<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
29
</numberChangedClasses>
<numberNewClasses>
12
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001815</classIRI>
<classLabel>severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A]</classLabel>
<newAxiom>&apos;severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A]&apos; SubClassOf &apos;has part&apos; some &apos;sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0004125</classIRI>
<classLabel>negative regulation of oxidative phosphorylation [Mitochondrial disorder]</classLabel>
<deletedAxiom>&apos;negative regulation of oxidative phosphorylation [Mitochondrial disorder]&apos; SubClassOf &apos;has result&apos; some &apos;hypofunction of mitochondrial fatty acid beta-oxidation [Mitochondrial disorder]&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of oxidative phosphorylation [Mitochondrial disorder]&apos; SubClassOf &apos;has result&apos; some &apos;hypofunction of mitochondrial fatty acid beta-oxidation [Mitochondrial disorder]&apos;</newAxiom>
<newAxiom>&apos;negative regulation of oxidative phosphorylation [Mitochondrial disorder]&apos; SubClassOf &apos;has result&apos; some http://purl.obolibrary.org/obo/TXPO_0000075</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0004222</classIRI>
<classLabel>GDF15(mouse)[mitochondrial disorder]</classLabel>
<deletedAxiom>&apos;GDF15(mouse)[mitochondrial disorder]&apos; SubClassOf &apos;has quality&apos; some &apos;predicted (quality)&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001692</classIRI>
<classLabel>sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]</classLabel>
<deletedAxiom>&apos;sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]&apos; SubClassOf &apos;severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A]&apos;</deletedAxiom>
<newAxiom>&apos;sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]&apos; SubClassOf &apos;severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A/ B (severe)]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001777</classIRI>
<classLabel>phospholipid metabolism imbalance [Phospholipidosis (mild)]</classLabel>
<newAxiom>&apos;phospholipid metabolism imbalance [Phospholipidosis (mild)]&apos; SubClassOf &apos;has result&apos; some &apos;phospholipid accumulation in lysosome [Phospholipidosis (mild)]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001778</classIRI>
<classLabel>phospholipid metabolism imbalance  [Phospholipidosis (severe) ]</classLabel>
<newAxiom>&apos;phospholipid metabolism imbalance  [Phospholipidosis (severe) ]&apos; SubClassOf &apos;has result&apos; some &apos;phospholipid accumulation in lysosome [Phospholipidosis (severe) ]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0000951</classIRI>
<classLabel>changing phospholipid homeostasis [Phospholipidosis]</classLabel>
<deletedAxiom>&apos;changing phospholipid homeostasis [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;changing phospholipid homeostasis [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (course)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0000946</classIRI>
<classLabel>changing balance of phospholipid metabolism [Phospholipidosis]</classLabel>
<deletedAxiom>&apos;changing balance of phospholipid metabolism [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;changing balance of phospholipid metabolism [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (course)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0000929</classIRI>
<classLabel>sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]</classLabel>
<deletedAxiom>&apos;sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]&apos; SubClassOf &apos;sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]&apos;</deletedAxiom>
<newAxiom>&apos;sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]&apos; SubClassOf &apos;sphingomyelin metabolism imbalance [Niemann Pick Disease Type A/ B]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003387</classIRI>
<classLabel>phospholipid biosynthetic process [Phospholipidosis]</classLabel>
<deletedAxiom>&apos;phospholipid biosynthetic process [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;phospholipid biosynthetic process [Phospholipidosis]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (normal course)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003385</classIRI>
<classLabel>hyperfunction of phospholipid synthesis gene expression [Phospholipidosis - normal]</classLabel>
<deletedAxiom>&apos;hyperfunction of phospholipid synthesis gene expression [Phospholipidosis - normal]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;hyperfunction of phospholipid synthesis gene expression [Phospholipidosis - normal]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (normal course)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003372</classIRI>
<classLabel>phospholipid metabolism imbalance [Phospholipidosis (moderate) ]</classLabel>
<newAxiom>&apos;phospholipid metabolism imbalance [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;has result&apos; some &apos;phospholipid accumulation in lysosome [Phospholipidosis (moderate) ]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003368</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (moderate) ]</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003362</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (mild)&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003468</classIRI>
<classLabel>sphingomyelinase gene mutation [Niemann Pick Disease Type A]</classLabel>
<deletedAxiom>&apos;sphingomyelinase gene mutation [Niemann Pick Disease Type A]&apos; SubClassOf &apos;has result&apos; some &apos;dysfunction of sphingomyelin degradation in the myelin sheath [Niemann Pick Disease Type A]&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003447</classIRI>
<classLabel>negative regulation of phospholipid hydrolysis [Phospholipidosis (severe) ]</classLabel>
<deletedAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (severe) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (severe) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (severe)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003449</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (severe) ]</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (severe) ]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (severe) ]&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003443</classIRI>
<classLabel>negative regulation of phospholipid hydrolysis [Phospholipidosis (moderate) ]</classLabel>
<deletedAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (moderate)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003444</classIRI>
<classLabel>negative regulation of phospholipid degradation [Phospholipidosis (moderate) ]</classLabel>
<deletedAxiom>&apos;negative regulation of phospholipid degradation [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of phospholipid degradation [Phospholipidosis (moderate) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (moderate)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003474</classIRI>
<classLabel>dysfunction of sphingomyelin degradation [Niemann Pick Disease Type A]</classLabel>
<newAxiom>&apos;dysfunction of sphingomyelin degradation [Niemann Pick Disease Type A]&apos; SubClassOf &apos;has part&apos; some &apos;dysfunction of sphingomyelin degradation in the myelin sheath [Niemann Pick Disease Type A]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003412</classIRI>
<classLabel>negative regulation of phospholipid hydrolysis [Phospholipidosis (mild)]</classLabel>
<deletedAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (mild)]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of phospholipid hydrolysis [Phospholipidosis (mild)]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (mild)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003580</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;sphingomyelin biosynthetic process&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;has result&apos; some &apos;sphingomyelin metabolism imbalance [Niemann Pick Disease Type B]&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;has context&apos; only &apos;course of Niemann–Pick disease type B&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;phospholipidosis dependent process&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos; SubClassOf &apos;has output&apos; some &apos;sphingomyelin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003578</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos; SubClassOf &apos;has context&apos; only http://purl.obolibrary.org/obo/TXPO_0001964</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos; SubClassOf &apos;has result&apos; some http://purl.obolibrary.org/obo/TXPO_0001908</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos; SubClassOf &apos;negative regulation of phospholipid hydrolysis [Phospholipidosis]&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (moderate)&apos; SubClassOf &apos;negatively regulates&apos; some &apos;phospholipid hydrolysis [Phospholipidosis]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003579</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)</classLabel>
<deletedAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane&apos;</deletedAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;has output&apos; some &apos;sphingomyelin&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;has result&apos; some &apos;sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;phospholipidosis dependent process&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;sphingomyelin biosynthetic process&apos;</newAxiom>
<newAxiom>&apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos; SubClassOf &apos;has context&apos; only &apos;course of Niemann–Pick disease type A&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0002217</classIRI>
<classLabel>negative regulation of phospholipid degradation [Phospholipidosis (severe) ]</classLabel>
<deletedAxiom>&apos;negative regulation of phospholipid degradation [Phospholipidosis (severe) ]&apos; SubClassOf &apos;dysfunctioning of&apos; some &apos;phospholipid catabolic process [Phospholipidosis]&apos;</deletedAxiom>
<deletedAxiom>&apos;negative regulation of phospholipid degradation [Phospholipidosis (severe) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (toxic course)&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of phospholipid degradation [Phospholipidosis (severe) ]&apos; SubClassOf &apos;has context&apos; only &apos;phospholipidosis (severe)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001482</classIRI>
<classLabel>sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]</classLabel>
<newAxiom>&apos;sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]&apos; SubClassOf &apos;has part&apos; some &apos;sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001469</classIRI>
<classLabel>course of Niemann–Pick disease type B</classLabel>
<newAxiom>&apos;course of Niemann–Pick disease type B&apos; SubClassOf &apos;has part&apos; some &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (mild)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001468</classIRI>
<classLabel>course of Niemann–Pick disease type A</classLabel>
<deletedAxiom>&apos;course of Niemann–Pick disease type A&apos; SubClassOf &apos;has part&apos; some &apos;sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]&apos;</deletedAxiom>
<deletedAxiom>&apos;course of Niemann–Pick disease type A&apos; SubClassOf &apos;has part&apos; some &apos;dysfunction of sphingomyelin degradation in the myelin sheath [Niemann Pick Disease Type A]&apos;</deletedAxiom>
<newAxiom>&apos;course of Niemann–Pick disease type A&apos; SubClassOf &apos;has part&apos; some &apos;CAD insertion into phospholipase binding site to lysosomal inner membrane (severe)&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003986</classIRI>
<classLabel>sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]</classLabel>
<deletedAxiom>&apos;sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]&apos; SubClassOf &apos;has part&apos; some &apos;sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]&apos;</deletedAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001964</classIRI>
<classLabel>phospholipidosis (latent)</classLabel>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has core process' only 'phospholipid metabolism balance [Phospholipidosis (latent) ]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'CAD accumulation in lysosome [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'phospholipidosis [course]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'hypofunction of phospholipid degradation [Phospholipidosis(latent)]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'phospholipid biosynthetic process [Phospholipidosis(latent)]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'phospholipid metabolism balance [Phospholipidosis (latent) ]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'maintaining phospholipid homeostasis [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'compound accumulation in lysosome [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'phospholipidosis (latent)' SubClassOf 'has part' some 'negative regulation of phospholipid degradation [Phospholipidosis (latent)]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0001908</classIRI>
<classLabel>negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]</classLabel>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has agent' some 'imipramine - phospholipase competition inhibitor [Phospholipidosis]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has result' some 'negative regulation of phospholipid degradation [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has agent' some 'tamoxifen phospholipase inhibitor[Phospholipidosis]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has molecular reaction' some 'negative regulation of phospholipid hydrolysis [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has agent' some 'amiodarone - phospholipase competition inhibitor [Phospholipidosis]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis]'</newAxiom>
<newAxiom>'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]' SubClassOf 'has molecular reaction' some 'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0005189</classIRI>
<classLabel>phospholipid biosynthetic process [Phospholipidosis(latent)]</classLabel>
<newAxiom>'phospholipid biosynthetic process [Phospholipidosis(latent)]' SubClassOf 'has result' some 'phospholipid metabolism balance [Phospholipidosis (latent) ]'</newAxiom>
<newAxiom>'phospholipid biosynthetic process [Phospholipidosis(latent)]' SubClassOf 'occurs in' some 'liver'</newAxiom>
<newAxiom>'phospholipid biosynthetic process [Phospholipidosis(latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
<newAxiom>'phospholipid biosynthetic process [Phospholipidosis(latent)]' SubClassOf 'phospholipidosis dependent process'</newAxiom>
<newAxiom>'phospholipid biosynthetic process [Phospholipidosis(latent)]' SubClassOf 'phospholipid biosynthetic process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0005143</classIRI>
<classLabel>central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]</classLabel>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'has state' some 'toxicological imbalance VL(defense)'</newAxiom>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A/ B]'</newAxiom>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'has context' only 'course of Niemann–Pick disease type A'</newAxiom>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'has part' some 'sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]'</newAxiom>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'has result' some 'sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]'</newAxiom>
<newAxiom>'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]' SubClassOf 'has part' some 'central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0003678</classIRI>
<classLabel>compound accumulation in lysosome [Phospholipidosis (latent)]</classLabel>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has result' some 'negative regulation of phospholipid degradation [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has participant' some 'imipramine _CAD [Phospholipidosis]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has participant' some 'clomipramine_CAD [Phospholipidosis]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'compound accumulation in lysosome [Phospholipidosis]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has participant' some 'gentamicin_phospholipase inhibitor [Phospholipidosis]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has part' some 'CAD accumulation in lysosome [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has participant' some 'amitriptyline [Phospholipidosis]'</newAxiom>
<newAxiom>'compound accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0004933</classIRI>
<classLabel>negative regulation of phospholipid degradation [Phospholipidosis (latent)]</classLabel>
<newAxiom>'negative regulation of phospholipid degradation [Phospholipidosis (latent)]' SubClassOf 'has result' some 'hypofunction of phospholipid degradation [Phospholipidosis(latent)]'</newAxiom>
<newAxiom>'negative regulation of phospholipid degradation [Phospholipidosis (latent)]' SubClassOf 'negative regulation of phospholipid degradation [Phospholipidosis]'</newAxiom>
<newAxiom>'negative regulation of phospholipid degradation [Phospholipidosis (latent)]' SubClassOf 'has part' some 'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'negative regulation of phospholipid degradation [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0002293</classIRI>
<classLabel>phospholipid metabolism balance [Phospholipidosis (latent) ]</classLabel>
<newAxiom>'phospholipid metabolism balance [Phospholipidosis (latent) ]' SubClassOf 'has state' some 'toxicological imbalance M=M (maintining homeostasis in the normal condition)'</newAxiom>
<newAxiom>'phospholipid metabolism balance [Phospholipidosis (latent) ]' SubClassOf 'has result' some 'maintaining phospholipid homeostasis [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'phospholipid metabolism balance [Phospholipidosis (latent) ]' SubClassOf 'phospholipid metabolism balance'</newAxiom>
<newAxiom>'phospholipid metabolism balance [Phospholipidosis (latent) ]' SubClassOf 'changing balance of phospholipid metabolism [Phospholipidosis]'</newAxiom>
<newAxiom>'phospholipid metabolism balance [Phospholipidosis (latent) ]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0002273</classIRI>
<classLabel>maintaining phospholipid homeostasis [Phospholipidosis (latent)]</classLabel>
<newAxiom>'maintaining phospholipid homeostasis [Phospholipidosis (latent)]' SubClassOf 'maintaining phospholipid homeostasis'</newAxiom>
<newAxiom>'maintaining phospholipid homeostasis [Phospholipidosis (latent)]' SubClassOf 'changing phospholipid homeostasis [Phospholipidosis]'</newAxiom>
<newAxiom>'maintaining phospholipid homeostasis [Phospholipidosis (latent)]' SubClassOf 'has state' some 'toxicological imbalance M=M (maintining homeostasis in the normal condition)'</newAxiom>
<newAxiom>'maintaining phospholipid homeostasis [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0005059</classIRI>
<classLabel>hypofunction of phospholipid degradation [Phospholipidosis(latent)]</classLabel>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'has participant' some 'PLA2 (canonical)[Phospholipidosis]'</newAxiom>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'dysfunctioning of' some 'phospholipid catabolic process [Phospholipidosis]'</newAxiom>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'hypofunction of phospholipid degradation [Phospholipidosis]'</newAxiom>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'has result' some 'phospholipid metabolism balance [Phospholipidosis (latent) ]'</newAxiom>
<newAxiom>'hypofunction of phospholipid degradation [Phospholipidosis(latent)]' SubClassOf 'has participant' some 'PLA2G15 (canonical)[Phospholipidosis]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0002522</classIRI>
<classLabel>CAD accumulation in lysosome [Phospholipidosis (latent)]</classLabel>
<newAxiom>'CAD accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
<newAxiom>'CAD accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'has result' some 'negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'CAD accumulation in lysosome [Phospholipidosis (latent)]' SubClassOf 'CAD accumulation in lysosome [Phospholipidosis]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0002572</classIRI>
<classLabel>CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]</classLabel>
<newAxiom>'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]' SubClassOf 'has result' some 'negative regulation of phospholipid hydrolysis [Phospholipidosis (latent)]'</newAxiom>
<newAxiom>'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]' SubClassOf 'has participant' some 'imipramine _CAD [Phospholipidosis]'</newAxiom>
<newAxiom>'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]' SubClassOf 'has context' only 'phospholipidosis (latent)'</newAxiom>
<newAxiom>'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]' SubClassOf 'negatively regulates' some 'phosphholipid binding by phospholipase [Phospholipidosis]'</newAxiom>
<newAxiom>'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]' SubClassOf 'CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis]'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/TXPO_0000075</classIRI>
<classLabel>increasing GDF15 level [mitochondrial disorder]</classLabel>
<newAxiom>'increasing GDF15 level [mitochondrial disorder]' SubClassOf 'Increasing GDF15 level'</newAxiom>
<newAxiom>'increasing GDF15 level [mitochondrial disorder]' SubClassOf 'has participant' some 'GDF15(mouse)[mitochondrial disorder]'</newAxiom>
<newAxiom>'increasing GDF15 level [mitochondrial disorder]' SubClassOf 'mitochondrial disorder dependent process'</newAxiom>
<newAxiom>'increasing GDF15 level [mitochondrial disorder]' SubClassOf 'has participant' some 'GDF15 (predicted)(human) [mitochondrial damage]'</newAxiom>
<newAxiom>'increasing GDF15 level [mitochondrial disorder]' SubClassOf 'has context' only 'mitochondrial damage [toxic course]'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>