@prefix : <http://example.org/msdo#MSCDO> .
@prefix dc: <http://purl.org/dc/elements/1.1/> .
@prefix atc: <http://www.whocc.no/atc_ddd_index/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix icps: <http://www.who.int/patientsafety/taxonomy/> .
@prefix msdo: <http://example.org/msdo#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix umls: <https://uts.nlm.nih.gov/uts/umls/> .
@prefix loinc: <http://loinc.org/rdf/> .
@prefix meddra: <http://purl.bioontology.org/ontology/MEDDRA/> .
@prefix rxnorm: <http://rxnav.nlm.nih.gov/REST/rxcui/> .
@prefix snomed: <http://snomed.info/id/> .
@base <http://example.org/msdo#MSCDO> .

<http://example.org/msdo#MSCDO> rdf:type owl:Ontology ;
                                 dc:creator "Anonymous (for peer review)" ;
                                 dc:date "2026" ;
                                 dc:description "A comprehensive ontology enabling ontology-driven human–AI co-decision-making for preventing medication-related harm, integrating medication knowledge, patient context, risk and safety, explainability, and ICPS-based prevention strategies." ;
                                 dc:title "Medication Safety Co-Decision Ontology (MSCDO)" .

#################################################################
#    Annotation properties
#################################################################

###  http://example.org/msdo#SPARQL_HighRisk
msdo:SPARQL_HighRisk rdf:type owl:AnnotationProperty ;
                     rdfs:comment """
SELECT ?medication ?event
WHERE {
  ?medication msdo:causesAdverseEvent ?event .
  ?event a msdo:AdverseDrugEvent .
}
""" .


###  http://example.org/msdo#SPARQL_PreventableErrors
msdo:SPARQL_PreventableErrors rdf:type owl:AnnotationProperty ;
                              rdfs:comment """
SELECT ?error ?factor ?strategy
WHERE {
  ?error a msdo:MedicationError .
  ?error msdo:hasContributingFactor ?factor .
  ?error msdo:mitigatedBy ?strategy .
}
""" .


###  http://purl.org/dc/elements/1.1/creator
dc:creator rdf:type owl:AnnotationProperty .


###  http://purl.org/dc/elements/1.1/date
dc:date rdf:type owl:AnnotationProperty .


###  http://purl.org/dc/elements/1.1/description
dc:description rdf:type owl:AnnotationProperty .


###  http://purl.org/dc/elements/1.1/title
dc:title rdf:type owl:AnnotationProperty .


###  http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled
<http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> rdf:type owl:AnnotationProperty .


###  http://www.w3.org/2004/02/skos/core#closeMatch
skos:closeMatch rdf:type owl:AnnotationProperty .


###  http://www.w3.org/2004/02/skos/core#exactMatch
skos:exactMatch rdf:type owl:AnnotationProperty .


#################################################################
#    Object Properties
#################################################################

###  http://example.org/msdo#associatedWith
msdo:associatedWith rdf:type owl:ObjectProperty ;
                    rdfs:domain msdo:Medication ,
                                msdo:MedicationEntity ,
                                rxnorm:ClinicalDrug ;
                    rdfs:range msdo:AdverseDrugEvent ,
                               msdo:AdverseDrugReaction ,
                               msdo:MedicationRelatedRisk ,
                               <http://purl.bioontology.org/ontology/MEDDRA/10002034> .


###  http://example.org/msdo#causesAdverseEvent
msdo:causesAdverseEvent rdf:type owl:ObjectProperty ;
                        rdfs:domain msdo:Medication ,
                                    msdo:MedicationEntity ,
                                    rxnorm:ClinicalDrug ;
                        rdfs:range msdo:AdverseDrugEvent ,
                                   msdo:MedicationRelatedRisk ,
                                   <http://purl.bioontology.org/ontology/MEDDRA/10002034> .


###  http://example.org/msdo#hasActiveIngredient
msdo:hasActiveIngredient rdf:type owl:ObjectProperty ;
                         rdfs:domain msdo:Medication ,
                                     msdo:MedicationEntity ,
                                     rxnorm:ClinicalDrug ;
                         rdfs:range msdo:ActiveIngredient .


###  http://example.org/msdo#hasClinicalCondition
msdo:hasClinicalCondition rdf:type owl:ObjectProperty ;
                          rdfs:domain msdo:Patient ,
                                      msdo:PatientContext ;
                          rdfs:range msdo:ClinicalCondition ,
                                     <http://snomed.info/id/404684003> .


###  http://example.org/msdo#hasContributingFactor
msdo:hasContributingFactor rdf:type owl:ObjectProperty ;
                           rdfs:domain msdo:MedicationError ,
                                       msdo:MedicationRelatedRisk ,
                                       icps:MedicationError ;
                           rdfs:range msdo:ContributingFactor ,
                                      icps:ContributingFactor .


###  http://example.org/msdo#hasGeneticRisk
msdo:hasGeneticRisk rdf:type owl:ObjectProperty ;
                    rdfs:domain msdo:Patient ,
                                msdo:PatientContext ;
                    rdfs:range msdo:PharmacogenomicProfile .


###  http://example.org/msdo#hasInteractionMechanism
msdo:hasInteractionMechanism rdf:type owl:ObjectProperty ;
                             rdfs:domain msdo:Medication ,
                                         msdo:MedicationEntity ,
                                         rxnorm:ClinicalDrug ;
                             rdfs:range msdo:DrugDrugInteraction .


###  http://example.org/msdo#hasOrganFunction
msdo:hasOrganFunction rdf:type owl:ObjectProperty ;
                      rdfs:domain msdo:Patient ,
                                  msdo:PatientContext ;
                      rdfs:range msdo:OrganFunction .


###  http://example.org/msdo#hasRiskProfile
msdo:hasRiskProfile rdf:type owl:ObjectProperty ;
                    rdfs:domain msdo:Medication ,
                                msdo:MedicationEntity ,
                                rxnorm:ClinicalDrug ;
                    rdfs:range msdo:RiskProfile .


###  http://example.org/msdo#hasSeverity
msdo:hasSeverity rdf:type owl:ObjectProperty ;
                 rdfs:domain msdo:DrugDrugInteraction ,
                             msdo:Medication ,
                             msdo:MedicationEntity ,
                             rxnorm:ClinicalDrug ;
                 rdfs:range msdo:Severity .


###  http://example.org/msdo#hasTherapeuticClass
msdo:hasTherapeuticClass rdf:type owl:ObjectProperty ;
                         rdfs:domain msdo:Medication ,
                                     msdo:MedicationEntity ,
                                     rxnorm:ClinicalDrug ;
                         rdfs:range msdo:TherapeuticClass ,
                                    atc:ATCCode .


###  http://example.org/msdo#interactsWith
msdo:interactsWith rdf:type owl:ObjectProperty ;
                   rdfs:domain msdo:Medication ,
                               msdo:MedicationEntity ,
                               rxnorm:ClinicalDrug ;
                   rdfs:range msdo:Medication ,
                              msdo:MedicationEntity ,
                              rxnorm:ClinicalDrug .


###  http://example.org/msdo#mitigatedBy
msdo:mitigatedBy rdf:type owl:ObjectProperty ;
                 rdfs:domain msdo:MedicationRelatedRisk ;
                 rdfs:range msdo:MitigatingAction .


###  http://example.org/msdo#overriddenBy
msdo:overriddenBy rdf:type owl:ObjectProperty ;
                  rdfs:domain msdo:DecisionArtifact ,
                              msdo:Recommendation ;
                  rdfs:range msdo:Clinician .


###  http://example.org/msdo#prescribedDrug
msdo:prescribedDrug rdf:type owl:ObjectProperty ;
                    rdfs:domain msdo:Patient ,
                                msdo:PatientContext ;
                    rdfs:range msdo:Medication ,
                               msdo:MedicationEntity ,
                               rxnorm:ClinicalDrug .


###  http://example.org/msdo#reviewedBy
msdo:reviewedBy rdf:type owl:ObjectProperty ;
                rdfs:domain msdo:DecisionArtifact ,
                            msdo:Recommendation ;
                rdfs:range msdo:Clinician .


#################################################################
#    Classes
#################################################################

###  http://example.org/msdo#AISystem
msdo:AISystem rdf:type owl:Class .


###  http://example.org/msdo#ActiveIngredient
msdo:ActiveIngredient rdf:type owl:Class ;
                      rdfs:comment "Pharmacologically active substance in a medication." ;
                      skos:exactMatch rxnorm:Ingredient .


###  http://example.org/msdo#AdverseDrugEvent
msdo:AdverseDrugEvent rdf:type owl:Class ;
                      owl:equivalentClass <http://purl.bioontology.org/ontology/MEDDRA/10002034> ;
                      rdfs:subClassOf msdo:MedicationRelatedRisk ,
                                      <http://purl.bioontology.org/ontology/MEDDRA/10002034> .


###  http://example.org/msdo#AdverseDrugReaction
msdo:AdverseDrugReaction rdf:type owl:Class ;
                         rdfs:subClassOf msdo:AdverseDrugEvent ,
                                         <http://purl.bioontology.org/ontology/MEDDRA/10002034> ;
                         skos:exactMatch <http://purl.bioontology.org/ontology/MEDDRA/10001000> .


###  http://example.org/msdo#AlternativeOption
msdo:AlternativeOption rdf:type owl:Class .


###  http://example.org/msdo#ClinicalCondition
msdo:ClinicalCondition rdf:type owl:Class ;
                       owl:equivalentClass <http://snomed.info/id/404684003> ;
                       rdfs:subClassOf <http://snomed.info/id/404684003> .


###  http://example.org/msdo#Clinician
msdo:Clinician rdf:type owl:Class ;
               skos:exactMatch <http://snomed.info/id/158965000> .


###  http://example.org/msdo#CoDecision
msdo:CoDecision rdf:type owl:Class ;
                rdfs:subClassOf msdo:HumanAIInteraction ;
                rdfs:comment "A shared clinical decision resulting from clinician–AI collaboration." .


###  http://example.org/msdo#Contraindication
msdo:Contraindication rdf:type owl:Class ;
                      skos:exactMatch <http://snomed.info/id/410684002> .


###  http://example.org/msdo#ContributingFactor
msdo:ContributingFactor rdf:type owl:Class ;
                        owl:equivalentClass icps:ContributingFactor ;
                        rdfs:subClassOf icps:ContributingFactor .


###  http://example.org/msdo#DecisionArtifact
msdo:DecisionArtifact rdf:type owl:Class ;
                      rdfs:comment "AI- or clinician-generated recommendations, explanations, and evidence." ;
                      rdfs:label "Decision Artifact" .


###  http://example.org/msdo#Detection
msdo:Detection rdf:type owl:Class ;
               skos:closeMatch icps:Detection .


###  http://example.org/msdo#Dose
msdo:Dose rdf:type owl:Class ;
          skos:closeMatch rxnorm:DoseForm .


###  http://example.org/msdo#DrugDrugInteraction
msdo:DrugDrugInteraction rdf:type owl:Class ;
                         skos:closeMatch umls:C0013227 .


###  http://example.org/msdo#Duration
msdo:Duration rdf:type owl:Class .


###  http://example.org/msdo#EmergingSafetySignal
msdo:EmergingSafetySignal rdf:type owl:Class .


###  http://example.org/msdo#EvidenceStrength
msdo:EvidenceStrength rdf:type owl:Class ;
                      skos:closeMatch umls:CUI .


###  http://example.org/msdo#Explanation
msdo:Explanation rdf:type owl:Class ;
                 rdfs:comment "Human-readable justification bridging AI reasoning and clinical understanding." .


###  http://example.org/msdo#Frequency
msdo:Frequency rdf:type owl:Class .


###  http://example.org/msdo#Guideline
msdo:Guideline rdf:type owl:Class ;
               skos:closeMatch umls:CUI .


###  http://example.org/msdo#HighRiskMedicationCombination
msdo:HighRiskMedicationCombination rdf:type owl:Class .


###  http://example.org/msdo#HumanAIInteraction
msdo:HumanAIInteraction rdf:type owl:Class ;
                        rdfs:comment "Collaborative decision-making processes between clinicians and AI systems." ;
                        rdfs:label "Human–AI Interaction" .


###  http://example.org/msdo#LaboratoryParameter
msdo:LaboratoryParameter rdf:type owl:Class ;
                         owl:equivalentClass loinc:LP29684-5 ;
                         rdfs:subClassOf loinc:LP29684-5 .


###  http://example.org/msdo#Medication
msdo:Medication rdf:type owl:Class ;
                owl:equivalentClass rxnorm:ClinicalDrug ;
                rdfs:subClassOf msdo:MedicationEntity ,
                                rxnorm:ClinicalDrug ;
                rdfs:comment "A clinical drug concept normalized using RxNorm." .


###  http://example.org/msdo#MedicationDiscrepancy
msdo:MedicationDiscrepancy rdf:type owl:Class .


###  http://example.org/msdo#MedicationEntity
msdo:MedicationEntity rdf:type owl:Class ;
                      rdfs:comment "Standardized medicinal product representation aligned with RxNorm and ATC." ;
                      rdfs:label "Medication Entity" ;
                      skos:closeMatch atc:ATCCode ;
                      skos:exactMatch rxnorm:Concept .


###  http://example.org/msdo#MedicationError
msdo:MedicationError rdf:type owl:Class ;
                     owl:equivalentClass icps:MedicationError ;
                     rdfs:subClassOf msdo:MedicationRelatedRisk ,
                                     icps:MedicationError .


###  http://example.org/msdo#MedicationRelatedRisk
msdo:MedicationRelatedRisk rdf:type owl:Class ;
                           rdfs:comment "Potential or actual harm associated with medication use, including errors and adverse events." ;
                           rdfs:label "Medication-Related Risk" ;
                           skos:exactMatch <http://purl.bioontology.org/ontology/MEDDRA/10000000> .


###  http://example.org/msdo#MedicationUseContext
msdo:MedicationUseContext rdf:type owl:Class ;
                          rdfs:comment "Stage of medication use (prescribing, dispensing, administration, monitoring)." ;
                          skos:closeMatch icps:Process .


###  http://example.org/msdo#MitigatingAction
msdo:MitigatingAction rdf:type owl:Class ;
                      skos:exactMatch icps:MitigatingFactors .


###  http://example.org/msdo#NearMiss
msdo:NearMiss rdf:type owl:Class ;
              owl:equivalentClass icps:NearMiss ;
              rdfs:subClassOf icps:NearMiss .


###  http://example.org/msdo#OrganFunction
msdo:OrganFunction rdf:type owl:Class ;
                   skos:closeMatch <http://snomed.info/id/363787002> .


###  http://example.org/msdo#Patient
msdo:Patient rdf:type owl:Class ;
             rdfs:subClassOf msdo:PatientContext ;
             skos:exactMatch <http://snomed.info/id/116154003> .


###  http://example.org/msdo#PatientContext
msdo:PatientContext rdf:type owl:Class ;
                    rdfs:comment "Patient-specific clinical, demographic, physiological, and genetic factors influencing medication safety." ;
                    rdfs:label "Patient Context" ;
                    skos:closeMatch umls:CUI .


###  http://example.org/msdo#PatientSafetyPrevention
msdo:PatientSafetyPrevention rdf:type owl:Class ;
                             rdfs:comment "ICPS-aligned prevention, detection, and mitigation mechanisms for medication-related harm." ;
                             rdfs:label "Patient Safety and Prevention" ;
                             skos:exactMatch icps:ConceptualFramework .


###  http://example.org/msdo#PharmacogenomicProfile
msdo:PharmacogenomicProfile rdf:type owl:Class ;
                            skos:closeMatch umls:C1704417 .


###  http://example.org/msdo#PolypharmacyContext
msdo:PolypharmacyContext rdf:type owl:Class ;
                         rdfs:comment "Concurrent use of multiple medications increasing cumulative risk." .


###  http://example.org/msdo#PreventiveStrategy
msdo:PreventiveStrategy rdf:type owl:Class ;
                        skos:exactMatch icps:PreventiveAction .


###  http://example.org/msdo#Probability
msdo:Probability rdf:type owl:Class .


###  http://example.org/msdo#Rationale
msdo:Rationale rdf:type owl:Class .


###  http://example.org/msdo#Recommendation
msdo:Recommendation rdf:type owl:Class ;
                    rdfs:subClassOf msdo:DecisionArtifact .


###  http://example.org/msdo#RequiresDoseAdjustment
msdo:RequiresDoseAdjustment rdf:type owl:Class .


###  http://example.org/msdo#RequiresEnhancedMonitoring
msdo:RequiresEnhancedMonitoring rdf:type owl:Class .


###  http://example.org/msdo#RequiresHumanOverrideReview
msdo:RequiresHumanOverrideReview rdf:type owl:Class .


###  http://example.org/msdo#RiskProfile
msdo:RiskProfile rdf:type owl:Class ;
                 skos:closeMatch icps:PatientCharacteristics .


###  http://example.org/msdo#RouteOfAdministration
msdo:RouteOfAdministration rdf:type owl:Class ;
                           skos:closeMatch <http://snomed.info/id/284009009> .


###  http://example.org/msdo#Severity
msdo:Severity rdf:type owl:Class ;
              skos:closeMatch meddra:Severity .


###  http://example.org/msdo#TherapeuticClass
msdo:TherapeuticClass rdf:type owl:Class ;
                      owl:equivalentClass atc:ATCCode ;
                      rdfs:subClassOf atc:ATCCode ;
                      rdfs:comment "Pharmacological or therapeutic grouping of medications." .


###  http://example.org/msdo#TriggerMedicationReview
msdo:TriggerMedicationReview rdf:type owl:Class .


###  http://example.org/msdo#TrustCalibration
msdo:TrustCalibration rdf:type owl:Class .


###  http://example.org/msdo#Uncertainty
msdo:Uncertainty rdf:type owl:Class .


###  http://loinc.org/rdf/LP29684-5
loinc:LP29684-5 rdf:type owl:Class ;
                rdfs:subClassOf msdo:LaboratoryParameter .


###  http://purl.bioontology.org/ontology/MEDDRA/10002034
<http://purl.bioontology.org/ontology/MEDDRA/10002034> rdf:type owl:Class ;
                                                       rdfs:subClassOf msdo:AdverseDrugEvent ,
                                                                       msdo:MedicationRelatedRisk .


###  http://rxnav.nlm.nih.gov/REST/rxcui/ClinicalDrug
rxnorm:ClinicalDrug rdf:type owl:Class ;
                    rdfs:subClassOf msdo:Medication ,
                                    msdo:MedicationEntity .


###  http://snomed.info/id/404684003
<http://snomed.info/id/404684003> rdf:type owl:Class ;
                                  rdfs:subClassOf msdo:ClinicalCondition .


###  http://www.who.int/patientsafety/taxonomy/ContributingFactor
icps:ContributingFactor rdf:type owl:Class ;
                        rdfs:subClassOf msdo:ContributingFactor .


###  http://www.who.int/patientsafety/taxonomy/MedicationError
icps:MedicationError rdf:type owl:Class ;
                     rdfs:subClassOf msdo:MedicationError ,
                                     msdo:MedicationRelatedRisk .


###  http://www.who.int/patientsafety/taxonomy/NearMiss
icps:NearMiss rdf:type owl:Class ;
              rdfs:subClassOf msdo:NearMiss .


###  http://www.whocc.no/atc_ddd_index/ATCCode
atc:ATCCode rdf:type owl:Class ;
            rdfs:subClassOf msdo:TherapeuticClass .


#################################################################
#    Individuals
#################################################################

###  http://example.org/msdo#ADR_Bleeding
msdo:ADR_Bleeding rdf:type owl:NamedIndividual ,
                           msdo:AdverseDrugEvent ,
                           msdo:AdverseDrugReaction ,
                           msdo:MedicationRelatedRisk ,
                           <http://purl.bioontology.org/ontology/MEDDRA/10002034> .


###  http://example.org/msdo#Amiodarone
msdo:Amiodarone rdf:type owl:NamedIndividual ,
                         msdo:Medication ,
                         msdo:MedicationEntity ,
                         rxnorm:ClinicalDrug .


###  http://example.org/msdo#CYP450Mechanism
msdo:CYP450Mechanism rdf:type owl:NamedIndividual ,
                              msdo:DrugDrugInteraction .


###  http://example.org/msdo#CYP450_Mechanism
msdo:CYP450_Mechanism rdf:type owl:NamedIndividual ,
                               msdo:DrugDrugInteraction .


###  http://example.org/msdo#Clinician_A
msdo:Clinician_A rdf:type owl:NamedIndividual ,
                          msdo:Clinician .


###  http://example.org/msdo#Discrepancy_1
msdo:Discrepancy_1 rdf:type owl:NamedIndividual ,
                            msdo:MedicationDiscrepancy ,
                            msdo:TriggerMedicationReview .


###  http://example.org/msdo#ElderlyPatient
msdo:ElderlyPatient rdf:type owl:NamedIndividual ,
                             msdo:Patient ,
                             msdo:PatientContext ,
                             msdo:RequiresDoseAdjustment ,
                             msdo:RequiresEnhancedMonitoring ;
                    msdo:hasGeneticRisk msdo:GeneticRisk_1 ;
                    msdo:hasOrganFunction msdo:RenalImpairment ;
                    msdo:prescribedDrug msdo:Warfarin .


###  http://example.org/msdo#ElderlyPatient001
msdo:ElderlyPatient001 rdf:type owl:NamedIndividual ,
                                msdo:Patient ,
                                msdo:PatientContext ,
                                msdo:RequiresEnhancedMonitoring ;
                       msdo:hasOrganFunction msdo:RenalImpairment ;
                       msdo:prescribedDrug msdo:Warfarin .


###  http://example.org/msdo#GeneticRisk_1
msdo:GeneticRisk_1 rdf:type owl:NamedIndividual ,
                            msdo:PharmacogenomicProfile .


###  http://example.org/msdo#HighSeverity
msdo:HighSeverity rdf:type owl:NamedIndividual ,
                           msdo:Severity .


###  http://example.org/msdo#NTW_Status
msdo:NTW_Status rdf:type owl:NamedIndividual ,
                         msdo:RiskProfile .


###  http://example.org/msdo#Recommendation_1
msdo:Recommendation_1 rdf:type owl:NamedIndividual ,
                               msdo:DecisionArtifact ,
                               msdo:Recommendation ,
                               msdo:RequiresHumanOverrideReview ;
                      msdo:reviewedBy msdo:Clinician_A .


###  http://example.org/msdo#RenalImpairment
msdo:RenalImpairment rdf:type owl:NamedIndividual ,
                              msdo:OrganFunction .


###  http://example.org/msdo#Warfarin
msdo:Warfarin rdf:type owl:NamedIndividual ,
                       msdo:DrugDrugInteraction ,
                       msdo:EmergingSafetySignal ,
                       msdo:HighRiskMedicationCombination ,
                       msdo:Medication ,
                       msdo:MedicationEntity ,
                       rxnorm:ClinicalDrug ;
              msdo:associatedWith msdo:ADR_Bleeding ;
              msdo:hasInteractionMechanism msdo:CYP450Mechanism ,
                                           msdo:CYP450_Mechanism ;
              msdo:hasRiskProfile msdo:NTW_Status ;
              msdo:hasSeverity msdo:HighSeverity ;
              msdo:interactsWith msdo:Amiodarone .


#################################################################
#    Rules
#################################################################

<d> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<adr> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<d1> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<d2> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<x> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<p> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<g> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<r> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

<c> rdf:type <http://www.w3.org/2003/11/swrl#Variable> .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 5 — Emerging Safety Signal" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Medication ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <d>
                                                     ] ;
                                           rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                      rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                  <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:associatedWith ;
                                                                  <http://www.w3.org/2003/11/swrl#argument1> <d> ;
                                                                  <http://www.w3.org/2003/11/swrl#argument2> <adr>
                                                                ] ;
                                                      rdf:rest rdf:nil
                                                    ]
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:EmergingSafetySignal ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <d>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 3 — Medication Discrepancy Review" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:MedicationDiscrepancy ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <x>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:TriggerMedicationReview ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <x>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 2 — Dose Adjustment" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Patient ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <p>
                                                     ] ;
                                           rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                      rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                  <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:hasGeneticRisk ;
                                                                  <http://www.w3.org/2003/11/swrl#argument1> <p> ;
                                                                  <http://www.w3.org/2003/11/swrl#argument2> <g>
                                                                ] ;
                                                      rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                 rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                             <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:prescribedDrug ;
                                                                             <http://www.w3.org/2003/11/swrl#argument1> <p> ;
                                                                             <http://www.w3.org/2003/11/swrl#argument2> <d>
                                                                           ] ;
                                                                 rdf:rest rdf:nil
                                                               ]
                                                    ]
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:RequiresDoseAdjustment ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <p>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 6 — Enhanced Monitoring" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Patient ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <p>
                                                     ] ;
                                           rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                      rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                  <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:hasOrganFunction ;
                                                                  <http://www.w3.org/2003/11/swrl#argument1> <p> ;
                                                                  <http://www.w3.org/2003/11/swrl#argument2> msdo:RenalImpairment
                                                                ] ;
                                                      rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                 rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                             <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:prescribedDrug ;
                                                                             <http://www.w3.org/2003/11/swrl#argument1> <p> ;
                                                                             <http://www.w3.org/2003/11/swrl#argument2> <d1>
                                                                           ] ;
                                                                 rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                            rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                                        <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:interactsWith ;
                                                                                        <http://www.w3.org/2003/11/swrl#argument1> <d1> ;
                                                                                        <http://www.w3.org/2003/11/swrl#argument2> <d2>
                                                                                      ] ;
                                                                            rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                                       rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                                                   <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:hasInteractionMechanism ;
                                                                                                   <http://www.w3.org/2003/11/swrl#argument1> <d1> ;
                                                                                                   <http://www.w3.org/2003/11/swrl#argument2> msdo:CYP450Mechanism
                                                                                                 ] ;
                                                                                       rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                                                  rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                                                              <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:hasRiskProfile ;
                                                                                                              <http://www.w3.org/2003/11/swrl#argument1> <d1> ;
                                                                                                              <http://www.w3.org/2003/11/swrl#argument2> msdo:NTW_Status
                                                                                                            ] ;
                                                                                                  rdf:rest rdf:nil
                                                                                                ]
                                                                                     ]
                                                                          ]
                                                               ]
                                                    ]
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:RequiresEnhancedMonitoring ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <p>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 4 — Human Override Review" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Recommendation ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <r>
                                                     ] ;
                                           rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                      rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                  <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:reviewedBy ;
                                                                  <http://www.w3.org/2003/11/swrl#argument1> <r> ;
                                                                  <http://www.w3.org/2003/11/swrl#argument2> <c>
                                                                ] ;
                                                      rdf:rest rdf:nil
                                                    ]
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:RequiresHumanOverrideReview ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <r>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

[ <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> "true"^^xsd:boolean ;
   rdfs:comment "" ;
   rdfs:label "Rule 1 — High Risk Drug Combination" ;
   rdf:type <http://www.w3.org/2003/11/swrl#Imp> ;
   <http://www.w3.org/2003/11/swrl#body> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Medication ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <d1>
                                                     ] ;
                                           rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                      rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                                  <http://www.w3.org/2003/11/swrl#classPredicate> msdo:Medication ;
                                                                  <http://www.w3.org/2003/11/swrl#argument1> <d2>
                                                                ] ;
                                                      rdf:rest [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                                                 rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#IndividualPropertyAtom> ;
                                                                             <http://www.w3.org/2003/11/swrl#propertyPredicate> msdo:interactsWith ;
                                                                             <http://www.w3.org/2003/11/swrl#argument1> <d1> ;
                                                                             <http://www.w3.org/2003/11/swrl#argument2> <d2>
                                                                           ] ;
                                                                 rdf:rest rdf:nil
                                                               ]
                                                    ]
                                         ] ;
   <http://www.w3.org/2003/11/swrl#head> [ rdf:type <http://www.w3.org/2003/11/swrl#AtomList> ;
                                           rdf:first [ rdf:type <http://www.w3.org/2003/11/swrl#ClassAtom> ;
                                                       <http://www.w3.org/2003/11/swrl#classPredicate> msdo:HighRiskMedicationCombination ;
                                                       <http://www.w3.org/2003/11/swrl#argument1> <d1>
                                                     ] ;
                                           rdf:rest rdf:nil
                                         ]
 ] .

###  Generated by the OWL API (version 4.5.29.2024-05-13T12:11:03Z) https://github.com/owlcs/owlapi