{"id":"http://purl.bioontology.org/ontology/MESH/D035321","synonym":["PIN2 Protein","TRF1 Proteins","TTAGGG Repeat Binding Factor 1","PIN2 Proteins","TRF1 Protein","TERF1 Protein","TERF1 Proteins"],"notation":"D035321","semanticType":["http://purl.bioontology.org/ontology/STY/T123","http://purl.bioontology.org/ontology/STY/T116"],"cui":["C0526985","C1136063"],"prefLabel":"Telomeric Repeat Binding Protein 1","definition":["An alternatively spliced form of telomeric repeat binding protein 1. In human it lacks 20 amino acids.","A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues."],"subClassOf":["http://purl.bioontology.org/ontology/MESH/D000089804","http://purl.bioontology.org/ontology/MESH/D034501"],"parents":[{"id":"http://purl.bioontology.org/ontology/MESH/D000089804","synonym":["Complex, Telomere POT1-TPP1","POT1 TPP1 Shelterin Complex","CST Complex","Telomeric Capping Complex","Shelterin Complex, POT1-TPP1","Ctc1 Stn1 Ten1 Complex","Telomere POT1 TPP1 Complex","Complex, Telomeric Capping","Telosomes","Telomeric Stn1 Ten1 Capping Complex","Complex, Ctc1-Stn1-Ten1","POT1-TPP1 Shelterin Complex","Telomere Cap Complex","Ctc1-Stn1-Ten1 Complex","POT1-TPP1 Complex, Telomere","Complex, CST","Telomere POT1-TPP1 Complex","Telosome","Capping Complex, Telomeric","Complex, POT1-TPP1 Shelterin","Complex, Shelterin","Telomeric Stn1-Ten1 Capping Complex"],"notation":"D000089804","semanticType":["http://purl.bioontology.org/ontology/STY/T123","http://purl.bioontology.org/ontology/STY/T116"],"cui":["C5445116","C5445115","C5545244","C3889653"],"prefLabel":"Shelterin Complex","definition":["A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2)."],"subClassOf":["http://purl.bioontology.org/ontology/MESH/D016615","http://purl.bioontology.org/ontology/MESH/D034501","http://purl.bioontology.org/ontology/MESH/D009698","http://purl.bioontology.org/ontology/MESH/D046912"],"label":[],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"prefixIRI":null,"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.bioontology.org/ontology/MESH/D000089804","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804","ontology":"https://data.bioontology.org/ontologies/MESH","children":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/children","parents":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/parents","descendants":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/descendants","ancestors":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/ancestors","instances":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/instances","tree":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/tree","notes":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/notes","mappings":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804/mappings","ui":"http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000089804","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.bioontology.org/ontology/MESH/D034501","synonym":["alpha-Subunit Telomer-Binding Protein","beta-Telomere-Binding Protein","Telomere Binding Proteins","Double Stranded Telomeric Binding Protein","Telomere Binding Proteins, Double Stranded","Telomere-Binding Proteins, Double Stranded","Single Stranded Telomere Binding Proteins","Telomer Binding Protein, alpha Subunit","Single Stranded Telomere Binding Protein","Telomere-Binding Proteins, Single-Stranded","Telomere Binding Protein","Single-Stranded Telomere-Binding Proteins","alpha Telomere Binding Protein","Single-Stranded Telomere-Binding Protein","Telomer Binding Protein, beta Subunit","beta-Subunit Telomer-Binding Protein","Telomere End-Binding Protein (TEBP)","Telomere Repeat Binding Factors","beta Telomere Binding Protein","Double Stranded Telomere Binding Proteins","Telomere Binding Proteins, Single Stranded","Telomere-Binding Proteins, Double-Stranded","Telomere-Binding Protein","Protein, Telomere-Binding","Telomer-Binding Protein, alpha-Subunit","Double-Stranded Telomeric Binding Protein","Telomere-Binding Protein, Single-Stranded","Double-Stranded Telomere-Binding Proteins","alpha-Telomere-Binding Protein","Telomere Repeat Binding Factor","Telomere Repeat Binding Proteins","Telomer-Binding Protein, beta-Subunit"],"notation":"D034501","semanticType":["http://purl.bioontology.org/ontology/STY/T123","http://purl.bioontology.org/ontology/STY/T116"],"cui":["C1136053","C0753508","C0379073","C0753512","C0209852","C0379074"],"prefLabel":"Telomere-Binding Proteins","definition":["Proteins that specifically bind to TELOMERES. Proteins in this class include those that perform functions such as telomere capping, telomere maintenance and telomere stabilization."],"subClassOf":["http://purl.bioontology.org/ontology/MESH/D004268","http://purl.bioontology.org/ontology/MESH/D002868"],"label":[],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"prefixIRI":null,"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.bioontology.org/ontology/MESH/D034501","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501","ontology":"https://data.bioontology.org/ontologies/MESH","children":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/children","parents":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/parents","descendants":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/descendants","ancestors":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/ancestors","instances":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/instances","tree":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/tree","notes":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/notes","mappings":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501/mappings","ui":"http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD034501","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"label":[],"obsolete":false,"prefixIRI":null,"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://www.w3.org/2004/02/skos/core#altLabel":["PIN2 Protein","TRF1 Proteins","TTAGGG Repeat Binding Factor 1","PIN2 Proteins","TRF1 Protein","TERF1 Protein","TERF1 Proteins"],"http://purl.bioontology.org/ontology/MESH/PM":["2003; TRF1 PROTEIN was indexed under DNA-BINDING PROTEINS 1997-2002"],"http://purl.bioontology.org/ontology/MESH/HN":["2003; for TRF1 PROTEIN use TELOMERE-BINDING PROTEINS (NM) 1997-2002;"],"http://purl.bioontology.org/ontology/MESH/mapped_from":["http://purl.bioontology.org/ontology/MESH/C572268","http://purl.bioontology.org/ontology/MESH/C455625"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://bioportal.bioontology.org/ontologies/umls/tui":["T116","T123"],"http://purl.bioontology.org/ontology/MESH/TERMUI":["T473206","T473210","T224753","T473213","T473205"],"http://purl.bioontology.org/ontology/MESH/TH":["NLM (2003)"],"http://purl.bioontology.org/ontology/MESH/MMR":["20210510"],"http://www.w3.org/2004/02/skos/core#notation":["D035321"],"http://bioportal.bioontology.org/ontologies/umls/hasSTY":["http://purl.bioontology.org/ontology/STY/T123","http://purl.bioontology.org/ontology/STY/T116"],"http://purl.bioontology.org/ontology/MESH/QB":["http://purl.bioontology.org/ontology/MESH/Q000097","http://purl.bioontology.org/ontology/MESH/Q000096","http://purl.bioontology.org/ontology/MESH/Q000172","http://purl.bioontology.org/ontology/MESH/Q000627","http://purl.bioontology.org/ontology/MESH/Q000648","http://purl.bioontology.org/ontology/MESH/Q000493","http://purl.bioontology.org/ontology/MESH/Q000494","http://purl.bioontology.org/ontology/MESH/Q000276","http://purl.bioontology.org/ontology/MESH/Q000138","http://purl.bioontology.org/ontology/MESH/Q000134","http://purl.bioontology.org/ontology/MESH/Q000266","http://purl.bioontology.org/ontology/MESH/Q000378","http://purl.bioontology.org/ontology/MESH/Q000008","http://purl.bioontology.org/ontology/MESH/Q000009","http://purl.bioontology.org/ontology/MESH/Q000032","http://purl.bioontology.org/ontology/MESH/Q000037","http://purl.bioontology.org/ontology/MESH/Q000191","http://purl.bioontology.org/ontology/MESH/Q000302","http://purl.bioontology.org/ontology/MESH/Q000145","http://purl.bioontology.org/ontology/MESH/Q000592","http://purl.bioontology.org/ontology/MESH/Q000737","http://purl.bioontology.org/ontology/MESH/Q000819","http://purl.bioontology.org/ontology/MESH/Q000502","http://purl.bioontology.org/ontology/MESH/Q000506","http://purl.bioontology.org/ontology/MESH/Q000187","http://purl.bioontology.org/ontology/MESH/Q000235","http://purl.bioontology.org/ontology/MESH/Q000633","http://purl.bioontology.org/ontology/MESH/Q000600","http://purl.bioontology.org/ontology/MESH/Q000652","http://purl.bioontology.org/ontology/MESH/Q000528"],"http://purl.bioontology.org/ontology/MESH/DX":["20030101"],"http://bioportal.bioontology.org/ontologies/umls/cui":["C0526985","C1136063"],"http://www.w3.org/2004/02/skos/core#prefLabel":["Telomeric Repeat Binding Protein 1"],"http://purl.bioontology.org/ontology/MESH/DC":["1"],"http://www.w3.org/2004/02/skos/core#definition":["An alternatively spliced form of telomeric repeat binding protein 1. In human it lacks 20 amino acids.","A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues."],"http://purl.bioontology.org/ontology/MESH/MN":["D12.776.660.235.700.750","D12.776.664.981.500","D12.776.260.735.750","A11.284.430.106.279.345.190.160.845.500.500"],"http://purl.bioontology.org/ontology/MESH/AQL":["AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR"],"http://purl.bioontology.org/ontology/MESH/RN":["0"],"http://purl.bioontology.org/ontology/MESH/MDA":["20011211"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.bioontology.org/ontology/MESH/D000089804","http://purl.bioontology.org/ontology/MESH/D034501"]},"@id":"http://purl.bioontology.org/ontology/MESH/D035321","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321","ontology":"https://data.bioontology.org/ontologies/MESH","children":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/children","parents":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/parents","descendants":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/descendants","ancestors":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/ancestors","instances":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/instances","tree":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/tree","notes":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/notes","mappings":"https://data.bioontology.org/ontologies/MESH/classes/http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321/mappings","ui":"http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD035321","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007f3ce7b5a038 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}