{"id":"http://purl.bioontology.org/ontology/MDRFRE/20000231","prefLabel":"Pneumonie infectieuse (SMQ)","notation":"20000231","semanticType":["http://purl.bioontology.org/ontology/STY/T185"],"cui":["C4524253"],"definition":["La pneumonie est une inflammation aiguë des poumons causée par une infection; c'est la cause la plus fréquente d'infection fatale acquise en milieu hospitalier et la cause la plus fréquente, globalement, de décès dans les pays en voie de développement. Aux États-Unis, deux à trois millions de personnes, par an, contractent une pneumonie; dont environ 60.000 sont fatales. Le diagnostic et la prise en charge dépendent de l'origine bactérienne, virale, fongique ou parasitaire de l'infection; de sa survenue en milieu communautaire, hospitalier ou autre établissement de soins et de sa manifestation chez un patient immunocompétent ou immunodéprimé. Les manifestations cliniques varient de formes indolentes à fulminantes; de sévérité modérée à fatale; le patient peut être fébrile et présenter une tachycardie, ou peut avoir des antécédents de frissons et/ou de sueurs; une toux productive ou non; des douleurs thoraciques pleurétiques peuvent survenir; d'autres symptômes peuvent inclure fatigue, céphalées, myalgies, arthralgies et des symptômes gastro-intestinaux; les complications de pneumonie sévère incluent l'insuffisance respiratoire, le choc septique et défaillance multiviscérale, coagulopathie et exacerbation de maladies morbides; elles peuvent ne pas être évidentes chez la personne âgée qui peut, au début, présenter l'apparition ou la réapparition de confusion avec quelques autres manifestations. Modalités du diagnostic: radiographie thoracique; signes cliniques; coloration de Gram et culture des crachats; hémoculture; tests d'antigènes urinaires à la recherche d'antigènes pneumococciques et de légionellose; tests d'amplification en chaîne par polymérase à la recherche d'infection respiratoire virale; titres d'anticorps IgM spécifiques; biomarqueurs. 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Les manifestations cliniques varient de formes indolentes à fulminantes; de sévérité modérée à fatale; le patient peut être fébrile et présenter une tachycardie, ou peut avoir des antécédents de frissons et/ou de sueurs; une toux productive ou non; des douleurs thoraciques pleurétiques peuvent survenir; d'autres symptômes peuvent inclure fatigue, céphalées, myalgies, arthralgies et des symptômes gastro-intestinaux; les complications de pneumonie sévère incluent l'insuffisance respiratoire, le choc septique et défaillance multiviscérale, coagulopathie et exacerbation de maladies morbides; elles peuvent ne pas être évidentes chez la personne âgée qui peut, au début, présenter l'apparition ou la réapparition de confusion avec quelques autres manifestations. Modalités du diagnostic: radiographie thoracique; signes cliniques; coloration de Gram et culture des crachats; hémoculture; tests d'antigènes urinaires à la recherche d'antigènes pneumococciques et de légionellose; tests d'amplification en chaîne par polymérase à la recherche d'infection respiratoire virale; titres d'anticorps IgM spécifiques; biomarqueurs. 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