,Life Style,,,FALSE,,,http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,,,,,Life_Style,生活习惯,,A manner of living that reflects the person's values and attitudes.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16795,,,,
"http://example.org/irAEs.owl#Helicobacter_pylori,_H.pylori",Helicobacter Pylori,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_5,,,,,_H.pylori,幽门螺杆菌,,"Bacteria that cause stomach inflammation (gastritis) and ulcers in the stomach. This bacteria is the most common cause of ulcers worldwide. It is often referred to as H. pylori. H. pylori infection is usually acquired from contaminated food and water and through person to person spread. The infection is common in crowded living conditions with poor sanitation. In countries with poor sanitation, 90% of the adult population can be infected. In the U.S., 30% of the adult population is infected. One out of six patients with H. pylori infection develops ulcers of the duodenum or the stomach. This bacteria is also believed to be associated with stomach cancer and a rare type of lymph gland tumor called gastric MALT lymphoma. Infected persons usually carry the infection indefinitely, unless treated with medications to eradicate the bacteria.",,,,,,,,SNOMED_CT:80774000|LOINC:LP16707-9,Campylobacter pylori|Helicobacter pylori|H.pylori,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14289,,,,
"http://example.org/irAEs.owl#Helicobacter_pylori,_H.pylori1",Helicobacter Pylori,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test,,,,,_H.pylori1,幽门螺杆菌,,"Bacteria that cause stomach inflammation (gastritis) and ulcers in the stomach. This bacteria is the most common cause of ulcers worldwide. It is often referred to as H. pylori. H. pylori infection is usually acquired from contaminated food and water and through person to person spread. The infection is common in crowded living conditions with poor sanitation. In countries with poor sanitation, 90% of the adult population can be infected. In the U.S., 30% of the adult population is infected. One out of six patients with H. pylori infection develops ulcers of the duodenum or the stomach. This bacteria is also believed to be associated with stomach cancer and a rare type of lymph gland tumor called gastric MALT lymphoma. Infected persons usually carry the infection indefinitely, unless treated with medications to eradicate the bacteria.",,,,,,,,SNOMED_CT:80774000|LOINC:LP16707-9,Campylobacter pylori|Helicobacter pylori|H.pylori,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14289,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_2,Laboratory Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests10,,,,,Organ_specific_Laboratory_Finding_2,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Ear_and_Labyrinth,Ear,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Ear_and_Labyrinth,耳,,"A sense organ needed for the detection of sound and for establishing balance. The outer ear consists of the auricle, the ear canal as well as the tympanic membrane. The middle ear is made up of an air-filled cavity behind the tympanic membrane that contains the ossicles (malleus, incus and stapes). The inner ear is made up of the cochlea needed for hearing and the vestibular apparatus required for balance.",,,,,,,,SOC:10013993|UBERON:0001690,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12394,,,,
http://example.org/irAEs.owl#Maculopapular_rash,Maculopapular Rash,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Maculopapular_rash,斑丘疹,"A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis.",A skin condition consisting of both macules and papules.,,,,,,,,ICD-11:EC91.Z|MedDRA:10025424,Maculo-papular exanthema|Maculopapular eruption|Maculopapular Lesion,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C75579,,,,
http://example.org/irAEs.owl#Weeks_Days,Weeks/ Days,,,FALSE,,,http://example.org/irAEs.owl#Treatment_Cycles,,,,,Weeks_Days,周/日,,,,,,,,,,,,,,,,,
"http://example.org/irAEs.owl#Synovitis,_Acne,_Pustulosis,_Hyperostosis,_and_Osteitis_Syndrome","Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome",,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,_and_Osteitis_Syndrome,SAPHO 综合征,,"A syndrome characterized by synovitis, acne, pustulosis, hyperostosis, and non-infectious osteomyelitis. Includes a spectrum of aseptic neutrophilic dermatoses associated with aseptic osteoarticular lesions.",,,,,,,,MedDRA:10051316|ICD-11:4A61,SAPHO Syndrome|Pustulo-Psoriatic Hyperostotic Spondyloarthritis|PPHS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C119049,,,,
http://example.org/irAEs.owl#Myocardium,Myocardium,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Myocardium,心肌,,The striated muscle tissue of the heart enveloped by the epicardium and the endocardium.,,,,,,,,UBERON:0002349,CARDIAC MUSCLE TISSUE|Cardiac Muscle|Heart Muscle|Myocardial Tissue,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12371,,,,
http://example.org/irAEs.owl#Pancytopenia,Pancytopenia,,,FALSE,,,http://example.org/irAEs.owl#Bone_Marrow,,,,,Pancytopenia,全血细胞减少症,,A finding of low numbers of red and white blood cells and platelets in the peripheral blood.,,,,,,,,MedDRA:10033661|ICD-11:3A70,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34889,,,,
http://example.org/irAEs.owl#Electrophysiological_Studies_3,Electrophysiological Examination,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies2,,,,,Electrophysiological_Studies_3,电生理学检查,,That branch of physiology that is concerned with the electric phenomena associated with living bodies and involved in their functional activity.,,,,,,,,LOINC:LP6252-3,Electrophysiology|Neurophysiology,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16540,,,,
http://example.org/irAEs.owl#Thyroperoxidase_Antibody,Thyroperoxidase Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Thyroperoxidase_Antibody,甲状腺过氧化物酶抗体,,Thyroperoxidase antibodies aid in the detection of autoimmune and Hashimoto's thyroiditis (LOINC).,Risk Factor,,,,,,,LOINC:LP40001-7|SNOMED_CT:118002003,Anti-TPO Measurement|TPOAb,,https://loinc.org/LP40001-7,,,,
"http://example.org/irAEs.owl#Immunohistochemistry,_IHC1",Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination1,,,,,_IHC1,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Immunohistochemistry Staining Method|Cell/Tissue, Immunohistochemistry|IHC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
"http://example.org/irAEs.owl#Immunohistochemistry,_IHC",Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination-1,,,,,_IHC,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Immunohistochemistry Staining Method|Cell/Tissue, Immunohistochemistry|IHC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
"http://example.org/irAEs.owl#Immunohistochemistry,_IHC2",Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination2,,,,,_IHC2,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Cell/Tissue, Immunohistochemistry
Immunohistochemistry Staining Method",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
"http://example.org/irAEs.owl#Immunohistochemistry,_IHC3",Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination3,,,,,_IHC3,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Immunohistochemistry Staining Method|Cell/Tissue, Immunohistochemistry|IHC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
http://example.org/irAEs.owl#Transverse_Myelitis,Transverse Myelitis,,,FALSE,,,http://example.org/irAEs.owl#Medulla_Spinalis,,,,,Transverse_Myelitis,横贯性脊髓炎,,"A neurologic disorder that is caused by inflammation across both sides of one level, or segment, of the spinal cord.",,,,,,,,MedDRA:10028527|ICD-11:8A41.0,Transverse Myelopathy Syndrome|myelitis; transverse,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C128378,,,,
http://example.org/irAEs.owl#Fluorescein_Angiography_FA,Fluorescein Angiography,,,FALSE,,,http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,,,,,Fluorescein_Angiography_FA,荧光素血管造影,,A diagnostic procedure that uses the fluorescence of fluorescein dye to examine the blood flow in the choroid and retina.,,,,,,,,SNOMED:172581008,Fluorescein Fluorescence Angiography|FA - fluorescein angiogram|fluorescein angiography of eye|FA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C190541,,,,
"http://example.org/irAEs.owl#Electrocardiography,_ECG1",Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_9,,,,,_ECG1,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
http://example.org/irAEs.owl#Neutrophil-to-Lymphocyte_Ratio,Neutrophil to Lymphocyte Ratio,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Neutrophil-to-Lymphocyte_Ratio,中性粒细胞与淋巴细胞比值,,The determination of the ratio of neutrophils compared to lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage.,"Over Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Histopathological_Examination_7,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_8,,,,,Histopathological_Examination_7,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,"Histopathology
Histopathologic Study
Histopathological",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#CCL5,C-C Motif Chemokine Ligand 5,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,CCL5,C-C 基序趋化因子配体 5,,"C-C motif chemokine 5 (91 aa, ~10 kDa) is encoded by the human CCL5 gene. This protein plays a role in both the release of histamine and chemoattraction of monocytes, memory T-helper cells and eosinophils.",Risk Factor,,,,,,,LOINC:98113-4,Chemokine (C-C Motif) Ligand 5|Eosinophil Chemotactic Cytokine|T-Cell Specific Protein p288|T-Cell RANTES Protein|Beta-Chemokine RANTES|Small Inducible Cytokine A5|EoCP|CCL5,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20483,,,,
http://example.org/irAEs.owl#继发性闭经,Secondary Amenorrhea,,,FALSE,,,http://example.org/irAEs.owl#卵巢,,,,,继发性闭经,继发性闭经,,"The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal.",,,,,,,,ICD-11:GA20.01|MedDRA:10062837,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113340,,,,
http://example.org/irAEs.owl#Combination_Therapy,Combination Radiotherapy,,,FALSE,,,http://example.org/irAEs.owl#Therapy_Method,,,,,Combination_Therapy,联合放疗,,Simultaneous or consecutive use of radiotherapy and one or more non-radiation based treatment modalities.,Risk Factor,,,,,,,,"Radiation, Combination",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C165192,,,,
http://example.org/irAEs.owl#Gastroscopy,Gastroscopy,,,FALSE,,,http://example.org/irAEs.owl#Endoscopic_Examinations1,,,,,Gastroscopy,胃肠镜检查,,Endoscopic examination of the stomach.,,,,,,,,,upper endoscopy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16604,,,,
http://example.org/irAEs.owl#JNK_Sign,MAPK Signaling Pathway,,,FALSE,,,http://example.org/irAEs.owl#Pathway,,,,,JNK_Sign,MAPK 信号通路,,"The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.[KEGG]",Risk Factor,,,,,,,KEGG_ID:map04010,,,https://www.kegg.jp/entry/map04010,,,,
http://example.org/irAEs.owl#Mean_corpuscular_volume_MCV,Mean corpuscular volume,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Mean_corpuscular_volume_MCV,平均红细胞体积,,The mean cell volume is the average volume of a red blood cell. This is a calculated value derived from the hematocrit and the red cell count.,,,,,,,,SNOMED:365615009,Ery. Mean Corpuscular Volume|RBC Mean Corpuscular Volume|Erythrocyte Mean Corpuscular Volume|MCV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64799,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test1,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_11,,,,,Clinical_Immunology_Test1,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunology,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
"http://example.org/irAEs.owl#Troponin_T_Cardiac_Muscle,_cTn",Troponin T Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_cTn,心肌肌钙蛋白 T,,"Troponin T, cardiac muscle (298 aa, ~36 kDa) is encoded by the human TNNT2 gene. This protein plays a role in cardiac muscle contraction.",,,,,,,,SNOMED_CT:102684000|LOINC:LP17145-1,"Troponin T, Cardiac Muscle|Cardiac Muscle Troponin T|TnTc|cTnT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104220,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA4",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding1,,,,,_ANA4,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA6",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding2,,,,,_ANA6,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA2",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,_ANA2,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA5",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding3,,,,,_ANA5,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA7",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,_ANA7,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,Risk Factor,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA3",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test1,,,,,_ANA3,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
"http://example.org/irAEs.owl#Antinuclear_Antibody,_ANA",Antinuclear Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_9,,,,,_ANA,抗核抗体,,An autoimmune antibody that is directed against structures within the nucleus of the cell.,,,,,,,,LOINC:LP20752-9|SNOMED_CT:45530001,Nuclear Antibody|ANF - Anti-nuclear factor|Antinuclear Factors|ANA|ANF|Nuclear Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70547,,,,
http://example.org/irAEs.owl#Imaging_Studies,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests,,,,,Imaging_Studies,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Imaging_Studies3,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests5,,,,,Imaging_Studies3,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Imaging_Studies2,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests4,,,,,Imaging_Studies2,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Imaging_Studies5,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,,,,,Imaging_Studies5,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Imaging_Studies1,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_&_Assessment_Tests,,,,,Imaging_Studies1,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Imaging_Studies4,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests7,,,,,Imaging_Studies4,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Therapy_Method,Treatment Regimen,,,FALSE,,,http://example.org/irAEs.owl#Trearment_Data,,,,,Therapy_Method,治疗方案,,"A treatment plan that specifies the dosage, the schedule, and the duration of treatment.",,,,,,,,,Treatment Regimen|Treatment Schedule|Treatment Protocol|regimen or line of therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C15697,,,,
http://example.org/irAEs.owl#anti-rola,Anti-GAD65 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,anti-rola,抗GAD65抗体,,"Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis (LOINC).",,,,,,,,LOINC:LP18489-2,anti-glutamate decarboxylase 2 autoantibody|Anti-glutamic acid decarboxylase 65 autoantibody|GAD65 autoantibody,,https://www.ncbi.nlm.nih.gov/mesh/?term=anti-GAD65+autoantibody,,,,
http://example.org/irAEs.owl#肾细胞癌,Renal Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#泌尿系统,,,,,肾细胞癌,肾细胞癌,,"A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy.",,,,,,,,ICD-11:2C90.0|MedDRA:10067946,Adenocarcinoma of Kidney|Kidney Adenocarcinoma|Renal Cell Cancer|Renal Cell Adenocarcinoma|RCC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9385,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Finding2,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding,,,,,Clinical_Chemistry_Finding2,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Diabetic_Ketoacidosis,Diabetic Ketoacidosis,,,FALSE,,,http://example.org/irAEs.owl#Pancreas_Islet,,,,,Diabetic_Ketoacidosis,糖尿病酮症酸中毒,,"The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.",,,,,,,,ICD-11:5A22.Y|MedDRA:10012671,Diabetic Ketoacidosis|Elevated ketones|KDA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C50530,,,,
http://example.org/irAEs.owl#宫颈腺癌,Cervical Adenocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#宫颈癌,,,,,宫颈腺癌,宫颈腺癌,,"An adenocarcinoma arising from the endocervical glandular epithelium. It is classified as either human papillomavirus-related or human papillomavirus-independent adenocarcinoma. Histologic variants include usual-type, mucinous, mesonephric, serous, clear cell, and endometrioid adenocarcinoma.",,,,,,,,MedDRA:10008224|ICD-11:2C77.1,Cervix Uteri Adenocarcinoma|Adenocarcinoma of Cervix|Endocervical Carcinoma|Endocervical Adenocarcinoma|Carcinoma of Endocervix|Adenocarcinoma of Cervix Uteri|Endocervical Carcer,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4029,,,,
http://example.org/irAEs.owl#Retroperitoneal_fibrosis,Retroperitoneal Fibrosis,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Retroperitoneal_fibrosis,腹膜后纤维化,,"A rare, serious disorder characterized by extensive fibrosis in the retroperitoneum. In most cases its etiology is unknown. In some cases it is related to autoimmunity or metastatic cancer. It leads to the entrapment and obstruction of vital retroperitoneal structures including the ureters.",,,,,,,,MedDRA:10038979|ICD-11:FB51.4,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26876,,,,
http://example.org/irAEs.owl#rs17080141,rs17080141,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs17080141,,,,Risk Factor,,,,,,,Canonical SPDI:NC_000005.10:180268484:T:A|Gene:MAPK9,,,https://www.ncbi.nlm.nih.gov/snp/?term=rs17080141,,,,
http://example.org/irAEs.owl#Weight,Weight,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,Weight,重量,,The vertical force exerted by a mass as a result of gravity.,Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25208,,,,
http://example.org/irAEs.owl#Erythroderma,Erythroderma,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Erythroderma,红皮病,"A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.

Grade 2: Erythema covering >90% BSA without associated symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143450",A generalized inflammatory cutaneous disorder characterized by erythema and desquamation.,,,,,,,,MedDRA:10015277|ICD-11:EB10,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C39646,,,,
http://example.org/irAEs.owl#Non-anatomical/Sys,Non-Organ-Specific irAEs,,,FALSE,,,http://example.org/irAEs.owl#immune_related_Adverse_Events_irAEs,,,,,Sys,非器官特异性免疫相关不良事件,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#皮肤和附属器,Skin Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,皮肤和附属器,皮肤肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#MicB,Microbiology Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Biomarker,,,,,MicB,微生物生物标志物,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_&_Assessment_Tests,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Blood_and_Lymphatic_system,,,,,_Assessment_Tests,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Peripheral_Nervous,Peripheral Nervous System,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Peripheral_Nervous,周围神经系统,,That part of the nervous system consisting of the nerves and neurons that reside or extend outside the central nervous system.,,,,,,,,UBERON:0000010,systema nervosum periphericum|pars peripherica||PNS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12465,,,,
http://example.org/irAEs.owl#Psoriatic_arthritis,Psoriatic Arthritis,,,FALSE,,,http://example.org/irAEs.owl#Joint_System,,,,,Psoriatic_arthritis,银屑病性关节炎,,Joint inflammation associated with psoriasis.,,,,,,,,ICD-11:FA21|MedDRA:10037160,Arthritis Psoriatica|Psoriatic Arthropathy|PA - Psoriatic arthritis|PA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61277,,,,
http://example.org/irAEs.owl#Esophageal_necrosis,Esophageal Necrosis,,,FALSE,,,http://example.org/irAEs.owl#Gastrointestinal_Tract,,,,,Esophageal_necrosis,食管坏死,"A disorder characterized by a necrotic process occurring in the esophageal wall.

Grade 3: Inability to aliment adequately by GI tract; invasive intervention indicated
Grade 4: Life-threatening consequences; urgent operative intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143455",A necrotic process involving the esophageal wall.,,,,,,,,MedDRA:10065727|ICD-11:DA2Y,Esophageal Necrotic Lesion,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78278,,,,
http://example.org/irAEs.owl#DQA1*0501,Human Leukocyte Antigen DQA1*05:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,irAEs.owl#DQA1*0501,人类白细胞抗原DQA1*05:01,,"Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor impportant for presenting antigens and triggering a humural immunity. The gene is highly polymorphic (as are other HLA genes), and allele type can correlate with various diseases (such as celiac). Antibodies formed in a transplant recipient to donor alleles can contribute to prediction of graft rejection.",Risk Factor,,,,,,,LOINC:LA30823-1|NCBI Gene ID:3117,HLA DQA1:05,,https://www.ncbi.nlm.nih.gov/gene/3117,,,,
http://example.org/irAEs.owl#Disease_2,Disease,,,FALSE,,,http://example.org/irAEs.owl#Skin_and_Subcutaneous_Tissue,,,,,Disease_2,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Psoriasis_like_Rashincluding_activite_Psoriasis_Pustular_Psoriasis,Psoriasis,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Psoriasis_like_Rashincluding_activite_Psoriasis_Pustular_Psoriasis,银屑病,,"An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.",,,,,,,,ICD-11:EA90|MedDRA:10037153,"Psoriasis, unspecified",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3346,,,,
http://example.org/irAEs.owl#Second_line,Second-Line Therapy,,,FALSE,,,http://example.org/irAEs.owl#Line_of_Therapy,,,,,Second_line,二线治疗,,"The second preferred therapy for a particular condition, used after first-line treatment fails or if a person cannot tolerate first-line drugs.",,,,,,,,,Second Line Therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C54350,,,,
http://example.org/irAEs.owl#DQB1*02,Human Leukocyte Antigen DQB1*02,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,irAEs.owl#DQB1*02,人类白细胞抗原DQB1*02,,"HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.",Risk Factor,,,,,,,LOINC:LP36436-1|NCBI Gene ID: 3119,HLA-DQB1*02,,https://www.ncbi.nlm.nih.gov/gene/3119,,,,
http://example.org/irAEs.owl#Urethra,Urethra,,,FALSE,,,http://example.org/irAEs.owl#Disease_4,,,,,Urethra,尿道,,The tube carrying urine from the bladder to outside of the body.,,,,,,,,UBERON:0000057,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12417,,,,
http://example.org/irAEs.owl#2,ECOG 2,,,FALSE,,,http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,,,,,irAEs.owl#2,东部肿瘤协作组 2分,,Ambulatory and capable of all self care but unable to carry out any work activities. Up and about more than 50% of waking hours.,Protective Factor,,,,,,,,ECOG Performance Status 2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105725,,,,
http://example.org/irAEs.owl#Pituitary,Pituitary,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,Pituitary,垂体,,"Pea-sized endocrine gland located at the base of the brain in the pituitary fossa. It produces and secretes hormones such as oxytocin and vasopressin, to regulate the activities of the hypothalamus.",,,,,,,,UBERON:0000007,"glandula pituitaria|Nervous System, Pituitary|Pituitary Gland",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12399,,,,
http://example.org/irAEs.owl#Eyelid,Eyelid,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Eyelid,眼睑,,A thin membrane of skin with the purpose of covering and protecting an eye.,,,,,,,,UBERON:0001711,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12713,,,,
http://example.org/irAEs.owl#PET_CT,Positron Emission Tomography and Computed Tomography Scan,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies5,,,,,PET_CT,正电子发射计算机断层扫描,,An imaging technique that utilizes positron emission tomography and computed tomography in a single machine.,,,,,,,,SNOMED_CT:450436003|LOINC:LP208649-6,"Scan, CT PET|PET Scans, CT|Positron Emission Tomography/Computed Tomography|PET+CT|PET-CT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C103512,,,,
http://example.org/irAEs.owl#Vascular_and_Lymphatic_System,Vascular System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Vascular_and_Lymphatic_System,脉管系统,,"The cardiovascular and lymphatic systems, collectively.",,,,,,,,SOC:10047065.0|UBERON:0007798,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C33854,,,,
http://example.org/irAEs.owl#Nervous_System,Nervous System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Nervous_System,神经系统,,"The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.",,,,,,,,UBERON:0001016|SOC:10029205,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12755,,,,
http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,Patient Characteristics,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,Demographic_and_Epidemiologic_Feature,患者特征,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature1,Demographic and Epidemiologic Features,,,FALSE,,,http://example.org/irAEs.owl#Impact_Factors,,,,,Demographic_and_Epidemiologic_Feature1,人口学与流行病学特征,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#IL-10,Interleukin-10,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test,,,,,IL-10,白介素-10,,"Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.",,,,,,,,LOINC:LP21163-8|SNOMED_CT:11267006,T-Cell Growth Inhibitory Factor|TGIF|IL-10,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20512,,,,
http://example.org/irAEs.owl#PTH,Parathyroid Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,PTH,甲状旁腺激素,,"Parathyroid hormone (115 aa, ~13 kDa) is encoded by the human PTH gene. This protein is involved in the modulation of calcium ion and phosphate concentration in the blood.",,,,,,,,SNOMED_CT:4076007|LOINC:LP18184-9,parathyrin|PTH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C41027,,,,
http://example.org/irAEs.owl#Bone_Marrow_Biopsy_BMB,Bone Marrow Biopsy,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination_7,,,,,Bone_Marrow_Biopsy_BMB,骨髓活检,,"A biopsy involving the removal of a core tissue containing bone spicules and hematopoietic elements embedded in the marrow stroma. This procedure is done in the hip area mainly for the diagnosis and evaluation of neoplastic and non-neoplastic hematopoietic disorders (e.g. anemias, leukemias, lymphomas) and the evaluation of the spread of solid tumors (e.g. carcinomas, sarcomas) and lymphomas for therapeutic purposes.",,,,,,,,SNOMED_CT:234326005,"Biopsy of Bone Marrow|Biopsy, Bone Marrow|BMB",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C15193,,,,
http://example.org/irAEs.owl#rs192921786,rs192921786,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs192921786,,,C/T single-nucleotide variation on chromosome 6,Risk Factor,,,,,,,Position:chr6:96732366 (GRCh38.p14),,,https://www.ncbi.nlm.nih.gov/snp/rs192921786/,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_7,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests4,,,,,Clinical_Humoral_and_Pathological_Examination_7,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Clinical_Immunology_9,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests,,,,,Clinical_Immunology_9,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Cardiac_Organ,Heart,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Cardiac_Organ,心脏,,A hollow organ located slightly to the left of the middle portion of the chest. It is composed of muscle and it is divided by a septum into two sides: the right side which receives de-oxygenated blood from the body and the left side which sends newly oxygenated blood to the body. Each side is composed of two chambers: the atrium (receiving blood) and ventricle (ejecting blood).,,,,,,,,UBERON:0000948|SOC:10007541.0,chambered heart|Cardiac System|Cardiac,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12727,,,,
http://example.org/irAEs.owl#Electroencephalogram_EEG_2,Electroencephalogram,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies1,,,,,Electroencephalogram_EEG_2,脑电图,,"The neurophysiologic exploration of the electrical activity of the brain by the application of electrodes to the scalp. The resulting traces are known as an electroencephalogram (EEG). This test is used to assess brain damage, epilepsy and other problems.",,,,,,,,LOINC:LP6239-0|SNOMED_CT:54550000,Electrical tracings;neurolo|Electroencephalography|EEG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38054,,,,
http://example.org/irAEs.owl#Brain_Stem_Encephalitis,Encephalitis,,,FALSE,,,http://example.org/irAEs.owl#Brainstem,,,,,Brain_Stem_Encephalitis,脑炎,"A disorder characterized by an infectious or inflammatory process involving the brain tissue.

Grade 3: IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221270","An inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes.",,,,,,,,ICD-11:8E4A.0|MedDRA:10014581,Encephalitis (disorder)|inflammation; cerebral|inflammation of the brain|Brain Inflammations,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26760,,,,
http://example.org/irAEs.owl#甲状腺癌,Thyroid Gland Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#Endocrine_and_Neuroendocrine_Tumours,,,,,甲状腺癌,甲状腺癌,,"A carcinoma arising from the thyroid gland. It includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic carcinoma.",,,,,,,,MedDRA:10066914|ICD-11:2D10,Cancer of Thyroid|Carcinoma of the Thyroid Gland|Cancer of the Thyroid|Thyroid Cancer|Thyroid Carcinoma|Carcinoma of the Thyroid|THCA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4815,,,,
http://example.org/irAEs.owl#Concomitant_Medication_Dose,Concomitant Medication Dose,,,FALSE,,,http://example.org/irAEs.owl#Concomitant_Medications,,,,,Concomitant_Medication_Dose,联合用药剂量,,An amount of concomitant medication.,,,,,,,,,CMDOSE,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C83221,,,,
http://example.org/irAEs.owl#Line_of_Therapy,Line of Therapy,,,FALSE,,,http://example.org/irAEs.owl#Trearment_Data,,,,,Line_of_Therapy,治疗线,,The sequence of therapies administered to a patient.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C133518,,,,
http://example.org/irAEs.owl#HLA-DR15_Antigen,Human Leukocyte Antigen DR15,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,HLA-DR15_Antigen,人类白细胞DR15,,HLA-DR15 antigen is a set of polymorphic glycoprotein complexes encoded by the human HLA-DRA and HLA-DRB1 genes. This protein complex is involved in the presentation of antigens to CD4+ T lymphocytes.,Risk Factor,,,,,,,LOINC:6803-1,"HLA Class II Histocompatibility Antigen Complex, DR15|Human leukocyte antigen DR15|Major Histocompatibility Complex, Class II, DR15|HLA-DR15",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105974,,,,
http://example.org/irAEs.owl#尿路上皮癌,Urothelial Cancer,,,FALSE,,,http://example.org/irAEs.owl#泌尿系统,,,,,尿路上皮癌,尿路上皮癌,,"A carcinoma that arises from the urothelial lining of the urinary tract (bladder, renal pelvis, ureter, or urethra).",,,,,,,,ICD-11:2C9Z|MedDRA:10064467,Transitional cell car. -uroth.|Uroepithelial Carcinoma|Transitional cell carcinoma of the urothelial tract,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4030,,,,
"http://example.org/irAEs.owl#Ultrasonic_Cardiogram,_UCG3",Ultrasonic Cardiogram,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies3,,,,,_UCG3,超声心动图,,A procedure that uses high-frequency sound waves (ultrasound) to create an image of the heart.,,,,,,,,SNOMED_CT:40701008|LOINC:LP6171-5,Echocardiography Test|Echocardiography|EC|UCG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16525,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test3,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_5,,,,,Clinical_Immunology_Test3,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#胆囊癌,Gallbladder Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,胆囊癌,胆囊腺癌,,"A malignant epithelial tumor arising from the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur.",,,,,,,,ICD-11:2C13|MedDRA:10017620,Cancer of Gallbladder|Gallbladder Cancer|Gall bladder carcinoma (adenocarcinoma),,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3844,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Digestive_System,,,,,Diagnostic_and_Assessment_Tests,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests8,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Renal_and_Urinary_System,,,,,Diagnostic_and_Assessment_Tests8,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests6,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Musculoskeletal_System_and_Connective_Tissue,,,,,Diagnostic_and_Assessment_Tests6,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests1,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Ear_and_Labyrinth,,,,,Diagnostic_and_Assessment_Tests1,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests3,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Eye,,,,,Diagnostic_and_Assessment_Tests3,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests5,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Immune_System,,,,,Diagnostic_and_Assessment_Tests5,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Respiratory_thoracic_and_Mediastinal_System,,,,,Diagnostic_and_Assessment_Tests9,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests2,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Endocrine_System,,,,,Diagnostic_and_Assessment_Tests2,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests4,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Cardiac_Organ,,,,,Diagnostic_and_Assessment_Tests4,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests7,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Nervous_System,,,,,Diagnostic_and_Assessment_Tests7,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Bladder,Bladder,,,FALSE,,,http://example.org/irAEs.owl#Disease_4,,,,,Bladder,膀胱,,"The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra.",,,,,,,,UBERON:0001255,Urinary Bladder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12414,,,,
http://example.org/irAEs.owl#Treatment_history,History of Medical Treatment Present,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,Treatment_history,治疗史,,An indication that a history of medical treatment is present.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C160179,,,,
http://example.org/irAEs.owl#Lung,Lung,,,FALSE,,,http://example.org/irAEs.owl#Disease_5,,,,,Lung,肺,,"One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border.",,,,,,,,UBERON:0002048,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12468,,,,
http://example.org/irAEs.owl#Alcohol_History,Alcohol History,,,FALSE,,,http://example.org/irAEs.owl#Life_Style,,,,,Alcohol_History,饮酒史,,A description of an individual's current and past experience with alcoholic beverage consumption.,Potential Factor,,,,,,,,Alcohol Use|Alcohol History,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C81229,,,,
http://example.org/irAEs.owl#HCO3,Serum Bicarbonate,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,HCO3,碳酸氢根离子,,A quantitative measurement of the amount of bicarbonate present in a sample of serum.,,,,,,,,LOINC:LP386569-0|SNOMED_CT:271239003,bicarbonate in serum|Serum bicarbonate level,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61022,,,,
http://example.org/irAEs.owl#Clinical_Hematology_3,Clinical Hematology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests,,,,,Clinical_Hematology_3,临床血液学检测,,A laboratory test to measure hematopoietic components and investigate hematologic disorders in a blood sample.,,,,,,,,SNOMED_CT:252275004,Hematology Test|Hematology Procedure|Blood Test,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49286,,,,
http://example.org/irAEs.owl#Demyelinating_Lesions,Demyelinating Lesions,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,Demyelinating_Lesions,脱髓鞘病变,,"A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.",,,,,,,,MedDRA:10048425|ICD-11:8A41,Demyelinating Diseases|Demyelinating Polyneuropathy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34527,,,,
http://example.org/irAEs.owl#Gram_Stain,Gram Stain,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test3,,,,,Gram_Stain,革兰氏染色,,"This is a method (named after the Danish bacteriologist, Hans Christian Gram) for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. Gram-positive organisms will appear blue-black or purple while Gram-negative organisms will appear red.",,,,,,,,SNOMED_CT:385484003|LOINC:LA19348-4,Gram Staining|Gram Staining Method,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23014,,,,
http://example.org/irAEs.owl#睾丸,Testis and Epididymis,,,FALSE,,,http://example.org/irAEs.owl#男性,,,,,睾丸,睾丸及附睾,,A crescent-like structure located in the upper and posterior surfaces of the testis. It consists of the efferent ductules and the duct of the epididymis. It facilitates the maturation of sperm that is produced in the testis. (Epididymis)|Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (Testis),,,,,,,,UBERON:0001301 (Epididymis)|UBERON:0000473 (Testis),,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12412 (Testis)|https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12328 (Epididymis),,,,
http://example.org/irAEs.owl#Platelet_count_PLT,Platelet Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Platelet_count_PLT,血小板计数,,The determination of the number of platelets in a biospecimen.,,,,,,,,SNOMED_CT:61928009|LOINC:LP14597-6,Blood Platelet Count|Platelet Number|Whole Blood Platelet Counts|Anucleated Thrombocytes|PLT|Platelets,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C51951,,,,
http://example.org/irAEs.owl#Non_Infection_Cystitis,Non-Infection Cystitis,,,FALSE,,,http://example.org/irAEs.owl#Bladder,,,,,Non_Infection_Cystitis,非感染性膀胱炎,"A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract.

Grade 1: Microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence
Grade 2: Moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity
Grade 3: Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated
Grade 4: Life-threatening consequences; urgent invasive intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143393",An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.,,,,,,,,ICD-11:GC00.Z|MedDRA:10063057,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78250,,,,
http://example.org/irAEs.owl#Diabetes_Mellitus,Diabetes Mellitus,,,FALSE,,,http://example.org/irAEs.owl#Pancreas_Islet,,,,,Diabetes_Mellitus,糖尿病,"A disorder characterized by increased Hgb A1C that may result in organ damage.

Grade 1: Abnormal glucose above baseline; diet changes only; no change in baseline diabetic management
Grade 2: Oral antiglycemic agent initiated; insulin sliding scale initiated
Grade 3: Insulin therapy initiated or increased; hospitalization indicated
Grade 4: Life-threatening consequences; urgent intervention indicated; diabetic ketoacidosis
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221091",A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.,,,,,,,,MedDRA:10012601|ICD-11:5A13.4,DM|Diabetes,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2985,,,,
http://example.org/irAEs.owl#Anti_PD_L1,PD-1 Ligand Inhibitor,,,FALSE,,,http://example.org/irAEs.owl#ICI_related_Drug_Names_2,,,,,Anti_PD_L1,PD-1配体抑制剂,,Any agent that binds to any of the ligands for the receptor programmed cell death protein 1 (PD-1; PD1); programmed death ligand 1 (PD-L1; CD274) and 2 (PD-L2; CD273).,,,,,,,,,PD-1 Ligand-targeting Agent,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C156893,,,,
http://example.org/irAEs.owl#CK-MB,Creatine Kinase MB,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding,,,,,CK-MB,肌酸激酶同工酶,,An isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type.,,,,,,,,LOINC:LP15513-2|SNOMED_CT:12016004,Creatine Phosphokinase-MB|MB Creatine Kinase|CPK-MB|CK-MB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C122778,,,,
http://example.org/irAEs.owl#Hemolytic_anemia,Hemolytic Anemia,,,FALSE,,,http://example.org/irAEs.owl#Red_Blood_Cell_RBC,,,,,Hemolytic_anemia,溶血性贫血,"Anemia resulting from hemolysis.

Grade 1: <10% drop in Hgb from last assessment; intervention not indicated
Grade 2: <=2 units of PRBCs transfused per day
Grade 3: >2 units of PRBCs per day indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220801","Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies.",,,,,,,,MedDRA:10019493|ICD-11:3A4Z,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34376,,,,
http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,Serum Electrolyte Test,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_12,,,,,Serum_Electrolyte_and_Acid_Base_Panel_5,血清电解质检测,,"Substances that ionize into anions and cations in body fluids. Electrolytes regulate nerve and muscle function and water distribution between cells, plasma, and interstitial fluid. Imbalances can cause serious physiologic effects, including seizures, cardiac arrhythmias and convulsions.",,,,,,,,LOINC:LP94298-4|SNOMED_CT:20109005,blood electrolyte levels|electrolytes serum,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C464,,,,
http://example.org/irAEs.owl#Fibrinogen_FIB,Fibrinogen,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,Fibrinogen_FIB,纤维蛋白原,,A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation.,"Below Baseline, Risk Factor",,,,,,,LOINC:LP14704-8|SNOMED_CT:418326009,Factor I human|Fibrinogen Human|FIB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C81126,,,,
http://example.org/irAEs.owl#Non_High_Density_Lipoprotein_Cholesterol_non_HDL_C,Non-High-Density Lipoprotein Cholesterol,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,Non_High_Density_Lipoprotein_Cholesterol_non_HDL_C,非高密度脂蛋白胆固醇,,Non-HDL cholesterol is the total cholesterol minus HDL cholesterol. Non-HDL cholesterol has been suggested as a better predictor of cardiovascular risk than LDL alone (LOINC).,,,,,,,,SNOMED_CT:312260007|LOINC:LP36472-6,Cholesterol.non HDL|non-HDL-C,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C116204,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test-1,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding,,,,,Clinical_Immunology_Test-1,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Fever,Pre-treatment Fever,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,Fever,治疗前发热,,Presence of fever within 3 weeks prior to the commencement of treatment,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Supportive_Care_During_Immunosuppressant_Therapy,Supportive Care During Immunosuppressant Therapy,,,FALSE,,,http://webprotege.stanford.edu/R9SLYezUwf5WcAMq9ZGLDPV,,,,,Supportive_Care_During_Immunosuppressant_Therapy,免疫抑制剂治疗期间的支持性护理,,,,,,,,,,,,"◆Monitoring of blood glucose levels
◆PPIs or H2 blockers to prevent gastritis
◆Antimicrobial and antifungal prophylaxis to prevent opportunistic infections
◆Vitamin D and calcium supplementation to prevent osteoporosis",,,,,
http://example.org/irAEs.owl#Grade_3,Grade 3,,,FALSE,,,http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,,,,,Grade_3,3 级,,Severe or medically significant but not immediately life threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL or severe impact on age appropriate normal daily activity (pediatric),,,,,,,,,,,,,,,
http://example.org/irAEs.owl#follicular_lymphoma,Follicular Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,follicular_lymphoma,滤泡性淋巴瘤,,"A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive.",,,,,,,,MedDRA:10085128|ICD-11:2A80,"Follicle Center Lymphoma|Follicular Centre Cell Lymphoma|Lymphoma, Follicular Centre Cell|Follicular Non-Hodgkin Lymphoma|FL",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3209,,,,
http://example.org/irAEs.owl#Erythrocyte_Sedimentation_Rate_ESR,Erythrocyte Sedimentation Rate,,,FALSE,,,http://example.org/irAEs.owl#Inflammatory_Marker_Panel_13,,,,,Erythrocyte_Sedimentation_Rate_ESR,红细胞沉降率,,A quantitative measurement of the distance that red blood cells travel in one hour in a sample of unclotted blood.,Risk Factor,,,,,,,SNOMED_CT:416838001|LOINC:LP16699-8,"Red blood cell sedimentation rate|Sedimentation rate, erythrocyte|ESR",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C74611,,,,
http://example.org/irAEs.owl#Nail,Nail,,,FALSE,,,http://example.org/irAEs.owl#Disease_2,,,,,Nail,甲,,The cutaneous plate on the dorsal surface of the distal end of a finger or toe.,,,,,,,,UBERON:0001705,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C33156,,,,
http://example.org/irAEs.owl#CD74,Anti-CD74 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,CD74,抗CD74抗体,,"ti-CD74 monoclonal antibody is a specific immunoglobulin that binds to CD74 (HLA-DRγ, the invariant chain of MHC class II molecules), and the humanized form of anti-CD74 antibody (hLL1, milatuzumab) can internalize rapidly into CD74+ malignant cells, serving as a novel therapeutic agent for B-cell malignancies by inducing cell apoptosis or inhibiting CD74-MIF signaling pathway (PubMed).",Risk Factor,,,,,,,,,,https://pubmed.ncbi.nlm.nih.gov/17875789/,,,,
http://example.org/irAEs.owl#Cytological_Examination,Cytological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_4,,,,,Cytological_Examination,细胞学检查,,"The light microscopic study of normal and abnormal cells in fine needle aspirates (FNAs), body cavity fluids, and smears.",,,,,,,,SNOMED_CT:702666009,Cytologic Procedure|Cytologic Technique|Cytologic Technics|Cytology,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16490,,,,
http://example.org/irAEs.owl#Cytological_Examination2,Cytological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_5,,,,,Cytological_Examination2,细胞学检查,,"The light microscopic study of normal and abnormal cells in fine needle aspirates (FNAs), body cavity fluids, and smears.",,,,,,,,SNOMED_CT:702666009,"Cytologic Technique
Cytologic Procedure
Cytologic Technics
Cytology",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16490,,,,
http://example.org/irAEs.owl#Clinical_Hematology_Test1,Clinical Hematology Finding,,,FALSE,,,http://example.org/irAEs.owl#Non_Organ_Special_Laboratory_Finding,,,,,Clinical_Hematology_Test1,临床血液学检测,,A laboratory test to measure hematopoietic components and investigate hematologic disorders in a blood sample.,,,,,,,,SNOMED_CT:252275004,Hematology Test|Hematology Procedure|Blood Test,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49286,,,,
http://example.org/irAEs.owl#Proportion_of_PD_L1_positive_cellsTPSCPS,Proportion of PD-L1 positive cells,,,FALSE,,,http://example.org/irAEs.owl#Oncologic_and_Treatment_Data,,,,,Proportion_of_PD_L1_positive_cellsTPSCPS,PD-L1 阳性细胞比例,,A score for tumor PD-L1 expression based on the percentage of viable tumor cells that are positive for PD-L1 staining.,,,,,,,,,PD-L1 Tumor Proportion Score|CD274 Tumor Proportion Score|CPS|PD-L1 TPS|TPS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C184941,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_9,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests3,,,,,Clinical_Humoral_and_Pathological_Examination_9,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Keratoconjunctivitis_Sicca_KCS_Dry_Eyes,Dry Eye Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Conjunctiva,,,,,Keratoconjunctivitis_Sicca_KCS_Dry_Eyes,干眼症,"A disorder characterized by dryness of the cornea and conjunctiva.

Grade 1: Clinical or diagnostic observations only; symptoms relieved by lubricants
Grade 2: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)
Grade 3: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143410",A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye.,,,,,,,,MedDRA:10023350|ICD-11:9A79,"Keratoconjunctivitis Sicca, KCS|Dry Eyes",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34553,,,,
http://example.org/irAEs.owl#卵巢生殖细胞,Ovarian Germ Cell Tumor,,,FALSE,,,http://example.org/irAEs.owl#卵巢癌,,,,,卵巢生殖细胞,卵巢生殖细胞肿瘤,,"A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma.",,,,,,,,MedDRA:10075820|ICD-11:2C73.Y,Ovarian Germ Cell Tumor|Germ Cell Neoplasm of Ovary|Germ Cell Tumor of the Ovary|GCT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3873,,,,
http://example.org/irAEs.owl#Inflammatory_Marker_Panel_13,Inflammatory Marker Panel,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test5,,,,,Inflammatory_Marker_Panel_13,血液炎症标志物,,A substance detectable in the blood that can be used to assess levels of inflammation in the body.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143955,,,,
http://example.org/irAEs.owl#Sclerosing_Cholangitis_Cholangitis,Sclerosing Cholangitis,,,FALSE,,,http://example.org/irAEs.owl#Hepatobiliary_System,,,,,Sclerosing_Cholangitis_Cholangitis,硬化性胆管炎,,"Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS (MSH).",,,,,,,,MedDRA:10039717|ICD-11:DC13,Primary Sclerosing Cholangitis|PSC,,https://www.ncbi.nlm.nih.gov/mesh/68015209,,,,
http://example.org/irAEs.owl#Capillary_Leak_Syndrome,Capillary Leak Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Capillary,,,,,Capillary_Leak_Syndrome,毛细血管渗漏综合征,"A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.

Grade 1: Asymptomatic
Grade 2: Symptomatic; medical intervention indicated
Grade 3: Severe symptoms
Grade 4: Life-threatening consequences
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143349","A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.",,,,,,,,ICD-11:BD5Y|MedDRA:10007196,Acute Vascular Leak Syndrome|AVLS|CLS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62578,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests11,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Vascular_and_Lymphatic_System,,,,,Diagnostic_and_Assessment_Tests11,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#鼻咽癌,Nasopharyngeal Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#头颈部肿瘤,,,,,鼻咽癌,鼻咽癌,,"A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.",,,,,,,,ICD-11:2B6B|MedDRA:10028793,nasopharyngeal cancer|Cancer of Nasopharynx|NPC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3871,,,,
http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,Serum Biochemical Tests,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_12,,,,,Serum_Biochemical_Tests_10,血清生化检测,,"Serum biochemical test refers to a laboratory technique that assesses the body's metabolic status, organ function, and aids in disease diagnosis by detecting the concentration or activity of various biochemical substances (including enzymes, electrolytes, metabolites, proteins, etc.) in serum. It adopts standardized sample collection, processing and analysis procedures to ensure the accuracy and reliability of results, providing an objective basis for clinical diagnosis and health monitoring.",,,,,,,,SNOMED_CT:314071004,Biochemical screening test,,,,,,
http://example.org/irAEs.owl#心内膜炎,Endocarditis,,,FALSE,,,http://example.org/irAEs.owl#心内膜,,,,,心内膜炎,心内膜炎,,Inflammation of the endocardium.,,,,,,,,MedDRA:10014665|ICD-11:BB4Z,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34582,,,,
http://example.org/irAEs.owl#心内膜,Endocardium,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,心内膜,心内膜,,The layer of endothelial cells and connective tissue lining the chambers of the heart.,,,,,,,,SNOMED_CT:37949006|UBERON:0002165,Endocardial,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C13004,,,,
http://example.org/irAEs.owl#Anti-Ro_Antibody,Anti-Ro Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti-Ro_Antibody,抗Ro抗体,,"An antinuclear antibody directed against 52 or 60 kDa RNA-binding proteins in the nucleus. They can be associated with multiple autoimmune disorders, primarily Sjogren syndrome and system lupus erythematosus. Maternal anti-Ro antibody positivity can be associated with neonatal lupus.",,,,,,,,SNOMED_CT:44212003|LOINC:LP39751-0,Anti-SSA/Ro Antibody|anti-Ro52 autoantibodies|Sjogren's Anti-SS-A autoantibody|SS-A - Sjogren's syndrome - A antibody|Sjogrens syndrome-A extractable nuclear Ab|anti ro antibodies,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121322,,,,
http://example.org/irAEs.owl#ROS1,"ROS Proto-Oncogene 1, Receptor Tyrosine Kinase",,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,ROS1,ROS 原癌基因 1，受体酪氨酸激酶,,"This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.",,,,,,,,NCBI Gene ID:6098,Oncogene ROS|ROS1,,https://www.ncbi.nlm.nih.gov/gene/6098,,,,
http://example.org/irAEs.owl#卵巢,Ovary,,,FALSE,,,http://example.org/irAEs.owl#女性,,,,,卵巢,卵巢,,One of the paired female reproductive glands containing the ova or germ cells; the ovary's stroma is a vascular connective tissue containing numbers of ovarian follicles enclosing the ova.,,,,,,,,UBERON:0000992,"Genital System, Female, Ovary|female organism genitalia gonad|female gonad|animal ovary|female organism reproductive system gonad",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12404,,,,
http://example.org/irAEs.owl#Recurrent_Pleural_Effusion,Pleural Effusion,,,FALSE,,,http://example.org/irAEs.owl#Pleura,,,,,Recurrent_Pleural_Effusion,胸腔积液,"A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)
Grade 3: Symptomatic with respiratory distress and hypoxia; operative intervention including chest tube or pleurodesis indicated
Grade 4: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143765","Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma.",,,,,,,,MedDRA:10035598|ICD-11:CB27,Fluid around lungs|Unspecified pleural effusion|Effusion pleural|Thoracic effusion,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3331,,,,
http://example.org/irAEs.owl#Fe,Serum Iron,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_8,,,,,Fe,血清铁离子,,The determination of the amount of iron present in a sample.,,,,,,,,LOINC:75689-0|SNOMED_CT:250216004,Fe,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C74679,,,,
http://example.org/irAEs.owl#Gastritis,Gastritis,,,FALSE,,,http://example.org/irAEs.owl#Gastrointestinal_Tract,,,,,Gastritis,胃炎,"A disorder characterized by inflammation of the stomach.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; altered GI function; medical intervention indicated
Grade 3: Severely altered eating or gastric function; TPN or hospitalization indicated
Grade 4: Life-threatening consequences; urgent operative intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C57812",Inflammation of the stomach.,,,,,,,,MedDRA:10017853|ICD-11:DA42,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26780,,,,
http://example.org/irAEs.owl#Lipodystrophy,Lipodystrophy,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Lipodystrophy,脂肪营养不良,,A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.,,,,,,,,ICD-11:EF01|MedDRA:10024608,Lipodsystrophic Syndromes,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C97093,,,,
http://example.org/irAEs.owl#Laboratory_Tests3,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests4,,,,,Laboratory_Tests3,实验室检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Lung_Cancer-irAE,pan-Cancer Immune-related Adverse Events (irAEs) Ontology,,,FALSE,,,http://www.w3.org/2002/07/owl#Thing,,,,,Lung_Cancer-irAE,泛癌免疫相关不良事件本体,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Eposcleritis,Episcleritis,,,FALSE,,,http://example.org/irAEs.owl#Sclera,,,,,Eposcleritis,表层巩膜炎,,Inflammation of the thin layer of tissue lining the sclera of the eye characterized by redness in the white portion of the eye.,,,,,,,,ICD-11:9B50|MedDRA:10015084,"Episcleritis, NOS|Bulbar Conjunctivitis",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C112189,,,,
http://example.org/irAEs.owl#Visual_Field_Test_Perimetry,Visual Field Test,,,FALSE,,,http://example.org/irAEs.owl#Functional_and_Subjective_Tests,,,,,Visual_Field_Test_Perimetry,视野检查,,"Method of measuring and mapping the scope of vision, from central to peripheral of each eye (MeSH).",,,,,,,,SNOMED:86944008|LOINC:LP29681-1,"Ophthalmology Visual Field measurements|Visual Field Exam|Examination of visual fields|Visual field study|VF - Visual field|Exam, Visual Field",,https://www.ncbi.nlm.nih.gov/mesh/?term=Visual+field+study,,,,
http://example.org/irAEs.owl#Peripheral_Blood_Smear_Review_Morphology,Peripheral Blood Smear Review / Morphology,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests,,,,,Peripheral_Blood_Smear_Review_Morphology,外周血涂片检查/形态学,,A sample of blood applied in a thin film to a microscope slide for study under a microscope.,,,,,,,,LOINC:LP33019-8|SNOMED_CT:104130000,Blood Smear|peripheral blood smear,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C79903,,,,
http://example.org/irAEs.owl#huxi,Thoracic Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,huxi,胸部肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#PD-1,Nivolumab & Ipilimumab,,,FALSE,,,http://example.org/irAEs.owl#PD-1/CTLA-4_dual_immune_checkpoint_inhibitor_combination,,,,,PD-1,,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Ultrasonic_Cardiogram_UCG_2,Ultrasonic Cardiogram,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies1,,,,,Ultrasonic_Cardiogram_UCG_2,超声心动图,,A procedure that uses high-frequency sound waves (ultrasound) to create an image of the heart.,,,,,,,,SNOMED_CT:40701008|LOINC:LP6171-5,Echocardiography Test|Echocardiography|UCG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16525,,,,
http://example.org/irAEs.owl#Hematological_Tumors,Haematolymphoid Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,Hematological_Tumors,血液淋巴系统肿瘤,,,,,,,,,,,,,,,,,
"http://example.org/irAEs.owl#Parathyroid_Hormone,_PTH1",Parathyroid Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_PTH1,甲状旁腺激素,,"Parathyroid hormone (115 aa, ~13 kDa) is encoded by the human PTH gene. This protein is involved in the modulation of calcium ion and phosphate concentration in the blood.",,,,,,,,SNOMED_CT:4076007|LOINC:LP18184-9,PTH|parathyrin,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C41027,,,,
http://example.org/irAEs.owl#Kidney,Kidney,,,FALSE,,,http://example.org/irAEs.owl#Disease_4,,,,,Kidney,肾脏,,"One of the two bean-shaped organs located on each side of the spine in the retroperitoneum. The right kidney is located below the liver and the left kidney below the diaphragm. The kidneys filter and secrete metabolic products and minerals from the blood, thus maintaining homeostasis. On the superior pole of each kidney there is an adrenal gland. Each kidney and adrenal gland is surrounded by fat.",,,,,,,,UBERON:0002113,"Urinary System, Kidney",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12415,,,,
http://example.org/irAEs.owl#Alkaline_Phosphatase1,Alkaline Phosphatase,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Alkaline_Phosphatase1,碱性磷酸酶,,An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum.,"Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests13,Diagnostic and Assessment Tests,,,FALSE,,,http://example.org/irAEs.owl#Reproductive_system_and_breast,,,,,Diagnostic_and_Assessment_Tests13,诊断与评估检验项目,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Doses,ICI-related Drug Dose,,,FALSE,,,http://example.org/irAEs.owl#Trearment_Data,,,,,Doses,ICI相关用药剂量,,"A quantity of an agent (such as substance or energy) administered, taken, or absorbed at one time.",,,,,,,,,treatment dose|Dose per Administration|Dose Level|TRTDOS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25488,,,,
http://example.org/irAEs.owl#HLA_Typing_2,Human Leukocyte AntigenTyping,,,FALSE,,,http://example.org/irAEs.owl#Molecular_Genetic_Finding3,,,,,HLA_Typing_2,人类白细胞抗原分型,,,,,,,,,,LOINC:62875-0|SNOMED:104412002,HLA Typing,,,,,,
http://example.org/irAEs.owl#T_lymphocyte_subset_analysis_2,T lymphocyte subset analysis,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding4,,,,,T_lymphocyte_subset_analysis_2,T淋巴细胞亚型分析,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Electrooculography,Electrooculography,,,FALSE,,,http://example.org/irAEs.owl#Electrophysiological_Studies_3,,,,,Electrooculography,眼电图,,An electrophysiologic test that measures the standing potential between the cornea and Bruch's membrane. Primary applications are in ophthalmological diagnosis and in recording eye movements.,,,,,,,,SNOMED_CT:398736007|LOINC:LP200650-2,Electro-oculogram examination|Electro Oculography|EOG - Electro-oculography|Electro-oculogram [EOG]|EOG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C190539,,,,
http://example.org/irAEs.owl#Artery,Artery,,,FALSE,,,http://example.org/irAEs.owl#Disease_12,,,,,Artery,动脉,,A blood vessel that carries blood away from the heart.,,,,,,,,UBERON:0004572,arterial subtree|arterial tree organ part,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12372,,,,
http://example.org/irAEs.owl#Hyponatremia,Hyponatremia,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Hyponatremia,低钠血症,"A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.

Grade 2: 125 - <130 mmol/L and asymptomatic
Grade 3: 125 - <130 mmol/L symptomatic; 120 - <125 mmol/L regardless of symptoms
Grade 4: <120 mmol/L; life-threatening consequences
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143571",Lower than normal levels of sodium in the circulating blood.,,,,,,,,MedDRA:10021038|ICD-11:5C72,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C37976,,,,
http://example.org/irAEs.owl#History_of_diabetes_mellitus,History of Diabetes Mellitus,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,History_of_diabetes_mellitus,糖尿病病史,,"A documented history of diabetes mellitus was defined in accordance with the diagnostic criteria recommended by the World Health Organization (WHO). Specifically, it refers to a previous diagnosis verified by either the presence of classic diabetic symptoms combined with a random plasma glucose level ≥ 11.1 mmol/L, a fasting plasma glucose level ≥ 7.0 mmol/L, a 2-hour plasma glucose level ≥ 11.1 mmol/L after a 75g oral glucose load, or consistent use of antidiabetic medications (including oral hypoglycemic drugs and insulin) for a confirmed diagnosis of diabetes mellitus.",Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Respiratory_thoracic_and_Mediastinal_System,"Respiratory, thoracic and Mediastinal System",,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Respiratory_thoracic_and_Mediastinal_System,呼吸、胸腔及纵隔系统,,"Respiratory System:The organs involved in the exchange of carbon dioxide and oxygen including the trachea, bronchi, and lung parenchyma.
Mediastinal System: Related to the mediastinum.",,,,,,,,UBERON: 0001004 & 0003728|SOC:10038738.0,,,"Respiratory System: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12779
Mediastinal: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25310",,,,
http://example.org/irAEs.owl#Platelet-to-Lymphocyte_Ratio,Platelet to Lymphocyte Ratio,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Platelet-to-Lymphocyte_Ratio,血小板与淋巴细胞比值,,"The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios (PubMed).","Over Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Computed_Tomography_Angiography_CTA,Computed Tomography Angiography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_9,,,,,Computed_Tomography_Angiography_CTA,计算机断层血管造影,,A type of computed tomography that is used to construct images of blood vessels.,,,,,,,,SNOMED_CT:418272005,CT ANGIOGRAPHY|CT Scan Angiography|CTA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C202408,,,,
http://example.org/irAEs.owl#Elevation_in_Lipase,Elevation in Lipase,,,FALSE,,,http://example.org/irAEs.owl#Pancreas,,,,,Elevation_in_Lipase,脂肪酶升高,"A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.

Grade 1: >ULN - 1.5 x ULN
Grade 2: >1.5 - 3.0 x ULN; >3.0 - 5.0 x ULN and asymptomatic
Grade 3: >3.0 - 5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic
Grade 4: >5.0 x ULN and with signs or symptoms
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143652",A laboratory test result which indicates increased levels of lipase in a biologic specimen.,,,,,,,,MedDRA:10067840|ICD-11:5C80,Lipase Increased|Hyperlipasemia,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78435,,,,
http://example.org/irAEs.owl#IRF4,Interferon Regulatory Factor 4,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,IRF4,干扰素调节因子 4,,This gene is involved in the regulation of B-cell differentiation and proliferation. It also plays a role in mediating the proliferation of mitogen-stimulated T cells.,,,,,,,,NCBI Gene ID: 3662,IRF4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18430,,,,
http://example.org/irAEs.owl#PD-1/CTLA-4_dual_immune_checkpoint_inhibitor_combination,PD-1/CTLA-4 dual immune checkpoint inhibitor combination,,,FALSE,,,http://example.org/irAEs.owl#ICI_related_Drug_Names_2,,,,,CTLA-4_dual_immune_checkpoint_inhibitor_combination,PD-1 抑制剂联合 CTLA-4 抑制剂双免疫疗法,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Finding,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests3,,,,,Clinical_Immunology_Finding,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Finding3,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_6,,,,,Clinical_Immunology_Finding3,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Finding4,Immunology Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Biomarker,,,,,Clinical_Immunology_Finding4,免疫学生物标志物,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Finding1,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_3,,,,,Clinical_Immunology_Finding1,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Finding2,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_2,,,,,Clinical_Immunology_Finding2,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Height,Height,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,Height,身高,,The vertical measurement or distance from the base to the top of a subject or participant.,Potential Factor,,,,,,,,Body Height,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C164634,,,,
http://example.org/irAEs.owl#Disease-1,Disease,,,FALSE,,,http://example.org/irAEs.owl#Ear_and_Labyrinth,,,,,Disease-1,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Disease,Disease,,,FALSE,,,http://example.org/irAEs.owl#Digestive_System,,,,,Disease,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Disease1,Disease,,,FALSE,,,http://example.org/irAEs.owl#Reproductive_system_and_breast,,,,,Disease1,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
"http://example.org/irAEs.owl#Electrocardiography,_ECG5",Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies1,,,,,_ECG5,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Finding,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests3,,,,,Clinical_Chemistry_Finding,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Biomarker,Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Impact_Factors,,,,,Biomarker,生物标志物,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#勃起功能障碍,Erectile Dysfunction,,,FALSE,,,http://example.org/irAEs.owl#阴茎,,,,,勃起功能障碍,勃起功能障碍,"A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.

Grade 1: Decrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump).
Grade 2: Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump).
Grade 3: Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present).
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55615",A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.,,,,,,,,ICD-11:HA01.1|MedDRA:10061461,Male Erectile Disorder|ED|impotence,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3133,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Test1,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_11,,,,,Clinical_Microbiology_Test1,临床微生物学检测,,,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#LH,Luteinizing Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,LH,黄体生成激素,,A heterodimeric glycoprotein hormone secreted by the gonadotropic cells of the anterior pituitary gland. This hormone is involved in stimulation of testosterone production by Leydig cells in males and triggering ovulation and corpus luteum development in females.,,,,,,,,SNOMED_CT:64182005|LOINC:LP14683-4,Interstitial Cell-Stimulating Hormone|ICSH|Lutropin|LH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C190789,,,,
http://example.org/irAEs.owl#Functional_Studies,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests2,,,,,Functional_Studies,功能性检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Tumor_Necrosis_Factor_alpha_TNF_α,Tumor Necrosis Factor-alpha,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Tumor_Necrosis_Factor_alpha_TNF_α,肿瘤坏死因子-α,,"A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates ""death receptors"" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04)","Over Baseline, Risk Factor",,,,,,,LOINC:LP18480-1|SNOMED_CT:39525005,Tumor Necrosis Factor (TNF-alpha)|Cachectin|TNF-Alpha|TNF-α|TNFA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20535,,,,
http://example.org/irAEs.owl#嗜酸性肉芽肿,Eosinophilic Granuloma,,,FALSE,,,http://example.org/irAEs.owl#Skeletal_System,,,,,嗜酸性肉芽肿,嗜酸性肉芽肿,,"A clinical variant of Langerhans cell histiocytosis characterized by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterized by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils, and small, mature lymphocytes.",,,,,,,,ICD-11:2B31.2Y|MedDRA:10014956,Chronic Unifocal Langerhans Cell Histiocytosis|Unifocal Langerhans Cell Histiocytosis|Monostotic Langerhans Cell Histiocytosis|Eosinophilic Xanthomatous Granuloma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3016,,,,
http://example.org/irAEs.owl#Durvalumab,Durvalumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_L1,,,,,Durvalumab,度伐利尤单抗,,"A monoclonal antibody directed against B7H1 (B7 homolog 1; programmed cell death ligand 1) with potential immunostimulating activity. Upon intravenous administration, durvalumab binds to the cell surface antigen B7H1, thereby blocking B7H1 signaling. This may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against B7H1-expressing tumor cells. B7H1, a member of the B7 protein superfamily and a negative regulator of cytokine synthesis, is overexpressed on certain tumor cell types.",,,,,,,,DrugBank ID:DB11714,Imfinzi|MEDI 4736,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C103194,,,,
http://example.org/irAEs.owl#Gallbladder,Gallbladder,,,FALSE,,,http://example.org/irAEs.owl#Disease,,,,,Gallbladder,胆囊,,A pear-shaped organ located under the liver that stores and concentrates bile secreted by the liver. From the gallbladder the bile is delivered through the bile ducts into the intestine thereby aiding the digestion of fat-containing foods.,,,,,,,,UBERON:0002110,"Gastrointestinal Tract, Gall Bladder|Gall Bladder|Gallbladder structure|cholecyst",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12377,,,,
http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,Complete Blood Count,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Hematology_Test1,,,,,Complete_Blood_Count_CBC_7,全血细胞计数,,"The determination of the number of red blood cells, white blood cells, and platelets in a biospecimen.",,,,,,,,SNOMED_CT:26604007|LOINC:LP99237-7,Full Blood Count|Blood Cell Count|CBC|FBC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C28133,,,,
http://example.org/irAEs.owl#Complete_Blood_Count_CBC_3,Complete Blood Count,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Hematology_3,,,,,Complete_Blood_Count_CBC_3,全血细胞计数,,"The determination of the number of red blood cells, white blood cells, and platelets in a biospecimen.",,,,,,,,LOINC:93340-8|SNOMED_CT:26604007,Full Blood Count|Blood Cell Count|CBC|FBC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C28133,,,,
http://example.org/irAEs.owl#消化,Digestive System Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,消化,消化系统肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Functional_Studies2,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests3,,,,,Functional_Studies2,功能性检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Luteinizing_Hormone,Luteinizing Hormine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,,,,,Luteinizing_Hormone,黄体生成激素,,A heterodimeric glycoprotein hormone secreted by the gonadotropic cells of the anterior pituitary gland. This hormone is involved in stimulation of testosterone production by Leydig cells in males and triggering ovulation and corpus luteum development in females.,,,,,,,,SNOMED_CT:64182005|LOINC:LP14683-4,Interstitial Cell-Stimulating Hormone|ICSH|LH|Lutropin,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C190789,,,,
http://example.org/irAEs.owl#HLA-A03,Human Leukocyte Antigen A03,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,HLA-A03,人类白细胞抗原A03,,"HLA class I histocompatibility antigen, A-0301 alpha chain (365 aa, ~41 kDa) is encoded by the human HLA-A gene. This protein is involved in the presentation of foreign antigens to the immune system. This isoform is associated with increased risk for multiple sclerosis and is a secondary risk factor for myasthenia gravis.",Risk Factor,,,,,,,,"Major Histocompatibility Complex, Class I, A*0301|HLA-A*030101|HLA-A0301 Antigen|MHC Class I Antigen A*0301|Leukocyte Antigen Class I-A0301|HLA Class I Histocompatibility Antigen, A-0301 Alpha Chain|MHC Class I Antigen HLA-A0301 Heavy Chain|A*03010101|A3.1|HLA-A3|HLA-A03",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C118485,,,,
http://example.org/irAEs.owl#acute_myeloid_leukemia,Acute Myeloid Leukemia,,,FALSE,,,http://example.org/irAEs.owl#acute_leukemias,,,,,acute_myeloid_leukemia,急性髓系白血病,,"A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).",,,,,,,,ICD-11:2A60.3|MedDRA:10000886,Hematopoeitic - Acute Myleogenous Leukemia (AML)|Acute Nonlymphocytic Leukemia|Acute granulocytic leukemia|Acute Myelocytic Leukemia|AML|ANLL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3171,,,,
http://example.org/irAEs.owl#间皮瘤,Mesothelioma,,,FALSE,,,http://example.org/irAEs.owl#huxi,,,,,间皮瘤,间皮瘤,,"A neoplasm characterized by the proliferation of neoplastic mesothelial cells. It usually arises from the pleura or peritoneum. This category includes malignant mesothelioma, adenomatoid tumor (benign mesothelioma), well differentiated papillary mesothelial tumor, and multicystic mesothelioma.",,,,,,,,ICD-11:2C26.0|MedDRA:10027406,Mesothelial Tumor|Mesothelial Neoplasm,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3786,,,,
http://example.org/irAEs.owl#Anti_CTLA_4,CTLA-4 Inhibitor,,,FALSE,,,http://example.org/irAEs.owl#ICI_related_Drug_Names_2,,,,,Anti_CTLA_4,CTLA-4 抑制剂,,Any agent that targets cytotoxic T-lymphocyte-associated protein 4 (CTLA-4; CTLA4; CD152).,,,,,,,,,CTLA-4-targeting Agent,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C191738,,,,
http://example.org/irAEs.owl#SNP,Single Nucleotide Polymorphism,,,FALSE,,,http://example.org/irAEs.owl#Molecular_Genetic_Finding3,,,,,SNP,单核苷酸多态性,,,,,,,,,,SNOMED:90603004,SNP,,,,,,
http://example.org/irAEs.owl#中性粒坚守,Neutropenia,,,FALSE,,,http://example.org/irAEs.owl#White_Blood_Cell_WBC,,,,,中性粒坚守,中性粒细胞减少症,"A finding based on laboratory test results that indicate a decrease in number of neutrophils (ANC) in a blood specimen.

Grade 1: <1500 - 1000/mm3; <1.5 - 1.0 x 10^9/L
Grade 2: <1500-1000/mm3; <1.5-1.0 x 10e9/L
Grade 3: <1000-500/mm3; <1.0-0.5 x 10e9/L
Grade 4: <100/mm3; <0.1 x 10^9/L
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221306",A decrease in the number of neutrophils in the peripheral blood.,,,,,,,,MedDRA:10029354|ICD-11:4B00.0,Neutrophil count decreased|Granulocytopenia,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C80520,,,,
http://example.org/irAEs.owl#Spleen,Spleen,,,FALSE,,,http://example.org/irAEs.owl#Disease_9,,,,,Spleen,脾脏,,"An organ that is part of the hematopoietic and immune systems. It is composed of the white pulp and the red pulp and is surrounded by a capsule. It is located in the left hypochondriac region. Its functions include lymphocyte production, blood cell storage, and blood cell destruction.",,,,,,,,UBERON:0002106,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12432,,,,
http://example.org/irAEs.owl#Gene,Gene,,,FALSE,,,http://example.org/irAEs.owl#Molecular_Genetic_Finding3,,,,,Gene,基因,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Early_Onset_Ramsay_Hunt_Syndrome,Herpes Zoster Oticus,,,FALSE,,,http://example.org/irAEs.owl#Disease-1,,,,,Early_Onset_Ramsay_Hunt_Syndrome,带状疱疹性耳病,,A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption.,,,,,,,,MedDRA:10063491|ICD-11:1E91.41,Ramsay Hunt Syndrome,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84763,,,,
http://example.org/irAEs.owl#Mild_to_moderate_AEs,Mild to Moderate AEs,,,FALSE,,,http://webprotege.stanford.edu/R9SLYezUwf5WcAMq9ZGLDPV,,,,,Mild_to_moderate_AEs,轻至中度不良事件,,,,,,,,,,,,"◆Provide symptomatic management.
◆Delay in immunotherapy may be recommended if unclear if irAE is developing or until AEs resolve to grade 1 or pre-treatment baseline.
◆Steroids may be required if AE does not improve. If hormone replacement is required, it is usually for lifetime and may continue beyond the completion of therapy with ICIs.",,,,,
http://example.org/irAEs.owl#Very_Low_Density_Lipoprotein_Cholesterol_VLDL_C,Very Low-Density Lipoprotein Cholesterol,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,Very_Low_Density_Lipoprotein_Cholesterol_VLDL_C,极低密度脂蛋白胆固醇,,"Very-low-density lipoprotein (VLDL) is a type of lipoprotein made by the liver. VLDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, intermediate-density lipoprotein, low-density lipoprotein, high-density lipoprotein) that enables fats and cholesterol to move within the water-based solution of the bloodstream. VLDL is assembled in the liver from cholesterol and apolipoproteins then is converted in the bloodstream to low-density lipoprotein (LDL). VLDL particles have a diameter of 30-80 nm and transports endogenous products, whereas chylomicrons transport exogenous (dietary) products (LOINC).",,,,,,,,LOINC:LP15492-9|SNOMED_CT:102740005,"VLDL cholesterol|VLDL Cholesterol|Cholesterol.in VLDL|Cholesterol, Prebetalipoprotein|VLDL-C",,https://loinc.org/LP15492-9/,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Finding,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests3,,,,,Clinical_Microbiology_Finding,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Finding1,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_6,,,,,Clinical_Microbiology_Finding1,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Finding2,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_2,,,,,Clinical_Microbiology_Finding2,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Geographic_Location,Geographic Location,,,FALSE,,,http://example.org/irAEs.owl#Demographics,,,,,Geographic_Location,地理位置,,"The consideration of geographic location as a variable in disease incident, transmission, and control.",Potential Factor,,,,,,,,"Epidemiology, Geographic Location",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18770,,,,
http://example.org/irAEs.owl#Direct_Bilirubin_DBIL,Direct Bilirubin,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Direct_Bilirubin_DBIL,直接胆红素,,The bilirubin is bound to glucuronide to form conjugated bilirubin (direct bilirubin). Direct Bilirubin measurement is accomplished by a colorimetric method. Direct Bilirubin in biological fluids reacts with sulfanilic acid at acidic pH to produce a red colored complex. The optical density of produced color has a direct relationship with Direct Bilirubin concentration in the solution.,,,,,,,,SNOMED_CT:54462003|LOINC:LP31926-6,Direct Bilirubin|BILDIR|DBIL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64481,,,,
http://example.org/irAEs.owl#Monotherapy,Monotherapy,,,FALSE,,,http://example.org/irAEs.owl#Therapy_Method,,,,,Monotherapy,单剂治疗,,Pharmacotherapy consisting of a single agent.,,,,,,,,,Single Drug Therapy|Drug Monotherapy|Single Agent Therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C157514,,,,
http://example.org/irAEs.owl#Radiotherapy_history,Radiotherapy History,,,FALSE,,,http://example.org/irAEs.owl#Treatment_history,,,,,Radiotherapy_history,放射治疗史,,An indicator that a person previously received radiation treatment for the same condition.,Risk Factor,,,,,,,,Prior Radiation Therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C15477,,,,
http://example.org/irAEs.owl#TGAb,Thyroglobulin Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test,,,,,TGAb,抗甲状腺球蛋白抗体,,Thyroglobulin is a 660-kd protein precursor of thyroid hormones.,,,,,,,,SNOMED_CT:121128008|LOINC:LP39996-1,Thyroglobulin Ab|TGAb,,https://loinc.org/LP39996-1/,,,,
http://example.org/irAEs.owl#MyositisMyalgia,Myositis,,,FALSE,,,http://example.org/irAEs.owl#Muscular_System,,,,,MyositisMyalgia,肌炎,"A disorder characterized by inflammation involving the skeletal muscles.

Grade 1: Mild pain
Grade 2: Moderate pain associated with weakness; pain limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Pain associated with severe weakness; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C146787","An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders.",,,,,,,,ICD-11:FB3Z|MedDRA:10028653,"Inflammatory Myopathy|Inflammatory disorder of muscle|Muscle Diseases, Inflammatory",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27578,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_3,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests6,,,,,Organ_specific_Laboratory_Finding_3,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Gonads,Gonads,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,Gonads,性腺,,A reproductive system organ that produces and releases either sperm (testis) or eggs (ovary).,,,,,,,,UBERON:0000991,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12725,,,,
http://example.org/irAEs.owl#rs469490,rs469490,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs469490,,,,Risk Factor,,,,,,,"Canonical SPDI:NC_000021.9:26235945:G:A,NC_000021.9:26235945:G:T",,,https://www.ncbi.nlm.nih.gov/snp/?term=rs469490,,,,
http://example.org/irAEs.owl#anti-PAAg,Anti-ds DNA Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_9,,,,,anti-PAAg,抗双链 DNA 抗体,,"A type of antinuclear antibody that specifically targets double stranded DNA; while these antibodies are sometimes detectable in multiple different autoimmune disorders, their presence is generally considered highly specific for systemic lupus erythematosus.",,,,,,,,LOINC:LP37936-9|SNOMED_CT:76731000,Anti-Double-Stranded DNA Antibody,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C114565,,,,
http://example.org/irAEs.owl#Scleroderma,Scleroderma,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Scleroderma,硬皮病,,"A localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys.",,,,,,,,ICD-11: 4A42|MedDRA:10039710,scleroderma disease|disease scleroderma|Progressive systemic scleroderma|Dermatosclerosis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26746,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests,,,,,Organ_specific_Laboratory_Finding,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#immune_related_Adverse_Events_irAEs,Immune-related Adverse Events,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,immune_related_Adverse_Events_irAEs,免疫相关不良事件,,An adverse event affecting the immune system.,,,,,,,,,AE_IMMUNE|irAEs,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C185661,,,,
http://example.org/irAEs.owl#N_Stage,N Category,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Stage,,,,,N_Stage,N 分期,,One criteria of the TNM staging system. N refers to the extent of lymph node involvement.,Risk Factor,,,,,,,,N Classification|N Stage,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25580,,,,
http://example.org/irAEs.owl#2_49,2-49%,,,FALSE,,,http://example.org/irAEs.owl#Proportion_of_PD_L1_positive_cellsTPSCPS,,,,,_49,,,,Candidate Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Giant_Cell_Arteritis,Giant Cell Arteritis,,,FALSE,,,http://example.org/irAEs.owl#Artery,,,,,Giant_Cell_Arteritis,巨细胞动脉炎,,"An autoimmune, systemic, giant cell granulomatous arteritis predominantly involving the arteries that supply blood to the central nervous system, head and eyes. Superficial arteries of the scalp that are involved tend to be enlarged and tender. Signs and symptoms include headaches, myalgias, visual disturbances, and skin necrosis.",,,,,,,,MedDRA:10018250|ICD-11:4A44.2,"Giant Cell Arteritis, Horton|CRANIAL ARTERITIS|Horton's disease|Horton's Giant Cell Arteritis|POLYMYALGIA RHEUMATICA",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35065,,,,
http://example.org/irAEs.owl#Cardiac_Conduction_System,Cardiac Conduction System,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Cardiac_Conduction_System,心脏传导系统,,The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat,,,,,,,,UBERON:0002350,,,https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0002350,,,,
http://example.org/irAEs.owl#Varicella_Zoster_Virus,Varicella Zoster Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test-2,,,,,Varicella_Zoster_Virus,带状疱疹病毒,,"An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles.",,,,,,,,SNOMED_CT:19551004|LOINC:LP14853-3,human alphaherpesvirus 3|chickenpox virus|Human herpesvirus 3|HHV-3|VZ Viruses|VZV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71091,,,,
http://example.org/irAEs.owl#Lambert_Eaton_Myasthenic_Syndrome_LEMS,Lambert-Eaton Myasthenic Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Neuromuscular_Junction_NMJ,,,,,Lambert_Eaton_Myasthenic_Syndrome_LEMS,兰伯特-伊顿肌无力综合征,,"A rare autoimmune presynaptic disorder characterized by impairment of the impulse transmission at the neuromuscular junction. It affects predominantly the proximal muscles of the lower extremities, resulting in muscle weakness and fatigability. It has been associated with small cell lung carcinoma.",,,,,,,,MedDRA:10067685|ICD-11:8C62,Eaton Lambert Syndrome|myasthenic syndrome|Lambert-Eaton syndrome|Myopathic-Myasthenic Syndrome of Eaton-Lambert|LEMS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3155,,,,
"http://example.org/irAEs.owl#Rheumatoid_Factor,_RF",Rheumatoid Factor,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,_RF,类风湿因子,,Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.,Risk Factor,,,,,,,SNOMED_CT:77089006|LOINC:LP16738-4,RhF - Rheumatoid factor|RA Factor|RF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C805,,,,
"http://example.org/irAEs.owl#Rheumatoid_Factor,_RF1",Rheumatoid Factor,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding2,,,,,_RF1,类风湿因子,,Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.,,,,,,,,SNOMED_CT:77089006|LOINC:LP16738-4,RhF - Rheumatoid factor|RA Factor|RF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C805,,,,
"http://example.org/irAEs.owl#Rheumatoid_Factor,_RF4",Rheumatoid Factor,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,_RF4,类风湿因子,,Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.,,,,,,,,SNOMED_CT:77089006|LOINC:LP16738-4,RhF - Rheumatoid factor|RA Factor|RF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C805,,,,
"http://example.org/irAEs.owl#Rheumatoid_Factor,_RF2",Rheumatoid Factor,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding1,,,,,_RF2,类风湿因子,,Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.,,,,,,,,SNOMED_CT:77089006|LOINC:LP16738-4,RhF - Rheumatoid factor|RF - Rheumatoid factor|RA Factor|RF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C805,,,,
"http://example.org/irAEs.owl#Rheumatoid_Factor,_RF3",Rheumatoid Factor,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test1,,,,,_RF3,类风湿因子,,Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.,,,,,,,,SNOMED_CT:77089006|LOINC:LP16738-4,RhF - Rheumatoid factor|RA Factor|RF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C805,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests2,,,,,Clinical_Immunology_Test,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#History_of_interstitial_pneumonia,History of interstitial pneumonia,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,History_of_interstitial_pneumonia,间质性肺炎病史,,A record of a patient's medical background regarding interstitial pneumonia.,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Test2,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_5,,,,,Clinical_Microbiology_Test2,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Immunotherapy_associated_Osteitis,Bone Necrosis,,,FALSE,,,http://example.org/irAEs.owl#Skeletal_System,,,,,Immunotherapy_associated_Osteitis,骨坏死,,Death of bone tissue due to traumatic or nontraumatic causes.,,,,,,,,ICD-11:FB81|MedDRA:10005994,Osteonecrosis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34880,,,,
http://example.org/irAEs.owl#C-C_motif_chemokine_ligand_5,C-X-C Motif Chemokine 5,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,C-C_motif_chemokine_ligand_5,C-X-C 基序趋化因子配体5,,"C-X-C motif chemokine 5 (114 aa, ~12 kDa) is encoded by the human CXCL5 gene. This protein is involved in both chemotaxis and activation of neutrophils.","Over Baseline, Risk Factor",,,,,,,,Chemokine (C-X-C motif) Ligand 5|Epithelial Neutrophil Activating Peptide 78|CXCL5|ENA-78,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20470,,,,
http://example.org/irAEs.owl#Indocyanine_Green_Angiography_ICGA,Indocyanine Green Angiography,,,FALSE,,,http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,,,,,Indocyanine_Green_Angiography_ICGA,吲哚菁绿血管造影,,A diagnostic imaging procedure to examine blood flow and associated pathology using intravenous indocyanine green dye.,,,,,,,,SNOMED:252823001,Indocyanine Green (ICG) Fluorescence Angiography|Angiography using indocyanine green|Indocyanine Green Fluorescence Angiography|ICGA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C175030,,,,
http://example.org/irAEs.owl#Treatment_Cycles,Treatment Cycles,,,FALSE,,,http://example.org/irAEs.owl#Trearment_Data,,,,,Treatment_Cycles,治疗周期,,"A period of active administration of a pharmacologic substance or other therapy, followed by a period of rest that is repeated on a regular schedule.",,,,,,,,,Cycle,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C223182,,,,
http://example.org/irAEs.owl#POU2AF1,POU Class 2 Associating Factor 1,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,POU2AF1,POU2 类相关因子 1,,Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex.|POU Class 2 Associating Factor 1,,,,,,,,NCBI Gene ID: 5450,BOB1|OBF-1|OBF1|OCAB|POU2AF1,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C97730,,,,
http://example.org/irAEs.owl#Platelet_to_Lymphocyte_Ratio_PLR,Platelet-to-Lymphocyte Ratio,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Platelet_to_Lymphocyte_Ratio_PLR,血小板与淋巴细胞比值,,"The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios (PubMed).","Over Baseline, Risk Factor",,,,,,,,PLR,,https://pubmed.ncbi.nlm.nih.gov/30809980/,,,,
http://example.org/irAEs.owl#Ophthalmoplegia,Ophthalmoplegia,,,FALSE,,,http://example.org/irAEs.owl#Ocular_Muscle,,,,,Ophthalmoplegia,眼肌麻痹,,Weakness or paralysis of at least one of the muscles controlling the movement of the eye. It results from degeneration of the muscles or the neural pathways involved in the eye movement. Representative disorders causing ophthalmoplegia include ocular myopathies and multiple sclerosis.,,,,,,,,MedDRA:10030875|ICD-11:9D01,Paralysis of extraocular eye movement|Paralysis oculomotor|Extraocular muscle paralysis|Muscle paralysis eye|Eye muscle paralysis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C79697,,,,
http://example.org/irAEs.owl#Pembrolizumab,Pembrolizumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Pembrolizumab,帕博利珠单抗,,"A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity.",,,,,,,,DrugBank ID:DB09037,BCD-201|GME751|MK 3475|QL2107|RPH-075|SB-27|SCH900475,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106432,,,,
http://example.org/irAEs.owl#Pembrolizumab=,Pembrolizumab & Ipilimumab,,,FALSE,,,http://example.org/irAEs.owl#PD-1/CTLA-4_dual_immune_checkpoint_inhibitor_combination,,,,,irAEs.owl#Pembrolizumab=,,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#不孕,Female Infertility,,,FALSE,,,http://example.org/irAEs.owl#卵巢,,,,,不孕,女性不孕,,Infertility in a woman.,,,,,,,,ICD-11:GA31|MedDRA:10016398,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C181774,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_13,,,,,Clinical_Chemistry_Finding3,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Complement_Component-42,Complement Component-4,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,Complement_Component-42,补体C4,,"Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.",,,,,,,,LOINC:LP16371-4|SNOMED_CT:300899005,Complement C4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70618,,,,
http://example.org/irAEs.owl#MMR,deficient Mismatch Repair,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,MMR,错配修复功能缺陷,,A finding indicating that a cellular sample has a functional loss of a protein involved in the DNA mismatch repair process.,Risk Factor,,,,,,,,MMR Protein Deficiency|MMR Protein Deficient|Mismatch Repair Protein Deficiency|dMMR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C137827,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_5,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests,,,,,Clinical_Microbiology_5,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Demographics,Demographics,,,FALSE,,,http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,,,,,Demographics,人口统计学,,"The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income).",,,,,,,,,Demographic Factor|Demographic Factors,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16495,,,,
http://example.org/irAEs.owl#Acrodermatitis,Acrodermatitis,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Acrodermatitis,肢端皮炎,,"An inflammatory skin condition affecting children. It is often associated with Epstein-Barr virus infection, hepatitis B infection or cytomegalovirus infection. It is characterized by the presence of cutaneous rashes and patches on the palms and soles. The trunk is not affected.",,,,,,,,ICD-11:EA90.41|MedDRA:10000593,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84532,,,,
"http://example.org/irAEs.owl#Antineutrophil_Cytoplasmic_Antibody,_ANCA",Antineutrophil Cytoplasmic Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,_ANCA,抗中性粒细胞胞浆抗体,,An autoantibody that recognizes antigens found in the cytoplasm of neutrophils.,,,,,,,,LOINC:LP39202-4|SNOMED_CT:23318004,"Anti-neutrophil cytoplasmic antibodies|Antibody, Antineutrophil Cytoplasmic|Neutrophil cytoplasmic Antibody|Neutrophil Cytoplasmic Autoantibody|Neutrophil cytoplasmic Ab|ANCA",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129400,,,,
"http://example.org/irAEs.owl#Antineutrophil_Cytoplasmic_Antibody,_ANCA1",Antineutrophil Cytoplasmic Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,_ANCA1,抗中性粒细胞胞浆抗体,,An autoantibody that recognizes antigens found in the cytoplasm of neutrophils.,,,,,,,,LOINC:LP39202-4|SNOMED_CT:23318004,"Anti-neutrophil cytoplasmic antibodies|Antibody, Antineutrophil Cytoplasmic|Neutrophil cytoplasmic Antibody|Neutrophil Cytoplasmic Autoantibody|Neutrophil cytoplasmic Ab|ANCA",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129400,,,,
http://example.org/irAEs.owl#Pancreatitis,Pancreatitis,,,FALSE,,,http://example.org/irAEs.owl#Pancreas,,,,,Pancreatitis,胰腺炎,"A disorder characterized by inflammation of the pancreas with no documented pancreas infection.

Grade 2: Radiologic findings only
Grade 3: Severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220645",Inflammation of the pancreas.,,,,,,,,ICD-11:DC32|MedDRA:10033645,Inflammatory Pancreatic Disease,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3306,,,,
http://example.org/irAEs.owl#Smoking_History,Smoking History,,,FALSE,,,http://example.org/irAEs.owl#Life_Style,,,,,Smoking_History,吸烟史,,The history of when and what an individual smoke(s) or smoked.,Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C156825,,,,
http://example.org/irAEs.owl#Endocardium,Endocardium,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Endocardium,心内膜,,The layer of endothelial cells and connective tissue lining the chambers of the heart.,,,,,,,,UBERON:0002165,Endocardial|Endocardium structure,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C13004,,,,
http://example.org/irAEs.owl#Camrelizumab,Camrelizumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Camrelizumab,卡瑞利珠单抗,,"A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1,) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody SHR-1210 binds to and blocks the binding of PD-1, expressed on activated T-lymphocytes, B-cells and natural killer (NK) cells, to its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs). This prevents the activation of PD-1 and its downstream signaling pathways. This restores immune function through the activation of cytotoxic T-lymphocytes (CTLs) and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.",,,,,,,,DrugBank ID:DB14776,AiRuiKa|Erica|HR301210|SHR 1210,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C123816,,,,
http://example.org/irAEs.owl#VKHD_like_Uveitis,Vogt-Koyanagi-Harada Disease-like Uvritis,,,FALSE,,,http://example.org/irAEs.owl#Uvea,,,,,VKHD_like_Uveitis,VKHD 样葡萄膜炎,,"A systemic inflammatory process affecting the inner ear, eyes, skin, and meninges. It is manifested with hearing disorders, panuveitis, alopecia, poliosis, vitiligo, neck stiffness, headaches, and focal neurologic signs.",,,,,,,,"MedDRA:10082001|ICD-11:9A96.1
ICD-11:ED63.3","VKH syndrome|Harada disease|Vogt's disease|Vogt-Koyanagi-Harada disease|Uveomeningoencephalitic Syndrome|Syndrome, VKH (Vogt Koyanagi Harada)|VKHD-like Uveitis",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85218,,,,
http://example.org/irAEs.owl#3,ECOG 3,,,FALSE,,,http://example.org/irAEs.owl#Eastern_Cooperative_Oncology_Group_Performance_Status_ECOG_PS,,,,,irAEs.owl#3,东部肿瘤协作组 3分,,"Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours.",Risk Factor,,,,,,,,ECOG Performance Status 3,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C105726,,,,
http://example.org/irAEs.owl#Thyroid,Thyroid,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,Thyroid,甲状腺,,An endocrine gland located at the base of the neck that produces and secretes thyroxine and other hormones. Thyroxine is important for metabolic control.,,,,,,,,UBERON:0002046,Thyroid Gland,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12400,,,,
http://example.org/irAEs.owl#Cardiac_Valves,Cardiac Valves,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Cardiac_Valves,心脏瓣膜,,"Any of the four heart valves, including the two atrioventricular valves and the two semilunar valves, which regulate the flow of blood through the chambers of the heart.",,,,,,,,UBERON:0000946,Valve of heart|Heart valve,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12729,,,,
http://example.org/irAEs.owl#NSCLC,Non-small Cell Lung Cancer,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer,,,,,NSCLC,非小细胞肺癌,,"A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.",,,,,,,,MedDRA:10061873|ICD-11:2C25.Y,Non-Small Cell Carcinoma of Lung|Non-Small Cell Cancer of the Lung|Lung Non-Small Cell Carcinoma|NSCLC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2926,,,,
http://example.org/irAEs.owl#Lactate_Dehydrogenase_LDH,Lactate Dehydrogenase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Lactate_Dehydrogenase_LDH,乳酸脱氢酶,,"A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.","Over Baseline, Risk Factor",,,,,,,LOINC:LP15033-1|SNOMED_CT:259319003,L-(+)-Lactate Dehydrogenase|L-Lactic Acid Dehydrogenase|LDH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25184,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test5,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Non_Organ_Special_Laboratory_Finding,,,,,Clinical_Immunology_Test5,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,Immunological Laboratory Method|Immunology Test|Immunoassay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Computerized_Tomography_(CT),Computerized Tomography,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies5,,,,,irAEs.owl#Computerized_Tomography_(CT),计算机断层扫描,,A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.,,,,,,,,SNOMED_CT:77477000|LOINC:LP6207-7,Computed Axial Tomography|Diagnostic CAT Scan|CAT|CAT Scan|CT|CT Scan,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17204,,,,
http://example.org/irAEs.owl#Cerebellum,Cerebellum,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Cerebellum,小脑,,"The portion of the brain located at the base of the skull that is responsible for balance, equilibrium and movement.",,,,,,,,UBERON:0002037,"BRAIN, CEREBELLUM",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12445,,,,
"http://example.org/irAEs.owl#Blood_Urea_Nitrogen,_BUN2",Blood Urea Nitrogen,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test2,,,,,_BUN2,血尿素氮,,The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.,,,,,,,,SNOMED_CT:95971004|LOINC:LP14492-0,urea nitrogen|BUN|Blood Urea,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1753,,,,
http://example.org/irAEs.owl#Ureteritis,Ureteritis,,,FALSE,,,http://example.org/irAEs.owl#Ureter,,,,,Ureteritis,输尿管炎,,An acute or chronic inflammatory process affecting the ureter.,,,,,,,,MedDRA:10051250|ICD-11:GB90.Y,"Inflammation of ureter|ureter inflammation|Ureteritis, NOS",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78666,,,,
http://example.org/irAEs.owl#Thyroglobulin_Antibody,Thyroglobulin Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Thyroglobulin_Antibody,抗甲状腺球蛋白抗体,,Thyroglobulin is a 660-kd protein precursor of thyroid hormones.,Risk Factor,,,,,,,SNOMED_CT:121128008|LOINC:LP39996-1,Thyroglobulin Ab|TGAb,,https://loinc.org/LP39996-1/,,,,
http://webprotege.stanford.edu/RDPJCwFs1yEp0lo2kkoBYrW,Tremelimumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_CTLA_4,,,,,RDPJCwFs1yEp0lo2kkoBYrW,曲美木单抗,,"A human IgG2 monoclonal antibody directed against the T-cell receptor protein cytotoxic T-lymphocyte-associated protein 4 (CTLA4). Tremelimumab binds to CTLA4 and blocks the binding of the antigen-presenting cell ligands B7-1 and B7-2 to CTLA4, resulting in inhibition of B7-CTLA4-mediated downregulation of T-cell activation; subsequently, B7-1 or B7-2 may interact with another T-cell surface receptor protein, CD28, resulting in a B7-CD28-mediated T-cell activation unopposed by B7-CTLA4-mediated inhibition.",,,,,,,,DrugBank ID:DB11771,Ticilimumab|CP 675|CP 675206|Imjudo,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49085,,,,
http://example.org/irAEs.owl#TSH,Thyroid-Stimulating Hormone,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding2,,,,,TSH,促甲状腺激素,,A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.,,,,,,,,SNOMED_CT:61167004|LOINC:LP14487-0,Thyrotropic Hormone|Thyrotropin|Thyreotropin|TSH,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2280,,,,
http://example.org/irAEs.owl#TSHR,FANCD2/FANCI-Associated Nuclease 1,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,TSHR,FANCD2/FANCI 相关核酸酶 1,,This gene is involved in the regulation of DNA repair.,,,,,,,,NCBI Gene ID: 22909,FAN1|FAN1 Gene,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C92478,,,,
http://example.org/irAEs.owl#Retina,Retina,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Retina,视网膜,,A light-sensitive membrane that lines the back wall of the eyeball. The retina is continuous with the optic nerve and this way transmits optical images to the brain.,,,,,,,,UBERON:0000966,retina of camera-type eye|inner layer of eyeball,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12343,,,,
http://example.org/irAEs.owl#Ocular_Muscle,Ocular Muscle,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Ocular_Muscle,眼肌,,A muscle that is part of the eye region.,,,,,,,,UBERON:0004277,,,https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0004277,,,,
http://example.org/irAEs.owl#Brochiolitis_and_Fully_Reversible_Bromchiectasis,Bronchiectasis,,,FALSE,,,http://example.org/irAEs.owl#Trachea_Bronchus,,,,,Brochiolitis_and_Fully_Reversible_Bromchiectasis,支气管扩张症,,"Segmental, irreversible dilation of the bronchial tree resulting in the accumulation of secretions which leads to obstruction. The most common cause is bacterial infection.",,,,,,,,ICD-11: CA26|MedDRA:10006445,Chronic dilatation of bronchus and bronchiole|Permanent enlargement of the airways of the lungs,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84475,,,,
http://example.org/irAEs.owl#Pulmonary_Function_Tests_PFTs,Pulmonary Function Tests,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_3,,,,,Pulmonary_Function_Tests_PFTs,肺功能检查,,A broad range of tests that are performed to assess how well lungs inhale and exhale air and how efficiently they transfer oxygen into the blood.,,,,,,,,SNOMED_CT:23426006|LOINC:52485-0,lung function test|Lung function|Pulmonary Function Testing|PTFs,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38081,,,,
http://example.org/irAEs.owl#Hypertension,History of Hypertension,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,Hypertension,高血压病史,,"History of hypertension refers to a prior diagnosis of hypertension, defined as office blood pressure ≥140/90 mmHg on three separate non-consecutive days, or regular use of antihypertensive medications.",Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Insurance_Type,Insurance Type,,,FALSE,,,http://example.org/irAEs.owl#Social_Economics_and_Lifestyle,,,,,Insurance_Type,保险类型,,"A mechanism for guarding against financial aspects of risk by making payments in the form of premiums to an insurance company, which pays an agreed-upon sum to the insured in the event of loss.",Protective Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16745,,,,
http://example.org/irAEs.owl#Age,Age,,,FALSE,,,http://example.org/irAEs.owl#Demographics,,,,,Age,年龄,,Time elapsed after birth.,"＞50 years, Risk Factor",,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25150,,,,
http://example.org/irAEs.owl#HIV,Human Immunodeficiency Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_5,,,,,HIV,人类免疫缺陷病毒,,"The virus isolated and recognized as the etiologic agent of AIDS. HIV-1 is classified as a lentivirus, a subtype of retroviruses.",,,,,,,,LOINC:LP17126-1|SNOMED_CT:19030005,Virus-HIV|HIV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14219,,,,
http://example.org/irAEs.owl#rs10204525,rs10204525,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs10204525,,,C/T single-nucleotide variation in the PDCD1 gene on chromosome 2,Risk Factor,,,,,,,Position:chr2:241850169 (GRCh38.p14)|Gene:PDCD1,,,https://www.ncbi.nlm.nih.gov/snp/rs10204525/,,,,
http://example.org/irAEs.owl#肿瘤特征,Oncoligic Features,,,FALSE,,,http://example.org/irAEs.owl#Impact_Factors,,,,,肿瘤特征,肿瘤特征,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Lipid_Panel,Lipid Panel,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_12,,,,,Lipid_Panel,血脂检测,,"Lipid profile test is a clinical blood test that measures the levels of key lipid components in the blood, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). It is a core tool for assessing the risk of cardiovascular diseases such as atherosclerosis, coronary heart disease, and stroke, and guiding the diagnosis and treatment of dyslipidemia (AHA).",,,,,,,,LOINC:LP433165-0|SNOMED_CT:16254007,,,https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/what-your-cholesterol-levels-mean,,,,
http://example.org/irAEs.owl#C-X-C_motif_chemokine_ligand_10,C-X-C motif chemokine ligand 10,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,C-X-C_motif_chemokine_ligand_10,C-X-C 基序趋化因子配体 10,,"C-X-C motif chemokine 10 (98 aa, ~11 kDa) is encoded by the human CXCL10 gene. This protein is involved in chemotaxis of monocytes and T-lymphocytes.",Risk Factor,,,,,,,,Interferon gamma-induced protein 10|CXCL10|Gamma IP10,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C28756,,,,
http://example.org/irAEs.owl#基地细胞癌,Basal Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#皮肤和附属器,,,,,基地细胞癌,基底细胞癌,,A carcinoma involving the basal cells.,,,,,,,,MedDRA:10004146|ICD-11:2C32,Malignant Basal Cell Neoplasm,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C156767,,,,
http://example.org/irAEs.owl#Cornea,Cornea,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Cornea,角膜,,"A dome-shaped, transparent, avascular tissue covering the front of the eye. It is composed of five layers: squamous epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. Refraction of light contributing to eye's focusing ability is its characteristic function. It contains unmyelinated nerve endings which are responsible for the high sensitivity of the tissue.",,,,,,,,UBERON:0000964,Human Cornea,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12342,,,,
http://example.org/irAEs.owl#宫颈癌,Cervical Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#女性生殖系统及乳腺,,,,,宫颈癌,宫颈癌,,A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are squamous cell carcinoma and adenocarcinoma.,,,,,,,,MedDRA:10008229|ICD-11:2C77,Cervical Cancer|Cancer of Cervix|Carcinoma of Cervix|Cancer of the Uterine Cervix,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9039,,,,
http://example.org/irAEs.owl#Capillary,Capillary,,,FALSE,,,http://example.org/irAEs.owl#Disease_12,,,,,Capillary,毛细血管,,A tiny vessel that can be either a blood capillary or a lymphatic capillary.,,,,,,,,UBERON:0001982,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12685,,,,
http://example.org/irAEs.owl#wujingzheng,Azoospermia,,,FALSE,,,http://example.org/irAEs.owl#睾丸,,,,,wujingzheng,无精症,"A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen.

Grade 2: Absence of sperm in ejaculate
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143312",Complete absence of spermatozoa in the semen.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C80076,,,,
"http://example.org/irAEs.owl#Nerve_Conduction_Velocity_Test,_NCV1",Nerve Conduction Velocity Test,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_4,,,,,_NCV1,神经传导速度测试,,A test that measures the speed of nerve activity along the length of a nerve. It is used to detect nerve damage or dysfunction.,,,,,,,,"SNOMED_CT:251568004|LOINC:LP429025-2
LOINC:LP429031-0",Nerve Conduction Velocity|NCV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C88502,,,,
"http://example.org/irAEs.owl#Interleukin-2,_IL-2",Interleukin-2,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test,,,,,_IL-2,白介素-2,,"Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.",,,,,,,,SNOMED_CT:68945006|LOINC:LP16470-4,T Cell Growth Factor|Interleukin II|IL2 Protein|IL-2|TSF|hIL-2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20507,,,,
http://example.org/irAEs.owl#Aute_Coronary_Syndrome_ACSCoronary_Toxicity,Acute Coronary Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Coronary_Artery,,,,,Aute_Coronary_Syndrome_ACSCoronary_Toxicity,急性冠脉综合征,A disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.,Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.,,,,,,,,MedDRA:10051592|ICD-11: BA4Z,ACS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C53652,,,,
"http://example.org/irAEs.owl#Arterial_Blood_Gas,_ABG",Arterial Blood Gas,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_3,,,,,_ABG,动脉血气分析,,A measurement of blood gas levels done for diagnostic purposes.,,,,,,,,SNOMED_CT:60170009|LOINC:24336-0,Measurement of systemic arterial blood gases|Blood Gas Analysis|Diagnostic Blood Gas Testing|Blood Gases|Arterial blood gas analysis|ABG|BG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71252,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_3,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests6,,,,,Clinical_Humoral_and_Pathological_Examination_3,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#脊索瘤,Chordoma,,,FALSE,,,http://example.org/irAEs.owl#软组织肿瘤,,,,,脊索瘤,脊索瘤,,"A low-grade malignant neoplasm that arises from the remnants of the fetal notochord. It affects almost exclusively the axial skeleton (skull and spine) and very rarely the appendicular skeleton and soft tissue. Although it can occur at all ages, it is more frequently seen in middle-aged adults. It tends to recur and may metastasize. The most common sites of metastasis are lung, bone, lymph nodes, and subcutaneous tissue.",,,,,,,,ICD-11:XH9GH0|MedDRA:10008747,"CHORDOMA, MALIGNANT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2947,,,,
http://example.org/irAEs.owl#Disease_6,Disease,,,FALSE,,,http://example.org/irAEs.owl#Nervous_System,,,,,Disease_6,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Culture1,Microbial Culture,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test3,,,,,Culture1,微生物培养,,Any laboratory procedure for growing microorganisms.,,,,,,,,SNOMED_CT:61594008|LOINC:LP6209-3,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25300,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_5,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,,,,,Organ_specific_Laboratory_Finding_5,实验室检查,,,,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#TPPA,Treponema Pallidum,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding1,,,,,TPPA,梅毒螺旋体,,"This panel includes terms to report both reagin antibody and Treponema pallidum total, IgG, and IgM antibodies by a variety of methods in serum specimens.",,,,,,,,SNOMED_CT:72904005|LOINC:LP14042-3,Microspironema pallidum|TP - Treponema pallidum|Spirillum pallidum|Spirochaeta pallida|T. palidum|TP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C86825,,,,
http://example.org/irAEs.owl#宫颈鳞癌,Cervical Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#宫颈癌,,,,,宫颈鳞癌,宫颈鳞状细胞癌,,A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis.,,,,,,,,MedDRA:10041848|ICD-11:2C77,Cervix Uteri Squamous Cell Carcinoma|Cervical Squamous Cell Cancer|Squamous Cell Carcinoma of Cervix|Squamous Cell Carcinoma of Cervix Uteri,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4028,,,,
http://example.org/irAEs.owl#Fanconi_syndrome,Fanconi Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Fanconi_syndrome,范尼可综合征,,"A genetic or acquired disorder characterized by impairment of the function of the proximal tubules of the kidney. It results in decreased reabsorption of electrolytes, glucose, amino acids, and other nutrients.",,,,,,,,MedDRA:10016219,De Toni-Debre-Fanconi Syndrome|Lignac-Fanconi Syndrome,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3034,,,,
http://example.org/irAEs.owl#Magnetic_Resonance_Angiography_MRA,Magnetic Resonance Angiography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_9,,,,,Magnetic_Resonance_Angiography_MRA,磁共振血管造影,,Angiography using magnetic resonance imaging.,,,,,,,,SNOMED_CT:241663008,"Magnetic resonance angiography|Magnetic resonance imaging of vessels|Angiography, Magnetic Resonance|MR Angiography|MA|MRA",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C190557,,,,
http://example.org/irAEs.owl#Muscular_System,Muscular System,,,FALSE,,,http://example.org/irAEs.owl#Disease_3,,,,,Muscular_System,肌肉系统,,One of the contractile organs of the body.,,,,,,,,UBERON:0000383,Muscle|Muscular,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C13056,,,,
http://example.org/irAEs.owl#Male,Male,,,FALSE,,,http://example.org/irAEs.owl#Sex,,,,,Male,男,,An individual who belongs to the sex that normally produces sperm.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20197,,,,
http://example.org/irAEs.owl#Oral_dysesthesia,Oral Dysesthesia,,,FALSE,,,http://example.org/irAEs.owl#Oral,,,,,Oral_dysesthesia,口腔感觉异常,"A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.

Grade 1: Mild discomfort; not interfering with oral intake
Grade 2: Moderate pain; interfering with oral intake
Grade 3: Disabling pain; tube feeding or TPN indicated
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143716","A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.",,,,,,,,ICD-11:DA0F.0|MedDRA:10054520,Burning Mouth Syndrome,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62545,,,,
http://example.org/irAEs.owl#胶质母细胞瘤,Glioblastoma,,,FALSE,,,http://example.org/irAEs.owl#神经系统,,,,,胶质母细胞瘤,胶质母细胞瘤,,"The most malignant astrocytic tumor (WHO grade 4). It is composed of poorly differentiated neoplastic astrocytes and is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation, and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres.",,,,,,,,ICD-11:2A00.00|MedDRA:10018336,"CNS, glioblastoma (GBM)|Glioblastoma Multiforme|Spongioblastoma multiforme|GBM",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3058,,,,
http://example.org/irAEs.owl#Molecular_Genetic_Finding3,Molecular Genetic Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Biomarker,,,,,Molecular_Genetic_Finding3,分子遗传学生物标志物,,Genetic testing done to determine the cause of a disease.,,,,,,,,SNOMED_CT:405825005,Diagnostic Clinical Genetics Service Type|Diagnostic Clinical Genetics Testing|Clinical Genetics,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C217381,,,,
http://example.org/irAEs.owl#Pleura,Pleura,,,FALSE,,,http://example.org/irAEs.owl#Disease_5,,,,,Pleura,胸膜,,The tissue that lines the wall of the thoracic cavity and the surface of the lungs.,,,,,,,,UBERON:0000977,PLEURAL TISSUE|wall of pleural sac,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12469,,,,
http://example.org/irAEs.owl#Activated_Partial_Thromboplastin_Time_APTT,Activated Partial Thromboplastin Time,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,Activated_Partial_Thromboplastin_Time_APTT,活化部分凝血活酶时间,,A measurement of the length of time that it takes for clotting to occur when activating reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture.,,,,,,,,LOINC:LP15957-1|SNOMED_CT:42525009,"Plasma Thromboplastin Test|Thromboplastin Time, Partial|aPTT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38462,,,,
http://example.org/irAEs.owl#Disease_3,Disease,,,FALSE,,,http://example.org/irAEs.owl#Musculoskeletal_System_and_Connective_Tissue,,,,,Disease_3,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Hair,Hair,,,FALSE,,,http://example.org/irAEs.owl#Disease_2,,,,,Hair,头发,,The filamentous outgrowth of the epidermis.,,,,,,,,UBERON:0001037,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C32705,,,,
http://example.org/irAEs.owl#hepatocellular_carcinoma,Hepatocellular Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,hepatocellular_carcinoma,肝细胞癌,,"A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.",,,,,,,,MedDRA:10073071|ICD-11:2C12.02,Hepatocellular Cancer|Carcinoma of Liver Cells|Liver Cell Carcinoma|Primary Carcinoma of Liver Cells|HCC|LIHC|hepatoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3099,,,,
http://example.org/irAEs.owl#Endocrine_and_Neuroendocrine_Tumours,Endocrine and Neuroendocrine Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,Endocrine_and_Neuroendocrine_Tumours,内分泌器官肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Intermediate_Density_Lipoprotein_Cholesterol_IDL_C,Intermediate-Density Lipoprotein Cholesterol,,,FALSE,,,http://example.org/irAEs.owl#Lipid_Panel,,,,,Intermediate_Density_Lipoprotein_Cholesterol_IDL_C,中间密度脂蛋白胆固醇,,"IDL (Intermediate-density lipoprotein) is a triglyceride rich, apo B-containing, lipoprotein intermediate in density and size between LDL and VLDL. Moderately increased levels of IDL cholesterol are closely associated with a high frequency of coronary artery disease (LOINC).",,,,,,,,LOINC:LP15490-3|SNOMED_CT:259569005,Intermediate Density Lipoprotein Cholesterol Measurement|IDL Cholesterol|IDL; Intermediate Density Lipoprotein|IDL-C,,https://loinc.org/LP15490-3,,,,
http://example.org/irAEs.owl#T4,Thyroxine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,T4,甲状腺素,,"A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function.",,,,,,,,LOINC:LP15900-1|SNOMED_CT:73187006,"L-3,5,5'-tetraiodothyronine|L-Thyroxine|levothyroxine|L-T4|T4",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2302,,,,
http://example.org/irAEs.owl#TB,Mycobacterium tuberculosis,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test2,,,,,TB,结核分枝杆菌,,"An obligate anaerobic, weakly Gram-positive species of mycobacterium that is the cause of most cases of tuberculosis.",,,,,,,,SNOMED_CT:113861009|LOINC:LP16659-2,Bacillus tuberculosis|TB bacillus|Human tubercle bacillus|Bacterium tuberculosis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C76370,,,,
http://example.org/irAEs.owl#T3,Triiodothyronine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,T3,三碘甲状腺原氨酸,,"A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity.",,,,,,,,LOINC:LP15922-5|SNOMED_CT:61275002,"Liothyronine|3,3',5-triiodo-L-thyronine|T3",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2303,,,,
http://example.org/irAEs.owl#IL-6,Interleukin-6,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_9,,,,,IL-6,白介素-6,,"Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells.",,,,,,,,LOINC:LP16474-6|SNOMED_CT:30965005,B-Cell Stimulatory Factor-2|CTL Differentiation Factor|BSF-2|HPGF|HSF|IFN-Beta-2|IL-6,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20451,,,,
http://example.org/irAEs.owl#IL-2,Interleukin-2,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_9,,,,,IL-2,白介素-2,,"Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.",,,,,,,,SNOMED_CT:68945006|LOINC:LP16470-4,T Cell Growth Factor|IL2 Protein|hIL-2|IL-2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20507,,,,
http://example.org/irAEs.owl#Mean_Platelet_Volume,Mean Platelet Volume,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Mean_Platelet_Volume,平均血小板体积,,The determination of the average size of the platelets present in a blood sample.,"Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Disease_4,Disease,,,FALSE,,,http://example.org/irAEs.owl#Renal_and_Urinary_System,,,,,Disease_4,疾病,,"Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.",,,,,,,,,Disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2991,,,,
http://example.org/irAEs.owl#Infusion_Related_Reaction_IRR,Infusion-Related Reaction,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Infusion_Related_Reaction_IRR,输液相关反应,"A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.

Grade 1: Mild transient reaction; infusion interruption not indicated; intervention not indicated
Grade 2: Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs
Grade 3: Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143583","A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may include pruritus, flushing, swelling, dyspnea, bronchospasm, and hypotension.",,,,,,,,MedDRA:10051792|ICD-11: NE80.Z,IRR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78361,,,,
http://example.org/irAEs.owl#WRN_gene,WRN,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,WRN_gene,WRN 基因,,This gene is involved in DNA repair and the unwinding of DNA.,,,,,,,,NCBI Gene ID: 7486,RECQ3|RECQL2|RECQL3,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20070|https://www.ncbi.nlm.nih.gov/gene/7486,,,,
http://example.org/irAEs.owl#Conjunctivitis,Conjunctivitis,,,FALSE,,,http://example.org/irAEs.owl#Conjunctiva,,,,,Conjunctivitis,结膜炎,"A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.

Grade 1: Asymptomatic or mild symptoms; intervention not indicated
Grade 2: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)
Grade 3: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Best corrected visual acuity of 20/200 or worse in the affected eye
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143384",Inflammation of the conjunctiva of the eye.,,,,,,,,ICD-11:9A60|MedDRA:10010741,Pink Eye,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34504,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Test3,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Non_Organ_Special_Laboratory_Finding,,,,,Clinical_Microbiology_Test3,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Microbiology Test",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Goodpasture_Disease,Anti-Glomerular Basement Membrane Disease,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Goodpasture_Disease,抗肾小球基底膜病,,An autoimmune disorder characterized by the production of autoantibodies against type IV collagen of the glomerular basement membrane of the kidney. In the majority of patients the immune reaction also extends to the alveolar capillary membrane of the lungs. The latter cases are referred to as Goodpasture Syndrome.,,,,,,,,ICD-11:MF85|MedDRA:10081981,Goodpasture's Syndrome|Goodpasture Syndrome,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84566,,,,
http://example.org/irAEs.owl#透明细胞癌,Ovarian Clear Cell Adenocarcinofibroma,,,FALSE,,,http://example.org/irAEs.owl#卵巢癌,,,,,透明细胞癌,卵巢透明细胞癌,,A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. The epithelial component is characterized by the presence of malignant epithelial cells with clear cytoplasm.,,,,,,,,MedDRA:10073268|ICD-11:2C72.0,Ovarian Clear Cell Malignant Adenofibroma|Clear cell adenocarcinofibroma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C40079,,,,
http://example.org/irAEs.owl#Electromyography_EMG_3,Electromyography,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies1,,,,,Electromyography_EMG_3,肌电图,,"An assessment of skeletal muscle function and nerve control, obtained by recording and studying the intrinsic electrical properties of the muscles.",,,,,,,,LOINC:LP6246-5|SNOMED_CT:42803009,electromyogram|EMG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38056,,,,
http://example.org/irAEs.owl#Viral_Serology_7,Viral Serology,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test3,,,,,Viral_Serology_7,血清病毒学,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Absolute_Eosinophil_Count,Absolute Eosinophil Count,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Absolute_Eosinophil_Count,绝对嗜酸性粒细胞计数,,The total number of white blood cells that are eosinophils. It is calculated by multiplying the white blood cell count by the percent of eosinophils in the differential white blood cell count.,"Over Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#anti-mi2,Anti-Mi-2 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,anti-mi2,抗Mi-2抗体,,association between autoantibodies to Mi-2 antigen in calf thymus extract & dermatomyositis (MeSH).,,,,,,,,SNOMED_CT:767025005|LOINC:LP39015-0,Mi-2 Antibody|Antibody to Mi-2|Mi-2 Ab,,https://www.ncbi.nlm.nih.gov/mesh/?term=Mi-2+antibodies,,,,
http://example.org/irAEs.owl#附睾睾丸炎,Epididymo-Orchitis,,,FALSE,,,http://example.org/irAEs.owl#睾丸,,,,,附睾睾丸炎,附睾睾丸炎,,"Inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation.",,,,,,,,ICD-11:GB02|MedDRA:10015005,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C97145,,,,
http://example.org/irAEs.owl#Grade_1,Grade 1,,,FALSE,,,http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,,,,,Grade_1,1 级,,Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Systemic_Lupus_Erythematosus_SLE,Systemic Lupus Erythematosus,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Systemic_Lupus_Erythematosus_SLE,系统性红斑狼疮,,An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.,,,,,,,,MedDRA:10042945|ICD-11: 4A40.0,"SLE - Lupus Erythematosus, Systemic|Lupus syndrome|Lupus erythematosus systemic|LUPUS, ERYTHEMATOSUS, SYSTEMIC|Systemic lupus erythematosus, unspecified|SLE",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3201,,,,
http://example.org/irAEs.owl#Endocrine_System,Endocrine System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Endocrine_System,内分泌系统,,"The body system that comprises the organs and glands that produce hormones that are secreted into the blood and control physiological functions that include reproduction, growth and development, metabolism, and stress responses.",,,,,,,,SOC:10014698|UBERON:0000949,"Body System, Endocrine/Metabolic|Hormonal System|Endocrine/Metabolic Organ System",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12705,,,,
http://example.org/irAEs.owl#Pericardium,Pericardium,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Pericardium,心包,,A conical membranous sac filled with serous fluid in which the heart as well as the roots of the aorta and other large blood vessels are contained.,,,,,,,,UBERON:0002407,Serous sac of pericardium|Pericardial sac structure|Pericardial structure|Human Pericardium,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C13005,,,,
http://example.org/irAEs.owl#Pericardial_Effusion_Cardiac_Tamponade,Pericardial Effusion,,,FALSE,,,http://example.org/irAEs.owl#Pericardium,,,,,Pericardial_Effusion_Cardiac_Tamponade,心包积液,"A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.

Grade 2: Asymptomatic effusion size small to moderate
Grade 3: Effusion with physiologic consequences
Grade 4: Life-threatening consequences; hospitalization
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143743","Fluid collection within the pericardial sac, usually due to inflammation.",,,,,,,,MedDRA:10034474|ICD-11:BB25,"Fluid, Pericardial|Pericardial Fluid",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3319,,,,
http://example.org/irAEs.owl#Immunohistochemistry_5,Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination_6,,,,,Immunohistochemistry_5,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Immunohistochemistry Staining Method|Cell/Tissue, Immunohistochemistry",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
http://example.org/irAEs.owl#Immunohistochemistry_6,Immunohistochemistry,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination_7,,,,,Immunohistochemistry_6,免疫组织化学,,"Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.",,,,,,,,SNOMED_CT:708097004,"Immunohistochemistry Staining Method|Cell/Tissue, Immunohistochemistry|IHC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C23020,,,,
http://example.org/irAEs.owl#Infectious_Diseases,Infectious Lung Disorder,,,FALSE,,,http://example.org/irAEs.owl#Lung,,,,,Infectious_Diseases,感染性肺部疾病,,,,,,,,,,ICD-11:CA40.0|MedDRA:10061229,Pulmonary Tuberculosis: Lung Tuberculosis|Pulmonary TB|Pneumocystis carinii Pneumonia|Pneumocystis Pneumonia: PJP|Pneumocystis jirovecii Pneumonia|Lung TB,,"Pulmonary Tuberculosis:https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26899
Chronic Pulmonary Aspergillosis: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C186432
Pneumocystis Pneumonia: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3334",,,,
http://example.org/irAEs.owl#IL-13,Interleukin-13,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-13,白介素13,,"Interleukin-13 (146 aa, ~16 kDa) is encoded by the human IL13 gene. This protein plays a role in the negative regulation of cytokine production and the positive regulation of B-cell proliferation.","Over Basline, Risk Factor",,,,,,,SNOMED_CT:707612009|LOINC:LP31544-7,IL-13,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20515,,,,
http://example.org/irAEs.owl#精液分析,Semen Analysis,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests4,,,,,精液分析,精液分析,,Standardized laboratory tests are conducted on semen samples obtained after ejaculation to assess male fertility potential.,,,,,,,,LOINC:54231-6|SNOMED_CT:1900001,,,https://loinc.org/54231-6/,,,,
"http://example.org/irAEs.owl#Electrocardiography,_ECG",Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items,,,,,_ECG,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_6,,,,,Clinical_Chemistry_Finding1,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_Finding12,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Laboratory_Tests4,,,,,Clinical_Chemistry_Finding12,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#食管癌,Esophageal Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,食管癌,食道鳞状细胞癌,,"A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor.",,,,,,,,MedDRA:10055476|ICD-11:2B70.1,Esophageal SCC|Esophageal Squamous Cell Cancer|Esophagus SCC|SCC of Esophagus|Esophageal Epidermoid Carcinoma|ESCC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4024,,,,
http://example.org/irAEs.owl#Conjunctiva,Conjunctiva,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Conjunctiva,结膜,,"A thin, transparent tissue divided into the palpebral conjunctiva (covering the inner side of the eye lid) and the bulbar conjunctiva.",,,,,,,,UBERON:0001811,tunica conjunctiva|wall of conjunctival sac,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12341,,,,
http://example.org/irAEs.owl#胰腺癌,Pancreatic Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,胰腺癌,胰腺癌,,"A carcinoma that arises from the exocrine or endocrine pancreas. The vast majority of pancreatic carcinomas arise from the exocrine pancreas and are almost always adenocarcinomas. The main subtype of pancreatic adenocarcinoma is ductal adenocarcinoma, which is the most frequently seen type of pancreatic carcinoma. The carcinomas that arise from the endocrine pancreas (islet cells) are neuroendocrine carcinomas",,,,,,,,ICD-11:2C10|MedDRA:10033609,Pancreas Cancer|Carcinoma of Pancreas|Cancer of Pancreas,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C207229,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_10,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests5,,,,,Clinical_Humoral_and_Pathological_Examination_10,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_11,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests11,,,,,Clinical_Humoral_and_Pathological_Examination_11,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Complement_Component-3,Complement Component-3,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test1,,,,,Complement_Component-3,补体C3,,"Complement C3 (1663 aa, ~187 kDa) is encoded by the human C3 gene. This protein plays a role in complement-mediated immunity.",,,,,,,,LOINC:LP16359-9|SNOMED_CT:10473000,C3 - Complement component 3|Complement C3,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C21527,,,,
http://example.org/irAEs.owl#Complement_Component-4,Complement Component-4,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test1,,,,,Complement_Component-4,补体C4,,"Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.",,,,,,,,LOINC:LP16371-4|SNOMED_CT:300899005,Complement C4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70618,,,,
http://example.org/irAEs.owl#HLA_DQ2,Human Leukocyte Antigen DQ2,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,HLA_DQ2,人类白细胞抗原HLA-DQ2,,"HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.",Risk Factor,,,,,,,LOINC:LP14894-7|SNOMED_CT:117164003|NCBI Gene ID:3991,HLA DQ2|HLA-DQB1,,https://www.ncbi.nlm.nih.gov/gene/3119,,,,
http://example.org/irAEs.owl#FT3,Free Triiodothyronine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,FT3,游离三碘甲状腺原氨酸,,A thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone used by the tissues is mainly T3. Most of the T3 circulating in blood is bound to a protein. T3 not bound is called free T3 (LOINC).,,,,,,,,SNOMED_CT:259356007|LOINC:LP29126-7,Free T3|T3FR|FT3,,https://loinc.org/LP29126-7/,,,,
http://example.org/irAEs.owl#哮喘病史,History of Asthma,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,哮喘病史,哮喘病史,,,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#复发性多软骨炎,Relapsing Polychondritis,,,FALSE,,,http://example.org/irAEs.owl#Skeletal_System,,,,,复发性多软骨炎,复发性多软骨炎,,A rare autoimmune disorder characterized by recurrent episodes of inflammation of cartilage and other connective tissues.,,,,,,,,ICD-11:FB82.3|MedDRA:10038304,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C157268,,,,
http://example.org/irAEs.owl#淋巴上皮癌,Lymphoepithelial Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#huxi,,,,,淋巴上皮癌,淋巴上皮癌,,"A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but also in the tonsils and rarely in other anatomic sites. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate.",,,,,,,,ICD-11:2C24.1|MedDRA:10082023,Lymphoepithelioma|Schmincke Tumor|Nasopharyngeal-Type Undifferentiated Carcinoma|Lymphoepithelioma-like carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4107,,,,
http://example.org/irAEs.owl#Glomerular_Filtration_Rate_GFR,Glomerular Filtration Rate,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_4,,,,,Glomerular_Filtration_Rate_GFR,肾小球滤过率,"Grade 1: <75 - 50% LLN
Grade 2: <50 - 25% LLN
Grade 3: <25% LLN, chronic dialysis not indicated
Grade 4: Chronic dialysis or renal transplant indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55159",A kidney function test that measures the fluid volume that is filtered from the kidney glomeruli to the Bowman's capsule per unit of time.,,,,,,,,SNOMED:80274001|LOINC:LP69203-5,"Filtration Rate, Glomerular|Rates, Glomerular Filtration|GFR - glomerular filtration rate|GFR",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C90505,,,,
http://example.org/irAEs.owl#软组织肿瘤,Soft Tissue and Bone Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,软组织肿瘤,软组织及骨肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#multiple_myeloma,Multiple Myeloma,,,FALSE,,,http://example.org/irAEs.owl#Hematological_Tumors,,,,,multiple_myeloma,多发性骨髓瘤,,"A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia.",,,,,,,,ICD-11:2A83.1|MedDRA:10028228,Plasma Cell Myeloma|Kahler disease|Multiple Myeloma/Plasma Cell Myeloma|myelomatosis|Plasma Cell Myeloma/Multiple Myeloma|MM|Myeloma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3242,,,,
http://example.org/irAEs.owl#Corneal_Fluorescein_Staining,Corneal Fluorescein Staining,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_9,,,,,Corneal_Fluorescein_Staining,角膜荧光素染色,,"A vital staining method that utilizes an orange phthalic indicator dye, which emits green fluorescence in the presence of alkaline solutions.",,,,,,,,SNOMED:406859001,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C158242,,,,
http://example.org/irAEs.owl#AMA,Anti-Mitochondrial Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test-1,,,,,AMA,抗线粒体抗体,,"Anti-mitochondrial antibodies (AMA) are autoantibodies that formed against mitochondria, primarily those in cells located in the liver. The presence of AMA in the blood or serum is associated with primary biliary cirrhosis (PBC), which causes scarring of liver tissue confined primarily to the bile duct drainage system. AMA is present in about 95% of cases of PBC (LOINC).",,,,,,,,SNOMED_CT:51950007|LOINC:LP39022-6,Antimitochondrial antibody|Mitochondria Ab|AMA,,https://loinc.org/LP39022-6/,,,,
http://example.org/irAEs.owl#集合管癌,Collecting Duct Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#泌尿系统,,,,,集合管癌,集合管癌,,"Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor.",,,,,,,,MedDRA:10073252|ICD-11:2C90.0,"Renal carcinoma, collecting duct type|Collecting Duct Renal Cell Carcinoma|Carcinoma of the Collecting Ducts of Bellini|Carcinoma of Collecting Ducts of Bellini|Carcinoma of the Kidney Collecting Duct|Bellini duct carcinoma|BDC|CDC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C6194,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_6,Laboratory Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests7,,,,,Organ_specific_Laboratory_Finding_6,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Histopathological_Examination_6,Histopathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_7,,,,,Histopathological_Examination_6,组织病理学检查,,The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.,,,,,,,,SNOMED_CT:250537006,Histopathology|Histopathologic Study|Histopathological,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18190,,,,
http://example.org/irAEs.owl#Ureter,Ureter,,,FALSE,,,http://example.org/irAEs.owl#Disease_4,,,,,Ureter,输尿管,,The thick-walled tube that carries urine from each kidney to the bladder.,,,,,,,,UBERON:0000056,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12416,,,,
http://example.org/irAEs.owl#Polymerase_Chain_Reaction_PCR_2,Polymerase Chain Reaction,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test3,,,,,Polymerase_Chain_Reaction_PCR_2,聚合酶链反应,,"A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample.",,,,,,,,SNOMED_CT:258066000|LOINC:LA26418-6,PCR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17003,,,,
http://example.org/irAEs.owl#mantle_cell_lymphoma,Mantle Cell Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,mantle_cell_lymphoma,套细胞淋巴瘤,,"A non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.",,,,,,,,MedDRA:10061275|ICD-11:2A85.5,Classical Mantle Cell Lymphoma|Mantle zone lymphoma|MCL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4337,,,,
http://example.org/irAEs.owl#Electron_Microscopy_EM,Electron Microscopy,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination1,,,,,Electron_Microscopy_EM,电子显微镜检查,,Any form of microscopy in which the interactions of electrons with the specimens are used to provide information about the final structure of that specimen.,,,,,,,,LOINC:LP6395-0|SNOMED_CT:73512001,EM - Electron microscopy|Electron microscopic study|Microscopy.electron|EM,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16854,,,,
"http://example.org/irAEs.owl#Blood_Urea_Nitrogen,_BU",Blood Urea Nitrogen,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_BU,血尿素氮,,The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.,,,,,,,,SNOMED_CT:95971004|LOINC:LP14492-0,urea nitrogen|BUN|Blood Urea,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1753,,,,
"http://example.org/irAEs.owl#Blood_Urea_Nitrogen,_BUN",Blood Urea Nitrogen,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding,,,,,_BUN,血尿素氮,,The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.,,,,,,,,SNOMED_CT:95971004|LOINC:LP14492-0,urea nitrogen|BUN|Blood Urea,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1753,,,,
http://example.org/irAEs.owl#Ethnicity,Ethnicity,,,FALSE,,,http://example.org/irAEs.owl#Demographics,,,,,Ethnicity,种族,,A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease.,Potential Factor,,,,,,,,Ethnic Groups|Patient Reported Ethnicity|Ethnic Origin|Ethnic Origins,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16564,,,,
http://example.org/irAEs.owl#rs2498632C,rs2498632,,,FALSE,,,http://example.org/irAEs.owl#SNP,,,,,rs2498632C,,,,Risk Factor,,,,,,,"Canonical SPDI:NC_000009.12:10271518:T:A,NC_000009.12:10271518:T:C|Gene:PTPRD",,,https://www.ncbi.nlm.nih.gov/snp/?term=rs2498632,,,,
http://example.org/irAEs.owl#Plateled_distribution_width_PDW,Platelet Distribution Width,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Plateled_distribution_width_PDW,血小板分布宽度,,A measurement of the range of platelet sizes in a blood specimen.,,,,,,,,SNOMED_CT:250313005|LOINC:LP29639-9,PDW,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C81962,,,,
"http://example.org/irAEs.owl#Urine_Protein/_Creatinine_Ratio,_UPCR",Urine Protein/ Creatinine Ratio,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_12,,,,,_UPCR,尿蛋白与肌酐比值,,The determination of the ratio of total protein compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.,,,,,,,,LOINC: 34366-5|SNOMED_CT:313500004,UPCR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C79463,,,,
http://example.org/irAEs.owl#Sclera,Sclera,,,FALSE,,,http://example.org/irAEs.owl#Disease_10,,,,,Sclera,巩膜,,"The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)",,,,,,,,UBERON:0001773,"Human Sclera|EYE, SCLERA|White of Eye",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12784,,,,
http://example.org/irAEs.owl#腺样囊性癌,Adenoid Cystic Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#头颈部肿瘤,,,,,腺样囊性癌,腺样囊性癌,,"A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.",,,,,,,,MedDRA:10053231|ICD-11:2D4Y,Cylindroid Adenocarcinoma|Adenocystic carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2970,,,,
http://example.org/irAEs.owl#anti-dsDNA,Anti-Platelet Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_9,,,,,anti-dsDNA,抗血小板抗体,,"Antiplatelet antibodies are immunoglobulins that act as target cells for immune reactions, leading to thrombocytopenia in many autoimmune diseases (PubMed).",,,,,,,,SNOMED_CT:121129000|LOINC:LP28760-4,Platelet Ab|Platelet antibody|antibody platelet,,https://pubmed.ncbi.nlm.nih.gov/3055952/,,,,
http://example.org/irAEs.owl#Clinical_Immunology_Test6,Clinical Immunology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_12,,,,,Clinical_Immunology_Test6,临床免疫学检测,,Laboratory test involving interaction of antigens with specific antibodies.,,,,,,,,SNOMED_CT:252511003,"Immunology Test 
Immunological Laboratory Method
Immunoassay",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16723,,,,
http://example.org/irAEs.owl#Uveitis_Panuveitis,Uveitis,,,FALSE,,,http://example.org/irAEs.owl#Uvea,,,,,Uveitis_Panuveitis,葡萄膜炎,"A disorder characterized by inflammation to the uvea of the eye.

Grade 1: Anterior uveitis with trace cells
Grade 2: Anterior uveitis with 1+ or 2+ cells
Grade 3: Anterior uveitis with 3+ or greater cells; intermediate posterior or pan-uveitis
Grade 4: Best corrected visual acuity of 20/200 or worse in the affected eye
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55901","A disorder characterized by inflammation of the entire uvea which includes the iris, ciliary body, and choroid. Causes include systemic infections, sarcoidosis, and cancers.",,,,,,,,MedDRA:10046851|ICD-11:9C20,"Intraocular inflammation|uvea; inflammation|uveitis was present|Uveitis, NOS|Uveitides",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26909,,,,
"http://example.org/irAEs.owl#Human_Leukocyte_Antigen_Measurement,_HLA_Measurement",Human Leukocyte Antigen B27,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,_HLA_Measurement,人类白细胞抗原B27,,A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family (MeSH).,,,,,,,,LOINC:LP16560-2|SNOMED_CT:34453005,HLA - Human leucocyte antigen B27|Human leucocyte antigen B27,,https://www.ncbi.nlm.nih.gov/mesh/68015796,,,,
http://example.org/irAEs.owl#Funduscopy_Ophthalmoscopy,Ophthalmoscopy,,,FALSE,,,http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,,,,,Funduscopy_Ophthalmoscopy,眼底镜检查,,A technique used to examine of the back (fundus) and other anatomical structures of the eye with a magnifying instrument.,,,,,,,,LOINC:LP149841-1|SNOMED:53524009,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C120698,,,,
http://example.org/irAEs.owl#Assess_thickness_of_saliva,Whole Saliva Flow Rate,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies1,,,,,Assess_thickness_of_saliva,全唾液流率,,,,,,,,,,SNOMED_CT:251339001,,,,,,,
http://example.org/irAEs.owl#黑色素瘤,Melanoma,,,FALSE,,,http://example.org/irAEs.owl#皮肤和附属器,,,,,黑色素瘤,黑色素瘤,,"A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.",,,,,,,,MedDRA:10053571|ICD-11:2C30,Malignant Melanoma|MM,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3224,,,,
http://example.org/irAEs.owl#HLA-DRB1*11：01,Human Leukocyte Antigen DRB1*11:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,：01,人类白细胞抗原DRB1*11：01,,"HLA class II histocompatibility antigen, DRB1-11 beta chain (266 aa, ~30 kDa) is encoded by the human HLA-DRB1 gene. This protein plays a role in antigen presentation to CD4-positive T cells.",Risk Factor,,,,,,,,"Human Leukocyte Antigen DRB1*11|HLA-DRB1*11:01|HLA Class II Histocompatibility Antigen, DRB1-11 Beta Chain|HLA-DR11 ANTIGEN|DR-11|DRB1*11",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C213687,,,,
http://example.org/irAEs.owl#parathyroid_gland,Parathyroid Gland,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,parathyroid_gland,甲状旁腺,,"One of two small paired endocrine glands, superior and inferior, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; these glands secrete parathyroid hormone that regulates the metabolism of calcium and phosphorus. The parenchyma is composed of chief and oxyphilic cells arranged in anastomosing cords.",,,,,,,,UBERON:0001132,Parathyroid,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12765,,,,
http://example.org/irAEs.owl#Pancreas_Islet,Pancreas Islet,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,Pancreas_Islet,胰岛,,A pancreatic cell that produces and secretes hormones such as insulin and glucagon.,,,,,,,,UBERON:0000016,endocrine pancreas cell,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C32885,,,,
http://example.org/irAEs.owl#Tislelizumab,Tislelizumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Tislelizumab,替雷利珠单抗,,"A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tislelizumab binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands programmed cell death-1 ligand 1 (PD-L1), and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin (Ig) superfamily expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity.",,,,,,,,DrugBank ID:DB14922,Tislelizumab-jsgr|BGB A317|Tevimbra,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121775,,,,
http://example.org/irAEs.owl#结直肠腺癌,Colorectal Adenocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,结直肠腺癌,结直肠腺癌,,"The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.",,,,,,,,ICD-11:2B92.0|MedDRA:10052360|ICD-11:2B90.Y,CRA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C5105,,,,
http://example.org/irAEs.owl#Educational_Level,Educational Level,,,FALSE,,,http://example.org/irAEs.owl#Social_Economics_and_Lifestyle,,,,,Educational_Level,教育水平,,"An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools.",Protective Factor,,,,,,,,Level of Education Attained,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17953,,,,
http://example.org/irAEs.owl#Werner_Syndrome_WS,Werner Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Werner_Syndrome_WS,韦纳综合征,,"A rare, autosomal recessive syndrome caused by mutations in the WRN gene. It is characterized by the appearance of accelerated aging following puberty. It is associated with the development of diabetes mellitus, atherosclerosis, cataracts, and cancer.",,,,,,,,MedDRA:10049429|ICD-11: LD2B,Adult Progeria|Adult Premature Aging Syndrome|Werner's Syndrome|WS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3447,,,,
http://example.org/irAEs.owl#First_line,First-Line Therapy,,,FALSE,,,http://example.org/irAEs.owl#Line_of_Therapy,,,,,First_line,一线治疗,,The preferred standard treatment for a particular condition.,,,,,,,,,first-line therapy|primary therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C45792,,,,
http://example.org/irAEs.owl#Creatinine_Cr,Creatinine,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Creatinine_Cr,肌酐,,"The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.",,,,,,,,LOINC:LP14355-9|SNOMED_CT:15373003,"2-Amino-1-methyl-1,5-dihydro-4H-imidazol-4-one|Cr",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C399,,,,
http://example.org/irAEs.owl#BMI,Body Mass Index,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,BMI,体重指数,,An individual's weight in kilograms divided by the square of the height in meters.,"Below Baseline, Risk Factor",,,,,,,,Quetelet Index|BMI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16358,,,,
http://example.org/irAEs.owl#Clinical_Microbiology_Test,Clinical Microbiology Finding,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding,,,,,Clinical_Microbiology_Test,临床微生物学检测,,A laboratory procedure to detect microorganisms in a sample.,,,,,,,,SNOMED_CT:19851009,"Laboratory Testing, Microbiology|Immunoassay",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49188,,,,
http://example.org/irAEs.owl#Burkitt’s_lymphoma,Burkitt’s Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,s_lymphoma,伯基特淋巴瘤,,"A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)].",,,,,,,,MedDRA:10006595|ICD-11:2A85.6,"Small Non-Cleaved Cell Lymphoma, Burkitt's Type|Burkitt Lymphoma|BL",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2912,,,,
"http://example.org/irAEs.owl#Electrocardiography,_ECG4",Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies,,,,,_ECG4,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
http://example.org/irAEs.owl#Cirrhosis,Cirrhosis,,,FALSE,,,http://example.org/irAEs.owl#Hepatobiliary_System,,,,,Cirrhosis,肝硬化,,"A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.",,,,,,,,ICD-11:DB93.1|MedDRA:10019642,Liver Cirrhosis|Cirrhosis of the Liver|Unspecified cirrhosis of liver,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2951,,,,
http://example.org/irAEs.owl#早发性卵巢功能不全,Premature Ovarian Insufficiency,,,FALSE,,,http://example.org/irAEs.owl#卵巢,,,,,早发性卵巢功能不全,早发性卵巢功能不全,"A disorder characterized by the development of oligomenorrhea or amenorrhea for at least 3 consecutive months and serum follicle-stimulating hormone (FSH) levels in the menopausal range before age 40. Symptoms of estrogen deficiency may include hot flashes, night sweats, mood swings, and vaginal dryness. Laboratory findings include elevated serum FSH. Other supportive laboratory findings include decreased serum estradiol and anti-Mullerian hormone (AMH) levels.

Grade 1: Intermittent/irregular menses for 3 consecutive months with basal FSH levels >25 IU/L but less than postmenopausal range.
Grade 2: Amenorrhea for 3 consecutive months with basal FSH levels >40 IU/L or in the postmenopausal range.
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220661","A disorder characterized by the development of oligomenorrhea or amenorrhea for at least 3 consecutive months and serum follicle-stimulating hormone (FSH) levels in the menopausal range before age 40. Symptoms of estrogen deficiency may include hot flashes, night sweats, mood swings, and vaginal dryness. Laboratory findings include elevated serum FSH. Other supportive laboratory findings include decreased serum estradiol and anti-Mullerian hormone (AMH) levels.",,,,,,,,ICD-11:GA30.6|MedDRA:10033169,Ovarian Function Insufficiency|POI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220661,,,,
http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,Cytokine Profile Testing,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding4,,,,,Cytokine_Profile_Testing_5,细胞因子检测,,A class of soluble glycoproteins which act nonenzymatically through specific receptors to regulate immune responses. Cytokines are derived from both immune and non-immune cells and are intercellular mediators that differ from hormones in that they are produced by a number of tissue or cell types rather than by specialized glands.,,,,,,,,SNOMED:75777003|LOINC:LP31391-3,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20464,,,,
http://example.org/irAEs.owl#Hemoglobin_Hb,Hemoglobin,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Hemoglobin_Hb,血红蛋白,,"The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.",,,,,,,,SNOMED_CT:38082009|LOINC:LP32067-8,Hb|Hgb,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16676,,,,
http://example.org/irAEs.owl#高纤饮食,"Low Fat, High Fiber Die",,,FALSE,,,http://example.org/irAEs.owl#Life_Style,,,,,高纤饮食,低脂高纤饮食,,A diet of foods that are high in carbohydrates and fiber and low in fat.,Protective Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16164,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_8,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_&_Assessment_Tests,,,,,Clinical_Humoral_and_Pathological_Examination_8,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#Trachea_Bronchus,Trachea & Bronchus,,,FALSE,,,http://example.org/irAEs.owl#Disease_5,,,,,Trachea_Bronchus,气管/支气管,,Trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea.,,,,,,,,UBERON:0000117,Trachea / Major Bronchi|wall of pleural sac,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12961,,,,
http://example.org/irAEs.owl#Organ_specific_examination_items,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests6,,,,,Organ_specific_examination_items,功能性检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#LYM,Lymphocyte Count,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,LYM,淋巴细胞计数,,The determination of the number of lymphocytes in a blood sample.,"Below Baseline, Risk Factor",,,,,,,SNOMED_CT:74765001|LOINC:LP14540-6,"blood lymphocyte count|Total lymphocyte count|Lymphocyte Count, Total|LYM",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C51949,,,,
http://example.org/irAEs.owl#Coxsackievirus,Human Coxsackie Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding,,,,,Coxsackievirus,人柯萨奇病毒,,"A nonenveloped, ssRNA virus in the family Picornaviridae and the genus Enterovirus.",,,,,,,,LOINC:LP21157-0|SNOMED_CT:57757007,Coxsackie Virus,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221640,,,,
http://example.org/irAEs.owl#EGFR,Epidermal Growth Factor Receptor,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,EGFR,表皮生长因子受体,,"The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).",Risk Factor,,,,,,,NCBI Gene ID:1956,EGFR,,https://www.ncbi.nlm.nih.gov/gene/1956,,,,
http://example.org/irAEs.owl#Lichen_planus_and_lichenoid_diseases,Lichen Planus & Lichenoid Diseases,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Lichen_planus_and_lichenoid_diseases,扁平苔藓和苔藓样疾病,,"A chronic, recurrent, pruritic inflammatory disorder of unknown etiology that affects the skin and mucus membranes. It presents with rashes and papules that tend to resolve spontaneously. It may be associated with hepatitis C. Certain drugs that contain arsenic or bismuth are associated with reactions mimicking lichen planus.",,,,,,,,ICD-11:EA83|MedDRA:10024429,Ruber planus|lichen ruber; Wilson|Lichen Ruber Planus,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3189,,,,
http://example.org/irAEs.owl#Interferon_gamma_IFN_γ,Interferon-gamma,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Interferon_gamma_IFN_γ,γ 干扰素,,"Interferon gamma (166 aa, ~19 kDa) is encoded by the human IFNG gene. This protein is involved in antiviral activity, macrophage activation, antiproliferative activity and immunopotentiation.",Risk Factor,,,,,,,SNOMED_CT:420303002|LOINC:LP18171-6,Immune Interferon|Interferon Gamma|Gamma Interferon|Gamma-Interferon|IFN-II|IFN-γ|IFNG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20496,,,,
http://example.org/irAEs.owl#Dermatomyositis_Amyopathic_Dermatomypsitis,Dermatomyositis,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Dermatomyositis_Amyopathic_Dermatomypsitis,皮肌炎,,Inflammation of the skin and muscle.,,,,,,,,ICD-11:4A41.0|MedDRA:10012503,"Polymyositis with skin involvement|Dermatopolymyositis, unspecified|Wagner-Unverricht syndrome|Dermatopolymyositis",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26744,,,,
http://example.org/irAEs.owl#Endomyocardial_Biopsy_EMB,Endomyocardial Biopsy,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination_6,,,,,Endomyocardial_Biopsy_EMB,心内膜心肌活检,,"Removal of myocardial tissue for microscopic examination, usually taken from the right heart using a transvenous approach.",,,,,,,,SNOMED_CT:387829002,EMB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C51674,,,,
http://example.org/irAEs.owl#IgG,Immunoglobulin G,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test-1,,,,,IgG,免疫球蛋白 G,,"An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.",,,,,,,,LOINC:LP14672-7|SNOMED:29246005,"immune globulin,gamma (IgG) human|Ab.IgG|IgG",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C568,,,,
http://example.org/irAEs.owl#IgG4,Immunoglobulin G4,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test-1,,,,,IgG4,免疫球蛋白 G4,,"Along with the immunoglobulin G3 subclass (IgG3), the IgG4 subtype makes up a minor part of circulating antibodies in healthy individuals. The IgG4 core hinge sequence contains 12 amino acids and two interchain disulfide bonds.This subtype has moderate affinity for binding Fc receptors and does not bind complement component C1q. The production of IgG4 can be stimulated following repeated or long-term exposure to antigen. Elevated levels are found in various diseases and infections and can be indicative of an fibroinflammatory syndrome known as IgG4-related disease.",,,,,,,,SNOMED_CT:48486004|LOINC:LP32397-9,IgG subclass 4|Immunoglobulin G Subclass 4|Immunoglobulin IgG4|Ab.IgG4|IgG4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78227,,,,
http://example.org/irAEs.owl#History_of_Autoimmune_Disease,Autoimmune Disease History,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,History_of_Autoimmune_Disease,自身免疫性疾病史,,A record of a patient's medical background regarding autoimmune disease.,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#浆液性癌,Ovarian Serous Adenocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#卵巢癌,,,,,浆液性癌,卵巢浆液性癌,,"An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia.",,,,,,,,MedDRA:10054913|ICD-11:2C72.1,Serous Adenocarcinoma of Ovary|Ovarian Serous Carcinoma|Serous Carcinoma of Ovary|Serous carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7550,,,,
http://example.org/irAEs.owl#KRAS,Kirsten Rat Rarcoma Viral Oncogene Homolog‌,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,KRAS,鼠类肉瘤病毒癌基因,,"This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.",,,,,,,,NCBI Gene ID:3845,K-ras,,https://www.ncbi.nlm.nih.gov/gene/3845,,,,
http://example.org/irAEs.owl#Trousseau_Syndrome,Trousseau Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Vein,,,,,Trousseau_Syndrome,Trousseau 综合征,,"Trousseau's syndrome refers to cancer-associated coagulopathy. The signs and symptoms of the syndrome are protean, and the underlying cancer is often occult.",,,,,,,,MedDRA:10060905,,,https://pubmed.ncbi.nlm.nih.gov/3046272/,,,,
http://example.org/irAEs.owl#Ultrasound,Ultrasound,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies12,,,,,Ultrasound,超声检查,,"High frequency sound, generally with a frequency greater than 20,000 Hz.",,,,,,,,SNOMED_CT:169228004|LOINC:11870-3,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64384,,,,
http://example.org/irAEs.owl#Troponin_I_Cardiac_Muscle,Troponin I Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Troponin_I_Cardiac_Muscle,心肌肌钙蛋白 I,,"Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells",Risk Factor,,,,,,,LOINC:LP14890-5|SNOMED_CT:116886006,Cardiac Troponin I|Troponin I.cardiac|TNNI3|cTnI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104226,,,,
http://example.org/irAEs.owl#Anthropometrics,Anthropometrics,,,FALSE,,,http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,,,,,Anthropometrics,人体测量学,,"A set of non-invasive, quantitative measurements of body composition and nutritional status which include height, weight, head circumference, body mass index (BMI), body circumferences, and skinfold thickness.",,,,,,,,,Anthropometrical Measurement|Anthropometric Measurement,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C219071,,,,
http://example.org/irAEs.owl#Granulocyte_Colony_Stimulating_Factor_G_CFS,Granulocyte Colony-Stimulating Factor,,,FALSE,,,http://example.org/irAEs.owl#Cytokine_Profile_Testing_5,,,,,Granulocyte_Colony_Stimulating_Factor_G_CFS,粒细胞集落刺激因子,,"Granulocyte colony-stimulating factor (207 aa, ~22 kDa) is encoded by the human CSF3 gene. This protein is involved in the regulation of the production, differentiation, and function of granulocytes.","Over Baseline, Risk Factor",,,,,,,SNOMED_CT:80572003|LOINC:LP89646-1,Colony Stimulating Factor 3|Colony-Stimulating Factor|CSF3|G-CSF,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26078,,,,
http://example.org/irAEs.owl#Neutrophil_to_Lymphocyte_Ratio_NLR,Neutrophil-to-Lymphocyte Ratio,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Neutrophil_to_Lymphocyte_Ratio_NLR,中性粒细胞与淋巴细胞比值,,The determination of the ratio of neutrophils compared to lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage.,"Over Baseline, Risk Factor",,,,,,,SNOMED_CT:250298004,Neutrophil/lymphocyte ratio|Neutrophil to Lymphocyte Ratio Measurement|Neutrophils/Lymphocytes|NLR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C141271,,,,
http://example.org/irAEs.owl#IL-2-1,Interleukin-2,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-2-1,白介素2,,"Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.","Over Baseline, Risk Factor",,,,,,,SNOMED_CT:68945006|LOINC:LP16470-4,T Cell Growth Factor|Thymocyte Stimulating Factor|Epidermal Thymocyte Activating Factor|Lymphocyte Mitogenic Factor|ETAF|IL-2|hIL-2,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20507,,,,
http://example.org/irAEs.owl#Third-Line_Therapy,Third-Line Therapy,,,FALSE,,,http://example.org/irAEs.owl#Line_of_Therapy,,,,,Third-Line_Therapy,三线治疗,,"Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.",,,,,,,,,Third Line Treatment|Third line of therapy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C94628,,,,
http://example.org/irAEs.owl#prostate_carcinoma,Prostate Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#泌尿系统,,,,,prostate_carcinoma,前列腺癌,,"One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.",,,,,,,,ICD-11:2C82|MedDRA:10007462,Cancer of Prostate|Prostate Cancer,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4863,,,,
http://example.org/irAEs.owl#Th17,T Helper 17 Cell,,,FALSE,,,http://example.org/irAEs.owl#Helper_T_cell_count,,,,,Th17,辅助T细胞17,,"A subset of helper T-lymphocytes which synthesize and secrete the interleukins (IL), IL-17A, -21 and -22. These cytokines mediate inflammation by increasing chemokine production, which leads to the recruitment of both monocytes and neutrophils to sites of infection or inflammation. Th17 cells modulate both host immunity against extracellular bacteria and fungi and inflammation. Overexpression of these cells is associated with tissue injury caused by autoimmune diseases.",,,,,,,,,Th17 Cell|Th17,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113815,,,,
http://example.org/irAEs.owl#CB,Chemistry Biomarker,,,FALSE,,,http://example.org/irAEs.owl#Biomarker,,,,,CB,化学生物标志物,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Cl,Serum Chloride,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,Cl,血清氯离子,,"A chlorine anion that forms the negatively charged part of certain salts, including sodium and hydrogen chloride salts, and is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating fluid in and out of cells.",,,,,,,,LOINC:LP15483-8|SNOMED_CT:271238006,Serum chloride ion|Chloride;|Cl-,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61021,,,,
http://example.org/irAEs.owl#Hyperthyroidism,Hyperthyroidism,,,FALSE,,,http://example.org/irAEs.owl#Thyroid,,,,,Hyperthyroidism,甲状腺功能亢进症,"A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe symptoms; hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143560","Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.",,,,,,,,ICD-11:5A02|MedDRA:10020850,Overactive Thyroid|Hyperthyroid,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3123,,,,
"http://example.org/irAEs.owl#Troponin_I_Cardiac_Muscle,_cTnI1",Troponin I Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test2,,,,,_cTnI1,心肌肌钙蛋白 I,,"Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells",,,,,,,,LOINC:LP14890-5|SNOMED_CT:116886006,Cardiac Troponin I|Troponin I.cardiac|TNNI3|cTnI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104226,,,,
"http://example.org/irAEs.owl#Troponin_I_Cardiac_Muscle,_cTnI3",Troponin I Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding3,,,,,_cTnI3,心肌肌钙蛋白 I,,"Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells",,,,,,,,LOINC:LP14890-5|SNOMED_CT:116886006,Cardiac Troponin I|Troponin I.cardiac|TNNI3|cTnI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104226,,,,
"http://example.org/irAEs.owl#Troponin_I_Cardiac_Muscle,_cTnI2",Troponin I Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,,,,,_cTnI2,心肌肌钙蛋白 I,,"Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells",,,,,,,,LOINC:LP14890-5|SNOMED_CT:116886006,Cardiac Troponin I|Troponin I.cardiac|TNNI3|cTnI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104226,,,,
http://example.org/irAEs.owl#Nerve_Conduction_Studies_NCS_2,Nerve Conduction Velocity Test,,,FALSE,,,http://example.org/irAEs.owl#Functional_Studies1,,,,,Nerve_Conduction_Studies_NCS_2,神经传导速度测试,,A test that measures the speed of nerve activity along the length of a nerve. It is used to detect nerve damage or dysfunction.,,,,,,,,"SNOMED_CT:251568004|LOINC:LP429025-2
LOINC:LP429031-0",Nerve Conduction Velocity|NCV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C88502,,,,
http://example.org/irAEs.owl#BP,Bullous Pemphigoid,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,BP,水疱性类天疱疮,,An autoimmune chronic skin disorder characterized by the presence of large blisters. It usually affects elderly people and tends to subside spontaneously.,,,,,,,,MedDRA:10006567|ICD-11:EB40,BP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84389,,,,
http://example.org/irAEs.owl#LUAD,Lung Adenocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#NSCLC,,,,,LUAD,肺腺癌,,"A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.",,,,,,,,ICD-11:2C25.0|MedDRA:10025031,Adenocarcinoma of Lung|Adenocarcinoma|LUAD,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3512,,,,
http://example.org/irAEs.owl#xiongxianliu,Thymoma,,,FALSE,,,http://example.org/irAEs.owl#huxi,,,,,xiongxianliu,胸腺瘤,,"A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course.",,,,,,,,MedDRA:10043670|ICD-11:2C27.2,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3411,,,,
http://example.org/irAEs.owl#Aortic_vasculitis,Vasculitis,,,FALSE,,,http://example.org/irAEs.owl#Artery,,,,,Aortic_vasculitis,血管炎,"A disorder characterized by inflammation involving the wall of a vessel.

Grade 1: Asymptomatic, intervention not indicated
Grade 2: Moderate symptoms, medical intervention indicated
Grade 3: Severe symptoms, medical intervention indicated (e.g., steroids)
Grade 4: Life-threatening consequences; evidence of peripheral or visceral ischemia; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C54741","An inflammatory process involving the wall of the vessels (large, medium, or small-sized vessels). The inflammatory process may cause necrosis or formation of granulomas in the vascular wall. It may be the result of an autoimmune disorder, infection, or malignancy. Representative examples include polyarteritis nodosa, temporal arteritis, Wegener granulomatosis, Kawasaki disease, Takayasu arteritis, and Henoch-Schonlein purpura.",,,,,,,,ICD-11:4A44|MedDRA:10047115,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26912,,,,
http://example.org/irAEs.owl#Blepharitis,Blepharitis,,,FALSE,,,http://example.org/irAEs.owl#Eyelid,,,,,Blepharitis,睑缘炎,,Inflammation of the eyelids near the eyelashes.,,,,,,,,MedDRA:10005148|ICD-11:9A02,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C112183,,,,
http://example.org/irAEs.owl#DRB11501,Human Leukocyte Antigen DRB1*15:01,,,FALSE,,,http://example.org/irAEs.owl#HLA_Typing_2,,,,,DRB11501,人类白细胞抗原DRB1*15:01,,"DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis, multiple sclerosis, systemic lupus erythematosus, cervical cancer (human papillomavirus infection), and Sjogren's syndrome associated with systemic lupus erythematosus.",Risk Factor,,,,,,,LOINC:LP99671-7,,,https://loinc.org/LP99671-7/,,,,
"http://example.org/irAEs.owl#Ultrasonic_Cardiogram,_UCG4",Ultrasonic Cardiogram,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items_9,,,,,_UCG4,超声心动图,,A procedure that uses high-frequency sound waves (ultrasound) to create an image of the heart.,,,,,,,,SNOMED_CT:40701008|LOINC:LP6171-5,Echocardiography Test|Echocardiography|EC|UCG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16525,,,,
http://example.org/irAEs.owl#Adrenal_Gland,Adrenal Gland,,,FALSE,,,http://example.org/irAEs.owl#Disease_7,,,,,Adrenal_Gland,肾上腺,,"A flattened, roughly triangular body resting upon the upper end of each kidney; it is one of the ductless glands furnishing internal secretions.",,,,,,,,UBERON:0002369,Adrenal; Adrenal structure|glandula adrenalis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12666,,,,
http://example.org/irAEs.owl#MRCT,Magnetic Resonance Cholangiopancreatography,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies,,,,,MRCT,磁共振胰胆管成像,,"A non-invasive procedure in which magnetic resonance imaging is used to visualize the intrahepatic and extrahepatic bile ducts, the pancreatic duct, and the surrounding parenchyma.",,,,,,,,SNOMED:314635004,"Cholangiopancreatography, Magnetic Resonance|MRCT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113775,,,,
http://example.org/irAEs.owl#女性生殖系统及乳腺,Female Genital Tumours,,,FALSE,,,http://example.org/irAEs.owl#Cancer_Type,,,,,女性生殖系统及乳腺,女性生殖系统肿瘤,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Cerebellar_Attaxia,Cerebellar Ataxia,,,FALSE,,,http://example.org/irAEs.owl#Cerebellum,,,,,Cerebellar_Attaxia,小脑性共济失调,,"Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA (MeSH).",,,,,,,,ICD-11:18A03.16|MedDRA:10008025,"Incoordinations, Cerebellar|Ataxia cerebellar|Cerebellar Incoordination",,https://www.ncbi.nlm.nih.gov/mesh/68002524,,,,
http://example.org/irAEs.owl#Colonoscopy,Colonoscopy,,,FALSE,,,http://example.org/irAEs.owl#Endoscopic_Examinations1,,,,,Colonoscopy,结肠镜检查,,Endoscopic examination of the luminal surface of the colon.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16450,,,,
http://example.org/irAEs.owl#C-peptide,C-peptide,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,C-peptide,C 肽,,"C peptide (31 aa, ~3 kDa) is encoded by the human INS gene. This protein is involved in both signal transduction and the modulation of blood flow.",,,,,,,,LOINC:LP15454-9|SNOMED_CT:39973008,Proinsulin C-Peptide|connecting peptide|Human Proinsulin C-Peptide,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C94608,,,,
http://example.org/irAEs.owl#marginal_zone_lymphoma,Marginal Zone Lymphoma,,,FALSE,,,http://example.org/irAEs.owl#非霍奇金淋巴瘤,,,,,marginal_zone_lymphoma,边缘区淋巴瘤,,"A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.",,,,,,,,MedDRA:10076596|ICD-11:2A85.0,marginal zone B-cell lymphoma|MZBCL|MZL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4341,,,,
http://example.org/irAEs.owl#Grade_5,Grade 5,,,FALSE,,,http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,,,,,Grade_5,5 级,,Death related to AE,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Cancer_Type,Primary Tumor Type,,,FALSE,,,http://example.org/irAEs.owl#Oncologic_and_Treatment_Data,,,,,Cancer_Type,原发肿瘤类型,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#BRAF_V600E,B-Raf Proto-oncogene V600E,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,BRAF_V600E,B-Raf 原癌基因V600E,,"This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.",,,,,,,,NCBI Gene ID:673,94 kDa B-raf protein|ONCOGENE BRAF|BRAF,,https://www.ncbi.nlm.nih.gov/gene/673,,,,
http://example.org/irAEs.owl#ECG_2,Electrocardiography,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies2,,,,,ECG_2,心电图,,A procedure that displays the electrical activity of the heart.,,,,,,,,LOINC:LP149975-7|SNOMED_CT:29303009,electrocardiogram|ECG|EKG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38053,,,,
"http://example.org/irAEs.owl#Hepatitis_C_Virus,_HCV1",Hepatitis C Virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Test,,,,,_HCV1,丙型肝炎病毒,,"A small, enveloped, positive sense single strand RNA virus in the family Flaviviridae. The genome consists of a single RNA molecule with a single open reading frame.",,,,,,,,SNOMED_CT:62944002|LOINC:LP14400-3,HCV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14312,,,,
http://example.org/irAEs.owl#History_of_Prior_Malignancy,Individual Cancer History,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,History_of_Prior_Malignancy,既往恶性肿瘤史,,A record of a patient's medical background regarding the occurrence of cancer and cancer-related problems.,,,,,,,,,prior malignancy|Cancer History|history_of_tumor,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18849,,,,
http://example.org/irAEs.owl#Tumor_Stage,Tumor Stage,,,FALSE,,,http://example.org/irAEs.owl#Oncologic_and_Treatment_Data,,,,,Tumor_Stage,肿瘤分期,,The extent of a cancer in the body.,,,,,,,,,Neoplasm Stage,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16899,,,,
http://example.org/irAEs.owl#Systemic_Sclerosis,Systemic Sclerosis,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Systemic_Sclerosis,系统性硬化症,,"A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.",,,,,,,,MedDRA:10042953|ICD-11: 4A42,"Diffuse Sclerosis|SSc, Diffuse Sclerosis|Systemic sclerosis, unspecified|Scleroderma, Systemic|Diffuse Scleroderma",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C72070,,,,
http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,Autoimmune Antibody Tests,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding4,,,,,Autoimmune_Antibody_Tests_13,自身抗体检测,,,,,,,,,,LOINC:LP417973-7,,,https://loinc.org/LP417973-7/,,,,
http://example.org/irAEs.owl#Hematocrit_HCT,Hematocrit,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Hematocrit_HCT,红细胞压积,,"Erythrocytes or red blood cells (RBCs) are the cells in the circulation that carry oxygen to and remove carbon dioxide from the tissues throughout the body. They are produced in the bone marrow in response to erythropoietin where they transition through six stages over a seven day period. When they are released into the circulation, their nucleus has been extruded and they measure 6-8 microns in diameter. The lifespan of RBCs is about 120 days. When the RBC ages the cell membrane becomes less pliable and tears as they cell travels through the micro vessels of the body. The damaged RBCs are removed from the circulation by the spleen. Variations in number, shape and size of RBCs are indicative of many diseases and disorders. There are many factors that may lead to decreased numbers of RBCs including hemorrhage, hemolysis, iron or vitamin deficiency, marrow failure and more. Larger than normal RBCs may be indicative of liver disease while smaller than normal RBCs are seen in thalassemias and other anemias (LOINC).","Over Baseline, Protective Factor",,,,,,,SNOMED_CT:28317006|LOINC:LP16699-8,Erythrocyte Volume Fraction|Packed Cell Volume|EVF|HCT,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64796,,,,
http://example.org/irAEs.owl#Anti_PD_1,PD1 Inhibitor,,,FALSE,,,http://example.org/irAEs.owl#ICI_related_Drug_Names_2,,,,,Anti_PD_1,PD1抑制剂,,An agent designed to interfere with the activity of programmed cell death protein 1 (PD1). PD1 inhibitors block T-cell apoptosis and act as non-specific activators of the immune system.,,,,,,,,,Programmed Cell Death Protein 1 Inhibitor|Protein PD-1 Inhibitor|Anti-PD-1 Agent|PD-1-targeting Agent,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C124946,,,,
http://example.org/irAEs.owl#Meninx,Meninx,,,FALSE,,,http://example.org/irAEs.owl#Disease_6,,,,,Meninx,脑膜,,Any one of three membranes that surround the brain and spinal cord.,,,,,,,,UBERON:0002360,Spinal Meninges|meninx of spinal cord|Meninges,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12348,,,,
"http://example.org/irAEs.owl#Hepatitis_B_Virus,_HBV1",Hepatitis B Virus,,,FALSE,,,http://example.org/irAEs.owl#Viral_Serology_7,,,,,_HBV1,乙肝病毒,,Hepatitis B Virus (HBV) is the prototype of the Hepadnavirus Family. Included in the family are the Woodchuck Hepatitis Virus (WHV) and the Duck Hepatitis B Virus (DHBV) which provide animal models of infection. The HBV genome is a partially double stranded circular DNA. A viral reverse transcriptase is bound to the 5' extremity of the long strand.,Risk Factor,,,,,,,SNOMED_CT:81665004|LOINC:LP14306-2,HBV,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14215,,,,
http://example.org/irAEs.owl#Coronary_Artery,Coronary Artery,,,FALSE,,,http://example.org/irAEs.owl#Disease_8,,,,,Coronary_Artery,冠状动脉,,One of two arteries that arise from the aortic sinuses of the ascending aorta and supply blood to the myocardium,,,,,,,,UBERON:0001621,"CORONARY ARTERY|ARTERY, CORONARY|Coronary artery structure",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12843,,,,
http://example.org/irAEs.owl#Combination_Chemotherapy,Combination Chemotherapy,,,FALSE,,,http://example.org/irAEs.owl#Therapy_Method,,,,,Combination_Chemotherapy,联合化疗,,Treatment using more than one anticancer drug.,Risk Factor,,,,,,,,"Combination Drug Therapy|Drug Therapy, Combination",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C191,,,,
http://example.org/irAEs.owl#AchR_Autoantibody,AchR Autoantibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Finding,,,,,AchR_Autoantibody,乙酰胆碱受体自身抗体,,An autoantibody that recognizes acetylcholine receptor proteins.,,,,,,,,SNOMED_CT:103189000|LOINC:LP36947-7,Anti-AchR Autoantibody|Acetylcholine receptor Ab|Anti-Acetylcholine Receptor Autoantibody|End-plate antibody|AchR Autoantibody|ACRA - Acetylcholine receptor antibody|ACHR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C212207,,,,
http://example.org/irAEs.owl#Helper_T_cell_count,Helper T Cell Count,,,FALSE,,,http://example.org/irAEs.owl#T_lymphocyte_subset_analysis_2,,,,,Helper_T_cell_count,辅助性 T 细胞计数,,"The measurement of the number of helper T lymphocytes, which are T lymphocytes that express CD4, in a cubic millimeter of blood. It is calculated by multiplying 1000 by both the total leukocyte count and the percent of helper T cells in the differential leukocyte count.","Below Beseline, Risk Factor",,,,,,,SNOMED_CT:29594005|LOINC:LP14443-3,Absolute CD4+ T Cells|Helper T Lymphocyte to Total Leukocyte per Cubic Millimeter Measurement|Absolute CD4 Expressing T Lymphocyte Count|Absolute CD4 Expressing T Cell Count,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C201183,,,,
http://example.org/irAEs.owl#Binocular_vision,Vision Assessment,,,FALSE,,,http://example.org/irAEs.owl#Functional_and_Subjective_Tests,,,,,Binocular_vision,视力评估,,"Tests to assess the ability to focus on and discern objects, colors, depth, etc.",,,,,,,,LOINC:LP147336-4|SNOMED_CT:268360001,assessment of vision|Assessing Vision|Binocular vision Test|vision test,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C156778,,,,
http://example.org/irAEs.owl#Grade_2,Grade 2,,,FALSE,,,http://example.org/irAEs.owl#Common_Terminology_Criteria_for_Adverse_Events_CTCAE_60,,,,,Grade_2,2 级,,"Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age appropriate normal daily activity (pediatric)*",,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Concomitant_Medication_Use_Duration,Concomitant Medication Use Duration,,,FALSE,,,http://example.org/irAEs.owl#Concomitant_Medications,,,,,Concomitant_Medication_Use_Duration,联合用药时间,,The period of time from start to finish of concomitant medication usage.,,,,,,,,,CMDUR,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C83224,,,,
http://example.org/irAEs.owl#Retinal_Vasculitis,Retinal Vasculitis,,,FALSE,,,http://example.org/irAEs.owl#Retina,,,,,Retinal_Vasculitis,视网膜血管炎,,"Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage.",,,,,,,,ICD-11:B78.12|MedDRA:10038905,Retinal Vascular Disorder|VASCULITIS RETINAL,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35170,,,,
http://example.org/irAEs.owl#Fulminant_Myocarditis,Myocarditis,,,FALSE,,,http://example.org/irAEs.owl#Myocardium,,,,,Fulminant_Myocarditis,心肌炎,"A disorder characterized by inflammation of the muscle tissue of the heart.

Grade 1: Asymptomatic with Lab or ECG findings only
Grade 2: Symptoms with moderate activity or exertion
Grade 3: Severe with symptoms at rest or with minimal activity or exertion; intervention indicated; new onset of symptoms
Grade 4: Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support); hemodynamically unstable requiring non-invasive or invasive ventilation; complete or high grade AV block; significant ventricular arrhythmia
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C146695",Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.,,,,,,,,ICD-11:BC42|MedDRA:10028606,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34831,,,,
"http://example.org/irAEs.owl#Anion_Gap,_AG",Anion Gap,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding1,,,,,_AG,阴离子间隙,,The determination of the unmeasured anions (those other than the chloride and bicarbonate anions) present in a sample.,,,,,,,,LOINC:41276-7|SNOMED_CT:25469001,Anion Gap Measurement; ANIONG|AG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C74685,,,,
"http://example.org/irAEs.owl#Anion_Gap,_AG1",Anion Gap,,,FALSE,,,http://example.org/irAEs.owl#Serum_Electrolyte_and_Acid_Base_Panel_5,,,,,_AG1,阴离子间隙,,The determination of the unmeasured anions (those other than the chloride and bicarbonate anions) present in a sample.,,,,,,,,LOINC:41276-7|SNOMED_CT:25469001,Anion Gap Measurement|AG|ANIONG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C74685,,,,
http://example.org/irAEs.owl#Immune_Thrombocytopenia_ITP,Immune Thrombocytopenia,,,FALSE,,,http://example.org/irAEs.owl#Thrombocyte,,,,,Immune_Thrombocytopenia_ITP,免疫性血小板减少症,"A disorder characterized by a decrease in number of platelets in a blood specimen.

Grade 2: <75,000 - 50,000/mm3; <75.0 - 50.0 x 10^9/L
Grade 3: <50,000 - 10,000/mm3; <50.0 - 10.0 x 10^9/L; transfusion indicated
Grade 4: <10,000/mm3; 10.0 x 10^9/L; life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220660","An autoimmune coagulation disorder characterized by isolated thrombocytopenia (a platelet count <100,000/microL), in the absence of any underlying disorder that may be associated with thrombocytopenia.",,,,,,,,ICD-11:3B64.10|MedDRA:10083842,Thrombocytopenia Due to Immune Destruction|ITP,,https://uts.nlm.nih.gov/uts/umls/concept/C0242584,,,,
http://example.org/irAEs.owl#Bronchoscopy_BRO,Bronchoscopy,,,FALSE,,,http://example.org/irAEs.owl#Endoscopic_Examinations2,,,,,Bronchoscopy_BRO,支气管镜检查,,Endoscopic examination of the tracheobronchial tree.,,,,,,,,LOINC:LP6158-2|SNOMED_CT:10847001,bronchial endoscopy|Tracheobronchial endoscopy|Endoscopy of bronchus|BRO,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16366,,,,
http://example.org/irAEs.owl#Albumin_ALB,Albumin,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Albumin_ALB,白蛋白,,"A family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands. Albumin is the main protein in blood plasma. Low serum levels occur in conditions associated with malnutrition, inflammation and liver and kidney diseases.","Below Baseline, Risk Factor",,,,,,,SNOMED_CT:52454007|LOINC:LP6118-6,ALB,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C214,,,,
http://example.org/irAEs.owl#TPOAb,Thyroperoxidase Antibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test,,,,,TPOAb,甲状腺过氧化物酶抗体,,Thyroperoxidase antibodies aid in the detection of autoimmune and Hashimoto's thyroiditis (LOINC).,,,,,,,,LOINC:LP40001-7|SNOMED_CT:118002003,Anti-TPO Measurement|TPOAb,,https://loinc.org/LP40001-7,,,,
http://example.org/irAEs.owl#Dual_PD-L1_Inhibition,Dual PD-L1 Inhibition,,,FALSE,,,http://example.org/irAEs.owl#ICI_related_Drug_Names_2,,,,,Dual_PD-L1_Inhibition,双 PD-L1 抑制剂联合,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_5,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests9,,,,,Clinical_Humoral_and_Pathological_Examination_5,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,LOINC:LP208905-2|SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#TGF-β_Signaling_Pathway,TGF-beta Signaling Pathway,,,FALSE,,,http://example.org/irAEs.owl#Pathway,,,,,TGF-β_Signaling_Pathway,TGF-beta 信号通路,,"The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.",Risk Factor,,,,,,,KEGG ID:map04350,,,https://www.kegg.jp/entry/map04350,,,,
http://example.org/irAEs.owl#Severe_AEs,Severe AEs,,,FALSE,,,http://webprotege.stanford.edu/R9SLYezUwf5WcAMq9ZGLDPV,,,,,Severe_AEs,严重不良事件,,,,,,,,,,,,"◆Discontinue immunotherapy. 
◆Initiate steroid therapy immediately. IV methylprednisolone should be considered until there is evidence of improvement in toxicity.
◆Additional immunosuppressant therapy may be required for steroid-unresponsive AEs.
◆Inpatient care and additional supportive care may be required. 
◆Ensure appropriately timed follow-up visits with oncologist or co-managing disease-specific subspecialist team for patients who required hospitalization for severe AEs. Close monitoring is encouraged as these patients are likely to have been started on new medications such as immunosuppressive agents and hormone replacement therapy that may require further adjustment or re-evaluation after hospitalization",,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_4,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests8,,,,,Organ_specific_Laboratory_Finding_4,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Geriatric_Nutritional_Risk_Index_GNRI,Geriatric Nutritional Risk Index,,,FALSE,,,http://example.org/irAEs.owl#Anthropometrics,,,,,Geriatric_Nutritional_Risk_Index_GNRI,老年营养风险指数,,"The GNRI is calculated using baseline body weight and ALB level as follows: 1.489 × ALB (g/L) + 41.7 × actual weight (kg)/ideal weight. Ideal weight was calculated using the Lorenz formula: height (cm) − 100 − ([height (cm) − 150]/4) for men. The actual weight/ideal weight ratio was regarded as 1, when the actual weight exceeded the ideal body weight. Individuals were classified into two nutrition risk groups based on the GNRI: no malnutrition (GNRI ≥ 100) and malnutrition (GNRI < 100) (PubMed).","＜100, Risk Factor",,,,,,,,GNRI,,https://pubmed.ncbi.nlm.nih.gov/16210706/,,,,
http://example.org/irAEs.owl#THY1,Thy-1 Cell Surface Antigen,,,FALSE,,,http://example.org/irAEs.owl#Gene,,,,,THY1,Thy-1 细胞表面抗原,,"This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants.",,,,,,,,NCBI Gene ID: 7070,Thy-1 T-Cell Antigen|CD90|THY1,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C73526,,,,
http://example.org/irAEs.owl#Meningitis,Meningitis,,,FALSE,,,http://example.org/irAEs.owl#Meninx,,,,,Meningitis,脑膜炎,"A disorder characterized by an infectious or inflammatory process of the meninges of the brain and/or spinal cord.

Grade 3: IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143670",A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.,,,,,,,,ICD-11:8E40.Y|MedDRA:10027199,"Inflammation of meninges|Meningococcal Infection|infection; brain, membranes|Meningitis of unspecified cause",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26828,,,,
http://example.org/irAEs.owl#Renal_and_Urinary_System,Renal and Urinary System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Renal_and_Urinary_System,肾脏和泌尿系统,,The organs involved in the creation and excretion of urine.,,,,,,,,SOC:10038359.0|UBERON:0001008,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12413,,,,
http://example.org/irAEs.owl#Urinalysis_3,Urinalysis,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_4,,,,,Urinalysis_3,尿液分析,,"Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine.",,,,,,,,LOINC:LP32744-2|SNOMED_CT:27171005,Urine examination|Assessing Urine|Urinalysis procedure|Analysis of urine|Urine Test,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17241,,,,
http://example.org/irAEs.owl#Severe_Akathisia,Akathisia,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,Severe_Akathisia,不安腿综合征,"A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.

Grade 1: Mild restlessness or increased motor activity
Grade 2: Moderate restlessness or increased motor activity; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe restlessness or increased motor activity; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143266",An uncomfortable feeling of inner restlessness and inability to stay still. It can be a side effect of psychotropic medications.,,,,,,,,MedDRA:10001540|ICD-11:7A80,feeling an alien urge to be in motion|motor restlessness,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78163,,,,
http://example.org/irAEs.owl#Slit_Lamp_Biomicroscopy,Slit-Lamp Biomicroscopy,,,FALSE,,,http://example.org/irAEs.owl#Morphological_and_Imaging_Tests,,,,,Slit_Lamp_Biomicroscopy,裂隙灯显微镜检查,,Examination of the anterior segment of the eye using a medical instrument called a slit lamp.,,,,,,,,LOINC:LP201209-6|SNOMED:55468007,"Slit Lamp Microscopy|Examinations, Slit Lamp|Slit-lamp tests|Slit Lamp Examination|Slit lamp examination, ocular|Microscopy, Slit Lamp",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C75583,,,,
http://example.org/irAEs.owl#骨肉瘤,Osteosarcoma,,,FALSE,,,http://example.org/irAEs.owl#软组织肿瘤,,,,,骨肉瘤,骨肉瘤,,"A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs.",,,,,,,,ICD-11:XH1XF3|MedDRA:10031291,"OSTEOSARCOMA, MALIGNANT|Osteogenic Sarcoma|Osteosarcoma, NOS",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9145,,,,
http://example.org/irAEs.owl#Conduction_Abnormalities,Cardiac Conduction Disorder,,,FALSE,,,http://example.org/irAEs.owl#Cardiac_Conduction_System,,,,,Conduction_Abnormalities,心脏传导障碍,"A disorder characterized by pathological irregularities in the cardiac conduction system.

Grade 1: Mild symptoms; intervention not indicated
Grade 2: Non-urgent medical intervention indicated
Grade 3: Symptomatic, urgent intervention indicated
Grade 4: Life-threatening consequences
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143380",A disorder affecting the conduction system that sends electrical signals in the myocardium.,,,,,,,,MedDRA:10000032|ICD-11:BC63,Conduction Abnormality|Conduction Abnormalities|Heart Conduction Disorder|Disorder of Cardiac Conduction|Conduction disorder,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78245,,,,
http://example.org/irAEs.owl#Laboratory_Tests,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_&_Assessment_Tests,,,,,Laboratory_Tests,实验室检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#TP53,Tumor Protein p53,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,TP53,肿瘤蛋白p53,,"This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants",,,,,,,,NCBI Gene ID:7157,p53 tumor suppressor gene|P53_HUMAN|TP53 Gene|TP53,,https://www.ncbi.nlm.nih.gov/datasets/gene/7157/,,,,
http://example.org/irAEs.owl#Aspartate_Transaminase1,Aspartate Transaminase,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Aspartate_Transaminase1,天冬氨酸氨基转移酶,,A family of pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. Aspartate aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-aspartate to alpha-ketoglutarate forming oxaloacetate and L-glutamate.,Risk Factor,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Immune_System,Immune System,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Immune_System,免疫系统,,"The complex group of organs like thymus, spleen, tonsils, lymphatic system, hematopoetic system and cells like lymphocytes, granulocytes, monocytes and macrophages that defends the body against infection or disease. It consists of a complex interrelated cellular, molecular and genetic component.",,,,,,,,UBERON:0002405|SOC:10021428.0,"organ system, allergic/immunologic",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12735,,,,
http://example.org/irAEs.owl#Clinical_Chemistry_12,Clinical Chemistry Finding,,,FALSE,,,http://example.org/irAEs.owl#Non_Organ_Special_Laboratory_Finding,,,,,Clinical_Chemistry_12,临床化学检测,,A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen.,,,,,,,,SNOMED_CT:11987000,Chemistry Procedure|Chemistry Test|Chemistry Measurement|Clinical Chemistry Finding|Chemistry Technique,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C49237,,,,
http://example.org/irAEs.owl#anti-SM_Antibody,Anti-Sm Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,anti-SM_Antibody,抗Sm抗体,,"An antinuclear antibody directed against small nuclear ribonucleoproteins (snRNPs), that is highly specific, but has poor sensitivity for systemic lupus erythematosus (SLE). Presence of anti-Sm antibodies are associated with central nervous system, kidney, lung and cardiac involvement in SLE, but are not indicative of disease activity.",,,,,,,,SNOMED_CT:726768007|LOINC:LP39757-7,Anti-Sm-RNP Antibody|Anti-Smith Antibod|Antibody to Smith Antigen|Smith antigen Ab|Anti-Sm/RNP Antibody,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121324,,,,
http://example.org/irAEs.owl#皮肤鳞状细胞癌,Cutaneous Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#皮肤和附属器,,,,,皮肤鳞状细胞癌,皮肤鳞状细胞癌,,A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated.,,,,,,,,MedDRA:10085908|ICD-11:2C31,Epidermoid Skin Carcinoma|Skin Squamous Cell Carcinoma|Epidermoid Carcinoma of Skin|Squamous cell carcinoma - skin|Skin Squamous Cell Cancer,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4819,,,,
"http://example.org/irAEs.owl#Ultrasonic_Cardiogram,_UCG2",Ultrasonic Cardiogram,,,FALSE,,,http://example.org/irAEs.owl#Imaging_Studies2,,,,,_UCG2,超声心动图,,A procedure that uses high-frequency sound waves (ultrasound) to create an image of the heart.,,,,,,,,SNOMED_CT:40701008|LOINC:LP6171-5,Echocardiography Test|Echocardiography|EC|UCG,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16525,,,,
http://example.org/irAEs.owl#Nivolumab,Nivolumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Nivolumab,纳武利尤单抗,,"A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.",,,,,,,,DrugBank ID:DB09035,ABP 206|BCD-263|BMS 936558|CMAB819|MDX 1106|NIVO|ONO 4538|Opdivo,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C68814,,,,
http://example.org/irAEs.owl#Uric_Acid_UA,Uric Acid,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Uric_Acid_UA,尿酸,,"A white tasteless odorless crystalline product of protein metabolism, found in the blood and urine, as well as trace amounts found in the various organs of the body. It can build up and form stones or crystals in various disease states.",,,,,,,,SNOMED_CT:1710001|LOINC:LP15935-7,"Uricum acidum|2,6,8-Trihydroxypurine|UA|Urate",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62652,,,,
http://example.org/irAEs.owl#Clinical_Humoral_and_Pathological_Examination_4,Clinical Pathological Examination,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests8,,,,,Clinical_Humoral_and_Pathological_Examination_4,临床病理学检查,,The evaluation of a disease process by a pathologist.,,,,,,,,SNOMED_CT:1255736009,Pathologic Examination|Pathologic Review|PATHOLOGICAL EVALUATION|Pathology Examination,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C125006,,,,
http://example.org/irAEs.owl#胆管癌,Cholangiocarcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,胆管癌,胆管细胞癌,,"A carcinoma that arises from the intrahepatic bile ducts, the hepatic ducts, or the common bile duct distal to the insertion of the cystic duct. The vast majority of tumors are adenocarcinomas.",,,,,,,,MedDRA:10008593|ICD-11:2C12.02,"Intrahepatic Bile Duct Cancer|CHOLANGIOCARCINOMA, MALIGNANT|Cholangiocellular Carcinoma|CC",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4436,,,,
http://example.org/irAEs.owl#Complement_Component-32,Complement Component-3,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test6,,,,,Complement_Component-32,补体C3,,"Complement C3 (1663 aa, ~187 kDa) is encoded by the human C3 gene. This protein plays a role in complement-mediated immunity.",,,,,,,,LOINC:LP16359-9|SNOMED_CT:10473000,C3 - Complement component 3|Complement C3,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C21527,,,,
http://example.org/irAEs.owl#Creatine_Phosphokinase_CPK,Creatine Kinase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Creatine_Phosphokinase_CPK,肌酸激酶,,"An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.","Below Baseline, Risk Factor",,,,,,,SNOMED_CT:75828004|LOINC:LP15510-8,"Phosphocreatine Kinase|ATP:Creatine Phosphotransferase|Creatine Phosphotransferase, ATP|Creatine Phosphokinase|CK|CPK",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113245,,,,
http://example.org/irAEs.owl#DIC,Disseminated Intravascular Coagulation,,,FALSE,,,http://example.org/irAEs.owl#Capillary,,,,,DIC,弥散性血管内凝血,"A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.

Grade 2: Laboratory findings with no bleeding
Grade 3: Laboratory findings and bleeding
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C55273","A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage.",,,,,,,,ICD-11:3B20|MedDRA:10012769,Hemorrhagic fibrinogenolysis|Defibrination syndrome|Consumptive Coagulopathy|DIC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2992,,,,
http://example.org/irAEs.owl#Immunofluorescence_Examination,Immunofluorescence Examination,,,FALSE,,,http://example.org/irAEs.owl#Histopathological_Examination1,,,,,Immunofluorescence_Examination,免疫荧光检查,,A microscopy staining method that utilizes immunofluorescent markers for use with histological applications of preserved cells.,,,,,,,,LOINC:LP6323-2|SNOMED:30662005,"assays immunofluorescence|Immunofluorescent Staining Method|Fluorescent linked immunoassay|Fluorescent immunoassay, NOS|IF",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C142337,,,,
http://example.org/irAEs.owl#Bronchitis,Bronchitis,,,FALSE,,,http://example.org/irAEs.owl#Trachea_Bronchus,,,,,Bronchitis,支气管炎,,An acute or chronic inflammatory process affecting the bronchi.,,,,,,,,ICD-11:CA20|MedDRA:10006451,"Bronchitis, not specified as acute or chronic|Bronchitis, NOS",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2911,,,,
http://example.org/irAEs.owl#IgA_Nephropathy_IgAN,IgA Nephropathy,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,IgA_Nephropathy_IgAN,IgA 肾,,A chronic autoimmune glomerulonephritis characterized by the deposition of immunoglobulin A in the mesangium of the glomeruli. It is manifested with hematuria and mild proteinuria.,,,,,,,,MedDRA:10021263|ICD-11:MF8Y,Berger's Disease|IGA Glomerulonephritis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34643,,,,
http://example.org/irAEs.owl#Prothrombin_Time_PT,Prothrombin Time,,,FALSE,,,http://example.org/irAEs.owl#Coagulation_Tests_4,,,,,Prothrombin_Time_PT,凝血酶原时间,,"A measurement of the clotting time of plasma recalcified in the presence of excess tissue thromboplastin; it is a measure of the extrinsic pathway of coagulation. It is used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage and vitamin K status. Factors measured are fibrinogen, prothrombin, and factors V, VII, and X.",,,,,,,,SNOMED_CT:396451008|LOINC:LP394042-8,Prothrombin Time Test|PT - Prothrombin time|Prothrombin Time|PT|PT assay,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62656,,,,
http://example.org/irAEs.owl#Sever_Oral_Mucositis,Oral Mucositis,,,FALSE,,,http://example.org/irAEs.owl#Oral,,,,,Sever_Oral_Mucositis,口腔黏膜炎,"A disorder characterized by ulceration or inflammation of the oral mucosal.

Grade 1: Asymptomatic or mild symptoms; intervention not indicated
Grade 2: Moderate pain or ulcer that does not interfere with oral intake; modified diet indicated
Grade 3: Severe pain; interfering with oral intake
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143679",Inflammation of the oral mucosa due to local or systemic factors.,,,,,,,,MedDRA:10045369|ICD-11:DA01.11,Mucositis oral|Stomatitis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26887,,,,
http://example.org/irAEs.owl#Myocardical_Necrosis,Myocardial infarction,,,FALSE,,,http://example.org/irAEs.owl#Myocardium,,,,,Myocardical_Necrosis,心肌梗死,"A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.

Grade 2:Asymptomatic; imaging or ECG features consistent with myocardial infarction which may be of uncertain age
Grade 3: Hemodynamically stable AND detection of a rise and/or fall of Cardiac troponin values with at least 1 value above the 99th percentile URL AND at least 1 of the following: 1) Symptoms of myocardial ischemia; 2) New ischemic ECG changes; 3) Development of pathological Q waves; 4) Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5) Identification of a coronary thrombus by angiography
Grade 4: Life-threatening consequences; hemodynamically UNstable AND detection of a rise and/or fall of Cardiac troponin values with at least 1 value above the 99th percentile URL AND at least 1 of the following: 1) Symptoms of myocardial ischemia; 2) New ischemic ECG changes; 3) Development of pathological Q waves; 4) Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5) Identification of a coronary thrombus by angiography
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220657","Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.",,,,,,,,ICD-11:BA41|MedDRA:10028595,Heart Attack|Myocardial Infarct|MI,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27996,,,,
http://example.org/irAEs.owl#IL-17,Interleukin-17A,,,FALSE,,,http://example.org/irAEs.owl#Interleukin,,,,,IL-17,白介素17A,,"Interleukin-17A (155 aa, ~18 kDa) is encoded by the human IL17A gene. This protein is involved in the positive regulation of cytokine production.","Over Baseline, Risk Factor",,,,,,,LOINC:LP431130-6,Interleukin 17 Precursor|Cytotoxic T-Lymphocyte-Associated Serine Esterase 8|CTLA-8|IL-17A,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C20519,,,,
http://example.org/irAEs.owl#Lipase_LPS,Lipase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Lipase_LPS,脂肪酶,,Lipase; an enzyme secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can be absorbed into the bloodstream.,,,,,,,,LOINC:LP14915-0|SNOMED_CT:72993008,Tributyrase|Triacylglycerol Hydrolase|Triacylglycerol acylhydrolase|Triacylglycerol lipase|LPS,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C37988,,,,
http://example.org/irAEs.owl#Fatigue,Fatigue,,,FALSE,,,http://example.org/irAEs.owl#Disease_13,,,,,Fatigue,疲劳,"A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.

Grade 1: Fatigue relieved by rest
Grade 2: Fatigue not relieved by rest; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity
Grade 3:  Fatigue not relieved by rest, limiting self-care ADL or severe impact on age-appropriate normal daily activity
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C146753",Overall tiredness and lack of energy.,,,,,,,,MedDRA:10016256|ICD-11: MG22,Lack of Energy|Lacking in energy|Tiredness|Weariness,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3036,,,,
http://example.org/irAEs.owl#板图,Alopecia,,,FALSE,,,http://example.org/irAEs.owl#Hair,,,,,板图,斑秃,"A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.

Grade1: Hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage.
Grade2: Hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact.
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C57898","Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions.",,,,,,,,ICD-11:ED70.2|MedDRA:10001760,Alopecia Areata|Hair Loss,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C50575,,,,
http://example.org/irAEs.owl#边缘性脑炎,Limbic Encephalitis,,,FALSE,,,http://example.org/irAEs.owl#Brainstem,,,,,边缘性脑炎,边缘性脑炎,,"A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia.",,,,,,,,MedDRA:10078012,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4350,,,,
"http://example.org/irAEs.owl#Epstein-Barr_virus,_EBV",Epstein-Barr Virus,,,FALSE,,,http://example.org/irAEs.owl#Viral_Serology_7,,,,,_EBV,爱泼斯坦 - 巴尔病毒,,"A species of Herpetoviridae that is responsible for infectious mononucleosis (glandular fever). Discovered in 1964, this virus has been associated with Burkitt's lymphoma in South African children and with nasopharyngeal carcinoma in Asian populations.",Risk Factor,,,,,,,SNOMED_CT:40168006|LOINC:LP14383-1,Virus-Epstein-Barr|Human Herpesvirus 4|Human Gammaherpesvirus 4|EBV|HHV-4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14204,,,,
"http://example.org/irAEs.owl#Epstein-Barr_virus,_EBV1",Epstein-Barr virus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding1,,,,,_EBV1,爱泼斯坦 - 巴尔病毒,,,,,,,,,,SNOMED_CT:40168006|LOINC:LP14383-1,Virus-Epstein-Barr|Human Herpesvirus 4|Human Gammaherpesvirus 4|EBV|HHV-4,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14204,,,,
http://example.org/irAEs.owl#Functional_Studies1,Functional Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests5,,,,,Functional_Studies1,功能学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Non_Organ_Special_Laboratory_Finding,General and Routine Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,Non_Organ_Special_Laboratory_Finding,通用与常规实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Atezolizumab,Atezolizumab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_L1,,,,,Atezolizumab,阿替利珠单抗,,"A humanized, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1; PDCD1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 (CD80) expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC).",,,,,,,,DrugBank ID:DB11595,MPDL 3280A|RG 7446|RO 5541267|Tecentriq,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106250,,,,
http://example.org/irAEs.owl#Reproductive_system_and_breast,Reproductive System and Breast,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Reproductive_system_and_breast,生殖系统和乳腺,,"Reproductive System: The organs and tissues involved in the production and maturation of gametes and in their union and subsequent development as offspring.
Breast: One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest.",,,,,,,,SOC:10038604.0|UBERON:0000990 & 0000310,Genital tract|Reproductive Organ System,,"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12841
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12971",,,,
http://example.org/irAEs.owl#C_Reactive_Protein_CRP,C-Reactive Protein,,,FALSE,,,http://example.org/irAEs.owl#Inflammatory_Marker_Panel_13,,,,,C_Reactive_Protein_CRP,C 反应蛋白,,"C-reactive protein (224 aa, ~25 kDa) is encoded by the human CRP gene. This protein is cleaved during biological activation and is associated with host defense mechanisms and inflammatory responses.","Over Baseline, Risk Factor",,,,,,,LOINC:LP15023-2|SNOMED_CT:61425002,CRP - C-reactive protein|High Sensitivity C Reactive Protein|CRP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C60651,,,,
http://example.org/irAEs.owl#Social_Economics_and_Lifestyle,Socioeconomic Factors,,,FALSE,,,http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,,,,,Social_Economics_and_Lifestyle,社会经济因素,,"Characteristics of a person such as education and occupation, used to describe the person's position in stratification systems, access to services, etc.",,,,,,,,,Measured Social Factor,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C17468,,,,
http://example.org/irAEs.owl#Hypopgysitis,Hypophysitis,,,FALSE,,,http://example.org/irAEs.owl#Pituitary,,,,,Hypopgysitis,垂体炎,"A disorder characterized by inflammation and cellular infiltration of the pituitary gland.

Grade 1: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2: Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143193",An inflammatory process in the pituitary gland.,,,,,,,,MedDRA:10062767|ICD-11:5A61.0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121147,,,,
http://example.org/irAEs.owl#乳腺,Breast,,,FALSE,,,http://example.org/irAEs.owl#Disease1,,,,,乳腺,乳腺,,One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest.,,,,,,,,UBERON:0000310,Breasts,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12971,,,,
http://example.org/irAEs.owl#尤文肉瘤,Ewing Sarcoma,,,FALSE,,,http://example.org/irAEs.owl#软组织肿瘤,,,,,尤文肉瘤,尤文肉瘤,,"A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.",,,,,,,,MedDRA:10015560|ICD-11:XH8KJ8,Ewing's Tumor|Ewing tumor|Ewing's Sarcoma|ES,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4817,,,,
http://example.org/irAEs.owl#Trearment_Data,Immune Checkpoint Inhibitor (ICI)-Treatment Data,,,FALSE,,,http://example.org/irAEs.owl#Lung_Cancer-irAE,,,,,Trearment_Data,免疫检查点抑制剂治疗数据,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Occupation,Occupation,,,FALSE,,,http://example.org/irAEs.owl#Social_Economics_and_Lifestyle,,,,,Occupation,职业,,"The consideration of occupation as a variable in disease incident, transmission, and control.",Protective Factor,,,,,,,,Epidemiology|Occupation,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18771,,,,
http://example.org/irAEs.owl#ERBB2,Erb-b2 Receptor Tyrosine Kinase 2,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,ERBB2,Erb-b2 受体酪氨酸激酶 2,,"This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.",,,,,,,,NCBI Gene ID:2064,"ONCOGENE ERBB2|human epidermal growth factor receptor 2|Genes, HER2|TKR1|ERBB2",,https://www.ncbi.nlm.nih.gov/gene/2064,,,,
http://example.org/irAEs.owl#Albumin,Albumin,,,FALSE,,,http://example.org/irAEs.owl#CB,,,,,Albumin,白蛋白,,"A family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands. Albumin is the main protein in blood plasma. Low serum levels occur in conditions associated with malnutrition, inflammation and liver and kidney diseases.","Below Baseline, Risk Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Female,Female,,,FALSE,,,http://example.org/irAEs.owl#Sex,,,,,Female,女,,"A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both.",,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16576,,,,
http://example.org/irAEs.owl#D=A,Durvalumab & Atezolizumab,,,FALSE,,,http://example.org/irAEs.owl#Dual_PD-L1_Inhibition,,,,,A,,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#cTnt,Troponin T Cardiac Muscle,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Finding,,,,,cTnt,心肌肌钙蛋白 T,,"Troponin T, cardiac muscle (298 aa, ~36 kDa) is encoded by the human TNNT2 gene. This protein plays a role in cardiac muscle contraction.",,,,,,,,SNOMED_CT:102684000|LOINC:LP17145-1,"Troponin T, Cardiac Muscle|Cardiac Muscle Troponin T|TnTc|cTnT",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C104220,,,,
http://example.org/irAEs.owl#Sintilimab,Sintilimab,,,FALSE,,,http://example.org/irAEs.owl#Anti_PD_1,,,,,Sintilimab,信迪利单抗,,"A recombinant human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1; PDCD1; PD1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, sintilimab binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands programmed cell death-1 ligand 1 (PD-L1), and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin (Ig) superfamily expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity.",,,,,,,,DrugBank ID:DB15765,Daboshu|IBI 308|Tyvyt,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C132992,,,,
http://example.org/irAEs.owl#Alkaline_Phosphatase_ALP,Alkaline Phosphatase,,,FALSE,,,http://example.org/irAEs.owl#Serum_Biochemical_Tests_10,,,,,Alkaline_Phosphatase_ALP,碱性磷酸酶,,An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum.,"Below Baseline, Risk Factor",,,,,,,SNOMED_CT:57056007|LOINC:LP15346-7,Alkaline Phosphomonoesterase|ALKP|ALP|Alk Phos|AlkPhos,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C16276,,,,
http://example.org/irAEs.owl#FT4,Free Thyroxine,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Chemistry_Test,,,,,FT4,游离甲状腺素,,Free T4 is the metabolically active fraction of thyroxine and is the precursor of triiodothyronine (T3). Free T4 is a sensitive test for thyroid function and is increased with hyperthyroidism and decreased with hypothyroidism. Free T4 is not affected by changes in thryoxine-binding proteins (LOINC).,,,,,,,,SNOMED_CT:86211008|LOINC:LP29119-2,Free T4|T4FR|FT4,,https://loinc.org/LP29119-2/,,,,
http://example.org/irAEs.owl#乳腺癌,Breast Cancer,,,FALSE,,,http://example.org/irAEs.owl#乳腺肿瘤,,,,,乳腺癌,乳腺癌,,"A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla.",,,,,,,,ICD-11:2C6Y|MedDRA:10006187,Mammary Carcinoma|Carcinoma of the Breast|Cancer of Breast|Breast Carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4872,,,,
http://example.org/irAEs.owl#HSV,Cytomegalovirus,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Microbiology_Finding2,,,,,HSV,巨细胞病毒,,"A genus of the family herpesviridae, subfamily betaherpesvirinae, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions.",,,,,,,,SNOMED_CT:407444007|LOINC:LP14255-1,"Salivary Gland Viruses|cytomegalovirus group|Genus Cytomegalovirus|Cytomegalovirus species|Viruses, Salivary Gland|CMV",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C14196,,,,
http://example.org/irAEs.owl#Viral_Serology,Viral Serology,,,FALSE,,,http://example.org/irAEs.owl#MicB,,,,,Viral_Serology,血清病毒学,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Elevated_Eosinophil_Count,Elevated Eosinophil Count,,,FALSE,,,http://example.org/irAEs.owl#White_Blood_Cell_WBC,,,,,Elevated_Eosinophil_Count,嗜酸性粒细胞计数升高,"A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood.

Grade 1: >ULN and >Baseline
Grade 3: Steroids initiated
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143190",Abnormal high level of eosinophils in the blood.,,,,,,,,ICD-11:4B02|MedDRA:10014945,Increased eosinophils|Eosinophil count high|Eosinophil count above reference range|Eosinophil count raised|Increased blood eosinophil number|Eosinophil count increased,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3015,,,,
http://example.org/irAEs.owl#Colitis,Colitis,,,FALSE,,,http://example.org/irAEs.owl#Gastrointestinal_Tract,,,,,Colitis,结肠炎,"A disorder characterized by inflammation of the colon.

Grade 1: Asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2: Abdominal pain; mucus or blood in stool
Grade 3: Severe abdominal pain; peritoneal signs
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C57134",Inflammation of the colon.,,,,,,,,MedDRA:10009887|ICD-11:DB33.Y,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26723,,,,
http://example.org/irAEs.owl#anti-insulin,Insulin Autoantibody,,,FALSE,,,http://example.org/irAEs.owl#Clinical_Immunology_Test,,,,,anti-insulin,胰岛素自身抗体,,An autoantibody that recognizes insulin. It is associated with type 1 diabetes.,,,,,,,,LOINC:LP14676-8|SNOMED_CT:399770003,Anti-INS Autoantibody|Anti-Insulin Autoantibody|insulin Ab,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C214503,,,,
http://example.org/irAEs.owl#Eye,Eye,,,FALSE,,,http://example.org/irAEs.owl#AnatomicalSystemic_irAEs,,,,,Eye,眼睛,,The organ of sight or vision.,,,,,,,,UBERON:0000970|SOC: 10015919,Ocular|Ophthalmic,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12401,,,,
http://example.org/irAEs.owl#Mediastinum,Mediastinum,,,FALSE,,,http://example.org/irAEs.owl#Disease_5,,,,,Mediastinum,纵隔,,"An anatomic site along the midline and under the sternum that contains the heart and pericardium, the bases of the great vessels, the trachea and bronchi, esophagus, thymus, lymph nodes, thoracic duct, phrenic and vagus nerves, and other structures and tissues.",,,,,,,,UBERON:0003728,mediastinal part of chest,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C12748,,,,
http://example.org/irAEs.owl#Polymyalgia_Rheumatica_PMR,Polymyalgia Rheumatica,,,FALSE,,,http://example.org/irAEs.owl#Disease_11,,,,,Polymyalgia_Rheumatica_PMR,风湿性多肌痛,,"A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.",,,,,,,,ICD-11: FA22|MedDRA:10036099,PRM,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85018,,,,
http://example.org/irAEs.owl#Past_Medical_History,Personal Medical History,,,FALSE,,,http://example.org/irAEs.owl#Demographic_and_Epidemiologic_Feature,,,,,Past_Medical_History,个人病史,,"A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies.",,,,,,,,,Medical History|General Medical History|personal history,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C18772,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_12,Laboratory Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests11,,,,,Organ_specific_Laboratory_Finding_12,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_13,Laboratory Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests12,,,,,Organ_specific_Laboratory_Finding_13,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Organ_specific_Laboratory_Finding_11,Laboratory Tests,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests5,,,,,Organ_specific_Laboratory_Finding_11,实验室检查,,"Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.",,,,,,,,SNOMED_CT:15220000|LOINC:104922-0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C25294,,,,
http://example.org/irAEs.owl#Hematocrit,Hematocrit,,,FALSE,,,http://example.org/irAEs.owl#Hematology_Birmarher,,,,,Hematocrit,红细胞压积,,"Erythrocytes or red blood cells (RBCs) are the cells in the circulation that carry oxygen to and remove carbon dioxide from the tissues throughout the body. They are produced in the bone marrow in response to erythropoietin where they transition through six stages over a seven day period. When they are released into the circulation, their nucleus has been extruded and they measure 6-8 microns in diameter. The lifespan of RBCs is about 120 days. When the RBC ages the cell membrane becomes less pliable and tears as they cell travels through the micro vessels of the body. The damaged RBCs are removed from the circulation by the spleen. Variations in number, shape and size of RBCs are indicative of many diseases and disorders. There are many factors that may lead to decreased numbers of RBCs including hemorrhage, hemolysis, iron or vitamin deficiency, marrow failure and more. Larger than normal RBCs may be indicative of liver disease while smaller than normal RBCs are seen in thalassemias and other anemias (LOINC).","Over Baseline, Protective Factor",,,,,,,,,,,,,,
http://example.org/irAEs.owl#Diarrhea_Doeliac_Disease,Diarrhea,,,FALSE,,,http://example.org/irAEs.owl#Gastrointestinal_Tract,,,,,Diarrhea_Doeliac_Disease,腹泻,"A disorder characterized by an increase in frequency and/or loose or watery bowel movements.

Grade 1: Change in consistency or frequency
Grade 2: Increase of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric); change in consistency or frequency AND limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3: Increase of >=7 stools per day over baseline; hospitalization indicated; severe increase in ostomy output compared to baseline; requires IV intervention; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C57788",Watery bowel movements.,,,,,,,,ICD-11:ME05.1|MedDRA:10012727,Loose Stools|Frequent Stools|Diarrheal Disease,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2987,,,,
http://example.org/irAEs.owl#Imaging_Studies12,Imaging Studies,,,FALSE,,,http://example.org/irAEs.owl#Diagnostic_and_Assessment_Tests13,,,,,Imaging_Studies12,影像学检查,,,,,,,,,,,,,,,,,
http://example.org/irAEs.owl#Checkpoint_Inhibitor_Pneumonitis_CIP,Pneumonitis,,,FALSE,,,http://example.org/irAEs.owl#Lung,,,,,Checkpoint_Inhibitor_Pneumonitis_CIP,肺炎,"A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.

Grade 2: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
Grade 3: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
Grade 4: Life-threatening consequences; urgent intervention indicated
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143767","An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.
Including the following diseases:
Interstitial Pneumonia: Inflammation of interstitial lung tissue, usually associated with infection.
Nonspecific Interstitial Pneumonia: Idiopathic interstitial pneumonia characterized by chronic inflammation and fibrosis in the interstitial lung tissue. It includes cases that cannot be classified into one of the other types of idiopathic interstitial pneumonia.
Acute Interstitial Pneumonia, AIP: A rare, rapidly progressing interstitial lung disorder characterized by diffuse and bilateral alveolar damage. Patients present with sudden onset of dyspnea and rapid development of respiratory failure. Management is supportive and hospitalization and mechanical ventilation are usually required.
Diffuse Alveolar Damage, DAD: A histologic finding evident following acute lung injury. It is characterized by an acute phase with edema, deposition of hyaline membranes, and inflammation and is followed by an organizing phase with alveolar septal fibrosis and type II pneumocyte hyperplasia.
Cryptogenic Organizing Pneumonia, COP: A form of organizing pneumonia with a non-infectious etiology. Excessive proliferation of granulation tissue occurs in alveolar ducts and alveoli and primarily causes injury to alveolar walls, but bronchioles may be affected.",,,,,,,,ICD-11:CB03|MedDRA:10035742,Checkpoint Inhibitor Pneumonitis|CIP,,"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3333
Including the following diseases:
Interstitial Pneumonia: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27006
Nonspecific Interstitial Pneumonia: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35717
Acute Interstitial Pneumonia, AIP: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35806
Diffuse Alveolar Damage, DAD: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C189012
Cryptogenic Organizing Pneumonia, COP: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62586",,,,
http://example.org/irAEs.owl#Vitiligo,Vitiligo,,,FALSE,,,http://example.org/irAEs.owl#Skin,,,,,Vitiligo,白癜风,,Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.,,,,,,,,ICD-11:ED63.0|MedDRA:10047642,Hypopigmentation of skin|Blotchy loss of skin color|Vitiligo vulgaris,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26915,,,,
http://example.org/irAEs.owl#Muscle_strength_testing,Muscle Strength Assessment,,,FALSE,,,http://example.org/irAEs.owl#Organ_specific_examination_items,,,,,Muscle_strength_testing,肌力评估,,An assessment to evaluate the ability to exert force on an object using muscles.,,,,,,,,SNOMED_CT:246294003|LOINC:80322-1,Muscle Strength Test|Muscle Strength,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C221674,,,,
http://example.org/irAEs.owl#口腔,Oral Cavity Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,口腔,口腔鳞状细胞癌,,"A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.",,,,,,,,MedDRA:10041857|ICD-11:2B6A.0,SCC of Oral Cavity|SCC of Mouth|Squamous Cell Carcinoma of Oral Cavity|Mouth Squamous Cell Carcinoma|Oral Cavity SCC|Mouth SCC|OSCC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4833,,,,
http://example.org/irAEs.owl#ICI_related_Drug_Names_2,Immune Checkpoint Inhibitors,,,FALSE,,,http://example.org/irAEs.owl#Trearment_Data,,,,,ICI_related_Drug_Names_2,免疫检查点抑制剂,,An agent that inhibits any of the immune checkpoint inhibitory proteins.,,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143250,,,,
http://example.org/irAEs.owl#Drug_Use_History,Drug Use History,,,FALSE,,,http://example.org/irAEs.owl#Past_Medical_History,,,,,Drug_Use_History,用药史,,"A description of an individual's current and past use and/or abuse of drugs and chemicals. This includes prescription medication, illicit drugs and recreational substances.",Risk Factor,,,,,,,,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C81246,,,,
http://example.org/irAEs.owl#Subcutaneous_tissue,Subcutaneous tissue,,,FALSE,,,http://example.org/irAEs.owl#Disease_2,,,,,Subcutaneous_tissue,皮下组织,,"A tissue sample that contains the epidermis, dermis, and subcutaneous adipose tissue.",,,,,,,,UBERON:0002072,SKIN/SUBCUTIS|Skin/Subcutaneous Tissue|Hypodermis,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C92441,,,,
http://example.org/irAEs.owl#Ureteroscopy,Ureteroscopy,,,FALSE,,,http://example.org/irAEs.owl#Endoscopic_Examinations,,,,,Ureteroscopy,输尿管镜检查,,Examination of the ureter using a specialized video camera (ureteroscope).,,,,,,,,SNOMED_CT:387717002,Endoscopy Procedures on the Ureter|Cystoscopy of ureter|Endoscopy of ureter|Cystoureteroscopy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C94308,,,,
http://example.org/irAEs.owl#Thrombotic_Microangiopathy_TMA,Thrombotic Microangiopathy,,,FALSE,,,http://example.org/irAEs.owl#Capillary,,,,,Thrombotic_Microangiopathy_TMA,血栓性微血管病,"A disorder characterized by a form of thrombotic microangiopathy with laboratory findings that indicate hemolytic anemia, severe thrombocytopenia, and renal insufficiency/failure.

Grade 2: Outpatient intervention indicated (e.g., modification of immunosuppression)
Grade 3: Transfusion or IV intervention indicated
Grade 4: Life-threatening consequences
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C220813","A microvascular coagulopathy that may result from systemic vascular endothelial injury triggering the development of a procoagulant state, activation of the complement cascade, and microthrombi formation. Signs may include hemolytic anemia, thrombocytopenia, hypertension and renal dysfunction.",,,,,,,,ICD-11:3B65|MedDRA:10043645,TMA,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62605,,,,
http://example.org/irAEs.owl#黑色素瘤眼,Ocular Melanoma,,,FALSE,,,http://example.org/irAEs.owl#Eye_and_Orbit_Tumours,,,,,黑色素瘤眼,眼部黑色素瘤,,A melanoma that arises from the structures of the eye.,,,,,,,,"ICD-11:2D01.0
ICD-11:2D00.0
ICD-11:2D07,2
ICD-11:2D04|MedDRA:10086693",Eye Melanoma|Melanoma of the Eye|Melanoma of Eye,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8562,,,,
"http://example.org/irAEs.owl#Anti-cyclic_Citrullinated_Peptide_Antibody,_Anti-CCP",Anti-Cyclic Citrullinated Peptide Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,_Anti-CCP,抗环状胍氨酸多肽抗体,,An autoantibody directed against peptides or proteins whose arginine residues have been enzymatically converted to citrulline. It is often associated with rheumatoid arthritis.,,,,,,,,SNOMED_CT:406518004|LOINC:LP37859-3,Anti-Perinuclear Factor Antibody|Anti-Keratin Antibody|ACPA|Anti-CCP,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121326,,,,
http://example.org/irAEs.owl#Anti-BP180_Antibody,Anti-BP180 Antibody,,,FALSE,,,http://example.org/irAEs.owl#Autoimmune_Antibody_Tests_13,,,,,Anti-BP180_Antibody,抗BP180抗体,,"Collagen alpha-1(XVII) chain (1497 aa, ~150 kDa) is encoded by the human COL17A1 gene. This protein plays a role in the attachment of keratinocytes to the basement membrane.",Risk Factor,,,,,,,LOINC:45188-0,BASEMENT MEMBRANE ZONE BP180|Type XVII Collagen Alpha-1|Bullous Pemphigoid Antigen 2|Alpha 1 Type XVII Collagen|180 kDa Bullous Pemphigoid Antigen 2|BMZ BP180|COL17A1,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C182139,,,,
http://example.org/irAEs.owl#Minimal_Change_Disease_MCD,Minimal Change Glomerulonephritis,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Minimal_Change_Disease_MCD,微小病变性肾小球肾炎,,A glomerular disorder characterized by the electron microscopic finding of loss of podocyte foot processes. Light microscopic examination does not show glomerular changes. Patients present with proteinuria and nephrotic syndrome.,,,,,,,,ICD-11:GB41|MedDRA:10058326,Glomerulonephritis minimal lesion|Minimal Change Glomerulonephritis|Nil disease|Lipoid Nephrosis|Lipid nephrosis|Minimal Change Disease|Minimal Change Nephropathy,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34844,,,,
http://example.org/irAEs.owl#JAK-STAT_Signaling_Pathway,JAK-STAT Signaling Pathway,,,FALSE,,,http://example.org/irAEs.owl#Pathway,,,,,JAK-STAT_Signaling_Pathway,JAK-STAT 信号通路,,"The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.[KEGG]",Risk Factor,,,,,,,KEGG ID:map04630,Janus Kinase/Signal Transducer and Activator of Transcription,,https://www.kegg.jp/entry/map04630,,,,
http://example.org/irAEs.owl#腕管综合征,Carpal Tunnel Syndrome,,,FALSE,,,http://example.org/irAEs.owl#Peripheral_Nervous,,,,,腕管综合征,腕管综合征,,"Entrapment of the median nerve in the wrist that is characterized by numbness, tingling and painful movement.",,,,,,,,MedDRA:10007697|ICD-11:8C10.0,,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34450,,,,
http://example.org/irAEs.owl#Acute_Interstitial_Nephritis_AIN,Interstitial Nephritis,,,FALSE,,,http://example.org/irAEs.owl#Kidney,,,,,Acute_Interstitial_Nephritis_AIN,间质性肾炎,,Inflammation of the renal tubules and supporting tissues of the kidney.,,,,,,,,MedDRA:10029134|ICD-11:GB54,"Interstitial Renal Diseases and Syndromes|IN - Interstitial nephritis|renal; disease, with interstitial nephritis|Nephritis interstitial|IN",,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26834,,,,
http://example.org/irAEs.owl#Rhabdomyolysis,Rhabdomyolysis,,,FALSE,,,http://example.org/irAEs.owl#Muscular_System,,,,,Rhabdomyolysis,横纹肌溶解症,"A disorder characterized by the breakdown of muscle tissue resulting in the release of muscle fiber contents into the bloodstream.

Grade 1: Asymptomatic, intervention not indicated; laboratory findings only
Grade 2: Non-urgent intervention indicated
Grade 3: Symptomatic, urgent intervention indicated
Grade 4: Life-threatening consequences; dialysis
Grade 5: Death
https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C143226",A clinical syndrome resulting from direct or indirect muscle injury and subsequent release of myoglobin into the plasma.,,,,,,,,ICD-11:8C84|MedDRA:10039020,RM,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C118318,,,,
http://example.org/irAEs.owl#Mean_corpuscular_hemoglobin_concentration_MCHC,Mean corpuscular hemoglobin concentration,,,FALSE,,,http://example.org/irAEs.owl#Complete_Blood_Count_CBC_7,,,,,Mean_corpuscular_hemoglobin_concentration_MCHC,平均红细胞血红蛋白浓度,,"The mean cell hemoglobin concentration (MCHC), which is the average concentration of hemoglobin in a given volume of blood. The MCHC is a calculated value derived from the measurement of hemoglobin and the hematocrit.",,,,,,,,SNOMED_CT:37254006,Erythrocyte Mean Corpuscular Hemoglobin Concentration|Ery. Mean Corpuscular HGB Concentration|MCHC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64798,,,,
http://example.org/irAEs.owl#内膜癌,Endometrial Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#女性生殖系统及乳腺,,,,,内膜癌,子宫内膜癌,,"A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation.",,,,,,,,ICD-11:2C76|MedDRA:10014743,Carcinoma of Endometrium|endometrial cancer|EC|UCEC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7558,,,,
http://example.org/irAEs.owl#实性假乳头,Solid Pseudopapillary Carcinoma of the Pancreas,,,FALSE,,,http://example.org/irAEs.owl#消化,,,,,实性假乳头,胰腺实性假乳头状肿瘤,,"A malignant neoplasm arising from the exocrine pancreas. It occurs predominantly in young women. It is characterized by the presence of extensive necrosis and hemorrhage and is composed of polyhedral cells forming solid and pseudopapillary patterns. There is morphologic evidence of perineural invasion, vascular invasion, or extensive invasion into the surrounding tissues.",,,,,,,,MedDRA:10069345|ICD-11:2C10.0,Pancreatic Solid Pseudopapillary Carcinoma|Solid pseudopapillary carcinoma,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C5728,,,,
http://example.org/irAEs.owl#LUSC,Lung Squamous Cell Carcinoma,,,FALSE,,,http://example.org/irAEs.owl#NSCLC,,,,,LUSC,肺鳞状细胞癌,,"A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.",,,,,,,,MedDRA:10041826|ICD-11:2C25.2,Squamous Cell Carcinoma of Lung|Epidermoid Cell Carcinoma of Lung|Lung Squamous Cell Carcinoma|LUSC,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3493,,,,
http://example.org/irAEs.owl#MSI-H,MicroSatellite Instability-High,,,FALSE,,,http://example.org/irAEs.owl#Tumor_Mutational_Burden_TMB,,,,,MSI-H,微卫星高度不稳定性,,The presence of genomic instability associated with defective DNA mismatch repair in greater than 30% of the microsatellite instability (MSI) biomarkers in a tumor sample.,Risk Factor,,,,,,,,High-Frequency Microsatellite Instability|Microsatellite Instability High|MSI high|MSI-H,,https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C36493,,,,
