{"id":"http://localhost/plosthes.2017-1#11322","parents":[{"id":"http://localhost/plosthes.2017-1#1440","prefLabel":"Enzymes","label":[],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"definition":[],"obsolete":false,"notation":null,"prefixIRI":null,"subClassOf":[],"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://localhost/plosthes.2017-1#1440","@type":"http://www.w3.org/2004/02/skos/core#Concept","links":{"self":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440","ontology":"https://data.bioontology.org/ontologies/PLOSTHES","children":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/children","parents":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/parents","descendants":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/descendants","ancestors":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/ancestors","instances":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/instances","tree":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/tree","notes":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/notes","mappings":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440/mappings","ui":"http://bioportal.bioontology.org/ontologies/PLOSTHES?p=classes&conceptid=http%3A%2F%2Flocalhost%2Fplosthes.2017-1%231440","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"prefLabel":"Protein kinases","label":[],"synonym":[],"definition":[],"obsolete":false,"notation":null,"prefixIRI":null,"subClassOf":[],"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://xmlns.com/foaf/0.1/homepage":["http://journals.plos.org/plosone/browse/protein_kinases"],"http://www.w3.org/2004/02/skos/core#narrower":["http://localhost/plosthes.2017-1#11537","http://localhost/plosthes.2017-1#11536"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2004/02/skos/core#Concept","http://www.w3.org/2002/07/owl#NamedIndividual"],"http://localhost/plosthes.2017-1#Previous_Classification":["10.60.150.60.230^Protein kinases|10.60.280.230.230^Protein kinases"],"http://localhost/plosthes.2017-1#alpha":["Protein kinases"],"http://www.w3.org/2004/02/skos/core#scopeNote":["Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [PMID: 3291115]: Serine/threonine-protein kinases Tyrosine-protein kinases Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins) http://www.ebi.ac.uk/interpro/entry/IPR000719 RD Eukaryotic protein kinases [1,2,3,4,5] are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common to both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. We have selected two of these regions to build signature patterns. The first region, which is located in the N-terminal extremity of the catalytic domain, is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. The second region, which is located in the central part of the catalytic domain, contains a conserved aspartic acid residue which is important for the catalytic activity of the enzyme [6]; we have derived two signature patterns for that region: one specific for serine/ threonine kinases and the other for tyrosine kinases. We also developed a profile which is based on the alignment in [1] and covers the entire catalytic domain. http://prosite.expasy.org/PDOC00100 RD"],"http://www.w3.org/2004/02/skos/core#broader":["http://localhost/plosthes.2017-1#1440"],"http://localhost/plosthes.2017-1#status":["Accepted"],"http://www.w3.org/2004/02/skos/core#prefLabel":["Protein kinases"]},"@id":"http://localhost/plosthes.2017-1#11322","@type":"http://www.w3.org/2004/02/skos/core#Concept","links":{"self":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322","ontology":"https://data.bioontology.org/ontologies/PLOSTHES","children":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/children","parents":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/parents","descendants":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/descendants","ancestors":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/ancestors","instances":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/instances","tree":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/tree","notes":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/notes","mappings":"https://data.bioontology.org/ontologies/PLOSTHES/classes/http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322/mappings","ui":"http://bioportal.bioontology.org/ontologies/PLOSTHES?p=classes&conceptid=http%3A%2F%2Flocalhost%2Fplosthes.2017-1%2311322","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}