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This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS)."],"subClassOf":["http://purl.bioontology.org/ontology/MESH/D000309","http://purl.bioontology.org/ontology/MESH/D018901","http://purl.bioontology.org/ontology/MESH/D038901","http://purl.bioontology.org/ontology/MESH/D020739","http://purl.bioontology.org/ontology/MESH/D020279"],"parents":[{"id":"http://purl.bioontology.org/ontology/MESH/D000309","synonym":["Hypofunction, Adrenal Gland","Hypoadrenalism","Adrenal Gland Hypofunction","Adrenal Insufficiencies"],"notation":"D000309","semanticType":["http://purl.bioontology.org/ontology/STY/T047"],"cui":["C0001623"],"prefLabel":"Adrenal Insufficiency","definition":["Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. 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