<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
23
</numberChangedClasses>
<numberNewClasses>
60
</numberNewClasses>
<numberDeletedClasses>
3
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0356</classIRI>
<classLabel>effect on alternative polyadenylation</classLabel>
<deletedAxiom>&apos;effect on alternative polyadenylation&apos; SubClassOf &apos;effect on RNA polyadenylation&apos;</deletedAxiom>
<newAxiom>&apos;effect on alternative polyadenylation&apos; SubClassOf &apos;misreplicated DNA&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0363</classIRI>
<classLabel>effect on RNA G-quadruplex</classLabel>
<deletedAxiom>&apos;effect on RNA G-quadruplex&apos; SubClassOf &apos;variation to RNA secondary structure&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0364</classIRI>
<classLabel>intron gain</classLabel>
<deletedAxiom>&apos;intron gain&apos; SubClassOf &apos;effect on RNA splicing&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0137</classIRI>
<classLabel>effect on DNA stem</classLabel>
<deletedAxiom>&apos;effect on DNA stem&apos; SubClassOf &apos;effect on DNA secondary structure&apos;</deletedAxiom>
<newAxiom>&apos;effect on DNA stem&apos; SubClassOf &apos;variation affecting RNA structure&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0205</classIRI>
<classLabel>uncharacterized chromosomal variation</classLabel>
<deletedAxiom>&apos;uncharacterized chromosomal variation&apos; SubClassOf &apos;chromosome variation&apos;</deletedAxiom>
<newAxiom>&apos;uncharacterized chromosomal variation&apos; SubClassOf &apos;microsatellite&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0331</classIRI>
<classLabel>misreplicated DNA</classLabel>
<deletedAxiom>&apos;misreplicated DNA&apos; SubClassOf &apos;DNA variation of non-genetic origin&apos;</deletedAxiom>
<newAxiom>&apos;misreplicated DNA&apos; SubClassOf &apos;protein coding RNA sequence&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0215</classIRI>
<classLabel>chromosome set number variation</classLabel>
<deletedAxiom>&apos;chromosome set number variation&apos; SubClassOf &apos;variation affecting DNA structure&apos;</deletedAxiom>
<newAxiom>&apos;chromosome set number variation&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0428</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0185</classIRI>
<classLabel>tandem repeat</classLabel>
<deletedAxiom>&apos;tandem repeat&apos; SubClassOf &apos;chromosomal amplification&apos;</deletedAxiom>
<newAxiom>&apos;tandem repeat&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0427</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0184</classIRI>
<classLabel>interspersed repeat</classLabel>
<deletedAxiom>&apos;interspersed repeat&apos; SubClassOf &apos;chromosomal amplification&apos;</deletedAxiom>
<newAxiom>&apos;interspersed repeat&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0427</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0187</classIRI>
<classLabel>copy number variation</classLabel>
<deletedAxiom>&apos;copy number variation&apos; SubClassOf &apos;chromosome structure variation&apos;</deletedAxiom>
<newAxiom>&apos;copy number variation&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some &apos;chromosomal amplification&apos;</newAxiom>
<newAxiom>&apos;copy number variation&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some &apos;chromosomal deletion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0186</classIRI>
<classLabel>minisatellite</classLabel>
<deletedAxiom>&apos;minisatellite&apos; SubClassOf &apos;tandem repeat&apos;</deletedAxiom>
<newAxiom>&apos;minisatellite&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0430</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0188</classIRI>
<classLabel>microsatellite</classLabel>
<deletedAxiom>&apos;microsatellite&apos; SubClassOf &apos;tandem repeat&apos;</deletedAxiom>
<newAxiom>&apos;microsatellite&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0430</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0381</classIRI>
<classLabel>exon loss</classLabel>
<deletedAxiom>&apos;exon loss&apos; SubClassOf &apos;effect on RNA splicing&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0153</classIRI>
<classLabel>effect on promoter activity</classLabel>
<deletedAxiom>&apos;effect on promoter activity&apos; SubClassOf &apos;effect on regulatory function of DNA&apos;</deletedAxiom>
<newAxiom>&apos;effect on promoter activity&apos; SubClassOf &apos;DNA variation classification&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0158</classIRI>
<classLabel>chromatin remodeling</classLabel>
<deletedAxiom>&apos;chromatin remodeling&apos; SubClassOf &apos;epigenetic DNA modification&apos;</deletedAxiom>
<newAxiom>&apos;chromatin remodeling&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some &apos;epigenetic DNA modification&apos;</newAxiom>
<newAxiom>&apos;chromatin remodeling&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some &apos;chromatin structure variation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0167</classIRI>
<classLabel>gene fusion</classLabel>
<deletedAxiom>&apos;gene fusion&apos; SubClassOf &apos;gene structure variation&apos;</deletedAxiom>
<newAxiom>&apos;gene fusion&apos; SubClassOf &apos;effect on DNA secondary structure&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0166</classIRI>
<classLabel>gene structure variation</classLabel>
<deletedAxiom>&apos;gene structure variation&apos; SubClassOf &apos;variation affecting DNA structure&apos;</deletedAxiom>
<newAxiom>&apos;gene structure variation&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0447</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0169</classIRI>
<classLabel>complete gene deletion</classLabel>
<deletedAxiom>&apos;complete gene deletion&apos; SubClassOf &apos;gene deletion&apos;</deletedAxiom>
<newAxiom>&apos;complete gene deletion&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0447</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0168</classIRI>
<classLabel>gene deletion</classLabel>
<deletedAxiom>&apos;gene deletion&apos; SubClassOf &apos;gene structure variation&apos;</deletedAxiom>
<newAxiom>&apos;gene deletion&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0447</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0174</classIRI>
<classLabel>effect on i motif</classLabel>
<deletedAxiom>&apos;effect on i motif&apos; SubClassOf &apos;effect on DNA secondary structure&apos;</deletedAxiom>
<newAxiom>&apos;effect on i motif&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0420</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0173</classIRI>
<classLabel>effect on DNA G-quadruplex</classLabel>
<deletedAxiom>&apos;effect on DNA G-quadruplex&apos; SubClassOf &apos;effect on DNA secondary structure&apos;</deletedAxiom>
<newAxiom>&apos;effect on DNA G-quadruplex&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some http://purl.obolibrary.org/obo/VariO_0426</newAxiom>
<newAxiom>&apos;effect on DNA G-quadruplex&apos; SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some http://purl.obolibrary.org/obo/VariO_0420</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0056</classIRI>
<classLabel>effect on enzyme reaction kinetics</classLabel>
<deletedAxiom>&apos;effect on enzyme reaction kinetics&apos; SubClassOf &apos;effect on protein activity&apos;</deletedAxiom>
<newAxiom>&apos;effect on enzyme reaction kinetics&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0435</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0170</classIRI>
<classLabel>partial gene deletion</classLabel>
<deletedAxiom>&apos;partial gene deletion&apos; SubClassOf &apos;gene deletion&apos;</deletedAxiom>
<newAxiom>&apos;partial gene deletion&apos; SubClassOf http://purl.obolibrary.org/obo/VariO_0447</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0378</classIRI>
<classLabel>DNA transposon</classLabel>
<newAxiom>'DNA transposon' SubClassOf 'DNA mobile genetic element insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0377</classIRI>
<classLabel>retrotransposon insertion</classLabel>
<newAxiom>'retrotransposon insertion' SubClassOf 'DNA mobile genetic element insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0379</classIRI>
<classLabel>LINE</classLabel>
<newAxiom>'LINE' SubClassOf 'retrotransposon insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0420</classIRI>
<classLabel>effect on four-stranded DNA</classLabel>
<newAxiom>'effect on four-stranded DNA' SubClassOf 'effect on DNA form'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0422</classIRI>
<classLabel>effect on intramolecular DNA triple helix</classLabel>
<newAxiom>'effect on intramolecular DNA triple helix' SubClassOf 'effect on DNA triple helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0421</classIRI>
<classLabel>effect on Z DNA</classLabel>
<newAxiom>'effect on Z DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0424</classIRI>
<classLabel>effect on DNA-RNA hybrid</classLabel>
<newAxiom>'effect on DNA-RNA hybrid' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'effect on DNA tertiary structure'</newAxiom>
<newAxiom>'effect on DNA-RNA hybrid' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'effect on RNA tertiary structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0423</classIRI>
<classLabel>effect on intermolecular DNA triple helix</classLabel>
<newAxiom>'effect on intermolecular DNA triple helix' SubClassOf 'effect on DNA triple helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0426</classIRI>
<classLabel>effect on four-stranded RNA</classLabel>
<newAxiom>'effect on four-stranded RNA' SubClassOf 'effect on RNA tertiary structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0425</classIRI>
<classLabel>effect on RNA triple helix</classLabel>
<newAxiom>'effect on RNA triple helix' SubClassOf 'effect on RNA tertiary structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0428</classIRI>
<classLabel>genome variation</classLabel>
<newAxiom>'genome variation' SubClassOf 'variation affecting DNA structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0427</classIRI>
<classLabel>type of chromosomal amplification</classLabel>
<newAxiom>'type of chromosomal amplification' SubClassOf 'chromosomal amplification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0429</classIRI>
<classLabel>complex genomic variation</classLabel>
<newAxiom>'complex genomic variation' SubClassOf 'genome variation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0431</classIRI>
<classLabel>effect on R loop</classLabel>
<newAxiom>'effect on R loop' SubClassOf 'effect on DNA-RNA hybrid'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0430</classIRI>
<classLabel>nucleotide expansion</classLabel>
<newAxiom>'nucleotide expansion' SubClassOf 'chromosomal amplification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0433</classIRI>
<classLabel>effect on D loop</classLabel>
<newAxiom>'effect on D loop' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'effect on DNA-RNA hybrid'</newAxiom>
<newAxiom>'effect on D loop' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'effect on intermolecular DNA triple helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0432</classIRI>
<classLabel>effect on T loop</classLabel>
<newAxiom>'effect on T loop' SubClassOf 'effect on DNA-RNA hybrid'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0435</classIRI>
<classLabel>effect on protein reaction kinetics</classLabel>
<newAxiom>'effect on protein reaction kinetics' SubClassOf 'effect on protein activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0434</classIRI>
<classLabel>DNA sugar variation</classLabel>
<newAxiom>'DNA sugar variation' SubClassOf 'variation affecting DNA structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0437</classIRI>
<classLabel>alternatively initiated mRNA transcript</classLabel>
<newAxiom>'alternatively initiated mRNA transcript' SubClassOf 'alternative form of RNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0436</classIRI>
<classLabel>matured RNA</classLabel>
<newAxiom>'matured RNA' SubClassOf 'RNA variation of non-genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0439</classIRI>
<classLabel>effect on RNA activity</classLabel>
<newAxiom>'effect on RNA activity' SubClassOf 'variation affecting RNA property'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0440</classIRI>
<classLabel>effect on RNA reaction kinetics</classLabel>
<newAxiom>'effect on RNA reaction kinetics' SubClassOf 'effect on RNA activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0442</classIRI>
<classLabel>effect on RNA specificity</classLabel>
<newAxiom>'effect on RNA specificity' SubClassOf 'effect on RNA activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0441</classIRI>
<classLabel>effect on RNA affinity</classLabel>
<newAxiom>'effect on RNA affinity' SubClassOf 'effect on RNA activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0444</classIRI>
<classLabel>de novo variation</classLabel>
<newAxiom>'de novo variation' SubClassOf 'DNA variation of genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0443</classIRI>
<classLabel>alternatively initiated protein</classLabel>
<newAxiom>'alternatively initiated protein' SubClassOf 'variation emerging at protein level'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0446</classIRI>
<classLabel>somatic variation</classLabel>
<newAxiom>'somatic variation' SubClassOf 'DNA variation of genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0445</classIRI>
<classLabel>germinal variation</classLabel>
<newAxiom>'germinal variation' SubClassOf 'DNA variation of genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0448</classIRI>
<classLabel>organellar DNA affected</classLabel>
<newAxiom>'organellar DNA affected' SubClassOf 'extrachromosomal DNA affected'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0447</classIRI>
<classLabel>immunological recognition molecule diversification</classLabel>
<newAxiom>'immunological recognition molecule diversification' SubClassOf 'chromosome structure variation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0449</classIRI>
<classLabel>extrachromosomal circular DNA</classLabel>
<newAxiom>'extrachromosomal circular DNA' SubClassOf 'extrachromosomal DNA affected'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0451</classIRI>
<classLabel>plastid DNA affected</classLabel>
<newAxiom>'plastid DNA affected' SubClassOf 'organellar DNA affected'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0450</classIRI>
<classLabel>mitochondrial DNA affected</classLabel>
<newAxiom>'mitochondrial DNA affected' SubClassOf 'organellar DNA affected'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0453</classIRI>
<classLabel>histone modification</classLabel>
<newAxiom>'histone modification' SubClassOf 'epigenetic DNA modification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0452</classIRI>
<classLabel>heptanucleotide expansion</classLabel>
<newAxiom>'heptanucleotide expansion' SubClassOf 'microsatellite'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0454</classIRI>
<classLabel>variation at topology associating domain</classLabel>
<newAxiom>'variation at topology associating domain' SubClassOf 'chromatin structure variation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0404</classIRI>
<classLabel>group II intron</classLabel>
<newAxiom>'group II intron' SubClassOf 'non-protein coding RNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0403</classIRI>
<classLabel>group I intron</classLabel>
<newAxiom>'group I intron' SubClassOf 'non-protein coding RNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0405</classIRI>
<classLabel>dicentric translocation</classLabel>
<newAxiom>'dicentric translocation' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'intrachromosomal translocation'</newAxiom>
<newAxiom>'dicentric translocation' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'interchromosomal translocation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0408</classIRI>
<classLabel>RNA chimera</classLabel>
<newAxiom>'RNA chimera' SubClassOf 'RNA variation of non-genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0407</classIRI>
<classLabel>edited DNA</classLabel>
<newAxiom>'edited DNA' SubClassOf 'DNA variation of non-genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0411</classIRI>
<classLabel>alternatively spliced RNA</classLabel>
<newAxiom>'alternatively spliced RNA' SubClassOf http://purl.obolibrary.org/obo/vario.obo#part_of some 'alternative form of RNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0413</classIRI>
<classLabel>effect on A DNA</classLabel>
<newAxiom>'effect on A DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0412</classIRI>
<classLabel>effect on catalytic DNA activity</classLabel>
<newAxiom>'effect on catalytic DNA activity' SubClassOf 'variation affecting DNA function'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0415</classIRI>
<classLabel>effect on C DNA</classLabel>
<newAxiom>'effect on C DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0414</classIRI>
<classLabel>effect on B DNA</classLabel>
<newAxiom>'effect on B DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0417</classIRI>
<classLabel>effect on S DNA</classLabel>
<newAxiom>'effect on S DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0416</classIRI>
<classLabel>effect on L DNA</classLabel>
<newAxiom>'effect on L DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0419</classIRI>
<classLabel>effect on H DNA</classLabel>
<newAxiom>'effect on H DNA' SubClassOf 'effect on intramolecular DNA triple helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0418</classIRI>
<classLabel>effect on D DNA</classLabel>
<newAxiom>'effect on D DNA' SubClassOf 'effect on DNA double helix'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0409</classIRI>
<classLabel>frameshifted RNA</classLabel>
<newAxiom>'frameshifted RNA' SubClassOf 'RNA variation of non-genetic origin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0389</classIRI>
<classLabel>pentanucleotide expansion</classLabel>
<newAxiom>'pentanucleotide expansion' SubClassOf 'microsatellite'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0388</classIRI>
<classLabel>LTR</classLabel>
<newAxiom>'LTR' SubClassOf 'retrotransposon insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0380</classIRI>
<classLabel>SINE</classLabel>
<newAxiom>'SINE' SubClassOf 'retrotransposon insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0394</classIRI>
<classLabel>effect on DNA cruciform</classLabel>
<newAxiom>'effect on DNA cruciform' SubClassOf 'effect on four-stranded DNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0395</classIRI>
<classLabel>self-cleavage by ribozyme activity</classLabel>
<newAxiom>'self-cleavage by ribozyme activity' SubClassOf 'variation affecting RNA structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0390</classIRI>
<classLabel>effect on DNA double helix</classLabel>
<newAxiom>'effect on DNA double helix' SubClassOf 'effect on DNA form'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0392</classIRI>
<classLabel>insertion sequence</classLabel>
<newAxiom>'insertion sequence' SubClassOf 'DNA mobile genetic element insertion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0391</classIRI>
<classLabel>plasmid affected</classLabel>
<newAxiom>'plasmid affected' SubClassOf 'extrachromosomal DNA affected'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0363</classIRI>
<classLabel>effect on RNA G-quadruplex</classLabel>
<newAxiom>'effect on RNA G-quadruplex' SubClassOf 'variation to RNA secondary structure'</newAxiom>
</deletedClass>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0364</classIRI>
<classLabel>intron gain</classLabel>
<newAxiom>'intron gain' SubClassOf 'effect on RNA splicing'</newAxiom>
</deletedClass>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/VariO_0381</classIRI>
<classLabel>exon loss</classLabel>
<newAxiom>'exon loss' SubClassOf 'effect on RNA splicing'</newAxiom>
</deletedClass>
</deletedClasses>
</diffReport>