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La physiopathologie de l'inflammation à médiation immunitaire causant la destruction des tissus peut impliquer des combinaisons de : cellules T autoréactives, autoanticorps, cytokines inflammatoires, activation du complément. Tous les troubles à médiation immunitaire n'ont pas nécessairement un mécanisme auto-immun spécifique. Certains agents d'immunothérapie du cancer ont été associés à des événements indésirables à médiation immunitaire de nature inflammatoire ou auto-immune.Il peut s'agir de déclenchement d'une affection à médiation immunitaire de novo, ou de l'exacerbation d'une anomalie préexistante. Les affections à médiation immunitaire sont également un risque potentiel avec les vaccins qui utilisent de nouveaux adjuvants pour renforcer la réponse immunitaire. Les conséquences sont variées : la peau, le tube digestif et l'appareil respiratoire sont les plus souvent concernés. Les événements neurologiques et les dysfonctionnements endocriniens sont des réactions moins fréquentes. 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