<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
2
</numberChangedClasses>
<numberNewClasses>
58
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000112</classIRI>
<classLabel>specimen role</classLabel>
<newAxiom>&apos;specimen role&apos; SubClassOf http://purl.obolibrary.org/obo/OMRSE_00000048</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000155</classIRI>
<classLabel>health insurance plan</classLabel>
<newAxiom>&apos;health insurance plan&apos; SubClassOf &apos;plan specification&apos;</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000453</classIRI>
<classLabel>measure function</classLabel>
<newAxiom>'measure function' SubClassOf 'realized in' only ('has_specified_output' some 'measurement datum')</newAxiom>
<newAxiom>'measure function' SubClassOf 'function'</newAxiom>
<newAxiom>'measure function' SubClassOf 'function of' some 'processed material'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000423</classIRI>
<classLabel>extract</classLabel>
<newAxiom>'extract' SubClassOf 'is_specified_output_of' some 'extraction'</newAxiom>
<newAxiom>'extract' SubClassOf 'processed material'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0302893</classIRI>
<classLabel>storage</classLabel>
<newAxiom>'storage' SubClassOf 'material maintenance'</newAxiom>
<newAxiom>'storage' SubClassOf 'has_specified_input' some 'material entity'</newAxiom>
<newAxiom>'storage' SubClassOf 'achieves_planned_objective' some 'material maintenance objective'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0302884</classIRI>
<classLabel>extraction</classLabel>
<newAxiom>'extraction' SubClassOf 'achieves_planned_objective' some 'separation into different composition objective'</newAxiom>
<newAxiom>'extraction' SubClassOf 'material component separation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBIB_0000077</classIRI>
<classLabel>first tissue removed date</classLabel>
<newAxiom>'first tissue removed date' SubClassOf 'date of specimen collection'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBIB_0000076</classIRI>
<classLabel>first blood draw date</classLabel>
<newAxiom>'first blood draw date' SubClassOf 'date of specimen collection'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001010</classIRI>
<classLabel>nucleic acid extract</classLabel>
<newAxiom>'nucleic acid extract' SubClassOf 'has grain' some 'nucleic acid'</newAxiom>
<newAxiom>'nucleic acid extract' SubClassOf 'extract'</newAxiom>
<newAxiom>'nucleic acid extract' SubClassOf 'processed specimen'</newAxiom>
<newAxiom>'nucleic acid extract' SubClassOf ('is_specified_output_of' some 'nucleic acid extraction') and ('has role' some 'specimen role')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/SO_0000001</classIRI>
<classLabel>region</classLabel>
<newAxiom>'region' SubClassOf 'generically dependent continuant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/CL_0000000</classIRI>
<classLabel>cell</classLabel>
<newAxiom>'cell' SubClassOf 'material entity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/CL_0000010</classIRI>
<classLabel>cultured cell</classLabel>
<newAxiom>'cultured cell' SubClassOf 'experimentally modified cell in vitro'</newAxiom>
<newAxiom>'cultured cell' SubClassOf ('is_specified_output_of' some 'establishing cell culture') or ('derives from' some ('is_specified_output_of' some 'establishing cell culture'))</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001885</classIRI>
<classLabel>specimen repository organization</classLabel>
<newAxiom>'specimen repository organization' EquivalentTo 'organization' and ('has role' some 
('service provider role' and ('realized in' some 
('material storage service' and ('has_specified_input' some 'specimen')))))</newAxiom>
<newAxiom>'specimen repository organization' SubClassOf 'organization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001891</classIRI>
<classLabel>sequencing facility organization</classLabel>
<newAxiom>'sequencing facility organization' SubClassOf 'molecular analysis facility organization'</newAxiom>
<newAxiom>'sequencing facility organization' EquivalentTo 'organization' and ('has role' some 
('service provider role' and ('realized in' some 'sequencing service')))</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBIB_0000100</classIRI>
<classLabel>date of surgical removal of specimen</classLabel>
<newAxiom>'date of surgical removal of specimen' SubClassOf 'date of specimen collection'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000639</classIRI>
<classLabel>material separation objective</classLabel>
<newAxiom>'material separation objective' SubClassOf 'material transformation objective'</newAxiom>
<newAxiom>'material separation objective' EquivalentTo 'portioning objective' or 'separation into different composition objective'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001900</classIRI>
<classLabel>specimen identifier assigned by specimen repository</classLabel>
<newAxiom>'specimen identifier assigned by specimen repository' EquivalentTo 'specimen identifier' and ('is_specified_output_of' some 
('assigning a centrally registered identifier' and ('has_participant' some 'specimen repository organization')))</newAxiom>
<newAxiom>'specimen identifier assigned by specimen repository' SubClassOf 'specimen identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001901</classIRI>
<classLabel>specimen identifier assigned by sequencing facility</classLabel>
<newAxiom>'specimen identifier assigned by sequencing facility' SubClassOf 'specimen identifier'</newAxiom>
<newAxiom>'specimen identifier assigned by sequencing facility' EquivalentTo 'specimen identifier' and ('is_specified_output_of' some 
('assigning a centrally registered identifier' and ('has_participant' some 'sequencing facility organization')))</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001904</classIRI>
<classLabel>sequencing service</classLabel>
<newAxiom>'sequencing service' EquivalentTo 'material service' and ('provides_service_consumer_with' some 'sequencing assay')</newAxiom>
<newAxiom>'sequencing service' SubClassOf 'material analysis service'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001912</classIRI>
<classLabel>cell freezing medium</classLabel>
<newAxiom>'cell freezing medium' SubClassOf 'processed material'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OMRSE_00000048</classIRI>
<classLabel>material entity role</classLabel>
<newAxiom>'material entity role' SubClassOf 'characteristic of' only 'material entity'</newAxiom>
<newAxiom>'material entity role' SubClassOf 'characteristic of' some 'material entity'</newAxiom>
<newAxiom>'material entity role' EquivalentTo 'role' and ('characteristic of' some 'material entity')</newAxiom>
<newAxiom>'material entity role' SubClassOf 'role'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001173</classIRI>
<classLabel>service</classLabel>
<newAxiom>'service' SubClassOf 'planned process'</newAxiom>
<newAxiom>'service' EquivalentTo 'planned process' and (('realizes' some 'service consumer role') and ('realizes' some 'service provider role'))</newAxiom>
<newAxiom>'service' SubClassOf 'has part' some 'planned process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001108</classIRI>
<classLabel>nucleic acid sequencer</classLabel>
<newAxiom>'nucleic acid sequencer' SubClassOf 'measurement device'</newAxiom>
<newAxiom>'nucleic acid sequencer' SubClassOf 'has function' some 'measure function'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001137</classIRI>
<classLabel>protein sequencer</classLabel>
<newAxiom>'protein sequencer' SubClassOf 'has function' some 'measure function'</newAxiom>
<newAxiom>'protein sequencer' SubClassOf 'measurement device'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000582</classIRI>
<classLabel>clnical measurement identifier</classLabel>
<newAxiom>'clnical measurement identifier' SubClassOf 'CRID'</newAxiom>
<newAxiom>'clnical measurement identifier' SubClassOf 'is about' some 'care site'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000583</classIRI>
<classLabel>payer plan</classLabel>
<newAxiom>'payer plan' SubClassOf 'plan specification'</newAxiom>
<newAxiom>'payer plan' SubClassOf 'personal information'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000586</classIRI>
<classLabel>payer plan period start date</classLabel>
<newAxiom>'payer plan period start date' SubClassOf 'payer plan temporal region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000587</classIRI>
<classLabel>payer plan period end date</classLabel>
<newAxiom>'payer plan period end date' SubClassOf 'payer plan temporal region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000584</classIRI>
<classLabel>payer plan temporal region</classLabel>
<newAxiom>'payer plan temporal region' SubClassOf 'temporal region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OPMI_0000585</classIRI>
<classLabel>payer plan period</classLabel>
<newAxiom>'payer plan period' SubClassOf 'payer plan temporal region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0100060</classIRI>
<classLabel>cultured cell population</classLabel>
<newAxiom>'cultured cell population' SubClassOf 'has grain' some 'cultured cell'</newAxiom>
<newAxiom>'cultured cell population' SubClassOf 'processed material'</newAxiom>
<newAxiom>'cultured cell population' SubClassOf 'is_specified_output_of' some 'maintaining cell culture'</newAxiom>
<newAxiom>'cultured cell population' SubClassOf 'has grain' only 'cultured cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000678</classIRI>
<classLabel>portioning objective</classLabel>
<newAxiom>'portioning objective' SubClassOf 'material separation objective'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000671</classIRI>
<classLabel>sample from organism</classLabel>
<newAxiom>'sample from organism' SubClassOf 'specimen from organism'</newAxiom>
<newAxiom>'sample from organism' SubClassOf 'derives from' some 'material anatomical entity'</newAxiom>
<newAxiom>'sample from organism' SubClassOf 'material sample'</newAxiom>
<newAxiom>'sample from organism' EquivalentTo ('is_specified_output_of' some 'collecting specimen from organism') and ('has role' some 'material sample role')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000681</classIRI>
<classLabel>separation into different composition objective</classLabel>
<newAxiom>'separation into different composition objective' SubClassOf 'material separation objective'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000740</classIRI>
<classLabel>material sample role</classLabel>
<newAxiom>'material sample role' SubClassOf 'specimen role'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000747</classIRI>
<classLabel>material sample</classLabel>
<newAxiom>'material sample' EquivalentTo 'material entity' and ('has role' some 'material sample role')</newAxiom>
<newAxiom>'material sample' SubClassOf 'specimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33696</classIRI>
<classLabel>nucleic acid</classLabel>
<newAxiom>'nucleic acid' SubClassOf 'macromolecule'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0600036</classIRI>
<classLabel>establishing cell culture</classLabel>
<newAxiom>'establishing cell culture' SubClassOf 'material processing'</newAxiom>
<newAxiom>'establishing cell culture' SubClassOf 'achieves_planned_objective' some 'material transformation objective'</newAxiom>
<newAxiom>'establishing cell culture' SubClassOf 'has_specified_input' some 'cell'</newAxiom>
<newAxiom>'establishing cell culture' SubClassOf 'has_specified_input' some 'culture medium'</newAxiom>
<newAxiom>'establishing cell culture' SubClassOf 'has_specified_output' some 'cultured cell population'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000832</classIRI>
<classLabel>measurement device</classLabel>
<newAxiom>'measurement device' EquivalentTo 'device' and ('has function' some 'measure function')</newAxiom>
<newAxiom>'measurement device' SubClassOf 'device'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000838</classIRI>
<classLabel>material maintenance</classLabel>
<newAxiom>'material maintenance' EquivalentTo 'achieves_planned_objective' some 'material maintenance objective'</newAxiom>
<newAxiom>'material maintenance' SubClassOf 'planned process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0600047</classIRI>
<classLabel>sequencing assay</classLabel>
<newAxiom>'sequencing assay' SubClassOf 'assay'</newAxiom>
<newAxiom>'sequencing assay' EquivalentTo 'assay' and (('realizes' some 
('function' and ('characteristic of' some 
('nucleic acid sequencer' or 'protein sequencer' or 'DNA sequencer')))) and ('has_specified_input' some 
('nucleic acid sequencer' or 'protein sequencer' or 'DNA sequencer'))) and (('realizes' some 
('evaluant role' and ('role of' some 
('nucleic acid extract' or ('has part' some 'protein'))))) and ('has_specified_input' some 
(('nucleic acid extract' or ('has part' some 'protein')) and ('has role' some 'evaluant role')))) and ('has_specified_output' some 'sequence data') and ('has_specified_output' some ('is about' some 'region'))</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0600014</classIRI>
<classLabel>material component separation</classLabel>
<newAxiom>'material component separation' SubClassOf 'has_specified_input' some 'material entity'</newAxiom>
<newAxiom>'material component separation' SubClassOf 'material processing'</newAxiom>
<newAxiom>'material component separation' EquivalentTo 'achieves_planned_objective' some 'material separation objective'</newAxiom>
<newAxiom>'material component separation' SubClassOf 'has_specified_output' some 'material entity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0600024</classIRI>
<classLabel>maintaining cell culture</classLabel>
<newAxiom>'maintaining cell culture' SubClassOf 'has_specified_input' some 
('culture medium' or 'cell freezing medium')</newAxiom>
<newAxiom>'maintaining cell culture' SubClassOf 'has_specified_output' some 'cultured cell population'</newAxiom>
<newAxiom>'maintaining cell culture' SubClassOf 'has_specified_input' some 'cultured cell population'</newAxiom>
<newAxiom>'maintaining cell culture' SubClassOf 'achieves_planned_objective' some 'material maintenance objective'</newAxiom>
<newAxiom>'maintaining cell culture' SubClassOf 'material maintenance'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0666667</classIRI>
<classLabel>nucleic acid extraction</classLabel>
<newAxiom>'nucleic acid extraction' SubClassOf 'has_specified_input' some 
('sample from organism' or 'organism' or 'cultured cell population')</newAxiom>
<newAxiom>'nucleic acid extraction' SubClassOf 'has_specified_output' some 'nucleic acid'</newAxiom>
<newAxiom>'nucleic acid extraction' SubClassOf 'extraction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000806</classIRI>
<classLabel>material maintenance objective</classLabel>
<newAxiom>'material maintenance objective' SubClassOf 'objective specification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000079</classIRI>
<classLabel>culture medium</classLabel>
<newAxiom>'culture medium' SubClassOf 'processed material'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000973</classIRI>
<classLabel>sequence data</classLabel>
<newAxiom>'sequence data' SubClassOf 'measurement datum'</newAxiom>
<newAxiom>'sequence data' SubClassOf 'measurement datum' and ('is about' some 'region')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000941</classIRI>
<classLabel>service consumer role</classLabel>
<newAxiom>'service consumer role' SubClassOf 'role'</newAxiom>
<newAxiom>'service consumer role' SubClassOf 'characteristic of' some 
('Homo sapiens' or 'organization')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000947</classIRI>
<classLabel>service provider role</classLabel>
<newAxiom>'service provider role' SubClassOf 'realized in' only 'planned process'</newAxiom>
<newAxiom>'service provider role' SubClassOf 'characteristic of' some 
('Homo sapiens' or 'organization')</newAxiom>
<newAxiom>'service provider role' SubClassOf 'role'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0000953</classIRI>
<classLabel>processed specimen</classLabel>
<newAxiom>'processed specimen' EquivalentTo 'processed material' and 'specimen'</newAxiom>
<newAxiom>'processed specimen' SubClassOf 'processed material'</newAxiom>
<newAxiom>'processed specimen' SubClassOf 'specimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/IAO_0000574</classIRI>
<classLabel>assigning a centrally registered identifier</classLabel>
<newAxiom>'assigning a centrally registered identifier' SubClassOf 'has_specified_output' some 'centrally registered identifier symbol'</newAxiom>
<newAxiom>'assigning a centrally registered identifier' SubClassOf 'has_participant' some 'centrally registered identifier registry'</newAxiom>
<newAxiom>'assigning a centrally registered identifier' SubClassOf 'planned process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001547</classIRI>
<classLabel>material analysis service</classLabel>
<newAxiom>'material analysis service' SubClassOf 'material service'</newAxiom>
<newAxiom>'material analysis service' EquivalentTo 'material service' and ('provides_service_consumer_with' some 'assay')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001557</classIRI>
<classLabel>material storage service</classLabel>
<newAxiom>'material storage service' EquivalentTo 'material service' and ('provides_service_consumer_with' some 'storage')</newAxiom>
<newAxiom>'material storage service' SubClassOf 'material maintenance service'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/CL_0000578</classIRI>
<classLabel>experimentally modified cell in vitro</classLabel>
<newAxiom>'experimentally modified cell in vitro' SubClassOf 'cell'</newAxiom>
<newAxiom>'experimentally modified cell in vitro' SubClassOf 'processed material'</newAxiom>
<newAxiom>'experimentally modified cell in vitro' SubClassOf 'is_specified_output_of' some 'material processing'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001515</classIRI>
<classLabel>material maintenance service</classLabel>
<newAxiom>'material maintenance service' SubClassOf 'material service'</newAxiom>
<newAxiom>'material maintenance service' EquivalentTo 'material service' and ('provides_service_consumer_with' some 'material maintenance')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001528</classIRI>
<classLabel>material service</classLabel>
<newAxiom>'material service' SubClassOf 'service'</newAxiom>
<newAxiom>'material service' EquivalentTo 'service' and ('provides_service_consumer_with' some 
(('has_specified_input' some 'material entity') or ('has_specified_output' some 'material entity')))</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0001616</classIRI>
<classLabel>specimen identifier</classLabel>
<newAxiom>'specimen identifier' SubClassOf 'denotes' only 'specimen'</newAxiom>
<newAxiom>'specimen identifier' SubClassOf 'centrally registered identifier symbol'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0002198</classIRI>
<classLabel>molecular analysis facility organization</classLabel>
<newAxiom>'molecular analysis facility organization' EquivalentTo 'organization' and ('has role' some 
('service provider role' and ('realized in' some 'material analysis service')))</newAxiom>
<newAxiom>'molecular analysis facility organization' SubClassOf 'organization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0400103</classIRI>
<classLabel>DNA sequencer</classLabel>
<newAxiom>'DNA sequencer' SubClassOf 'has function' some 'measure function'</newAxiom>
<newAxiom>'DNA sequencer' SubClassOf 'measurement device'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/OBIB_0000714</classIRI>
<classLabel>date of specimen collection</classLabel>
<newAxiom>'date of specimen collection' SubClassOf 'data item' and ('is about' some 
('one-dimensional temporal region' and ('has part' some 
('one-dimensional temporal region' and ('has temporal occupant' some 'specimen collection process')))))</newAxiom>
<newAxiom>'date of specimen collection' SubClassOf 'data item'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>