175 435 3 http://purl.obolibrary.org/obo/TXPO_0000504 malfunctioning of regulation of gene expression 'malfunctioning of regulation of gene expression' SubClassOf 'malfunctioning process' 'malfunctioning of regulation of gene expression' SubClassOf 'malfunctioning of controlling' http://purl.obolibrary.org/obo/TXPO_0000558 positive regulation of macrophage derived foam cell differentiation [Phospholipidosis (severe)] 'positive regulation of macrophage derived foam cell differentiation [Phospholipidosis (severe)]' SubClassOf 'positive regulation of macrophage derived foam cell differentiation' http://purl.obolibrary.org/obo/TXPO_0001867 negative regulator role of transport 'negative regulator role of transport' SubClassOf 'role of negatively regulating' some 'transport' 'negative regulator role of transport' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'transport' http://purl.obolibrary.org/obo/TXPO_0001866 inhibitor role of BSEP bile acid transport 'inhibitor role of BSEP bile acid transport' SubClassOf 'inhibitor role of regulating' some 'bile acid and bile salt transport' 'inhibitor role of BSEP bile acid transport' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'bile acid and bile salt transport' http://purl.obolibrary.org/obo/TXPO_0004077 energy supply 'energy supply' SubClassOf 'providing' 'energy supply' SubClassOf 'supplying from stored substance(s)' http://purl.obolibrary.org/obo/CHEBI_4659 disulfiram 'disulfiram' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_78444 'disulfiram' SubClassOf 'has role' some 'apoptosis inducer' 'disulfiram' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'disulfiram' SubClassOf 'has role' some 'NF-kappaB inhibitor' 'disulfiram' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_37733 'disulfiram' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35487 'disulfiram' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_24127 'disulfiram' SubClassOf 'has role' some 'angiogenesis inhibitor' 'disulfiram' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50276 http://purl.obolibrary.org/obo/TXPO_0004043 negative regulator of tumor cell proliferation 'negative regulator of tumor cell proliferation' SubClassOf 'capable of positively regulating' some 'cell proliferation' 'negative regulator of tumor cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell proliferation' http://purl.obolibrary.org/obo/TXPO_0004045 negative regulator of cell proliferation 'negative regulator of cell proliferation' SubClassOf 'capable of positively regulating' some 'cell proliferation' 'negative regulator of cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell proliferation' http://purl.obolibrary.org/obo/TXPO_0004100 malfunctioning of cobalamin biosynthetic process 'malfunctioning of cobalamin biosynthetic process' SubClassOf 'malfunctioning process' 'malfunctioning of cobalamin biosynthetic process' SubClassOf 'malfunction of biosynthesis' http://purl.obolibrary.org/obo/CHEBI_38161 chelator 'chelator' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52214 http://purl.obolibrary.org/obo/TXPO_0000623 regulator role of receiving 'regulator role of receiving' SubClassOf 'capable of regulating' some 'receiving' 'regulator role of receiving' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'receiving' http://purl.obolibrary.org/obo/TXPO_0000601 storing 'storing' SubClassOf 'manifests phenotype' some 'increased accumulation (quality)' 'storing' SubClassOf 'manifests phenotype' some 'accumulation (quality)' http://purl.obolibrary.org/obo/CHEBI_41774 tamoxifen 'tamoxifen' SubClassOf 'has role' some 'estrogen receptor antagonist' 'tamoxifen' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_62872 'tamoxifen' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50837 'tamoxifen' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50739 'tamoxifen' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'tamoxifen' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_37700 'tamoxifen' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50646 'tamoxifen' SubClassOf 'has role' some 'angiogenesis inhibitor' http://purl.obolibrary.org/obo/TXPO_0004129 tumor cell death 'tumor cell death' SubClassOf 'has input' some 'cell' 'tumor cell death' SubClassOf 'has input' some ('cell' and ('has quality' some 'neoplastic (quality)')) http://purl.obolibrary.org/obo/CHEBI_16755 chenodeoxycholic acid 'chenodeoxycholic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_75771 'chenodeoxycholic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_77746 'chenodeoxycholic acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_135028 pirprofen 'pirprofen' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/TXPO_0004238 cyclin B1-CDK1 complex (human) [mitochondrial disorder] 'cyclin B1-CDK1 complex (human) [mitochondrial disorder]' SubClassOf 'has component' some 'CCNB1 (human) [mitochondrial disorder]' 'cyclin B1-CDK1 complex (human) [mitochondrial disorder]' SubClassOf 'has component' some 'CDK1 (predicted)(human) [mitochondrial damage]' 'cyclin B1-CDK1 complex (human) [mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'CCNB1 (human) [mitochondrial disorder]' 'cyclin B1-CDK1 complex (human) [mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'CDK1 (predicted)(human) [mitochondrial damage]' http://purl.obolibrary.org/obo/TXPO_0004239 cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder] 'cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder]' SubClassOf 'has component' some 'CDK1 (predicted)(human) [mitochondrial damage]' 'cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder]' SubClassOf 'has component' some 'CCNB1 (human) [mitochondrial disorder]' 'cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'CDK1 (predicted)(human) [mitochondrial damage]' 'cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'CCNB1 (human) [mitochondrial disorder]' http://purl.obolibrary.org/obo/CHEBI_9352 sulindac 'sulindac' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'sulindac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'sulindac' SubClassOf 'has role' some 'apoptosis inducer' 'sulindac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50266 'sulindac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35544 'sulindac' SubClassOf 'has role' some 'antineoplastic agent' 'sulindac' SubClassOf 'has role' some 'non-narcotic analgesic' 'sulindac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_66993 'sulindac' SubClassOf 'has role' some 'analgesic' 'sulindac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35493 http://purl.obolibrary.org/obo/CHEBI_77731 p53 activator 'p53 activator' SubClassOf 'activator of' some 'p53 (mol)' http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor 'enzyme inhibitor' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52206 'enzyme inhibitor' SubClassOf 'inhibitor (reaction)' http://purl.obolibrary.org/obo/CHEBI_49167 anti-asthmatic drug 'anti-asthmatic drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_65023 http://purl.obolibrary.org/obo/CHEBI_9753 troglitazone 'troglitazone' SubClassOf 'has role' some 'anticonvulsant' 'troglitazone' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50249 'troglitazone' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'troglitazone' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35526 'troglitazone' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50427 'troglitazone' SubClassOf 'has role' some 'antioxidant' 'troglitazone' SubClassOf 'has role' some 'vasodilator agent' 'troglitazone' SubClassOf 'has role' some 'antineoplastic agent' http://purl.obolibrary.org/obo/TXPO_0002905 Bip-unfolded protein complex 1 [ER stress - refolding] 'Bip-unfolded protein complex 1 [ER stress - refolding]' SubClassOf 'has component' some 'unfolded protein' 'Bip-unfolded protein complex 1 [ER stress - refolding]' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'Bip-unfolded protein complex 1 [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'unfolded protein' 'Bip-unfolded protein complex 1 [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/TXPO_0002906 Bip-Unfolded Protein complex 2 [ER stress - refolding] 'Bip-Unfolded Protein complex 2 [ER stress - refolding]' SubClassOf 'has component' some 'unfolded protein' 'Bip-Unfolded Protein complex 2 [ER stress - refolding]' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'Bip-Unfolded Protein complex 2 [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'unfolded protein' 'Bip-Unfolded Protein complex 2 [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/TXPO_0002907 Bip-unfolded protein complex 3 [ER stress - inflammation] 'Bip-unfolded protein complex 3 [ER stress - inflammation]' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'Bip-unfolded protein complex 3 [ER stress - inflammation]' SubClassOf 'has component' some 'unfolded protein' 'Bip-unfolded protein complex 3 [ER stress - inflammation]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'unfolded protein' 'Bip-unfolded protein complex 3 [ER stress - inflammation]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/TXPO_0001634 ACETALDEHYDE (canonical)[Lipidosis] 'ACETALDEHYDE (canonical)[Lipidosis]' SubClassOf 'lipidosis dependent molecule (canonical)' 'ACETALDEHYDE (canonical)[Lipidosis]' SubClassOf 'lipidosis dependent chemical compound' http://purl.obolibrary.org/obo/CHEBI_51450 bosentan 'bosentan' SubClassOf 'has role' some 'antihypertensive agent' 'bosentan' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_51451 'bosentan' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/CHEBI_52717 bortezomib 'bortezomib' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_37670 'bortezomib' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35820 'bortezomib' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'bortezomib' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_52726 http://purl.obolibrary.org/obo/GO_0051168 nuclear export 'nuclear export' SubClassOf 'has target start location' some 'nucleus' 'nuclear export' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'nucleus' http://purl.obolibrary.org/obo/GO_0051170 import into nucleus 'import into nucleus' SubClassOf 'has target end location' some 'nucleus' 'import into nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'nucleus' http://purl.obolibrary.org/obo/TXPO_0000336 amino acid conjugatied bile acid transport into bile canaliculus 'amino acid conjugatied bile acid transport into bile canaliculus' SubClassOf 'has target end location' some 'bile canaliculus' 'amino acid conjugatied bile acid transport into bile canaliculus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'bile canaliculus' http://purl.obolibrary.org/obo/TXPO_0000330 transcription regulator 'transcription regulator' SubClassOf 'capable of regulating' some 'transcription, DNA-templated' 'transcription regulator' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'transcription, DNA-templated' http://purl.obolibrary.org/obo/TXPO_0000327 apoptosis regulator role 'apoptosis regulator role' SubClassOf 'capable of regulating' some 'apoptotic process' 'apoptosis regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'apoptotic process' http://purl.obolibrary.org/obo/TXPO_0002980 Translocation of XBP1s from the cytosol to the nucleus 'Translocation of XBP1s from the cytosol to the nucleus' SubClassOf 'has target start location' some 'cytosol' 'Translocation of XBP1s from the cytosol to the nucleus' SubClassOf 'has target end location' some 'nucleus' 'Translocation of XBP1s from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytosol' 'Translocation of XBP1s from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'nucleus' http://purl.obolibrary.org/obo/CHEBI_50183 P450 inhibitor 'P450 inhibitor' SubClassOf 'role of negatively regulating' some 'Cytochrome P450' 'P450 inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'cytochrome P450 activation' 'P450 inhibitor' SubClassOf http://purl.obolibrary.org/obo/CHEBI_76898 http://purl.obolibrary.org/obo/CHEBI_50185 fatty acid synthesis inhibitor 'fatty acid synthesis inhibitor' SubClassOf 'inhibitor role of regulating' some 'fatty acid biosynthetic process' 'fatty acid synthesis inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'fatty acid biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0001700 increaing in fatty acid inflow into hepatocyte [Phpspholipidosis(moderate)] 'increaing in fatty acid inflow into hepatocyte [Phpspholipidosis(moderate)]' SubClassOf 'phospholipidosis dependent process' http://purl.obolibrary.org/obo/GO_0030970 retrograde protein transport, ER to cytosol 'retrograde protein transport, ER to cytosol' SubClassOf 'has target start location' some 'endoplasmic reticulum' 'retrograde protein transport, ER to cytosol' SubClassOf 'has target end location' some 'cytosol' 'retrograde protein transport, ER to cytosol' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'cytosol' 'retrograde protein transport, ER to cytosol' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'endoplasmic reticulum' http://purl.obolibrary.org/obo/TXPO_0000487 autophagy inducer 'autophagy inducer' SubClassOf 'capable of positively regulating' some 'autophagy' 'autophagy inducer' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'autophagy' http://purl.obolibrary.org/obo/TXPO_0003188 LPS translocation from gut to liver 'LPS translocation from gut to liver' SubClassOf 'has target end location' some 'liver' 'LPS translocation from gut to liver' SubClassOf 'has target start location' some 'intestine' 'LPS translocation from gut to liver' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'intestine' 'LPS translocation from gut to liver' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'liver' http://purl.obolibrary.org/obo/TXPO_0003157 Bip-unfolded protein complex [ER stress] 'Bip-unfolded protein complex [ER stress]' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'Bip-unfolded protein complex [ER stress]' SubClassOf 'has component' some 'unfolded protein [ER stress]' 'Bip-unfolded protein complex [ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' 'Bip-unfolded protein complex [ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'unfolded protein [ER stress]' http://purl.obolibrary.org/obo/TXPO_0003159 regulator of cell proliferation 'regulator of cell proliferation' SubClassOf 'capable of regulating' some 'cell proliferation' 'regulator of cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell proliferation' http://purl.obolibrary.org/obo/TXPO_0000931 troglitazone [Cholestasis] 'troglitazone [Cholestasis]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' 'troglitazone [Cholestasis]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' http://purl.obolibrary.org/obo/TXPO_0003224 nuclear receptor 'nuclear receptor' SubClassOf 'capable of regulating' some 'transcription, DNA-templated' 'nuclear receptor' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'transcription, DNA-templated' http://purl.obolibrary.org/obo/CHEBI_35660 HIV protease inhibitor 'HIV protease inhibitor' SubClassOf http://purl.obolibrary.org/obo/CHEBI_37670 'HIV protease inhibitor' SubClassOf http://purl.obolibrary.org/obo/CHEBI_64946 http://purl.obolibrary.org/obo/CHEBI_22333 alkylating agent 'alkylating agent' SubClassOf 'mutagen' http://purl.obolibrary.org/obo/TXPO_0004500 formation of DNA adducts 'formation of DNA adducts' SubClassOf 'DNA binding' 'formation of DNA adducts' SubClassOf 'binding (with molecule)' http://purl.obolibrary.org/obo/CHEBI_46195 paracetamol 'paracetamol' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/CHEBI_35497 androgen antagonist 'androgen antagonist' SubClassOf http://purl.obolibrary.org/obo/CHEBI_49020 http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug 'tranquilizing drug' SubClassOf 'central nervous system depressant' http://purl.obolibrary.org/obo/CHEBI_35475 non-steroidal anti-inflammatory drug 'non-steroidal anti-inflammatory drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_35842 http://purl.obolibrary.org/obo/CHEBI_35480 analgesic 'analgesic' SubClassOf 'pharmacological role' http://purl.obolibrary.org/obo/CHEBI_35553 perhexiline 'perhexiline' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/CHEBI_59517 DNA synthesis inhibitor 'DNA synthesis inhibitor' SubClassOf 'inhibitor role of regulating' some 'DNA biosynthetic process' 'DNA synthesis inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'DNA biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0003388 phospholipid transport from lysosome 'phospholipid transport from lysosome' SubClassOf 'has target end location' some 'cytosol' 'phospholipid transport from lysosome' SubClassOf 'has target start location' some 'lysosome' 'phospholipid transport from lysosome' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'cytosol' 'phospholipid transport from lysosome' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'lysosome' http://purl.obolibrary.org/obo/TXPO_0002044 glutathione conjugation inhibotor role 'glutathione conjugation inhibotor role' SubClassOf 'capable of regulating' some 'glutathione conjugation' 'glutathione conjugation inhibotor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'glutathione conjugation' http://purl.obolibrary.org/obo/CHEBI_47519 ketoconazole 'ketoconazole' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/TXPO_0002031 oxidative phosphorylation inhibitor role 'oxidative phosphorylation inhibitor role' SubClassOf 'inhibitor role of regulating' some 'oxidative phosphorylation' 'oxidative phosphorylation inhibitor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'oxidative phosphorylation' http://purl.obolibrary.org/obo/TXPO_0003355 transportng lysosomal enzyme from ribosome to lysosome 'transportng lysosomal enzyme from ribosome to lysosome' SubClassOf 'has target end location' some 'lysosome' 'transportng lysosomal enzyme from ribosome to lysosome' SubClassOf 'has target start location' some 'ribosome' 'transportng lysosomal enzyme from ribosome to lysosome' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'lysosome' 'transportng lysosomal enzyme from ribosome to lysosome' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'ribosome' http://purl.obolibrary.org/obo/TXPO_0004611 trimeric UHRF1 repression complex (human) [hepatocarcinogenesis] 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf 'has component' some 'UHRF1 (predicted)(human) [hepatocarcinogenesis]' 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf 'has component' some 'DNMT1 (human) [hepatocarcinogenesis]' 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf 'has component' some 'USP7 (human) [hepatocarcinogenesis]' 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'USP7 (human) [hepatocarcinogenesis]' 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'DNMT1 (human) [hepatocarcinogenesis]' 'trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'UHRF1 (predicted)(human) [hepatocarcinogenesis]' http://purl.obolibrary.org/obo/TXPO_0004268 neutrophil migration [mitochondrial disorder] 'neutrophil migration [mitochondrial disorder]' SubClassOf 'has target end location' some 'liver' 'neutrophil migration [mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'liver' http://purl.obolibrary.org/obo/TXPO_0004264 metabolic dysfunction of precursor metabolites and energy generation [mitochondrial disorder] 'metabolic dysfunction of precursor metabolites and energy generation [mitochondrial disorder]' SubClassOf 'has input' only 'generation of precursor metabolites and energy' http://purl.obolibrary.org/obo/TXPO_0004266 monocyte migration [mitochondrial disorder] 'monocyte migration [mitochondrial disorder]' SubClassOf 'has target end location' some 'liver' 'monocyte migration [mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'liver' http://purl.obolibrary.org/obo/GO_0005747 mitochondrial respiratory chain complex I 'mitochondrial respiratory chain complex I' SubClassOf 'has component' some 'mitochondrial respiratory chain complex I subunit' 'mitochondrial respiratory chain complex I' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'mitochondrial respiratory chain complex I subunit' http://purl.obolibrary.org/obo/TXPO_0004314 respiratory chain inhibitor role 'respiratory chain inhibitor role' SubClassOf 'inhibitor role of regulating' some 'respiratory electron transport chain' http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent 'antimicrobial agent' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger 'molecular messenger' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_23888 drug 'drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52217 http://purl.obolibrary.org/obo/TXPO_0004337 troglitazone [mitochondrial disorder] 'troglitazone [mitochondrial disorder]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' 'troglitazone [mitochondrial disorder]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role 'pharmacological role' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_88230 autophagy inhibitor 'autophagy inhibitor' SubClassOf 'inhibitor role of regulating' some 'autophagy' 'autophagy inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'autophagy' http://purl.obolibrary.org/obo/TXPO_0003051 refolding promoting factor role 'refolding promoting factor role' SubClassOf 'capable of positively regulating' some 'protein refolding' 'refolding promoting factor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'protein refolding' http://purl.obolibrary.org/obo/TXPO_0000832 cell death inhibitor 'cell death inhibitor' SubClassOf 'inhibitor role of regulating' some 'cell death' 'cell death inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'cell death' http://purl.obolibrary.org/obo/CHEBI_47780 clomipramine 'clomipramine' SubClassOf 'has role' some 'antidepressant' 'clomipramine' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'clomipramine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_77402 'clomipramine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_48279 'clomipramine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50949 'clomipramine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_48278 http://purl.obolibrary.org/obo/TXPO_0004441 C9orf72 (predicted)(human) [mitochondrial damage] 'C9orf72 (predicted)(human) [mitochondrial damage]' SubClassOf 'mitochondrial damage dependent molecule (human in vitro)' http://purl.obolibrary.org/obo/TXPO_0002374 p450 activator 'p450 activator' SubClassOf 'capable of positively regulating' some 'Cytochrome P450' 'p450 activator' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cytochrome P450 activation' http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor (reaction) 'inhibitor (reaction)' EquivalentTo 'role' and ('inhibitor role of regulating' some 'process') 'inhibitor (reaction)' SubClassOf 'biological role' 'inhibitor (reaction)' EquivalentTo 'role' and (http://purl.obolibrary.org/obo/RO_0002599 some 'process') http://purl.obolibrary.org/obo/TXPO_0002362 phospholipid biosynthetic positive regulator role 'phospholipid biosynthetic positive regulator role' SubClassOf 'capable of positively regulating' some 'phospholipid biosynthetic process' 'phospholipid biosynthetic positive regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'phospholipid biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0002358 lipid metabolic regulator role 'lipid metabolic regulator role' SubClassOf 'capable of regulating' some 'lipid metabolic process' 'lipid metabolic regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'lipid metabolic process' http://purl.obolibrary.org/obo/TXPO_0002357 PPARalpha inactivation [lipidosis] 'PPARalpha inactivation [lipidosis]' SubClassOf 'has agent' some 'ACETALDEHYDE (canonical)[Fibrosis]' 'PPARalpha inactivation [lipidosis]' SubClassOf 'has agent' some 'ACETALDEHYDE (canonical)[Lipidosis]' http://purl.obolibrary.org/obo/TXPO_0001025 peroxisomal proliferation in hepatocyte (severe) [Eosinophilic granular degeneration] 'peroxisomal proliferation in hepatocyte (severe) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') 'peroxisomal proliferation in hepatocyte (severe) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') http://purl.obolibrary.org/obo/TXPO_0001023 peroxisomal proliferation in hepatocyte (moderate) [Eosinophilic granular degeneration] 'peroxisomal proliferation in hepatocyte (moderate) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') 'peroxisomal proliferation in hepatocyte (moderate) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') http://purl.obolibrary.org/obo/TXPO_0001016 peroxisomal proliferation in hepatocyte (mild) [Eosinophilic granular degeneration] 'peroxisomal proliferation in hepatocyte (mild) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') 'peroxisomal proliferation in hepatocyte (mild) [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') http://purl.obolibrary.org/obo/TXPO_0003678 biochemical role 'biochemical role' SubClassOf 'biological role' http://purl.obolibrary.org/obo/TXPO_0002394 glutathione biosynthetic limiting enzyme agent role 'glutathione biosynthetic limiting enzyme agent role' SubClassOf 'capable of regulating' some 'glutathione biosynthetic process' 'glutathione biosynthetic limiting enzyme agent role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'glutathione biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0002399 p53 inhibitor 'p53 inhibitor' SubClassOf 'inhibitor role of regulating' some 'p53 (mol)' 'p53 inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'p53 activation' http://purl.obolibrary.org/obo/TXPO_0002397 cell death inducer 'cell death inducer' SubClassOf 'capable of positively regulating' some 'cell death' 'cell death inducer' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell death' http://purl.obolibrary.org/obo/TXPO_0004933 Chlorendic Acid 'Chlorendic Acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0004934 Chlorendic Acid [hepatocarcinogenesis] 'Chlorendic Acid [hepatocarcinogenesis]' SubClassOf 'Chlorendic Acid' 'Chlorendic Acid [hepatocarcinogenesis]' SubClassOf http://purl.obolibrary.org/obo/CHEBI_76603 http://purl.obolibrary.org/obo/TXPO_0004983 glutathione transport from cytoplasm into mitochondria 'glutathione transport from cytoplasm into mitochondria' SubClassOf 'has target start location' some 'cytoplasm' 'glutathione transport from cytoplasm into mitochondria' SubClassOf 'has target end location' only 'mitochondrion' 'glutathione transport from cytoplasm into mitochondria' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 only 'mitochondrion' 'glutathione transport from cytoplasm into mitochondria' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytoplasm' http://purl.obolibrary.org/obo/TXPO_0003654 glutathione synthesis regulating agent role 'glutathione synthesis regulating agent role' SubClassOf 'capable of regulating' some 'glutathione biosynthetic process' 'glutathione synthesis regulating agent role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'glutathione biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0003648 fatty accid metabolic regulator role 'fatty accid metabolic regulator role' SubClassOf 'capable of regulating' some 'fatty acid metabolic process' 'fatty accid metabolic regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'fatty acid metabolic process' http://purl.obolibrary.org/obo/TXPO_0003647 phospholipid metabolic regulator role 'phospholipid metabolic regulator role' SubClassOf 'capable of regulating' some 'phospholipid metabolic process' 'phospholipid metabolic regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'phospholipid metabolic process' http://purl.obolibrary.org/obo/TXPO_0002494 NF-kappaB transport into nucleus 'NF-kappaB transport into nucleus' SubClassOf 'has target end location' some 'nucleus' 'NF-kappaB transport into nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'nucleus' http://purl.obolibrary.org/obo/TXPO_0002488 glutathione export from hepatocyte 'glutathione export from hepatocyte' SubClassOf 'has target start location' some 'hepatocyte' 'glutathione export from hepatocyte' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'hepatocyte' http://purl.obolibrary.org/obo/GO_0006649 phospholipid transfer to membrane 'phospholipid transfer to membrane' SubClassOf 'has target end location' some 'biological membrane' 'phospholipid transfer to membrane' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'biological membrane' http://purl.obolibrary.org/obo/CHEBI_48407 antiparkinson drug 'antiparkinson drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_66956 http://purl.obolibrary.org/obo/TXPO_0002466 Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding] 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding]' SubClassOf 'has target start location' some 'endoplasmic reticulum' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding]' SubClassOf 'has target end location' some 'golgi apparatus' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'golgi apparatus' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding]' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'endoplasmic reticulum' http://purl.obolibrary.org/obo/TXPO_0002465 Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi' SubClassOf 'has target start location' some 'endoplasmic reticulum' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi' SubClassOf 'has target end location' some 'golgi apparatus' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'endoplasmic reticulum' 'Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'golgi apparatus' http://purl.obolibrary.org/obo/TXPO_0001195 JNK translocation from cytoplasm to mitochondria 'JNK translocation from cytoplasm to mitochondria' SubClassOf 'has target end location' some 'mitochondrion' 'JNK translocation from cytoplasm to mitochondria' SubClassOf 'has target start location' some 'cytoplasm' 'JNK translocation from cytoplasm to mitochondria' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'mitochondrion' 'JNK translocation from cytoplasm to mitochondria' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytoplasm' http://purl.obolibrary.org/obo/TXPO_0002406 cell death modulator role 'cell death modulator role' SubClassOf 'capable of regulating' some 'cell death' 'cell death modulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell death' http://purl.obolibrary.org/obo/TXPO_0002405 BIP-stress sensor complex 'BIP-stress sensor complex' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'BIP-stress sensor complex' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/TXPO_0002400 glutathione biosynthetic promoting agent 'glutathione biosynthetic promoting agent' SubClassOf 'capable of positively regulating' some 'glutathione biosynthetic process' 'glutathione biosynthetic promoting agent' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'glutathione biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0003726 regulator of immune response 'regulator of immune response' SubClassOf 'capable of regulating' some 'inflammatory response' 'regulator of immune response' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'inflammatory response' http://purl.obolibrary.org/obo/TXPO_0003769 ACETALDEHYDE (canonical)[Fibrosis] 'ACETALDEHYDE (canonical)[Fibrosis]' SubClassOf 'hepatic fibrosis dependent molecule (canonical)' 'ACETALDEHYDE (canonical)[Fibrosis]' SubClassOf 'hepatic fibrosis dependent chemical compound' http://purl.obolibrary.org/obo/CHEBI_47381 diclofenac 'diclofenac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35493 'diclofenac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_88188 'diclofenac' SubClassOf 'has role' some 'non-narcotic analgesic' 'diclofenac' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'diclofenac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_78298 'diclofenac' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35544 'diclofenac' SubClassOf 'has role' some 'xenobiotic' http://purl.obolibrary.org/obo/CHEBI_133190 fatty acid oxidation inhibitor 'fatty acid oxidation inhibitor' SubClassOf 'inhibitor role of regulating' some 'fatty acid oxidation' 'fatty acid oxidation inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'fatty acid oxidation' http://purl.obolibrary.org/obo/TXPO_0002115 Bip-unfolded protein complex 'Bip-unfolded protein complex' SubClassOf 'has component' some 'unfolded protein [ER stress]' 'Bip-unfolded protein complex' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'Bip-unfolded protein complex' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'unfolded protein [ER stress]' 'Bip-unfolded protein complex' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/TXPO_0002110 BIP-ATF6 complex (canonical)[ER stress] 'BIP-ATF6 complex (canonical)[ER stress]' SubClassOf 'has component' some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -ATF6 pathway]' 'BIP-ATF6 complex (canonical)[ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -ATF6 pathway]' http://purl.obolibrary.org/obo/TXPO_0002111 BIP-IRE1 complex (canonical)[ER stress] 'BIP-IRE1 complex (canonical)[ER stress]' SubClassOf 'has component' some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -IRE1 pathway]' 'BIP-IRE1 complex (canonical)[ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -IRE1 pathway]' http://purl.obolibrary.org/obo/TXPO_0002109 BIP-PERK complex (canonical)[ER stress] 'BIP-PERK complex (canonical)[ER stress]' SubClassOf 'has component' some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [short-term]]' 'BIP-PERK complex (canonical)[ER stress]' SubClassOf 'has component' some 'PERK - signal sensor (canonical)[Perk signalling system]' 'BIP-PERK complex (canonical)[ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [short-term]]' 'BIP-PERK complex (canonical)[ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'PERK - signal sensor (canonical)[Perk signalling system]' http://purl.obolibrary.org/obo/TXPO_0002108 BIP-STRESS sensor complex (canonical)[ER stress] 'BIP-STRESS sensor complex (canonical)[ER stress]' SubClassOf 'has component' some 'GRP78 (canonical)[ER stress]' 'BIP-STRESS sensor complex (canonical)[ER stress]' SubClassOf http://purl.obolibrary.org/obo/RO_0002180 some 'GRP78 (canonical)[ER stress]' http://purl.obolibrary.org/obo/CHEBI_10110 zidovudine 'zidovudine' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'zidovudine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_53756 'zidovudine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35221 http://purl.obolibrary.org/obo/TXPO_0003486 triglyceride transport from hepatocyte to extrahepatic 'triglyceride transport from hepatocyte to extrahepatic' SubClassOf 'has target start location' some 'hepatocyte' 'triglyceride transport from hepatocyte to extrahepatic' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'hepatocyte' http://purl.obolibrary.org/obo/CHEBI_490877 didanosine 'didanosine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_53756 'didanosine' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'didanosine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_63090 'didanosine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35221 http://purl.obolibrary.org/obo/CHEBI_5296 gemfibrozil 'gemfibrozil' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'gemfibrozil' SubClassOf 'has role' some 'antilipemic drug' http://purl.obolibrary.org/obo/CHEBI_135649 alpidem 'alpidem' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/TXPO_0002196 lipid synthesis regulator role 'lipid synthesis regulator role' SubClassOf 'capable of regulating' some 'lipid biosynthetic process' 'lipid synthesis regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'lipid biosynthetic process' http://purl.obolibrary.org/obo/TXPO_0002247 cell cycle regulator role 'cell cycle regulator role' SubClassOf 'capable of regulating' some 'cell cycle' 'cell cycle regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell cycle' http://purl.obolibrary.org/obo/TXPO_0003572 positive regulator of immune response 'positive regulator of immune response' SubClassOf 'capable of positively regulating' some 'inflammatory response' 'positive regulator of immune response' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'inflammatory response' http://purl.obolibrary.org/obo/TXPO_0003564 positive regulator of cell cycle phase transition role 'positive regulator of cell cycle phase transition role' SubClassOf 'capable of positively regulating' some 'cell cycle phase transition' 'positive regulator of cell cycle phase transition role' SubClassOf 'capable of regulating' some 'cell cycle phase transition' 'positive regulator of cell cycle phase transition role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell cycle phase transition' 'positive regulator of cell cycle phase transition role' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell cycle phase transition' http://purl.obolibrary.org/obo/TXPO_0003562 G1/S transition of mitotic cell cycle 'G1/S transition of mitotic cell cycle' SubClassOf 'capable of regulating' some 'cell cycle G1/S phase transition' 'G1/S transition of mitotic cell cycle' SubClassOf 'capable of positively regulating' some 'cell cycle G1/S phase transition' 'G1/S transition of mitotic cell cycle' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell cycle G1/S phase transition' 'G1/S transition of mitotic cell cycle' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell cycle G1/S phase transition' http://purl.obolibrary.org/obo/TXPO_0002229 increasing uptake amount of mitochondrial calcium ion 'increasing uptake amount of mitochondrial calcium ion' SubClassOf 'has target start location' some 'cytoplasm' 'increasing uptake amount of mitochondrial calcium ion' SubClassOf 'has target end location' some 'mitochondrion' 'increasing uptake amount of mitochondrial calcium ion' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'mitochondrion' 'increasing uptake amount of mitochondrial calcium ion' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytoplasm' http://purl.obolibrary.org/obo/CHEBI_65191 second generation antipsychotic 'second generation antipsychotic' SubClassOf http://purl.obolibrary.org/obo/CHEBI_35476 http://purl.obolibrary.org/obo/CHEBI_50925 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 'EC 2.7.11.* (protein-serine/threonine kinase) inhibitor' SubClassOf http://purl.obolibrary.org/obo/CHEBI_76812 http://purl.obolibrary.org/obo/CHEBI_50924 sorafenib 'sorafenib' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'sorafenib' SubClassOf 'has role' some 'angiogenesis inhibitor' 'sorafenib' SubClassOf 'has role' some 'antineoplastic agent' 'sorafenib' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_38637 http://purl.obolibrary.org/obo/TXPO_0002286 cytokine production inducer 'cytokine production inducer' SubClassOf 'capable of positively regulating' some 'cytokine production' 'cytokine production inducer' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cytokine production' http://purl.obolibrary.org/obo/TXPO_0002284 immune responsor role 'immune responsor role' SubClassOf 'capable of regulating' some 'immune response' 'immune responsor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'immune response' http://purl.obolibrary.org/obo/TXPO_0002287 IL-2 production inducer 'IL-2 production inducer' SubClassOf 'capable of positively regulating' some 'interleukin-2 production' 'IL-2 production inducer' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'interleukin-2 production' http://purl.obolibrary.org/obo/CHEBI_50902 genotoxin 'genotoxin' SubClassOf 'aetiopathogenetic role' http://purl.obolibrary.org/obo/CHEBI_50908 hepatotoxic agent 'hepatotoxic agent' SubClassOf 'aetiopathogenetic role' http://purl.obolibrary.org/obo/TXPO_0002272 positive regulator of tumor cell proliferation 'positive regulator of tumor cell proliferation' SubClassOf 'capable of positively regulating' some 'tumor cell proliferation' 'positive regulator of tumor cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'tumor cell proliferation' http://purl.obolibrary.org/obo/TXPO_0002271 positive regulator of cell proliferation 'positive regulator of cell proliferation' SubClassOf 'capable of positively regulating' some 'cell proliferation' 'positive regulator of cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell proliferation' http://purl.obolibrary.org/obo/TXPO_0002270 positive regulator of cell cycle arrest role 'positive regulator of cell cycle arrest role' SubClassOf 'capable of positively regulating' some 'cell cycle arrest' 'positive regulator of cell cycle arrest role' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell cycle arrest' http://purl.obolibrary.org/obo/CHEBI_24621 hormone 'hormone' SubClassOf 'agonist' http://purl.obolibrary.org/obo/TXPO_0002269 positive regulator of cell cycle role 'positive regulator of cell cycle role' SubClassOf 'capable of positively regulating' some 'cell cycle' 'positive regulator of cell cycle role' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'cell cycle' http://purl.obolibrary.org/obo/TXPO_0002261 positive regulator of tumor growth 'positive regulator of tumor growth' SubClassOf 'capable of regulating' some 'tumor growth' 'positive regulator of tumor growth' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'tumor growth' http://purl.obolibrary.org/obo/TXPO_0003534 regulator of tumor cell proliferation 'regulator of tumor cell proliferation' SubClassOf 'capable of regulating' some 'cell proliferation' 'regulator of tumor cell proliferation' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'cell proliferation' http://purl.obolibrary.org/obo/CHEBI_36044 antiviral drug 'antiviral drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_36043 'antiviral drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_22587 http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug 'antibacterial drug' SubClassOf http://purl.obolibrary.org/obo/CHEBI_36043 http://purl.obolibrary.org/obo/CHEBI_48001 protein synthesis inhibitor 'protein synthesis inhibitor' SubClassOf 'inhibitor role of regulating' some 'protein production' 'protein synthesis inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'protein production' http://purl.obolibrary.org/obo/CHEBI_64909 poison 'poison' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator 'membrane transport modulator' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52208 http://purl.obolibrary.org/obo/GO_0000266 mitochondrial fission 'mitochondrial fission' SubClassOf 'has input' some 'cell' 'mitochondrial fission' SubClassOf 'has input' some 'mitochondrion' http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor 'pathway inhibitor' SubClassOf 'enzyme inhibitor' http://purl.obolibrary.org/obo/TXPO_0000105 peroxisomal proliferation in hepatocyte [Eosinophilic granular degeneration] 'peroxisomal proliferation in hepatocyte [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') 'peroxisomal proliferation in hepatocyte [Eosinophilic granular degeneration]' SubClassOf not ('occurs in' some 'homo sapiens') http://purl.obolibrary.org/obo/CHEBI_76967 human xenobiotic metabolite 'human xenobiotic metabolite' SubClassOf http://purl.obolibrary.org/obo/CHEBI_77746 http://purl.obolibrary.org/obo/TXPO_0000131 lipid transport to mitochondria 'lipid transport to mitochondria' SubClassOf 'has target end location' some 'mitochondrion' 'lipid transport to mitochondria' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'mitochondrion' http://purl.obolibrary.org/obo/CHEBI_63581 stavudine 'stavudine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_59897 'stavudine' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'stavudine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35221 'stavudine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_22587 http://purl.obolibrary.org/obo/TXPO_0005059 saturated fatty acid 'saturated fatty acid' SubClassOf 'lipid' http://purl.obolibrary.org/obo/TXPO_0005058 saturated fatty acid [mitochondrial disorder] 'saturated fatty acid [mitochondrial disorder]' SubClassOf 'saturated fatty acid' 'saturated fatty acid [mitochondrial disorder]' SubClassOf http://purl.obolibrary.org/obo/CHEBI_26607 http://purl.obolibrary.org/obo/CHEBI_25212 metabolite 'metabolite' SubClassOf 'biochemical role' 'metabolite' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52206 http://purl.obolibrary.org/obo/CHEBI_39867 valproic acid 'valproic acid' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) 'valproic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50905 'valproic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_35477 'valproic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_51374 'valproic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_61115 'valproic acid' SubClassOf 'has role' some 'anticonvulsant' 'valproic acid' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_63726 http://purl.obolibrary.org/obo/CHEBI_68495 apoptosis inducer 'apoptosis inducer' SubClassOf 'capable of positively regulating' some 'apoptotic process' 'apoptosis inducer' SubClassOf http://purl.obolibrary.org/obo/RO_0002598 some 'apoptotic process' 'apoptosis inducer' SubClassOf http://purl.obolibrary.org/obo/CHEBI_52206 http://purl.obolibrary.org/obo/CHEBI_68494 apoptosis inhibitor 'apoptosis inhibitor' SubClassOf 'inhibitor role of regulating' some 'apoptotic process' 'apoptosis inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'apoptotic process' http://purl.obolibrary.org/obo/CHEBI_32499 amineptine 'amineptine' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_51039 'amineptine' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/CHEBI_44445 nimesulide 'nimesulide' SubClassOf 'has role' some http://purl.obolibrary.org/obo/CHEBI_50629 'nimesulide' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/TXPO_0000269 bile acid transport to hepatocyte 'bile acid transport to hepatocyte' SubClassOf 'has target end location' some 'hepatocyte' 'bile acid transport to hepatocyte' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'hepatocyte' http://purl.obolibrary.org/obo/CHEBI_7573 nilutamide 'nilutamide' SubClassOf 'has role' some 'androgen antagonist' 'nilutamide' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/CHEBI_2663 amiodarone 'amiodarone' SubClassOf 'has attribute' some (http://purl.obolibrary.org/obo/TXPO_0004321 and ('has attribute value' some http://purl.obolibrary.org/obo/TXPO_0004323)) http://purl.obolibrary.org/obo/TXPO_0002587 moving A to the inside of B 'moving A to the inside of B' SubClassOf 'changing distance' 'moving A to the inside of B' SubClassOf 'changing the relationship between inside and outside' http://purl.obolibrary.org/obo/CHEBI_73240 NF-kappaB inhibitor 'NF-kappaB inhibitor' SubClassOf 'inhibitor (reaction)' http://purl.obolibrary.org/obo/TXPO_0003888 tumor progression inhibitor 'tumor progression inhibitor' SubClassOf 'inhibitor role of regulating' some 'tumor cell survial' 'tumor progression inhibitor' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'tumor cell survial' http://purl.obolibrary.org/obo/TXPO_0003929 gluconeogenesis inhibitor role 'gluconeogenesis inhibitor role' SubClassOf 'inhibitor role of regulating' some 'gluconeogenesis' 'gluconeogenesis inhibitor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'gluconeogenesis' http://purl.obolibrary.org/obo/TXPO_0003917 Translocation of CAR from the cytosol to the nucleus 'Translocation of CAR from the cytosol to the nucleus' SubClassOf 'has target start location' some 'cytosol' 'Translocation of CAR from the cytosol to the nucleus' SubClassOf 'has target end location' some 'nucleus' 'Translocation of CAR from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'nucleus' 'Translocation of CAR from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytosol' http://purl.obolibrary.org/obo/TXPO_0000053 Translocation of ATF6 from the cytosol to the nucleus 'Translocation of ATF6 from the cytosol to the nucleus' SubClassOf 'has target start location' some 'cytosol' 'Translocation of ATF6 from the cytosol to the nucleus' SubClassOf 'has target end location' some 'nucleus' 'Translocation of ATF6 from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'nucleus' 'Translocation of ATF6 from the cytosol to the nucleus' SubClassOf http://purl.obolibrary.org/obo/RO_0002338 some 'cytosol' http://purl.obolibrary.org/obo/TXPO_0000056 bile acid transport regulator role 'bile acid transport regulator role' SubClassOf 'capable of regulating' some 'bile acid and bile salt transport' 'bile acid transport regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'bile acid and bile salt transport' http://purl.obolibrary.org/obo/TXPO_0000082 bile acid transport inhibitor role 'bile acid transport inhibitor role' SubClassOf 'inhibitor role of regulating' some 'bile acid and bile salt transport' 'bile acid transport inhibitor role' SubClassOf http://purl.obolibrary.org/obo/RO_0002599 some 'bile acid and bile salt transport' http://purl.obolibrary.org/obo/TXPO_0002629 autophagy regulator role 'autophagy regulator role' SubClassOf 'capable of regulating' some 'autophagy' 'autophagy regulator role' SubClassOf http://purl.obolibrary.org/obo/RO_0002596 some 'autophagy' http://purl.obolibrary.org/obo/TXPO_0002620 negative regulator role of stress sensor 'negative regulator role of stress sensor' EquivalentTo 'role' and ('role of negatively regulating' some ('material entity' and ('has role' some 'stress sensor'))) 'negative regulator role of stress sensor' EquivalentTo 'role' and (http://purl.obolibrary.org/obo/RO_0002599 some ('material entity' and ('has role' some 'stress sensor'))) http://purl.obolibrary.org/obo/TXPO_0002693 bile acid and bile salt transport to hepatocyte 'bile acid and bile salt transport to hepatocyte' SubClassOf 'has target end location' some 'hepatocyte' 'bile acid and bile salt transport to hepatocyte' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'hepatocyte' http://purl.obolibrary.org/obo/TXPO_0000032 bosentan [Cholestasis] 'bosentan [Cholestasis]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' 'bosentan [Cholestasis]' SubClassOf 'has role' some 'inhibitor role of BSEP bile acid transport' http://purl.obolibrary.org/obo/TXPO_0002681 negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis] 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'bosentan [Cholestasis]' 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'troglitazone [Cholestasis]' 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'rifampicin [Cholestasis]' 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'bosentan [Cholestasis]' 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'troglitazone [Cholestasis]' 'negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]' SubClassOf 'has agent' some 'rifampicin [Cholestasis]' http://purl.obolibrary.org/obo/TXPO_0000002 phospholipase transport to lysosome 'phospholipase transport to lysosome' SubClassOf 'has target end location' some 'lysosome' 'phospholipase transport to lysosome' SubClassOf http://purl.obolibrary.org/obo/RO_0002339 some 'lysosome' http://purl.obolibrary.org/obo/CHEBI_38234 DNA polymerase inhibitor 'DNA polymerase inhibitor' SubClassOf 'EC 2.7.7.* (nucleotidyltransferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_39548 atorvastatin 'atorvastatin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'atorvastatin' SubClassOf 'organic molecular entity' 'atorvastatin' SubClassOf 'has role' some 'xenobiotic' 'atorvastatin' SubClassOf 'has role' some 'environmental contaminant' http://purl.obolibrary.org/obo/CHEBI_3387 carbamazepine 'carbamazepine' SubClassOf 'has role' some 'non-narcotic analgesic' 'carbamazepine' SubClassOf 'has role' some 'mitogen' 'carbamazepine' SubClassOf 'has role' some 'environmental contaminant' 'carbamazepine' SubClassOf 'organic molecular entity' 'carbamazepine' SubClassOf 'has role' some 'antimanic drug' 'carbamazepine' SubClassOf 'has role' some 'xenobiotic' 'carbamazepine' SubClassOf 'has role' some 'analgesic' 'carbamazepine' SubClassOf 'has role' some 'anticonvulsant' 'carbamazepine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'carbamazepine' SubClassOf 'has role' some 'drug allergen' 'carbamazepine' SubClassOf 'has role' some 'glutamate transporter activator' 'carbamazepine' SubClassOf 'has role' some 'sodium channel blocker' 'carbamazepine' SubClassOf 'has role' some 'EC 3.5.1.98 (histone deacetylase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_5937 Interferon alfa-2a 'Interferon alfa-2a' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'Interferon alfa-2a' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_5938 Interferon beta-1b 'Interferon beta-1b' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'Interferon beta-1b' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_28901 busulfan 'busulfan' SubClassOf 'organic molecular entity' 'busulfan' SubClassOf 'has role' some 'antineoplastic agent' 'busulfan' SubClassOf 'has role' some 'alkylating agent' 'busulfan' SubClassOf 'has role' some 'carcinogenic agent' 'busulfan' SubClassOf 'has role' some 'insect sterilant' 'busulfan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'busulfan' SubClassOf 'has role' some 'teratogenic agent' http://purl.obolibrary.org/obo/CHEBI_5958 Iproniazid 'Iproniazid' SubClassOf 'organic molecular entity' 'Iproniazid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor 'EC 3.4.21.* (serine endopeptidase) inhibitor' SubClassOf 'EC 3.4.* (hydrolases acting on peptide bond) inhibitor' http://purl.obolibrary.org/obo/CHEBI_45409 ritonavir 'ritonavir' SubClassOf 'has role' some 'antiviral drug' 'ritonavir' SubClassOf 'has role' some 'environmental contaminant' 'ritonavir' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ritonavir' SubClassOf 'has role' some 'HIV protease inhibitor' 'ritonavir' SubClassOf 'has role' some 'xenobiotic' 'ritonavir' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_8107 phenytoin 'phenytoin' SubClassOf 'has role' some 'drug allergen' 'phenytoin' SubClassOf 'organic molecular entity' 'phenytoin' SubClassOf 'has role' some 'anticonvulsant' 'phenytoin' SubClassOf 'has role' some 'teratogenic agent' 'phenytoin' SubClassOf 'has role' some 'sodium channel blocker' 'phenytoin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_9448 terbinafine 'terbinafine' SubClassOf 'has role' some 'P450 inhibitor' 'terbinafine' SubClassOf 'has role' some 'EC 1.14.13.132 (squalene monooxygenase) inhibitor' 'terbinafine' SubClassOf 'has role' some 'sterol biosynthesis inhibitor' 'terbinafine' SubClassOf 'organic molecular entity' 'terbinafine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_53784 antispasmodic drug 'antispasmodic drug' SubClassOf 'muscle relaxant' http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator 'iron chelator' SubClassOf 'chelator' http://purl.obolibrary.org/obo/CHEBI_53756 HIV-1 reverse transcriptase inhibitor 'HIV-1 reverse transcriptase inhibitor' SubClassOf 'anti-HIV-1 agent' 'HIV-1 reverse transcriptase inhibitor' SubClassOf 'EC 3.1.26.13 (retroviral ribonuclease H) inhibitor' http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor 'EC 3.2.1.* (glycosidase) inhibitor' SubClassOf 'EC 3.2.* (glycosylase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_135009 nitrefazole 'nitrefazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'nitrefazole' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_135005 milnacipran 'milnacipran' SubClassOf 'organic molecular entity' 'milnacipran' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_44032 indinavir 'indinavir' SubClassOf 'has role' some 'HIV protease inhibitor' 'indinavir' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_175901 gemcitabine 'gemcitabine' SubClassOf 'has role' some 'immunosuppressive agent' 'gemcitabine' SubClassOf 'has role' some 'photosensitizing agent' 'gemcitabine' SubClassOf 'has role' some 'xenobiotic' 'gemcitabine' SubClassOf 'has role' some 'antiviral drug' 'gemcitabine' SubClassOf 'has role' some 'environmental contaminant' 'gemcitabine' SubClassOf 'has role' some 'antimetabolite' 'gemcitabine' SubClassOf 'has role' some 'prodrug' 'gemcitabine' SubClassOf 'has role' some 'radiosensitizing agent' 'gemcitabine' SubClassOf 'has role' some 'antineoplastic agent' 'gemcitabine' SubClassOf 'organic molecular entity' 'gemcitabine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'gemcitabine' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'gemcitabine' SubClassOf 'has role' some 'EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor' http://purl.obolibrary.org/obo/TXPO_0004211 toxicity (attribute) 'toxicity (attribute)' SubClassOf 'non-meta generic quality' http://purl.obolibrary.org/obo/CHEBI_9337 sulfathiazole 'sulfathiazole' SubClassOf 'organic molecular entity' 'sulfathiazole' SubClassOf 'has role' some 'EC 2.5.1.15 (dihydropteroate synthase) inhibitor' 'sulfathiazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'sulfathiazole' SubClassOf 'has role' some 'antiinfective agent' 'sulfathiazole' SubClassOf 'has role' some 'drug allergen' 'sulfathiazole' SubClassOf 'has role' some 'environmental contaminant' 'sulfathiazole' SubClassOf 'has role' some 'xenobiotic' http://purl.obolibrary.org/obo/CHEBI_9334 sulfasalazine 'sulfasalazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'sulfasalazine' SubClassOf 'has role' some 'drug allergen' 'sulfasalazine' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'sulfasalazine' SubClassOf 'organic molecular entity' 'sulfasalazine' SubClassOf 'has role' some 'antiinfective agent' 'sulfasalazine' SubClassOf 'has role' some 'EC 2.5.1.18 (glutathione transferase) inhibitor' 'sulfasalazine' SubClassOf 'has role' some 'gastrointestinal drug' http://purl.obolibrary.org/obo/CHEBI_45304 rifapentine 'rifapentine' SubClassOf 'organic molecular entity' 'rifapentine' SubClassOf 'has role' some 'leprostatic drug' 'rifapentine' SubClassOf 'has role' some 'antitubercular agent' http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent 'neurotransmitter agent' SubClassOf 'pharmacological role' 'neurotransmitter agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite 'human metabolite' SubClassOf 'mammalian metabolite' http://purl.obolibrary.org/obo/CHEBI_77748 EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor 'EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor' SubClassOf 'EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor' http://purl.obolibrary.org/obo/CHEBI_90710 receptor modulator 'receptor modulator' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50172 acitretin 'acitretin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'acitretin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_50176 keratolytic drug 'keratolytic drug' SubClassOf 'dermatologic drug' http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug 'dermatologic drug' SubClassOf 'drug' http://purl.obolibrary.org/obo/TXPO_0005188 sitaxsentan 'sitaxsentan' SubClassOf 'organic molecular entity' 'sitaxsentan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005187 natalizumab 'natalizumab' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'natalizumab' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005184 interferon alfacon-1 'interferon alfacon-1' SubClassOf 'organic molecular entity' 'interferon alfacon-1' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005183 interferon beta-1a 'interferon beta-1a' SubClassOf 'organic molecular entity' 'interferon beta-1a' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005186 peginterferon alfa-2b 'peginterferon alfa-2b' SubClassOf 'organic molecular entity' 'peginterferon alfa-2b' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005185 infliximab 'infliximab' SubClassOf 'organic molecular entity' 'infliximab' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005180 gemtuzumab ozogamicin 'gemtuzumab ozogamicin' SubClassOf 'organic molecular entity' 'gemtuzumab ozogamicin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005182 interferon alfa-2b 'interferon alfa-2b' SubClassOf 'organic molecular entity' 'interferon alfa-2b' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005181 asparaginase 'asparaginase' SubClassOf 'organic molecular entity' 'asparaginase' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005177 falnidamol 'falnidamol' SubClassOf 'organic molecular entity' 'falnidamol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005176 xenazoic acid 'xenazoic acid' SubClassOf 'organic molecular entity' 'xenazoic acid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005179 alaproclate 'alaproclate' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'alaproclate' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005178 mepazine 'mepazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'mepazine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005173 suloctidil 'suloctidil' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'suloctidil' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005172 pentostatin 'pentostatin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'pentostatin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005175 tetrabamate 'tetrabamate' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'tetrabamate' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005174 fenclozic acid 'fenclozic acid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'fenclozic acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005171 nialamide 'nialamide' SubClassOf 'organic molecular entity' 'nialamide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005170 moxisylyte 'moxisylyte' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'moxisylyte' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_49159 leukotriene antagonist 'leukotriene antagonist' SubClassOf 'hormone antagonist' http://purl.obolibrary.org/obo/CHEBI_9763 trovafloxacin 'trovafloxacin' SubClassOf 'organic molecular entity' 'trovafloxacin' SubClassOf 'has role' some 'hepatotoxic agent' 'trovafloxacin' SubClassOf 'has role' some 'antimicrobial agent' 'trovafloxacin' SubClassOf 'has role' some 'antibacterial drug' 'trovafloxacin' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'trovafloxacin' SubClassOf 'has role' some 'topoisomerase IV inhibitor' 'trovafloxacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_37153 EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor 'EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor' SubClassOf 'EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_51451 endothelin receptor antagonist 'endothelin receptor antagonist' SubClassOf 'hormone antagonist' http://purl.obolibrary.org/obo/CHEBI_9727 Trimethadione 'Trimethadione' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_52726 proteasome inhibitor 'proteasome inhibitor' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_27779 griseofulvin 'griseofulvin' SubClassOf 'has role' some 'antibacterial agent' 'griseofulvin' SubClassOf 'has role' some 'Penicillium metabolite' 'griseofulvin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'griseofulvin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005169 isocarboxazid 'isocarboxazid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005166 cinchophen 'cinchophen' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'cinchophen' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005165 azacitidine 'azacitidine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005168 fipexide 'fipexide' SubClassOf 'organic molecular entity' 'fipexide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005167 exifone 'exifone' SubClassOf 'organic molecular entity' 'exifone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005162 fiduxosin 'fiduxosin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'fiduxosin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005161 triacetyldiphenolisatin 'triacetyldiphenolisatin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'triacetyldiphenolisatin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005164 phenoxypropazine 'phenoxypropazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'phenoxypropazine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005163 pafuramidine 'pafuramidine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'pafuramidine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005160 pralnacasan 'pralnacasan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'pralnacasan' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005159 aplaviroc 'aplaviroc' SubClassOf 'organic molecular entity' 'aplaviroc' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005158 divalproex sodium 'divalproex sodium' SubClassOf 'organic molecular entity' 'divalproex sodium' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005155 ticrynafen 'ticrynafen' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ticrynafen' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005154 nilotinib hydrochloride monohydrate 'nilotinib hydrochloride monohydrate' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005157 dronedarone hydrochloride 'dronedarone hydrochloride' SubClassOf 'organic molecular entity' 'dronedarone hydrochloride' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005156 raltegravir potassium 'raltegravir potassium' SubClassOf 'organic molecular entity' 'raltegravir potassium' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005151 cyclosporine 'cyclosporine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'cyclosporine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005150 niacin 'niacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'niacin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005153 entecavir 'entecavir' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005152 aminosalicylic acid 'aminosalicylic acid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'aminosalicylic acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005148 propylthiouracil 'propylthiouracil' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'propylthiouracil' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005147 methyldopa 'methyldopa' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'methyldopa' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005149 isoniazid 'isoniazid' SubClassOf 'organic molecular entity' 'isoniazid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005144 indomethacin 'indomethacin' SubClassOf 'organic molecular entity' 'indomethacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005146 dactinomycin 'dactinomycin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'dactinomycin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005145 rifampin 'rifampin' SubClassOf 'organic molecular entity' 'rifampin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/TXPO_0005140 Less-DILI-Concern 'Less-DILI-Concern' SubClassOf 'toxicity value' http://purl.obolibrary.org/obo/TXPO_0005142 No-DILI-Concern 'No-DILI-Concern' SubClassOf 'toxicity value' http://purl.obolibrary.org/obo/CHEBI_4868 estramustine 'estramustine' SubClassOf 'has role' some 'radiation protective agent' 'estramustine' SubClassOf 'has role' some 'antineoplastic agent' 'estramustine' SubClassOf 'has role' some 'alkylating agent' 'estramustine' SubClassOf 'organic molecular entity' 'estramustine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_100241 ciprofloxacin 'ciprofloxacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ciprofloxacin' SubClassOf 'has role' some 'environmental contaminant' 'ciprofloxacin' SubClassOf 'has role' some 'antibacterial drug' 'ciprofloxacin' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'ciprofloxacin' SubClassOf 'has role' some 'antiinfective agent' 'ciprofloxacin' SubClassOf 'has role' some 'xenobiotic' 'ciprofloxacin' SubClassOf 'has role' some 'antimicrobial agent' 'ciprofloxacin' SubClassOf 'organic molecular entity' 'ciprofloxacin' SubClassOf 'has role' some 'EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor' 'ciprofloxacin' SubClassOf 'has role' some 'topoisomerase IV inhibitor' http://purl.obolibrary.org/obo/CHEBI_4877 ethambutol 'ethambutol' SubClassOf 'organic molecular entity' 'ethambutol' SubClassOf 'has role' some 'antitubercular agent' 'ethambutol' SubClassOf 'has role' some 'xenobiotic' 'ethambutol' SubClassOf 'has role' some 'environmental contaminant' 'ethambutol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor 'EC 4.* (lyase) inhibitor' SubClassOf 'enzyme inhibitor' http://purl.obolibrary.org/obo/CHEBI_76712 EC 4.2.* (C-O lyase) inhibitor 'EC 4.2.* (C-O lyase) inhibitor' SubClassOf 'EC 4.* (lyase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor 'EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76726 EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 'EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76727 EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor 'EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76731 EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor 'EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76733 EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor 'EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor 'EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76737 EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor 'EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76740 EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor 'EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 'EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76744 EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor 'EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor' SubClassOf 'EC 1.* (oxidoreductase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor 'EC 3.1.* (ester hydrolase) inhibitor' SubClassOf 'EC 3.* (hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76761 EC 3.2.* (glycosylase) inhibitor 'EC 3.2.* (glycosylase) inhibitor' SubClassOf 'EC 3.* (hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 'EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor' SubClassOf 'EC 3.* (hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 'EC 3.1.1.* (carboxylic ester hydrolase) inhibitor' SubClassOf 'EC 3.1.* (ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor 'EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor' SubClassOf 'EC 3.1.* (ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor 'EC 3.4.21.26 (prolyl oligopeptidase) inhibitor' SubClassOf 'EC 3.4.21.* (serine endopeptidase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76785 EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor 'EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor' SubClassOf 'EC 3.1.* (ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor 'EC 2.4.2.* (pentosyltransferase) inhibitor' SubClassOf 'EC 2.4.* (glycosyltransferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76797 EC 2.5.1.18 (glutathione transferase) inhibitor 'EC 2.5.1.18 (glutathione transferase) inhibitor' SubClassOf 'EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_51371 muscle relaxant 'muscle relaxant' SubClassOf 'neuromuscular agent' http://purl.obolibrary.org/obo/CHEBI_51372 neuromuscular agent 'neuromuscular agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent 'GABA agent' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_76697 EC 5.99.* (other isomerases) inhibitor 'EC 5.99.* (other isomerases) inhibitor' SubClassOf 'EC 5.* (isomerase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist 'hormone antagonist' SubClassOf 'hormone receptor modulator' 'hormone antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_27690 acetazolamide 'acetazolamide' SubClassOf 'has role' some 'EC 4.2.1.1 (carbonic anhydrase) inhibitor' 'acetazolamide' SubClassOf 'has role' some 'diuretic' 'acetazolamide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'acetazolamide' SubClassOf 'organic molecular entity' 'acetazolamide' SubClassOf 'has role' some 'anticonvulsant' http://purl.obolibrary.org/obo/CHEBI_49005 deferasirox 'deferasirox' SubClassOf 'organic molecular entity' 'deferasirox' SubClassOf 'has role' some 'iron chelator' 'deferasirox' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_52629 EC 3.1.26.13 (retroviral ribonuclease H) inhibitor 'EC 3.1.26.13 (retroviral ribonuclease H) inhibitor' SubClassOf 'anti-HIV-1 agent' 'EC 3.1.26.13 (retroviral ribonuclease H) inhibitor' SubClassOf 'EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor' http://purl.obolibrary.org/obo/CHEBI_575568 atovaquone 'atovaquone' SubClassOf 'has role' some 'EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor' 'atovaquone' SubClassOf 'organic molecular entity' 'atovaquone' SubClassOf 'has role' some 'EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor' 'atovaquone' SubClassOf 'has role' some 'antifungal agent' 'atovaquone' SubClassOf 'has role' some 'EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor' 'atovaquone' SubClassOf 'has role' some 'antimalarial' http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug 'cholinergic drug' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_39669 diflunisal 'diflunisal' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'diflunisal' SubClassOf 'organic molecular entity' 'diflunisal' SubClassOf 'has role' some 'non-narcotic analgesic' 'diflunisal' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' http://purl.obolibrary.org/obo/CHEBI_44185 methotrexate 'methotrexate' SubClassOf 'has role' some 'immunosuppressive agent' 'methotrexate' SubClassOf 'has role' some 'dermatologic drug' 'methotrexate' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'methotrexate' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'methotrexate' SubClassOf 'has role' some 'abortifacient' 'methotrexate' SubClassOf 'has role' some 'antimetabolite' 'methotrexate' SubClassOf 'has role' some 'EC 1.5.1.3 (dihydrofolate reductase) inhibitor' 'methotrexate' SubClassOf 'organic molecular entity' 'methotrexate' SubClassOf 'has role' some 'antirheumatic drug' 'methotrexate' SubClassOf 'has role' some 'antineoplastic agent' http://purl.obolibrary.org/obo/CHEBI_114785 erlotinib 'erlotinib' SubClassOf 'organic molecular entity' 'erlotinib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'erlotinib' SubClassOf 'has role' some 'antineoplastic agent' 'erlotinib' SubClassOf 'has role' some 'epidermal growth factor receptor antagonist' 'erlotinib' SubClassOf 'has role' some 'protein kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_32246 Tolvaptan 'Tolvaptan' SubClassOf 'organic molecular entity' 'Tolvaptan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_76603 Chlorendic Acid 'Chlorendic Acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_9588 ticlopidine 'ticlopidine' SubClassOf 'has role' some 'hematologic agent' 'ticlopidine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ticlopidine' SubClassOf 'has role' some 'platelet aggregation inhibitor' 'ticlopidine' SubClassOf 'has role' some 'P2Y12 receptor antagonist' 'ticlopidine' SubClassOf 'organic molecular entity' 'ticlopidine' SubClassOf 'has role' some 'fibrin modulating drug' 'ticlopidine' SubClassOf 'has role' some 'anticoagulant' http://purl.obolibrary.org/obo/CHEBI_76655 EC 2.1.* (C1-transferase) inhibitor 'EC 2.1.* (C1-transferase) inhibitor' SubClassOf 'EC 2.* (transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76661 EC 2.3.* (acyltransferase) inhibitor 'EC 2.3.* (acyltransferase) inhibitor' SubClassOf 'EC 2.* (transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 'EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor' SubClassOf 'EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor 'EC 2.4.* (glycosyltransferase) inhibitor' SubClassOf 'EC 2.* (transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor 'EC 2.7.* (P-containing group transferase) inhibitor' SubClassOf 'EC 2.* (transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76114 benoxaprofen 'benoxaprofen' SubClassOf 'has role' some 'antipyretic' 'benoxaprofen' SubClassOf 'has role' some 'EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor' 'benoxaprofen' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'benoxaprofen' SubClassOf 'has role' some 'non-narcotic analgesic' 'benoxaprofen' SubClassOf 'organic molecular entity' 'benoxaprofen' SubClassOf 'has role' some 'hepatotoxic agent' 'benoxaprofen' SubClassOf 'has role' some 'nephrotoxin' 'benoxaprofen' SubClassOf 'has role' some 'antipsoriatic' 'benoxaprofen' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'benoxaprofen' SubClassOf 'has role' some 'protein kinase C agonist' http://purl.obolibrary.org/obo/CHEBI_76133 droxicam 'droxicam' SubClassOf 'has role' some 'platelet aggregation inhibitor' 'droxicam' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'droxicam' SubClassOf 'has role' some 'hepatotoxic agent' 'droxicam' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'droxicam' SubClassOf 'organic molecular entity' 'droxicam' SubClassOf 'has role' some 'prodrug' 'droxicam' SubClassOf 'has role' some 'non-narcotic analgesic' 'droxicam' SubClassOf 'has role' some 'cyclooxygenase 1 inhibitor' http://purl.obolibrary.org/obo/CHEBI_76158 ibufenac 'ibufenac' SubClassOf 'has role' some 'non-narcotic analgesic' 'ibufenac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'ibufenac' SubClassOf 'has role' some 'hepatotoxic agent' 'ibufenac' SubClassOf 'organic molecular entity' 'ibufenac' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ibufenac' SubClassOf 'has role' some 'EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_119486 efavirenz 'efavirenz' SubClassOf 'organic molecular entity' 'efavirenz' SubClassOf 'has role' some 'antiviral drug' 'efavirenz' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'efavirenz' SubClassOf 'has role' some 'HIV-1 reverse transcriptase inhibitor' http://purl.obolibrary.org/obo/CHEBI_73913 antifolate 'antifolate' SubClassOf 'antimetabolite' http://purl.obolibrary.org/obo/CHEBI_88188 drug allergen 'drug allergen' SubClassOf 'drug' 'drug allergen' SubClassOf 'allergen' http://purl.obolibrary.org/obo/CHEBI_61951 microtubule-destabilising agent 'microtubule-destabilising agent' SubClassOf 'antimitotic' 'microtubule-destabilising agent' SubClassOf 'tubulin modulator' http://purl.obolibrary.org/obo/CHEBI_71219 pazopanib 'pazopanib' SubClassOf 'has role' some 'tyrosine kinase inhibitor' 'pazopanib' SubClassOf 'has role' some 'vascular endothelial growth factor receptor antagonist' 'pazopanib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'pazopanib' SubClassOf 'has role' some 'antineoplastic agent' 'pazopanib' SubClassOf 'organic molecular entity' 'pazopanib' SubClassOf 'has role' some 'angiogenesis modulating agent' http://purl.obolibrary.org/obo/CHEBI_35634 EC 1.17.3.2 (xanthine oxidase) inhibitor 'EC 1.17.3.2 (xanthine oxidase) inhibitor' SubClassOf 'EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_140921 Hedgehog signaling pathway inhibitor 'Hedgehog signaling pathway inhibitor' SubClassOf 'pathway inhibitor' http://purl.obolibrary.org/obo/CHEBI_35640 adrenergic uptake inhibitor 'adrenergic uptake inhibitor' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_48923 erythromycin 'erythromycin' SubClassOf 'has role' some 'bacterial metabolite' 'erythromycin' SubClassOf 'has role' some 'environmental contaminant' 'erythromycin' SubClassOf 'organic molecular entity' 'erythromycin' SubClassOf 'has role' some 'xenobiotic' 'erythromycin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist 'protein kinase agonist' SubClassOf 'agonist' http://purl.obolibrary.org/obo/CHEBI_77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor 'EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor' SubClassOf 'EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_134965 tilbroquinol 'tilbroquinol' SubClassOf 'organic molecular entity' 'tilbroquinol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_29688 telithromycin 'telithromycin' SubClassOf 'organic molecular entity' 'telithromycin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_31941 oxaliplatin 'oxaliplatin' SubClassOf 'has role' some 'antineoplastic agent' 'oxaliplatin' SubClassOf 'organic molecular entity' 'oxaliplatin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'oxaliplatin' SubClassOf 'has role' some 'mutagen' http://purl.obolibrary.org/obo/CHEBI_35493 antipyretic 'antipyretic' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_35498 diuretic 'diuretic' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent 'antipsychotic agent' SubClassOf 'tranquilizing drug' http://purl.obolibrary.org/obo/CHEBI_35477 antimanic drug 'antimanic drug' SubClassOf 'tranquilizing drug' http://purl.obolibrary.org/obo/CHEBI_6717 mefenamic acid 'mefenamic acid' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'mefenamic acid' SubClassOf 'has role' some 'antirheumatic drug' 'mefenamic acid' SubClassOf 'has role' some 'antipyretic' 'mefenamic acid' SubClassOf 'has role' some 'EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor' 'mefenamic acid' SubClassOf 'has role' some 'environmental contaminant' 'mefenamic acid' SubClassOf 'organic molecular entity' 'mefenamic acid' SubClassOf 'has role' some 'analgesic' 'mefenamic acid' SubClassOf 'has role' some 'xenobiotic' 'mefenamic acid' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_35487 EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor 'EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor' SubClassOf 'EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_48876 muscarinic antagonist 'muscarinic antagonist' SubClassOf 'cholinergic antagonist' http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist 'cholinergic antagonist' SubClassOf 'cholinergic drug' http://purl.obolibrary.org/obo/CHEBI_35569 alpha-adrenergic agonist 'alpha-adrenergic agonist' SubClassOf 'adrenergic agonist' 'alpha-adrenergic agonist' SubClassOf 'alpha-adrenergic drug' http://purl.obolibrary.org/obo/CHEBI_35530 beta-adrenergic antagonist 'beta-adrenergic antagonist' SubClassOf 'beta-adrenergic drug' 'beta-adrenergic antagonist' SubClassOf 'adrenergic antagonist' http://purl.obolibrary.org/obo/CHEBI_35526 hypoglycemic agent 'hypoglycemic agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_101278 diltiazem 'diltiazem' SubClassOf 'has role' some 'calcium channel blocker' 'diltiazem' SubClassOf 'has role' some 'antihypertensive agent' 'diltiazem' SubClassOf 'has role' some 'vasodilator agent' 'diltiazem' SubClassOf 'organic molecular entity' 'diltiazem' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor 'EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor' SubClassOf 'EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' http://purl.obolibrary.org/obo/CHEBI_240107 bromfenac 'bromfenac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'bromfenac' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'bromfenac' SubClassOf 'has role' some 'non-narcotic analgesic' 'bromfenac' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_24852 insecticide 'insecticide' SubClassOf 'pesticide' http://purl.obolibrary.org/obo/CHEBI_64018 protein kinase C agonist 'protein kinase C agonist' SubClassOf 'protein kinase agonist' http://purl.obolibrary.org/obo/CHEBI_66991 sympatholytic agent 'sympatholytic agent' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_66993 tocolytic agent 'tocolytic agent' SubClassOf 'reproductive control drug' http://purl.obolibrary.org/obo/CHEBI_66987 radiation protective agent 'radiation protective agent' SubClassOf 'protective agent' http://purl.obolibrary.org/obo/CHEBI_66956 antidyskinesia agent 'antidyskinesia agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_28680 cytarabine 'cytarabine' SubClassOf 'has role' some 'antiviral agent' 'cytarabine' SubClassOf 'has role' some 'antineoplastic agent' 'cytarabine' SubClassOf 'has role' some 'immunosuppressive agent' 'cytarabine' SubClassOf 'organic molecular entity' 'cytarabine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'cytarabine' SubClassOf 'has role' some 'antimetabolite' http://purl.obolibrary.org/obo/CHEBI_16664 albendazole 'albendazole' SubClassOf 'has role' some 'microtubule-destabilising agent' 'albendazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'albendazole' SubClassOf 'organic molecular entity' 'albendazole' SubClassOf 'has role' some 'anthelminthic drug' 'albendazole' SubClassOf 'has role' some 'tubulin modulator' http://purl.obolibrary.org/obo/CHEBI_60798 excitatory amino acid antagonist 'excitatory amino acid antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_134891 sulfacarbamide 'sulfacarbamide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'sulfacarbamide' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_4439 dermatan 'dermatan' SubClassOf 'organic molecular entity' 'dermatan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_59897 EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor 'EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor' SubClassOf 'DNA polymerase inhibitor' 'EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor' SubClassOf 'antiviral agent' http://purl.obolibrary.org/obo/CHEBI_59886 HIV fusion inhibitor 'HIV fusion inhibitor' SubClassOf 'anti-HIV agent' 'HIV fusion inhibitor' SubClassOf 'antiviral drug' http://purl.obolibrary.org/obo/CHEBI_34559 benzarone 'benzarone' SubClassOf 'organic molecular entity' 'benzarone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_33231 antitubercular agent 'antitubercular agent' SubClassOf 'antimycobacterial drug' http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent 'antiviral agent' SubClassOf 'antimicrobial agent' http://purl.obolibrary.org/obo/CHEBI_47868 photosensitizing agent 'photosensitizing agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_71476 EC 2.3.1.85 (fatty acid synthase) inhibitor 'EC 2.3.1.85 (fatty acid synthase) inhibitor' SubClassOf 'EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator 'tubulin modulator' SubClassOf 'pharmacological role' http://purl.obolibrary.org/obo/TXPO_0004322 toxicity value 'toxicity value' SubClassOf 'categorical' http://purl.obolibrary.org/obo/TXPO_0004323 Most-DILI-Concern 'Most-DILI-Concern' SubClassOf 'toxicity value' http://purl.obolibrary.org/obo/CHEBI_63090 EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor 'EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor' SubClassOf 'EC 2.4.2.* (pentosyltransferase) inhibitor' http://purl.obolibrary.org/obo/TXPO_0004320 drug toxicity 'drug toxicity' SubClassOf 'toxicity (attribute)' http://purl.obolibrary.org/obo/CHEBI_59826 progestin 'progestin' SubClassOf 'progestogen' http://purl.obolibrary.org/obo/TXPO_0004321 drug liver toxicity 'drug liver toxicity' SubClassOf 'drug toxicity' http://purl.obolibrary.org/obo/CHEBI_35845 gout suppressant 'gout suppressant' SubClassOf 'antirheumatic drug' http://purl.obolibrary.org/obo/CHEBI_35846 renal agent 'renal agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor 'lipoxygenase inhibitor' SubClassOf 'EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor' http://purl.obolibrary.org/obo/CHEBI_35841 uricosuric drug 'uricosuric drug' SubClassOf 'gout suppressant' 'uricosuric drug' SubClassOf 'renal agent' http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug 'antirheumatic drug' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_64371 neurotransmitter transporter modulator 'neurotransmitter transporter modulator' SubClassOf 'membrane transport modulator' 'neurotransmitter transporter modulator' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_64370 glutamate transporter activator 'glutamate transporter activator' SubClassOf 'neurotransmitter transporter modulator' http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator 'hormone receptor modulator' SubClassOf 'drug' 'hormone receptor modulator' SubClassOf 'receptor modulator' http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug 'antiprotozoal drug' SubClassOf 'antiparasitic agent' 'antiprotozoal drug' SubClassOf 'antimicrobial drug' http://purl.obolibrary.org/obo/CHEBI_35816 leprostatic drug 'leprostatic drug' SubClassOf 'antimycobacterial drug' http://purl.obolibrary.org/obo/CHEBI_64355 posaconazole 'posaconazole' SubClassOf 'organic molecular entity' 'posaconazole' SubClassOf 'has role' some 'trypanocidal drug' http://purl.obolibrary.org/obo/CHEBI_38068 antimalarial 'antimalarial' SubClassOf 'antiplasmodial drug' http://purl.obolibrary.org/obo/CHEBI_51039 dopamine uptake inhibitor 'dopamine uptake inhibitor' SubClassOf 'dopaminergic agent' http://purl.obolibrary.org/obo/CHEBI_53559 topoisomerase IV inhibitor 'topoisomerase IV inhibitor' SubClassOf 'topoisomerase inhibitor' http://purl.obolibrary.org/obo/CHEBI_52214 ligand 'ligand' SubClassOf 'chemical role' http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical 'pharmaceutical' SubClassOf 'role' http://purl.obolibrary.org/obo/CHEBI_3090 bicalutamide 'bicalutamide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'bicalutamide' SubClassOf 'has role' some 'environmental contaminant' 'bicalutamide' SubClassOf 'has role' some 'antineoplastic agent' 'bicalutamide' SubClassOf 'organic molecular entity' 'bicalutamide' SubClassOf 'has role' some 'androgen antagonist' 'bicalutamide' SubClassOf 'has role' some 'xenobiotic' http://purl.obolibrary.org/obo/CHEBI_134728 mebanazine 'mebanazine' SubClassOf 'organic molecular entity' 'mebanazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role 'biophysical role' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role 'biochemical role' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_3023 benzbromarone 'benzbromarone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'benzbromarone' SubClassOf 'organic molecular entity' 'benzbromarone' SubClassOf 'has role' some 'uricosuric drug' http://purl.obolibrary.org/obo/CHEBI_134762 isaxonine 'isaxonine' SubClassOf 'organic molecular entity' 'isaxonine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_4305 dacarbazine 'dacarbazine' SubClassOf 'has role' some 'alkylating agent' 'dacarbazine' SubClassOf 'has role' some 'prodrug' 'dacarbazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'dacarbazine' SubClassOf 'has role' some 'carcinogenic agent' 'dacarbazine' SubClassOf 'has role' some 'antineoplastic agent' 'dacarbazine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_71415 nitrofurantoin 'nitrofurantoin' SubClassOf 'has role' some 'antiinfective agent' 'nitrofurantoin' SubClassOf 'has role' some 'hepatotoxic agent' 'nitrofurantoin' SubClassOf 'organic molecular entity' 'nitrofurantoin' SubClassOf 'has role' some 'antibacterial drug' 'nitrofurantoin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_4315 danazol 'danazol' SubClassOf 'organic molecular entity' 'danazol' SubClassOf 'has role' some 'estrogen antagonist' 'danazol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'danazol' SubClassOf 'has role' some 'anti-estrogen' http://purl.obolibrary.org/obo/CHEBI_4317 dantrolene 'dantrolene' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'dantrolene' SubClassOf 'has role' some 'muscle relaxant' 'dantrolene' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor 'EC 2.* (transferase) inhibitor' SubClassOf 'enzyme inhibitor' http://purl.obolibrary.org/obo/CHEBI_6916 mexiletine 'mexiletine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'mexiletine' SubClassOf 'has role' some 'anti-arrhythmia drug' 'mexiletine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_83317 sterol biosynthesis inhibitor 'sterol biosynthesis inhibitor' SubClassOf 'inhibitor' 'sterol biosynthesis inhibitor' SubClassOf 'biochemical role' http://purl.obolibrary.org/obo/CHEBI_35705 immunosuppressive agent 'immunosuppressive agent' SubClassOf 'immunomodulator' http://purl.obolibrary.org/obo/CHEBI_52290 mitogen 'mitogen' SubClassOf 'biological role' http://purl.obolibrary.org/obo/CHEBI_40279 allopurinol 'allopurinol' SubClassOf 'organic molecular entity' 'allopurinol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'allopurinol' SubClassOf 'has role' some 'antimetabolite' 'allopurinol' SubClassOf 'has role' some 'EC 1.17.3.2 (xanthine oxidase) inhibitor' 'allopurinol' SubClassOf 'has role' some 'gout suppressant' 'allopurinol' SubClassOf 'has role' some 'radical scavenger' http://purl.obolibrary.org/obo/CHEBI_367163 darunavir 'darunavir' SubClassOf 'has role' some 'antiviral drug' 'darunavir' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'darunavir' SubClassOf 'organic molecular entity' 'darunavir' SubClassOf 'has role' some 'HIV protease inhibitor' http://purl.obolibrary.org/obo/CHEBI_17347 testosterone 'testosterone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'testosterone' SubClassOf 'has role' some 'androgen' 'testosterone' SubClassOf 'has role' some 'Daphnia magna metabolite' 'testosterone' SubClassOf 'has role' some 'human metabolite' 'testosterone' SubClassOf 'organic molecular entity' 'testosterone' SubClassOf 'has role' some 'mouse metabolite' http://purl.obolibrary.org/obo/CHEBI_31653 glafenine 'glafenine' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'glafenine' SubClassOf 'has role' some 'inhibitor' 'glafenine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'glafenine' SubClassOf 'organic molecular entity' 'glafenine' SubClassOf 'has role' some 'non-narcotic analgesic' http://purl.obolibrary.org/obo/CHEBI_5132 flutamide 'flutamide' SubClassOf 'has role' some 'androgen antagonist' 'flutamide' SubClassOf 'organic molecular entity' 'flutamide' SubClassOf 'has role' some 'antineoplastic agent' 'flutamide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_5165 Fosphenytoin 'Fosphenytoin' SubClassOf 'organic molecular entity' 'Fosphenytoin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_5120 fluoxymesterone 'fluoxymesterone' SubClassOf 'has role' some 'anabolic agent' 'fluoxymesterone' SubClassOf 'has role' some 'antineoplastic agent' 'fluoxymesterone' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_6402 leflunomide 'leflunomide' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'leflunomide' SubClassOf 'organic molecular entity' 'leflunomide' SubClassOf 'has role' some 'antiparasitic agent' 'leflunomide' SubClassOf 'has role' some 'pyrimidine synthesis inhibitor' 'leflunomide' SubClassOf 'has role' some 'EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor' 'leflunomide' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'leflunomide' SubClassOf 'has role' some 'antineoplastic agent' 'leflunomide' SubClassOf 'has role' some 'EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor' 'leflunomide' SubClassOf 'has role' some 'tyrosine kinase inhibitor' 'leflunomide' SubClassOf 'has role' some 'hepatotoxic agent' 'leflunomide' SubClassOf 'has role' some 'prodrug' 'leflunomide' SubClassOf 'has role' some 'immunosuppressive agent' http://purl.obolibrary.org/obo/CHEBI_50790 EC 1.14.14.14 (aromatase) inhibitor 'EC 1.14.14.14 (aromatase) inhibitor' SubClassOf 'EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_50777 etonogestrel 'etonogestrel' SubClassOf 'has role' some 'progestin' 'etonogestrel' SubClassOf 'organic molecular entity' 'etonogestrel' SubClassOf 'has role' some 'female contraceptive drug' 'etonogestrel' SubClassOf 'has role' some 'contraceptive drug' http://purl.obolibrary.org/obo/CHEBI_50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor 'EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor' SubClassOf 'topoisomerase inhibitor' http://purl.obolibrary.org/obo/CHEBI_50751 anti-estrogen 'anti-estrogen' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50748 antipsoriatic 'antipsoriatic' SubClassOf 'dermatologic drug' http://purl.obolibrary.org/obo/CHEBI_50739 estrogen receptor modulator 'estrogen receptor modulator' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator 'immunomodulator' SubClassOf 'biological role' 'immunomodulator' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50837 estrogen antagonist 'estrogen antagonist' SubClassOf 'hormone antagonist' http://purl.obolibrary.org/obo/CHEBI_35221 antimetabolite 'antimetabolite' SubClassOf 'biochemical role' http://purl.obolibrary.org/obo/CHEBI_37886 adrenergic agonist 'adrenergic agonist' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_37887 adrenergic antagonist 'adrenergic antagonist' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_65023 anti-asthmatic agent 'anti-asthmatic agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_65001 EC 3.1.1.3 (triacylglycerol lipase) inhibitor 'EC 3.1.1.3 (triacylglycerol lipase) inhibitor' SubClassOf 'EC 3.1.1.* (carboxylic ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_6343 labetalol 'labetalol' SubClassOf 'organic molecular entity' 'labetalol' SubClassOf 'has role' some 'alpha-adrenergic antagonist' 'labetalol' SubClassOf 'has role' some 'sympatholytic agent' 'labetalol' SubClassOf 'has role' some 'beta-adrenergic antagonist' 'labetalol' SubClassOf 'has role' some 'antihypertensive agent' 'labetalol' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_135814 benziodarone 'benziodarone' SubClassOf 'organic molecular entity' 'benziodarone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_6367 lamotrigine 'lamotrigine' SubClassOf 'has role' some 'antidepressant' 'lamotrigine' SubClassOf 'has role' some 'anticonvulsant' 'lamotrigine' SubClassOf 'has role' some 'xenobiotic' 'lamotrigine' SubClassOf 'has role' some 'calcium channel blocker' 'lamotrigine' SubClassOf 'has role' some 'antimanic drug' 'lamotrigine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'lamotrigine' SubClassOf 'has role' some 'environmental contaminant' 'lamotrigine' SubClassOf 'has role' some 'excitatory amino acid antagonist' 'lamotrigine' SubClassOf 'has role' some 'non-narcotic analgesic' 'lamotrigine' SubClassOf 'organic molecular entity' 'lamotrigine' SubClassOf 'has role' some 'EC 3.4.21.26 (prolyl oligopeptidase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_135829 alatrofloxacin 'alatrofloxacin' SubClassOf 'organic molecular entity' 'alatrofloxacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_7640 nortriptyline 'nortriptyline' SubClassOf 'has role' some 'analgesic' 'nortriptyline' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'nortriptyline' SubClassOf 'organic molecular entity' 'nortriptyline' SubClassOf 'has role' some 'adrenergic uptake inhibitor' 'nortriptyline' SubClassOf 'has role' some 'antineoplastic agent' 'nortriptyline' SubClassOf 'has role' some 'antidepressant' 'nortriptyline' SubClassOf 'has role' some 'apoptosis inducer' 'nortriptyline' SubClassOf 'has role' some 'drug metabolite' http://purl.obolibrary.org/obo/CHEBI_23092 chemosterilant 'chemosterilant' SubClassOf 'pesticide' http://purl.obolibrary.org/obo/CHEBI_5004 fenoprofen 'fenoprofen' SubClassOf 'organic molecular entity' 'fenoprofen' SubClassOf 'has role' some 'antipyretic' 'fenoprofen' SubClassOf 'has role' some 'cyclooxygenase 1 inhibitor' 'fenoprofen' SubClassOf 'has role' some 'cyclooxygenase 2 inhibitor' 'fenoprofen' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'fenoprofen' SubClassOf 'has role' some 'drug allergen' 'fenoprofen' SubClassOf 'has role' some 'non-narcotic analgesic' 'fenoprofen' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug 'reproductive control drug' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50694 minocycline 'minocycline' SubClassOf 'organic molecular entity' 'minocycline' SubClassOf 'has role' some 'Escherichia coli metabolite' 'minocycline' SubClassOf 'has role' some 'antibacterial drug' 'minocycline' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_50691 abortifacient 'abortifacient' SubClassOf 'reproductive control drug' http://purl.obolibrary.org/obo/CHEBI_50673 methimazole 'methimazole' SubClassOf 'has role' some 'antithyroid drug' 'methimazole' SubClassOf 'organic molecular entity' 'methimazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_50683 EC 1.5.1.3 (dihydrofolate reductase) inhibitor 'EC 1.5.1.3 (dihydrofolate reductase) inhibitor' SubClassOf 'EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor' 'EC 1.5.1.3 (dihydrofolate reductase) inhibitor' SubClassOf 'antifolate' http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor 'protein kinase inhibitor' SubClassOf 'EC 2.7.* (P-containing group transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_50671 antithyroid drug 'antithyroid drug' SubClassOf 'hormone antagonist' http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor 'protease inhibitor' SubClassOf 'EC 3.4.* (hydrolases acting on peptide bond) inhibitor' http://purl.obolibrary.org/obo/CHEBI_50646 bone density conservation agent 'bone density conservation agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_49668 gefitinib 'gefitinib' SubClassOf 'has role' some 'antineoplastic agent' 'gefitinib' SubClassOf 'organic molecular entity' 'gefitinib' SubClassOf 'has role' some 'epidermal growth factor receptor antagonist' 'gefitinib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_50630 cyclooxygenase 1 inhibitor 'cyclooxygenase 1 inhibitor' SubClassOf 'EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_50629 cyclooxygenase 2 inhibitor 'cyclooxygenase 2 inhibitor' SubClassOf 'EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_50627 EC 3.2.1.1 (alpha-amylase) inhibitor 'EC 3.2.1.1 (alpha-amylase) inhibitor' SubClassOf 'EC 3.2.1.* (glycosidase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_23018 EC 4.2.1.1 (carbonic anhydrase) inhibitor 'EC 4.2.1.1 (carbonic anhydrase) inhibitor' SubClassOf 'EC 4.2.1.* (hydro-lyases) inhibitor' http://purl.obolibrary.org/obo/CHEBI_36335 trypanocidal drug 'trypanocidal drug' SubClassOf 'antiprotozoal drug' http://purl.obolibrary.org/obo/CHEBI_78298 environmental contaminant 'environmental contaminant' SubClassOf 'chemical role' http://purl.obolibrary.org/obo/CHEBI_48406 EC 2.1.1.6 (catechol O-methyltransferase) inhibitor 'EC 2.1.1.6 (catechol O-methyltransferase) inhibitor' SubClassOf 'EC 2.1.1.* (methyltransferases) inhibitor' http://purl.obolibrary.org/obo/CHEBI_37733 EC 3.1.1.8 (cholinesterase) inhibitor 'EC 3.1.1.8 (cholinesterase) inhibitor' SubClassOf 'EC 3.1.1.* (carboxylic ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_36413 anabolic agent 'anabolic agent' SubClassOf 'hormone' http://purl.obolibrary.org/obo/CHEBI_37700 EC 2.7.11.13 (protein kinase C) inhibitor 'EC 2.7.11.13 (protein kinase C) inhibitor' SubClassOf 'EC 2.7.11.* (protein-serine/threonine kinase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_31596 febuxostat 'febuxostat' SubClassOf 'organic molecular entity' 'febuxostat' SubClassOf 'has role' some 'EC 1.17.3.2 (xanthine oxidase) inhibitor' 'febuxostat' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_28241 papaverine 'papaverine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'papaverine' SubClassOf 'has role' some 'vasodilator agent' 'papaverine' SubClassOf 'has role' some 'antispasmodic drug' 'papaverine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_681569 clofarabine 'clofarabine' SubClassOf 'has role' some 'antimetabolite' 'clofarabine' SubClassOf 'organic molecular entity' 'clofarabine' SubClassOf 'has role' some 'antineoplastic agent' http://purl.obolibrary.org/obo/CHEBI_135706 niperotidine 'niperotidine' SubClassOf 'organic molecular entity' 'niperotidine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_46081 fluconazole 'fluconazole' SubClassOf 'organic molecular entity' 'fluconazole' SubClassOf 'has role' some 'environmental contaminant' 'fluconazole' SubClassOf 'has role' some 'xenobiotic' 'fluconazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'fluconazole' SubClassOf 'has role' some 'P450 inhibitor' http://purl.obolibrary.org/obo/CHEBI_7953 pemoline 'pemoline' SubClassOf 'organic molecular entity' 'pemoline' SubClassOf 'has role' some 'central nervous system stimulant' 'pemoline' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_135774 ebrotidine 'ebrotidine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ebrotidine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_48676 fibrin modulating drug 'fibrin modulating drug' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_36796 duloxetine 'duloxetine' SubClassOf 'has role' some 'EC 3.4.21.26 (prolyl oligopeptidase) inhibitor' 'duloxetine' SubClassOf 'organic molecular entity' 'duloxetine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent 'antiinfective agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent 'antiparasitic agent' SubClassOf 'antiinfective agent' http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug 'anthelminthic drug' SubClassOf 'antiparasitic agent' http://purl.obolibrary.org/obo/CHEBI_35444 antinematodal drug 'antinematodal drug' SubClassOf 'nematicide' 'antinematodal drug' SubClassOf 'anthelminthic drug' http://purl.obolibrary.org/obo/CHEBI_10112 zileuton 'zileuton' SubClassOf 'organic molecular entity' 'zileuton' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'zileuton' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'zileuton' SubClassOf 'has role' some 'EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor' 'zileuton' SubClassOf 'has role' some 'leukotriene antagonist' 'zileuton' SubClassOf 'has role' some 'anti-asthmatic drug' http://purl.obolibrary.org/obo/CHEBI_10100 zafirlukast 'zafirlukast' SubClassOf 'organic molecular entity' 'zafirlukast' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'zafirlukast' SubClassOf 'has role' some 'anti-asthmatic agent' 'zafirlukast' SubClassOf 'has role' some 'leukotriene antagonist' http://purl.obolibrary.org/obo/CHEBI_127342 atomoxetine 'atomoxetine' SubClassOf 'has role' some 'environmental contaminant' 'atomoxetine' SubClassOf 'has role' some 'xenobiotic' 'atomoxetine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'atomoxetine' SubClassOf 'has role' some 'adrenergic uptake inhibitor' 'atomoxetine' SubClassOf 'has role' some 'antidepressant' 'atomoxetine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_65259 GABA antagonist 'GABA antagonist' SubClassOf 'GABA agent' 'GABA antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_65232 EC 3.4.21.5 (thrombin) inhibitor 'EC 3.4.21.5 (thrombin) inhibitor' SubClassOf 'EC 3.4.21.* (serine endopeptidase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_83039 crustacean metabolite 'crustacean metabolite' SubClassOf 'animal metabolite' http://purl.obolibrary.org/obo/CHEBI_83056 Daphnia magna metabolite 'Daphnia magna metabolite' SubClassOf 'Daphnia metabolite' http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite 'Daphnia metabolite' SubClassOf 'crustacean metabolite' http://purl.obolibrary.org/obo/CHEBI_65207 vascular endothelial growth factor receptor antagonist 'vascular endothelial growth factor receptor antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_77103 EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor 'EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor' SubClassOf 'EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_77102 EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor 'EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor' SubClassOf 'EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_77105 EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor 'EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor' SubClassOf 'EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor' http://purl.obolibrary.org/obo/CHEBI_77106 EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor 'EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor' SubClassOf 'EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_78444 EC 3.1.1.1 (carboxylesterase) inhibitor 'EC 3.1.1.1 (carboxylesterase) inhibitor' SubClassOf 'EC 3.1.1.* (carboxylic ester hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_59285 EC 1.14.13.132 (squalene monooxygenase) inhibitor 'EC 1.14.13.132 (squalene monooxygenase) inhibitor' SubClassOf 'EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor 'EC 3.4.* (hydrolases acting on peptide bond) inhibitor' SubClassOf 'EC 3.* (hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_135641 pipamazine 'pipamazine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'pipamazine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_135666 tasosartan 'tasosartan' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'tasosartan' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_7864 oxymetholone 'oxymetholone' SubClassOf 'organic molecular entity' 'oxymetholone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'oxymetholone' SubClassOf 'has role' some 'anabolic agent' 'oxymetholone' SubClassOf 'has role' some 'androgen' http://purl.obolibrary.org/obo/CHEBI_62872 EC 1.2.3.1 (aldehyde oxidase) inhibitor 'EC 1.2.3.1 (aldehyde oxidase) inhibitor' SubClassOf 'EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_48561 dopaminergic antagonist 'dopaminergic antagonist' SubClassOf 'dopaminergic agent' http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent 'dopaminergic agent' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_48549 tolrestat 'tolrestat' SubClassOf 'has role' some 'EC 1.1.1.21 (aldehyde reductase) inhibitor' 'tolrestat' SubClassOf 'organic molecular entity' 'tolrestat' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_37890 alpha-adrenergic antagonist 'alpha-adrenergic antagonist' SubClassOf 'adrenergic antagonist' 'alpha-adrenergic antagonist' SubClassOf 'alpha-adrenergic drug' http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug 'beta-adrenergic drug' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug 'alpha-adrenergic drug' SubClassOf 'adrenergic agent' http://purl.obolibrary.org/obo/CHEBI_50859 bexarotene 'bexarotene' SubClassOf 'organic molecular entity' 'bexarotene' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'bexarotene' SubClassOf 'has role' some 'antineoplastic agent' http://purl.obolibrary.org/obo/CHEBI_48550 EC 1.1.1.21 (aldehyde reductase) inhibitor 'EC 1.1.1.21 (aldehyde reductase) inhibitor' SubClassOf 'EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_7820 oxandrolone 'oxandrolone' SubClassOf 'has role' some 'anabolic agent' 'oxandrolone' SubClassOf 'has role' some 'androgen' 'oxandrolone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'oxandrolone' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_10023 voriconazole 'voriconazole' SubClassOf 'has role' some 'P450 inhibitor' 'voriconazole' SubClassOf 'organic molecular entity' 'voriconazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_50949 serotonin uptake inhibitor 'serotonin uptake inhibitor' SubClassOf 'serotonergic drug' http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent 'angiogenesis modulating agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist 'histamine antagonist' SubClassOf 'antagonist' 'histamine antagonist' SubClassOf 'histaminergic drug' http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent 'adrenergic agent' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_65172 ximelagatran 'ximelagatran' SubClassOf 'has role' some 'anticoagulant' 'ximelagatran' SubClassOf 'has role' some 'prodrug' 'ximelagatran' SubClassOf 'has role' some 'serine protease inhibitor' 'ximelagatran' SubClassOf 'has role' some 'EC 3.4.21.5 (thrombin) inhibitor' 'ximelagatran' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'ximelagatran' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug 'histaminergic drug' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_50905 teratogenic agent 'teratogenic agent' SubClassOf 'aetiopathogenetic role' http://purl.obolibrary.org/obo/CHEBI_2948 azathioprine 'azathioprine' SubClassOf 'has role' some 'antimetabolite' 'azathioprine' SubClassOf 'has role' some 'immunosuppressive agent' 'azathioprine' SubClassOf 'has role' some 'carcinogenic agent' 'azathioprine' SubClassOf 'has role' some 'antineoplastic agent' 'azathioprine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'azathioprine' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'azathioprine' SubClassOf 'has role' some 'prodrug' 'azathioprine' SubClassOf 'has role' some 'hepatotoxic agent' 'azathioprine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_25944 pesticide 'pesticide' SubClassOf 'role' http://purl.obolibrary.org/obo/CHEBI_61015 nephrotoxin 'nephrotoxin' SubClassOf 'poison' http://purl.obolibrary.org/obo/CHEBI_63673 chemokine receptor 5 antagonist 'chemokine receptor 5 antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug 'antimicrobial drug' SubClassOf 'antiinfective agent' 'antimicrobial drug' SubClassOf 'antimicrobial agent' http://purl.obolibrary.org/obo/CHEBI_64964 EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor 'EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor' SubClassOf 'EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor' 'EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor' SubClassOf 'lipoxygenase inhibitor' http://purl.obolibrary.org/obo/CHEBI_63630 tolcapone 'tolcapone' SubClassOf 'has role' some 'antiparkinson drug' 'tolcapone' SubClassOf 'has role' some 'EC 2.1.1.6 (catechol O-methyltransferase) inhibitor' 'tolcapone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'tolcapone' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_63629 tizanidine 'tizanidine' SubClassOf 'has role' some 'alpha-adrenergic agonist' 'tizanidine' SubClassOf 'has role' some 'muscle relaxant' 'tizanidine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'tizanidine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_63628 tipranavir 'tipranavir' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'tipranavir' SubClassOf 'has role' some 'HIV protease inhibitor' 'tipranavir' SubClassOf 'organic molecular entity' 'tipranavir' SubClassOf 'has role' some 'antiviral drug' http://purl.obolibrary.org/obo/CHEBI_49323 contraceptive drug 'contraceptive drug' SubClassOf 'reproductive control drug' http://purl.obolibrary.org/obo/CHEBI_49324 female contraceptive drug 'female contraceptive drug' SubClassOf 'contraceptive drug' http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent 'anti-HIV agent' SubClassOf 'antiviral agent' http://purl.obolibrary.org/obo/CHEBI_64947 anti-HIV-1 agent 'anti-HIV-1 agent' SubClassOf 'anti-HIV agent' http://purl.obolibrary.org/obo/CHEBI_63613 nevirapine 'nevirapine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'nevirapine' SubClassOf 'has role' some 'HIV-1 reverse transcriptase inhibitor' 'nevirapine' SubClassOf 'has role' some 'antiviral drug' 'nevirapine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_63608 maraviroc 'maraviroc' SubClassOf 'has role' some 'chemokine receptor 5 antagonist' 'maraviroc' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'maraviroc' SubClassOf 'has role' some 'HIV fusion inhibitor' 'maraviroc' SubClassOf 'organic molecular entity' 'maraviroc' SubClassOf 'has role' some 'antiviral drug' http://purl.obolibrary.org/obo/CHEBI_64926 serine protease inhibitor 'serine protease inhibitor' SubClassOf 'protease inhibitor' http://purl.obolibrary.org/obo/CHEBI_64915 antiplasmodial drug 'antiplasmodial drug' SubClassOf 'antiparasitic agent' 'antiplasmodial drug' SubClassOf 'antiprotozoal drug' http://purl.obolibrary.org/obo/CHEBI_64911 antimitotic 'antimitotic' SubClassOf 'pharmacological role' http://purl.obolibrary.org/obo/CHEBI_38633 sodium channel blocker 'sodium channel blocker' SubClassOf 'sodium channel modulator' http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor 'tyrosine kinase inhibitor' SubClassOf 'protein kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_135512 clometacin 'clometacin' SubClassOf 'organic molecular entity' 'clometacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_3766 clozapine 'clozapine' SubClassOf 'has role' some 'xenobiotic' 'clozapine' SubClassOf 'has role' some 'GABA antagonist' 'clozapine' SubClassOf 'has role' some 'second generation antipsychotic' 'clozapine' SubClassOf 'has role' some 'muscarinic antagonist' 'clozapine' SubClassOf 'has role' some 'dopaminergic antagonist' 'clozapine' SubClassOf 'has role' some 'histamine antagonist' 'clozapine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'clozapine' SubClassOf 'has role' some 'environmental contaminant' 'clozapine' SubClassOf 'has role' some 'EC 3.4.21.26 (prolyl oligopeptidase) inhibitor' 'clozapine' SubClassOf 'has role' some 'serotonergic antagonist' 'clozapine' SubClassOf 'organic molecular entity' 'clozapine' SubClassOf 'has role' some 'adrenergic antagonist' http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor 'EC 4.2.1.* (hydro-lyases) inhibitor' SubClassOf 'EC 4.2.* (C-O lyase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_67239 EC 3.2.1.20 (alpha-glucosidase) inhibitor 'EC 3.2.1.20 (alpha-glucosidase) inhibitor' SubClassOf 'EC 3.2.1.* (glycosidase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_68563 P2Y12 receptor antagonist 'P2Y12 receptor antagonist' SubClassOf 'purinergic receptor P2 antagonist' http://purl.obolibrary.org/obo/CHEBI_3732 clarithromycin 'clarithromycin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'clarithromycin' SubClassOf 'has role' some 'antibacterial drug' 'clarithromycin' SubClassOf 'has role' some 'xenobiotic' 'clarithromycin' SubClassOf 'has role' some 'protein synthesis inhibitor' 'clarithromycin' SubClassOf 'organic molecular entity' 'clarithromycin' SubClassOf 'has role' some 'environmental contaminant' http://purl.obolibrary.org/obo/CHEBI_68543 pyrimidine synthesis inhibitor 'pyrimidine synthesis inhibitor' SubClassOf 'pathway inhibitor' http://purl.obolibrary.org/obo/CHEBI_68542 EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor 'EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor' SubClassOf 'EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite 'fungal metabolite' SubClassOf 'eukaryotic metabolite' http://purl.obolibrary.org/obo/CHEBI_31257 bendazac 'bendazac' SubClassOf 'has role' some 'radical scavenger' 'bendazac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'bendazac' SubClassOf 'organic molecular entity' 'bendazac' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_76964 Penicillium metabolite 'Penicillium metabolite' SubClassOf 'fungal metabolite' http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite 'bacterial metabolite' SubClassOf 'prokaryotic metabolite' http://purl.obolibrary.org/obo/CHEBI_474180 caspofungin 'caspofungin' SubClassOf 'has role' some 'antiinfective agent' 'caspofungin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_76971 Escherichia coli metabolite 'Escherichia coli metabolite' SubClassOf 'bacterial metabolite' http://purl.obolibrary.org/obo/CHEBI_86328 antifungal agrochemical 'antifungal agrochemical' SubClassOf 'pesticide' http://purl.obolibrary.org/obo/CHEBI_85012 thrombopoietin receptor agonist 'thrombopoietin receptor agonist' SubClassOf 'agonist' http://purl.obolibrary.org/obo/CHEBI_85010 eltrombopag 'eltrombopag' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'eltrombopag' SubClassOf 'has role' some 'thrombopoietin receptor agonist' 'eltrombopag' SubClassOf 'has role' some 'xenobiotic' 'eltrombopag' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_73044 lumiracoxib 'lumiracoxib' SubClassOf 'has role' some 'cyclooxygenase 2 inhibitor' 'lumiracoxib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'lumiracoxib' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'lumiracoxib' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor 'EC 5.* (isomerase) inhibitor' SubClassOf 'enzyme inhibitor' http://purl.obolibrary.org/obo/CHEBI_63598 levofloxacin 'levofloxacin' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'levofloxacin' SubClassOf 'has role' some 'topoisomerase IV inhibitor' 'levofloxacin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'levofloxacin' SubClassOf 'has role' some 'antibacterial drug' 'levofloxacin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_63589 etravirine 'etravirine' SubClassOf 'has role' some 'HIV-1 reverse transcriptase inhibitor' 'etravirine' SubClassOf 'has role' some 'antiviral agent' 'etravirine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'etravirine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_50266 prodrug 'prodrug' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50267 protective agent 'protective agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50276 EC 5.99.1.2 (DNA topoisomerase) inhibitor 'EC 5.99.1.2 (DNA topoisomerase) inhibitor' SubClassOf 'topoisomerase inhibitor' http://purl.obolibrary.org/obo/CHEBI_421707 abacavir 'abacavir' SubClassOf 'has role' some 'HIV-1 reverse transcriptase inhibitor' 'abacavir' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'abacavir' SubClassOf 'has role' some 'drug allergen' 'abacavir' SubClassOf 'has role' some 'antiviral drug' 'abacavir' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent 'hematologic agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_50249 anticoagulant 'anticoagulant' SubClassOf 'hematologic agent' http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor 'topoisomerase inhibitor' SubClassOf 'EC 5.99.1.* (miscellaneous isomerase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_38503 EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor 'EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor' SubClassOf 'EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor' 'EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor' SubClassOf 'respiratory-chain inhibitor' http://purl.obolibrary.org/obo/CHEBI_2376 acarbose 'acarbose' SubClassOf 'has role' some 'EC 3.2.1.20 (alpha-glucosidase) inhibitor' 'acarbose' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'acarbose' SubClassOf 'organic molecular entity' 'acarbose' SubClassOf 'has role' some 'EC 3.2.1.1 (alpha-amylase) inhibitor' 'acarbose' SubClassOf 'has role' some 'hypoglycemic agent' http://purl.obolibrary.org/obo/CHEBI_94686 orlistat 'orlistat' SubClassOf 'has role' some 'bacterial metabolite' 'orlistat' SubClassOf 'has role' some 'anti-obesity agent' 'orlistat' SubClassOf 'organic molecular entity' 'orlistat' SubClassOf 'has role' some 'EC 3.1.1.3 (triacylglycerol lipase) inhibitor' 'orlistat' SubClassOf 'has role' some 'EC 2.3.1.85 (fatty acid synthase) inhibitor' 'orlistat' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_3655 chlorzoxazone 'chlorzoxazone' SubClassOf 'has role' some 'sedative' 'chlorzoxazone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'chlorzoxazone' SubClassOf 'organic molecular entity' 'chlorzoxazone' SubClassOf 'has role' some 'muscle relaxant' http://purl.obolibrary.org/obo/CHEBI_26607 saturated fatty acid 'saturated fatty acid' SubClassOf 'lipid' http://purl.obolibrary.org/obo/CHEBI_4995 felbamate 'felbamate' SubClassOf 'has role' some 'neuroprotective agent' 'felbamate' SubClassOf 'organic molecular entity' 'felbamate' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'felbamate' SubClassOf 'has role' some 'anticonvulsant' http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor 'EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor' SubClassOf 'EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor' http://purl.obolibrary.org/obo/CHEBI_31183 alclofenac 'alclofenac' SubClassOf 'has role' some 'drug allergen' 'alclofenac' SubClassOf 'organic molecular entity' 'alclofenac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'alclofenac' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'alclofenac' SubClassOf 'has role' some 'non-narcotic analgesic' http://purl.obolibrary.org/obo/CHEBI_76817 EC 2.7.10.* (protein-tyrosine kinase) inhibitor 'EC 2.7.10.* (protein-tyrosine kinase) inhibitor' SubClassOf 'EC 2.7.* (P-containing group transferase) inhibitor' 'EC 2.7.10.* (protein-tyrosine kinase) inhibitor' SubClassOf 'protein kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_67105 insect sterilant 'insect sterilant' SubClassOf 'insecticide' 'insect sterilant' SubClassOf 'chemosterilant' http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 'EC 2.7.11.* (protein-serine/threonine kinase) inhibitor' SubClassOf 'EC 2.7.* (P-containing group transferase) inhibitor' 'EC 2.7.11.* (protein-serine/threonine kinase) inhibitor' SubClassOf 'protein kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_76815 EC 2.7.7.* (nucleotidyltransferase) inhibitor 'EC 2.7.7.* (nucleotidyltransferase) inhibitor' SubClassOf 'EC 2.7.* (P-containing group transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_3619 chlormezanone 'chlormezanone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'chlormezanone' SubClassOf 'has role' some 'muscle relaxant' 'chlormezanone' SubClassOf 'has role' some 'anxiolytic drug' 'chlormezanone' SubClassOf 'has role' some 'antipsychotic agent' 'chlormezanone' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_4953 exemestane 'exemestane' SubClassOf 'has role' some 'xenobiotic' 'exemestane' SubClassOf 'has role' some 'EC 1.14.14.14 (aromatase) inhibitor' 'exemestane' SubClassOf 'has role' some 'antineoplastic agent' 'exemestane' SubClassOf 'has role' some 'environmental contaminant' 'exemestane' SubClassOf 'organic molecular entity' 'exemestane' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_76830 EC 5.99.1.* (miscellaneous isomerase) inhibitor 'EC 5.99.1.* (miscellaneous isomerase) inhibitor' SubClassOf 'EC 5.99.* (other isomerases) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76834 EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 'EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor' SubClassOf 'EC 2.* (transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 'EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor' SubClassOf 'EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76838 EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor 'EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor' SubClassOf 'EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 'EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor' SubClassOf 'EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor' http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor 'EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor' SubClassOf 'EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76840 EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 'EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' SubClassOf 'EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor' http://purl.obolibrary.org/obo/CHEBI_45783 imatinib 'imatinib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'imatinib' SubClassOf 'has role' some 'tyrosine kinase inhibitor' 'imatinib' SubClassOf 'organic molecular entity' 'imatinib' SubClassOf 'has role' some 'antineoplastic agent' 'imatinib' SubClassOf 'has role' some 'apoptosis inducer' http://purl.obolibrary.org/obo/CHEBI_76848 EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor 'EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor' SubClassOf 'EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76850 EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor 'EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor' SubClassOf 'EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76852 EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor 'EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor' SubClassOf 'EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_44423 hydroxyurea 'hydroxyurea' SubClassOf 'has role' some 'DNA synthesis inhibitor' 'hydroxyurea' SubClassOf 'organic molecular entity' 'hydroxyurea' SubClassOf 'has role' some 'antimetabolite' 'hydroxyurea' SubClassOf 'has role' some 'EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor' 'hydroxyurea' SubClassOf 'has role' some 'immunomodulator' 'hydroxyurea' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'hydroxyurea' SubClassOf 'has role' some 'teratogenic agent' 'hydroxyurea' SubClassOf 'has role' some 'antimitotic' 'hydroxyurea' SubClassOf 'has role' some 'genotoxin' 'hydroxyurea' SubClassOf 'has role' some 'antineoplastic agent' 'hydroxyurea' SubClassOf 'has role' some 'radical scavenger' http://purl.obolibrary.org/obo/CHEBI_76853 EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor 'EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor' SubClassOf 'EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76858 EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor 'EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor' SubClassOf 'EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76863 EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor 'EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor' SubClassOf 'EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76866 EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor 'EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor' SubClassOf 'EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor' http://purl.obolibrary.org/obo/CHEBI_4909 etodolac 'etodolac' SubClassOf 'has role' some 'non-steroidal anti-inflammatory drug' 'etodolac' SubClassOf 'has role' some 'cyclooxygenase 2 inhibitor' 'etodolac' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'etodolac' SubClassOf 'has role' some 'non-narcotic analgesic' 'etodolac' SubClassOf 'has role' some 'antipyretic' 'etodolac' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor 'EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor' SubClassOf 'EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor 'EC 2.1.1.* (methyltransferases) inhibitor' SubClassOf 'EC 2.1.* (C1-transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_74213 EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor 'EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor' SubClassOf 'EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor 'EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor' SubClassOf 'EC 2.3.* (acyltransferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor 'EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor' SubClassOf 'EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor' http://purl.obolibrary.org/obo/CHEBI_76898 EC 1.14.14.1 (unspecific monooxygenase) inhibitor 'EC 1.14.14.1 (unspecific monooxygenase) inhibitor' SubClassOf 'EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor' http://purl.obolibrary.org/obo/CHEBI_600520 micafungin 'micafungin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'micafungin' SubClassOf 'has role' some 'antiinfective agent' 'micafungin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_8863 Riluzole 'Riluzole' SubClassOf 'organic molecular entity' 'Riluzole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_48279 serotonergic antagonist 'serotonergic antagonist' SubClassOf 'serotonergic drug' http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug 'serotonergic drug' SubClassOf 'neurotransmitter agent' http://purl.obolibrary.org/obo/CHEBI_50502 EC 2.5.1.15 (dihydropteroate synthase) inhibitor 'EC 2.5.1.15 (dihydropteroate synthase) inhibitor' SubClassOf 'EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_38940 sunitinib 'sunitinib' SubClassOf 'organic molecular entity' 'sunitinib' SubClassOf 'has role' some 'immunomodulator' 'sunitinib' SubClassOf 'has role' some 'angiogenesis inhibitor' 'sunitinib' SubClassOf 'has role' some 'vascular endothelial growth factor receptor antagonist' 'sunitinib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'sunitinib' SubClassOf 'has role' some 'EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor' 'sunitinib' SubClassOf 'has role' some 'antineoplastic agent' 'sunitinib' SubClassOf 'has role' some 'neuroprotective agent' http://purl.obolibrary.org/obo/CHEBI_49603 lapatinib 'lapatinib' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'lapatinib' SubClassOf 'has role' some 'antineoplastic agent' 'lapatinib' SubClassOf 'organic molecular entity' 'lapatinib' SubClassOf 'has role' some 'tyrosine kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_91079 purinergic receptor P2 antagonist 'purinergic receptor P2 antagonist' SubClassOf 'antagonist' http://purl.obolibrary.org/obo/CHEBI_74518 anti-obesity agent 'anti-obesity agent' SubClassOf 'pharmacological role' http://purl.obolibrary.org/obo/CHEBI_135358 oxyphenisatine 'oxyphenisatine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'oxyphenisatine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_135357 zimeldine 'zimeldine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'zimeldine' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor 'EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor' SubClassOf 'EC 3.* (hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_31446 Cyclofenil 'Cyclofenil' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'Cyclofenil' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_116225 nomifensine 'nomifensine' SubClassOf 'organic molecular entity' 'nomifensine' SubClassOf 'has role' some 'dopamine uptake inhibitor' 'nomifensine' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) http://purl.obolibrary.org/obo/CHEBI_7494 nefazodone 'nefazodone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'nefazodone' SubClassOf 'has role' some 'analgesic' 'nefazodone' SubClassOf 'has role' some 'serotonergic antagonist' 'nefazodone' SubClassOf 'has role' some 'antidepressant' 'nefazodone' SubClassOf 'has role' some 'serotonin uptake inhibitor' 'nefazodone' SubClassOf 'organic molecular entity' 'nefazodone' SubClassOf 'has role' some 'alpha-adrenergic antagonist' http://purl.obolibrary.org/obo/CHEBI_7466 nandrolone 'nandrolone' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'nandrolone' SubClassOf 'has role' some 'human metabolite' 'nandrolone' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_132992 radiosensitizing agent 'radiosensitizing agent' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_61115 EC 3.5.1.98 (histone deacetylase) inhibitor 'EC 3.5.1.98 (histone deacetylase) inhibitor' SubClassOf 'EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_62434 EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor 'EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor' SubClassOf 'tyrosine kinase inhibitor' 'EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor' SubClassOf 'EC 2.7.10.* (protein-tyrosine kinase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_25491 nematicide 'nematicide' SubClassOf 'pesticide' http://purl.obolibrary.org/obo/CHEBI_50427 platelet aggregation inhibitor 'platelet aggregation inhibitor' SubClassOf 'hematologic agent' http://purl.obolibrary.org/obo/CHEBI_149836 tigecycline 'tigecycline' SubClassOf 'has role' some 'antibacterial drug' 'tigecycline' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_63726 neuroprotective agent 'neuroprotective agent' SubClassOf 'protective agent' http://purl.obolibrary.org/obo/CHEBI_24127 fungicide 'fungicide' SubClassOf 'antifungal agent' 'fungicide' SubClassOf 'pesticide' http://purl.obolibrary.org/obo/CHEBI_135273 clomacran 'clomacran' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'clomacran' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_55346 anidulafungin 'anidulafungin' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/CHEBI_6067 isotretinoin 'isotretinoin' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'isotretinoin' SubClassOf 'has role' some 'antineoplastic agent' 'isotretinoin' SubClassOf 'has role' some 'teratogenic agent' 'isotretinoin' SubClassOf 'organic molecular entity' 'isotretinoin' SubClassOf 'has role' some 'keratolytic drug' http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite 'eukaryotic metabolite' SubClassOf 'metabolite' http://purl.obolibrary.org/obo/CHEBI_6076 itraconazole 'itraconazole' SubClassOf 'organic molecular entity' 'itraconazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'itraconazole' SubClassOf 'has role' some 'P450 inhibitor' 'itraconazole' SubClassOf 'has role' some 'Hedgehog signaling pathway inhibitor' 'itraconazole' SubClassOf 'has role' some 'EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor' http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite 'animal metabolite' SubClassOf 'eukaryotic metabolite' http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite 'mammalian metabolite' SubClassOf 'animal metabolite' http://purl.obolibrary.org/obo/CHEBI_55324 gastrointestinal drug 'gastrointestinal drug' SubClassOf 'drug' http://purl.obolibrary.org/obo/CHEBI_74440 epidermal growth factor receptor antagonist 'epidermal growth factor receptor antagonist' SubClassOf 'antagonist' 'epidermal growth factor receptor antagonist' SubClassOf 'protein kinase inhibitor' http://purl.obolibrary.org/obo/CHEBI_75771 mouse metabolite 'mouse metabolite' SubClassOf 'mammalian metabolite' http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite 'prokaryotic metabolite' SubClassOf 'metabolite' http://purl.obolibrary.org/obo/CHEBI_45979 thiabendazole 'thiabendazole' SubClassOf 'has role' some 'antinematodal drug' 'thiabendazole' SubClassOf 'has attribute' some ('drug liver toxicity' and ('has attribute value' some 'Most-DILI-Concern')) 'thiabendazole' SubClassOf 'organic molecular entity' 'thiabendazole' SubClassOf 'has role' some 'antifungal agrochemical' http://purl.obolibrary.org/obo/TXPO_0003678 biochemical role 'biochemical role' SubClassOf 'biological role' http://purl.obolibrary.org/obo/TXPO_0004933 Chlorendic Acid 'Chlorendic Acid' SubClassOf 'organic molecular entity' http://purl.obolibrary.org/obo/TXPO_0005059 saturated fatty acid 'saturated fatty acid' SubClassOf 'lipid'