{"id":"http://purl.bioontology.org/ontology/MDRFRE/20000133","prefLabel":"Encéphalopathie/délire non infectieux (SMQ)","notation":"20000133","semanticType":["http://purl.bioontology.org/ontology/STY/T185"],"cui":["C1964002"],"definition":["'L'encéphalopathie et le délire ont communément des étiologies infectieuses ou métaboliques. Peut aussi être d'origine médicamenteuse (objectif de cette SMQ). Dans le cas de certaines affections métaboliques, il est possible qu'un médicament ait un rôle contribuant ou causatif dans l'anomalie métabolique sous-jacente. L'encéphalopathie et le délire peuvent être rapportés de façon synonyme, mais le délire peut avoir un champ plus étroit. 1) Encéphalopathie : Définie comme une maladie dégénérative ou diffuse du cerveau, altérant la structure ou la fonction cérébrale. De nombreux sous-types existent, dont : biliaire ; démyélinisante ; Wernicke ; secondaire à une infection ; et secondaire à des troubles métaboliques d'origine médicamenteuse comme l'encéphalopathie hépatique, l'hyperammoniémie, l'hypoglycémie, l'urémie. Leucoencéphalopathie (encéphalopathie avec lésions de la substance blanche) ; peut-être secondaire à une hypertension d'origine médicamenteuse. Sa principale caractéristique est un état mental altéré. D'autres symptômes incluent : léthargie, fluctuation de l'état de conscience, nystagmus, tremblements, démence, crises, myoclonie, faiblesse musculaire. Un œdème cérébral est courant. 2) Délire (état confusionnel aigu) : Le délire est un état clinique caractérisé par les troubles fluctuants de la cognition, de l'humeur, de l'attention, de l'excitation et de la conscience de soi. Peut être dû à des maladies cérébrales principales, ou secondaires à d'autres maladies. Parmi les causes, on citera : métabolique; toxique (médicaments ou produits chimiques) ; structurelle (occlusion vasculaire et infarctus cérébral) ; hémorragie intracérébrale ; tumeurs cérébrales principales ou métastatiques ; et infection. Parmi les signes et symptômes, on citera : troubles de la conscience avec désorientation, changements de personnalité et d'humeur, délires, hallucinations (généralement visuelles), paranoïa, symptômes de privation, agitation, troubles du langage."],"label":[],"synonym":[],"obsolete":false,"prefixIRI":null,"subClassOf":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"parents":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["20000133"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_ALGO":["N"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://bioportal.bioontology.org/ontologies/umls/tui":["T185"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_LEVEL":["1"],"http://www.w3.org/2004/02/skos/core#notation":["20000133"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_STATUS":["A"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_SOURCE":["1) Jain K. Drug induced neurological disorders. 2001; 2nd edition: p. 23. 2) National Institute of Neurological Disorders and Stroke, 2006. 3) Encephalopathy. Gale Encyclopedia of Neurological Disorders 2005. From the Thomson Gale Group Inc. 4) Beehrs M and Berkow R. The Merck Manual of Diagnosis and Therapy. 17th edition; 1999: 362-3. 5) Beehrs M and Berkow R. The Merck Manual of Diagnosis and Therapy. 17th edition; 1999: Chapter 171."],"http://bioportal.bioontology.org/ontologies/umls/hasSTY":["http://purl.bioontology.org/ontology/STY/T185"],"http://bioportal.bioontology.org/ontologies/umls/cui":["C1964002"],"http://www.w3.org/2004/02/skos/core#prefLabel":["Encéphalopathie/délire non infectieux (SMQ)"],"http://www.w3.org/2004/02/skos/core#definition":["'L'encéphalopathie et le délire ont communément des étiologies infectieuses ou métaboliques. Peut aussi être d'origine médicamenteuse (objectif de cette SMQ). 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D'autres symptômes incluent : léthargie, fluctuation de l'état de conscience, nystagmus, tremblements, démence, crises, myoclonie, faiblesse musculaire. Un œdème cérébral est courant. 2) Délire (état confusionnel aigu) : Le délire est un état clinique caractérisé par les troubles fluctuants de la cognition, de l'humeur, de l'attention, de l'excitation et de la conscience de soi. Peut être dû à des maladies cérébrales principales, ou secondaires à d'autres maladies. Parmi les causes, on citera : métabolique; toxique (médicaments ou produits chimiques) ; structurelle (occlusion vasculaire et infarctus cérébral) ; hémorragie intracérébrale ; tumeurs cérébrales principales ou métastatiques ; et infection. 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