{"id":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2021","synonym":["thymidylate synthase inhibitor","Thymidylate Synthase Inhibitor","Thymidylate Synthetase Inhibitors"],"prefixIRI":"Thesaurus:C2021","definition":["Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation."],"label":["Thymidylate Synthase Inhibitor"],"prefLabel":"Thymidylate Synthase Inhibitor","subClassOf":["http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471"],"parents":[{"id":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471","synonym":["Enzyme Inhibitor","Enzyme Inhibitor Drug","Enzyme Antagonist","Enzyme Inhibitor Agent"],"prefixIRI":"Thesaurus:C471","definition":["A pharmacological agent that inhibits the catalytic activity of an enzyme."],"label":["Enzyme Inhibitor"],"prefLabel":"Enzyme Inhibitor","subClassOf":["http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471","ontology":"https://data.bioontology.org/ontologies/NCIT","children":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/children","parents":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/parents","descendants":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/descendants","ancestors":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/ancestors","instances":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/instances","tree":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/tree","notes":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/notes","mappings":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471/mappings","ui":"http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C471","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/prefixIRI":["Thesaurus:C2021"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#NHC0":["C2021"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97":["Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation."],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325":["A drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer."],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P368":["CHEBI:63720"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366":["Thymidylate_Synthase_Inhibitor"],"http://www.w3.org/2000/01/rdf-schema#label":["Thymidylate Synthase Inhibitor"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90":["thymidylate synthase inhibitor","Thymidylate Synthase Inhibitor","Thymidylate Synthetase Inhibitors"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207":["C1373008"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108":["Thymidylate Synthase Inhibitor"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471"],"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106":["Chemical Viewed Functionally"]},"@id":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2021","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021","ontology":"https://data.bioontology.org/ontologies/NCIT","children":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/children","parents":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/parents","descendants":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/descendants","ancestors":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/ancestors","instances":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/instances","tree":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/tree","notes":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/notes","mappings":"https://data.bioontology.org/ontologies/NCIT/classes/http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021/mappings","ui":"http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2021","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007f164711e4a0 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-4e1a2c81a965/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}