{"id":"http://purl.obolibrary.org/obo/GO_0010629","prefLabel":"negative regulation of gene expression","definition":["Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form."],"notation":"GO:0010629","label":["negative regulation of gene expression"],"subClassOf":["http://purl.obolibrary.org/obo/GO_0010468","http://purl.obolibrary.org/obo/GO_0010605"],"parents":[{"id":"http://purl.obolibrary.org/obo/GO_0010468","prefLabel":"regulation of gene expression","definition":["Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form."],"synonym":["regulation of gene product expression","regulation of protein expression"],"notation":"GO:0010468","xref":"Wikipedia:Regulation_of_gene_expression","label":["regulation of gene expression"],"subClassOf":["http://purl.obolibrary.org/obo/GO_0060255"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"prefixIRI":null,"semanticType":[],"cui":[],"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/GO_0010468","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468","ontology":"https://data.bioontology.org/ontologies/OMP","children":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/children","parents":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/parents","descendants":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/descendants","ancestors":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/ancestors","instances":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/instances","tree":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/tree","notes":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/notes","mappings":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468/mappings","ui":"http://bioportal.bioontology.org/ontologies/OMP?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010468","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.obolibrary.org/obo/GO_0010605","prefLabel":"negative regulation of macromolecule metabolic process","definition":["Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass."],"notation":"GO:0010605","label":["negative regulation of macromolecule metabolic process"],"subClassOf":["http://purl.obolibrary.org/obo/GO_0060255","http://purl.obolibrary.org/obo/GO_0009892"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"prefixIRI":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/GO_0010605","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605","ontology":"https://data.bioontology.org/ontologies/OMP","children":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/children","parents":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/parents","descendants":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/descendants","ancestors":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/ancestors","instances":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/instances","tree":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/tree","notes":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/notes","mappings":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605/mappings","ui":"http://bioportal.bioontology.org/ontologies/OMP?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010605","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"obsolete":false,"prefixIRI":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["negative regulation of gene expression"],"http://www.geneontology.org/formats/oboInOwl#hasOBONamespace":["biological_process"],"http://purl.obolibrary.org/obo/IAO_0000115":["Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form."],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://www.geneontology.org/formats/oboInOwl#id":["GO:0010629"],"http://www.w3.org/2004/02/skos/core#notation":["GO:0010629"],"http://www.w3.org/2000/01/rdf-schema#label":["negative regulation of gene expression"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/GO_0010468","http://purl.obolibrary.org/obo/GO_0010605"],"http://purl.obolibrary.org/obo/RO_0002212":["http://purl.obolibrary.org/obo/GO_0010467"]},"@id":"http://purl.obolibrary.org/obo/GO_0010629","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629","ontology":"https://data.bioontology.org/ontologies/OMP","children":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/children","parents":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/parents","descendants":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/descendants","ancestors":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/ancestors","instances":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/instances","tree":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/tree","notes":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/notes","mappings":"https://data.bioontology.org/ontologies/OMP/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629/mappings","ui":"http://bioportal.bioontology.org/ontologies/OMP?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0010629","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007f7a6f2fb688 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-4e1a2c81a965/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}