{"id":"http://purl.bioontology.org/ontology/MDRFRE/20000178","prefLabel":"Ostéoporose/ostéopénie (SMQ)","notation":"20000178","semanticType":["http://purl.bioontology.org/ontology/STY/T185"],"cui":["C2721747"],"definition":["Ostéoporose : Affection squelettique systémique avec masse osseuse diminuée et détérioration de la microarchitecture osseuse. Ostéopénie : forme moins grave de perte osseuse. Produit un risque de fracture accru. Sites courants de perte osseuse et fractures : vertèbres thoraciques/lombaires, côtes, extrémité sup. du fémur, extrémité inf. du radius. En général aucun signe ou symptôme, sauf : diminution de la taille corporelle et cyphose jusqu'à la survenue de fractures. Pathogenèse : génétique ; médicamenteuse ; alimentaire ; race ethnique ; sexe ; style de vie ; niveau d'activité. Type 1 (post-ménopausique) : plus courant ; résulte d'une déficience en hormones sexuelles ; recrutement/réactivité accrus des précurseurs ostéoclasiques et résorption osseuse accélérée, plus rapides que la formation osseuse ; réduction de l'os trabéculaire avec risque accru de fracture ; déficience oestrogénique pouvant augmenter la sensibilité des os à l'hormone parathyroïdienne, menant à une libération accrue de calcium osseux, une diminution de l'excrétion rénale du calcium et une production accrue de la 1,25-dihydroxyvitamine D ; déficience gonadique peuvant aussi augmenter la production des cytokines qui influencent les ostéoclastes. Type 2 (sénile) : touche les deux sexes ; formation osseuse et production rénale en 1,25(OH)2 D3 réduites ; perte d'os cortical et trabéculaire avec risque accru de fracture. Type 3 : origine médicamenteuse ou dû à d'autres états menant à une perte osseuse accrue due à divers mécanismes. Densité minérale osseuse souvent utilisée comme mesure approximative de la résistance des os. Définition de l'ostéoporose par l'OMS : densité osseuse de 2,5 écarts types en dessous de la moyenne pour les jeunes femmes adultes de race blanche. Marqueurs du remodelage osseux (phosphatase alcaline spécifique de l'os, ostéocalcine, peptides du procollagène de type I et déoxypyridinoline urinaire) parfois utilisés pour surveiller la réponse au traitement."],"label":[],"synonym":[],"obsolete":false,"prefixIRI":null,"subClassOf":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"parents":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["20000178"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_ALGO":["N"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://bioportal.bioontology.org/ontologies/umls/tui":["T185"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_LEVEL":["1"],"http://www.w3.org/2004/02/skos/core#notation":["20000178"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_STATUS":["A"],"http://purl.bioontology.org/ontology/MDRFRE/SMQ_SOURCE":["Hobar, C. Osteoporosis. eMedicine, 16 December 2005 (http://www.emedicine.com/MED/topic1693.htm); WHO/Forum for Collaborative HIV Research Joint Meeting: ARV Drugs Adverse Events, Case Definition, Grading, Laboratory Diagnosis and Treatment Monitoring, Background Document (Draft), 28 - 29 February 2008; Dorland's Medical Dictionary (http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/six/000076562.htm"],"http://bioportal.bioontology.org/ontologies/umls/hasSTY":["http://purl.bioontology.org/ontology/STY/T185"],"http://bioportal.bioontology.org/ontologies/umls/cui":["C2721747"],"http://www.w3.org/2004/02/skos/core#prefLabel":["Ostéoporose/ostéopénie (SMQ)"],"http://www.w3.org/2004/02/skos/core#definition":["Ostéoporose : Affection squelettique systémique avec masse osseuse diminuée et détérioration de la microarchitecture osseuse. Ostéopénie : forme moins grave de perte osseuse. Produit un risque de fracture accru. Sites courants de perte osseuse et fractures : vertèbres thoraciques/lombaires, côtes, extrémité sup. du fémur, extrémité inf. du radius. En général aucun signe ou symptôme, sauf : diminution de la taille corporelle et cyphose jusqu'à la survenue de fractures. Pathogenèse : génétique ; médicamenteuse ; alimentaire ; race ethnique ; sexe ; style de vie ; niveau d'activité. 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