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Otras anomalías incluyen alteraciones dentarias, hipotonía y laxitud articular, sinostosis radiocubital, defectos cardíacos, displasia de cadera y disfunción ovárica. 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de cromosoma sexual causada por la presencia de dos cromosomas X adicionales en mujeres (48 XXXX en lugar de 46 XX). No se conoce su prevalencia pero hasta el momento se han alrededor de 40 casos en la bibliografía. Se asocia con retraso del habla, dificultades del aprendizaje, retraso del desarrollo y dismorfismo facial. Aunque la severidad de la enfermedad es variable, las dificultades del aprendizaje y el retraso del desarrollo en general son leves a moderados. Hipertelorismo, hendiduras palpebrales inclinadas hacia arriba, pliegues en el epicanto y puente nasal plano son características faciales habitualmente asociadas. Otras anomalías incluyen alteraciones dentarias, hipotonía y laxitud articular, sinostosis radiocubital, defectos cardíacos, displasia de cadera y disfunción ovárica. También se ha reportado susceptibilidad aumentada a infecciones durante la niñez. Se considera que este síndrome es consecuencia de la no disyunción materna sucesiva durante la meiosis.","Anomalía de cromosoma sexual causada por la presencia de dos cromosomas X adicionales en mujeres (48 XXXX en lugar de 46 XX). Se asocia con retraso del habla, dificultades del aprendizaje, retraso del desarrollo y dismorfismo facial. Aunque la severidad de la enfermedad es variable, las dificultades del aprendizaje y el retraso del desarrollo en general son leves a moderados. Hipertelorismo, hendiduras palpebrales inclinadas hacia arriba, pliegues en el epicanto y puente nasal plano son características faciales habitualmente asociadas. Otras anomalías incluyen alteraciones dentarias, hipotonía y laxitud articular, sinostosis radiocubital, defectos cardíacos, displasia de cadera y disfunción ovárica. 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