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Chronic tubulointerstitial disease: can gradually develop over years; involves interstitial infiltrate, fibrosis, tubular atrophy and dysfunction, and eventually renal dysfunction; interstitial inflammation and scarring of the renal parenchyma is associated with gross changes, including papillary blunting and marked calyceal deformities; can be detected by imaging; systemic insults, such as genetic disorders, hypertension, toxins, etc., feature symmetric and bilateral disease; other causes of chronic disease may result in unequal renal scarring, and may involve one or both kidneys; principal etiologies include: toxins; drugs; autoimmune, genetic, and neoplastic disorders; obstructive uropathy."],"label":[],"synonym":[],"obsolete":false,"prefixIRI":null,"subClassOf":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"parents":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.bioontology.org/ontology/MEDDRA/SMQ_STATUS":["A"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://bioportal.bioontology.org/ontologies/umls/tui":["T185"],"http://www.w3.org/2004/02/skos/core#notation":["20000221"],"http://purl.bioontology.org/ontology/MEDDRA/SMQ_LEVEL":["1"],"http://bioportal.bioontology.org/ontologies/umls/hasSTY":["http://purl.bioontology.org/ontology/STY/T185"],"http://purl.bioontology.org/ontology/MEDDRA/SMQ_ALGO":["N"],"http://purl.bioontology.org/ontology/MEDDRA/SOS":["Severe forms of acute tubulointerstitial nephritis may lead to acute renal failure. 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