{"id":"http://purl.bioontology.org/ontology/MDRFRE/20000044","prefLabel":"Syndrome malin des neuroleptiques (SMQ)","notation":"20000044","semanticType":["http://purl.bioontology.org/ontology/STY/T185"],"cui":["C1869046"],"definition":["Le syndrome malin des neuroleptiques (SMN) est une affection rare mais potentiellement fatale caractérisée par : hyperthermie, rigidité musculaire, altération de l'état de conscience et dysfonctionnement autonome. C'est une complication du traitement par neuroleptiques. Des symptômes similaires à ceux du SMN ont été signalés chez les patients non schizophrènes traités par réducteurs de la dopamine (comme la réserpine), après la privation d'agonistes indirects des récepteurs de la dopamine chez les patients atteints de la maladie de Parkinson, et en association à une intoxication aux agents anticholinergiques, amphétamines, carbonate de lithium, cocaïne et phencyclidine. Le diagnostic est généralement fondé sur le développement d'une rigidité musculaire grave et d'une température élevée chez les patients traités par neuroleptiques, qui s'accompagnent de différentes combinaisons de dysfonctionnement autonome (diaphorèse, incontinence, tachycardie, pression artérielle élevée ou labile), dysphagie, tremblement, myoclonie, changements de l'état de conscience allant de la confusion au coma, mutisme, leucocytose et constatation biologique de lésion musculaire, comme une élévation de la créatine phosphokinase (CPK) Il ne semble pas y avoir de différences majeures entre la présentation clinique observée sous neuroleptiques conventionnels et celle observée avec les agents antipsychotiques atypiques plus récents."],"label":[],"synonym":[],"obsolete":false,"prefixIRI":null,"subClassOf":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"parents":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["20000044"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_ALGO":["A or (B and C and D)"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://bioportal.bioontology.org/ontologies/umls/tui":["T185"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_LEVEL":["1"],"http://purl.bioontology.org/ontology/MDRFRE/SOS":["Algorithme : un cas sera retenu pour examen plus approfondi s'il présente au moins un des PT figurant dans la catégorie A (portée étroite) ou une combinaison quelconque d'au moins un PT de chacune des trois catégories B, C et D (portée large). Catégorie A (portée étroite) : le PT Syndrome malin des neuroleptiques, le PT Syndrome sérotoninergique ou le PT Hyperthermie maligne représentant des spécifiquement le SMN ou une des pathologies similaires : syndrome sérotoninergique ou hyperthermie maligne (lesquels peuvent aisément faire l'objet d'un diagnostic erroné de SMN). Définitions des catégories B, C et D* (portée large) : Catégorie B =(PT se rapportant à la fièvre); Catégorie C (PT se rapportant à la rigidité musculaire ou aux lésions) ; Catégorie D (autres PT pertinents se rapportant au SMN, y compris les résultats d'investigations). *Noter que la catégorie A correspond à la catégorie 1 de la documentation du CIOMS. Les catégories B, C et D correspondent aux termes de recherche de catégorie 2 se rapportant à la fièvre, aux termes de recherche de catégorie 2 se rapportant à la rigidité musculaire/aux lésions, et aux autres termes de recherche de catégorie 2 pertinents se rapportant au SMN, respectivement."],"http://www.w3.org/2004/02/skos/core#notation":["20000044"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_STATUS":["A"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_SOURCE":["1) Levenson JL. Neuroleptic malignant syndrome. Amer J Psychiatry 1985; 142(10):1137-1145. 2) Caroff SN and Mann SC. Neuroleptic malignant syndrome. Medical Clinics of North America 1993; 77(1):185-202. 3) Neuroleptic malignant syndrome. Diagnostic and Statistical Manual of Mental Disorders (4th Ed). American Psychiatric Association: Washington DC, 1994, pg. 739-742. 4) Velamoor VR. Neuroleptic malignant syndrome: recognition, prevention and management. Drug Safety 1998; 19(1):73-82. 5) Neuroleptic malignant syndrome. Reporting Adverse Drug Reactions: Definitions of Terms and Criteria for Their Use. Bankowski Z, Bruppacher R, Crusius I et al (Eds). Council for International Organizations of Medical Sciences: Geneva, 1999, pg. 31-32. 6) Simpson GM, Pi EH, and Sramek JJ. Neuroleptic and antipsychotic drugs. Meyler's Side Effects of Drugs (14th Ed). Dukes MNG and Aronson JK (Eds). Elsevier: New York, 2000, pg. 139-163. 7) Crismon ML and Dorson PG. Schizophrenia. Pharmacotherapy: A Pathophysiologic Approach (5th Ed). DiPiro JT, Talbert RL, Yee GC et al (Eds). McGraw-Hill: New York, 2002, pg. 1219-1242. 8) Hasan S and Buckley P. Novel antipsychotics and the neuroleptic malignant syndrome: a review and critique. Amer J Psychiatry 1998; 155(8):1113-1116. 9) Caroff SN, Mann SC, and Campbell EC. Atypical antipsychotics and neuroleptic malignant syndrome. Psychiatric Annals 2000; 30(5):314-321. 10) Ananth J, Parameswaran S, and Gunatilake S et al. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiatry 2004; 65(4):464-470."],"http://bioportal.bioontology.org/ontologies/umls/hasSTY":["http://purl.bioontology.org/ontology/STY/T185"],"http://bioportal.bioontology.org/ontologies/umls/cui":["C1869046"],"http://www.w3.org/2004/02/skos/core#prefLabel":["Syndrome malin des neuroleptiques (SMQ)"],"http://www.w3.org/2004/02/skos/core#definition":["Le syndrome malin des neuroleptiques (SMN) est une affection rare mais potentiellement fatale caractérisée par : hyperthermie, rigidité musculaire, altération de l'état de conscience et dysfonctionnement autonome. C'est une complication du traitement par neuroleptiques. Des symptômes similaires à ceux du SMN ont été signalés chez les patients non schizophrènes traités par réducteurs de la dopamine (comme la réserpine), après la privation d'agonistes indirects des récepteurs de la dopamine chez les patients atteints de la maladie de Parkinson, et en association à une intoxication aux agents anticholinergiques, amphétamines, carbonate de lithium, cocaïne et phencyclidine. Le diagnostic est généralement fondé sur le développement d'une rigidité musculaire grave et d'une température élevée chez les patients traités par neuroleptiques, qui s'accompagnent de différentes combinaisons de dysfonctionnement autonome (diaphorèse, incontinence, tachycardie, pression artérielle élevée ou labile), dysphagie, tremblement, myoclonie, changements de l'état de conscience allant de la confusion au coma, mutisme, leucocytose et constatation biologique de lésion musculaire, comme une élévation de la créatine phosphokinase (CPK) Il ne semble pas y avoir de différences majeures entre la présentation clinique observée sous neuroleptiques conventionnels et celle observée avec les agents antipsychotiques atypiques plus 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