format-version: 1.2
date: 05:12:2010 15:19
saved-by: wasiladahdul
auto-generated-by: OBO-Edit 2.1-beta2
synonymtypedef: PLURAL "PLURAL"
default-namespace: vertebrate_anatomy
namespace-id-rule: * VAO:$sequence(7,0,9999999)$
treat-xrefs-as-equivalent: TAO
treat-xrefs-as-equivalent: CL
treat-xrefs-as-equivalent: GO
import: http://obo.cvs.sourceforge.net/*checkout*/obo/obo/ontology/anatomy/caro/caro.obo

[Term]
id: VAO:0000000
name: chondrogenic element
def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." [VAO:curator]
synonym: "cartilaginous element" EXACT []
is_a: VAO:0000128 ! skeletal element

[Term]
id: VAO:0000001
name: surface structure
def: "Organism subdivision which is the collection of anatomical structures on the body surface." [ZFIN:curator]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: VAO:0000002
name: mode of ossification
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo\, PMID\:17572649]
xref: GO:0001503

[Term]
id: VAO:0000003
name: permanent cartilage
def: "Chondrogenic element that is composed of cartilage that is not replaced." [VAO:curator]
is_a: VAO:0000000 ! chondrogenic element
relationship: develops_from VAO:0000092 ! chondrogenic condensation
relationship: has_part VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000004
name: opercle bone
def: "Dermal bone that forms the postero-dorsal part of the opercular series. The opercle articulates with the hyomandibula antero-dorsally and with the subopercle ventrally. The opercle is a paired bone." [TAO:curator]
synonym: " operculare " EXACT []
synonym: "opercles" EXACT []
synonym: "operculum" EXACT []
xref: TAO:0000250
is_a: VAO:0000130 ! dermal bone

[Term]
id: VAO:0000005
name: basihyal element
is_a: VAO:0000139 ! endochondral element
relationship: OBO_REL:part_of VAO:0000018 ! ventral hyoid arch

[Term]
id: VAO:0000006
name: cell condensation
def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." [VAO:curator]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: VAO:0000007
name: basihyal bone
def: "Endochondral bone that is median and is the anterior-most bone of the ventral hyoid arch." [TAO:curator]
synonym: "basihyoid" EXACT []
synonym: "glossohyal" EXACT []
xref: TAO:0000316
is_a: VAO:0000005 ! basihyal element
is_a: VAO:0000145 ! endochondral bone
relationship: develops_from VAO:0000014 ! basihyal cartilage

[Term]
id: VAO:0000008
name: neural crest cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [VAO:curator]
xref: CL:0000333
is_a: CARO:0000013 ! cell

[Term]
id: VAO:0000009
name: notochordal cell
def: "Cell of the notochord, often vacuolated or resembles a chondrocyte." [VAO:curator]
is_a: CARO:0000013 ! cell
relationship: develops_from VAO:0000010 ! notochordal mesodermal cell

[Term]
id: VAO:0000010
name: notochordal mesodermal cell
is_a: VAO:0000011 ! mesodermal cell

[Term]
id: VAO:0000011
name: mesodermal cell
def: "Cell derived from mesoderm." [VAO:curator]
xref: CL:0000222
is_a: CARO:0000013 ! cell

[Term]
id: VAO:0000012
name: skeletogenic cell
def: "Cell that has the potential to form a skeletal cell type (e.g., cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [VAO:curator]
is_a: CARO:0000013 ! cell
relationship: produces VAO:0000013 ! mineralized tissue
relationship: produces VAO:0000020 ! mineralized extracellular matrix

[Term]
id: VAO:0000013
name: mineralized tissue
is_a: VAO:0000015 ! skeletal tissue

[Term]
id: VAO:0000014
name: basihyal cartilage
def: "Pharyngeal arch cartilage that is median and is the anterior-most cartilage of the ventral hyoid arch." [TAO:curator]
synonym: "copula 1" EXACT []
xref: TAO:0001510
is_a: VAO:0000005 ! basihyal element
is_a: VAO:0000146 ! transient cartilaginous element
relationship: develops_from VAO:0000016 ! basihyal condensation

[Term]
id: VAO:0000015
name: skeletal tissue
def: "Connective tissue that functions in mechanical and structural support." [VAO:curator]
is_a: VAO:0000017 ! portion of connective tissue
relationship: develops_from VAO:0000012 ! skeletogenic cell

[Term]
id: VAO:0000016
name: basihyal condensation
is_a: VAO:0000092 ! chondrogenic condensation

[Term]
id: VAO:0000017
name: portion of connective tissue
def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibres and ground substance." [VAO:curator]
is_a: CARO:0000043 ! portion of tissue

[Term]
id: VAO:0000018
name: ventral hyoid arch
synonym: "ventral visceral arch 2" EXACT []
xref: TAO:0001402
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: VAO:0000019
name: chordablast
def: "Epithelial cell that is large, vacuolated, and part of the notochord." [VAO:curator]
is_a: CARO:0000077 ! epithelial cell
relationship: OBO_REL:part_of VAO:0000032 ! notochord

[Term]
id: VAO:0000020
name: mineralized extracellular matrix
def: "Extracellular matrix that is mineralized." [VAO:curator]
is_a: VAO:0000021 ! proteinaceous extracellular matrix

[Term]
id: VAO:0000021
name: proteinaceous extracellular matrix
def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. [GOC:mtg_sensu, ISBN:0198547684]." [GO:[GOC\:mtg_sensu\, ISBN\:0198547684\], VAO:curator]
is_a: VAO:0000022 ! extracellular matrix

[Term]
id: VAO:0000022
name: extracellular matrix
def: "Combination of protein fibers, ground substance and tissue fluid; typically has embedded cells." [VAO:curator]
synonym: "ECM" EXACT [VAO:curator]
is_a: CARO:0000040 ! acellular anatomical structure

[Term]
id: VAO:0000025
name: odontogenic papilla
def: "Cell condensation that is a well-defined population of densely organized mesenchymal cells that aggregates adjacent to an epithelium." [VAO:curator]
synonym: "dental papilla" EXACT [VAO:curator]
synonym: "odontogenic condensation" EXACT [VAO:curator]
is_a: VAO:0000006 ! cell condensation

[Term]
id: VAO:0000027
name: skeletal system
def: "Multi-element, multi-tissue anatomical cluster." [VAO:curator]
is_a: CARO:0000011 ! anatomical system

[Term]
id: VAO:0000028
name: integumentary papilla
def: "Odontogenic papilla that is located in the integument." [VAO:curator]
synonym: "scale papilla" EXACT [VAO:curator]
is_a: VAO:0000025 ! odontogenic papilla
relationship: has_location VAO:0000029 ! integument

[Term]
id: VAO:0000029
name: integument
def: "Surface structure that is the outer protective covering of the body." [VAO:curator]
is_a: VAO:0000001 ! surface structure

[Term]
id: VAO:0000030
name: oropharyngeal papilla
def: "Odontogenic papilla located along the jaws or pharyngeal skeleton." [VAO:curator]
synonym: "oropharyngeal dental papilla" EXACT [VAO:curator]
is_a: VAO:0000025 ! odontogenic papilla
relationship: has_location VAO:0000034 ! oropharynx

[Term]
id: VAO:0000032
name: notochord
def: "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue." [VAO:curator]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: VAO:0000034
name: oropharynx
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: VAO:0000035
name: dermal skeleton
def: "Skeletal system that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." [VAO:curator]
synonym: "dermal skeletal system" RELATED [VAO:curator]
synonym: "dermoskeleton" RELATED [VAO:curator]
synonym: "desmoskeleton" RELATED [VAO:curator]
synonym: "exoskeleton" RELATED [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000036
name: perichondrium
def: "Fibrous connective tissue that surrounds cartilage." [VAO:curator]
is_a: VAO:0000017 ! portion of connective tissue

[Term]
id: VAO:0000037
name: endoskeleton
def: "Skeletal system that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." [VAO:curator]
synonym: "replacement skeleton" EXACT [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000038
name: preameloblast
def: "Skeletogenic cell that has the potential to develop into an ameloblast." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000008 ! neural crest cell
relationship: overlies VAO:0000025 ! odontogenic papilla

[Term]
id: VAO:0000039
name: chordoblast
def: "Skeletogenic cell that is derived from the notochordal mesoderm and produces notochordal tissue (and cartilage tissue in some taxa)." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000010 ! notochordal mesodermal cell
relationship: produces VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000040
name: cartilage tissue
def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [VAO:curator]
synonym: "cartilage" EXACT [VAO:curator]
synonym: "chondrogenic tissue" EXACT [VAO:curator]
is_a: VAO:0000015 ! skeletal tissue
relationship: OBO_REL:part_of VAO:0000037 ! endoskeleton

[Term]
id: VAO:0000041
name: preodontoblast
def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a neural crest cell." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000008 ! neural crest cell
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla
relationship: OBO_REL:part_of VAO:0000071 ! pre-dentine
relationship: produces VAO:0000071 ! pre-dentine

[Term]
id: VAO:0000043
name: precementoblast
def: "Skeletogenic cell that has the potential to develop into a cementoblast." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000008 ! neural crest cell
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla

[Term]
id: VAO:0000044
name: prechondroblast
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000008 ! neural crest cell
relationship: develops_from VAO:0000009 ! notochordal cell
relationship: develops_from VAO:0000011 ! mesodermal cell

[Term]
id: VAO:0000045
name: preosteoblast
def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [VAO:curator]
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000008 ! neural crest cell
relationship: develops_from VAO:0000011 ! mesodermal cell
relationship: OBO_REL:part_of VAO:0000046 ! osteoid

[Term]
id: VAO:0000046
name: osteoid
def: "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." [VAO:curator]
synonym: "pre-bone" EXACT [VAO:curator]
synonym: "prebone" EXACT [VAO:curator]
is_a: VAO:0000021 ! proteinaceous extracellular matrix
is_a: VAO:0000047 ! bone tissue

[Term]
id: VAO:0000047
name: bone tissue
def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [VAO:curator]
synonym: "bone" EXACT [VAO:curator]
synonym: "osteogenic tissue" EXACT [VAO:curator]
is_a: VAO:0000015 ! skeletal tissue
relationship: OBO_REL:part_of VAO:0000035 ! dermal skeleton
relationship: OBO_REL:part_of VAO:0000037 ! endoskeleton

[Term]
id: VAO:0000048
name: scale
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000049
name: cranial skeleton
def: "Skeletal system of head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: OBO_REL:part_of VAO:0000056 ! axial skeleton

[Term]
id: VAO:0000050
name: dense regular connective tissue
def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." [VAO:curator]
is_a: VAO:0000017 ! portion of connective tissue

[Term]
id: VAO:0000051
name: lepidosteoid scale
def: "Multi-layer ganoid scale composed of ganoine and cellular bone." [VAO:curator]
is_a: VAO:0000052 ! ganoid scale

[Term]
id: VAO:0000052
name: ganoid scale
def: "Thick, rhomboid-shaped integumentary skeletal element composed of multiple tissues including ganoine and bone." [VAO:curator]
is_a: VAO:0000048 ! scale

[Term]
id: VAO:0000053
name: vacuolated notochordal tissue
def: "Connective tissue that is matrix-poor with large number of vacuolated cells." [VAO:curator]
synonym: "notochord proper" EXACT [VAO:curator]
is_a: VAO:0000017 ! portion of connective tissue
relationship: OBO_REL:part_of VAO:0000032 ! notochord

[Term]
id: VAO:0000054
name: perichordal tissue
def: "Fibrous connective tissue that surrounds the notochord; includes a layer of elastin." [VAO:curator]
comment: Derived from cells surrounding the notochord (possibly the slerotome). Disparate from (not derived from) notochord.
synonym: "notochord" RELATED [VAO:curator]
synonym: "perichordal connective tissue" EXACT [VAO:curator]
synonym: "perichordal sheath" EXACT [VAO:curator]
synonym: "perichordal sheath tissue" EXACT [VAO:curator]
is_a: VAO:0000017 ! portion of connective tissue
relationship: OBO_REL:part_of VAO:0000032 ! notochord

[Term]
id: VAO:0000055
name: polypteroid scale
def: "Multi-tissue structure composed of ganoine, dentine, elasmodine and cellular bone." [VAO:curator]
synonym: "polypterid scale" EXACT [VAO:curator]
is_a: VAO:0000052 ! ganoid scale

[Term]
id: VAO:0000056
name: axial skeleton
def: "Anatomical cluster of the central body axis including vertebrae, notochord, ribs, and sternum." [VAO:curator]
synonym: "axial skeletal system" EXACT [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000058
name: chondroblast
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [VAO:curator]
xref: CL:0000058
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000044 ! prechondroblast
relationship: OBO_REL:part_of VAO:0000040 ! cartilage tissue
relationship: produces VAO:0000040 ! cartilage tissue
relationship: produces VAO:0000059 ! avascular GAG-rich matrix

[Term]
id: VAO:0000059
name: avascular GAG-rich matrix
def: "Proteinaceous extracellular matrix that is avascular and consists primarily of glycosaminoglycans." [VAO:curator]
synonym: "avascular glycosaminoglycan-rich matrix" EXACT [VAO:curator]
synonym: "cartilage matrix" EXACT [VAO:curator]
synonym: "cartilage-like matrix" EXACT [VAO:curator]
is_a: VAO:0000021 ! proteinaceous extracellular matrix

[Term]
id: VAO:0000060
name: osteoblast
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [VAO:curator]
xref: CL:0000062
is_a: VAO:0000012 ! skeletogenic cell
relationship: capable_of_producing VAO:0000020 ! mineralized extracellular matrix
relationship: OBO_REL:part_of VAO:0000046 ! osteoid
relationship: produces VAO:0000046 ! osteoid
relationship: transformation_of VAO:0000045 ! preosteoblast

[Term]
id: VAO:0000061
name: cementoblast
def: "Skeletogenic cell that produces cementum (= bone of attachment), is part of the odontogenic papilla, and develops from a precementoblast cell." [VAO:curator]
xref: CL:0000061
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000043 ! precementoblast
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla
relationship: produces VAO:0000062 ! cementum

[Term]
id: VAO:0000062
name: cementum
def: "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." [VAO:curator]
synonym: "bone of attachment" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000063
name: odontoid tissue
def: "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." [VAO:curator]
synonym: "dental tissue" RELATED [VAO:curator]
synonym: "odontogenic tissue" EXACT [VAO:curator]
is_a: VAO:0000015 ! skeletal tissue
relationship: develops_from VAO:0000025 ! odontogenic papilla
relationship: OBO_REL:part_of VAO:0000035 ! dermal skeleton

[Term]
id: VAO:0000064
name: ameloblast
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [VAO:curator]
xref: CL:0000059
is_a: VAO:0000012 ! skeletogenic cell
relationship: overlies VAO:0000025 ! odontogenic papilla
relationship: produces VAO:0000065 ! enamel
relationship: produces VAO:0000066 ! pre-enamel
relationship: transformation_of VAO:0000038 ! preameloblast

[Term]
id: VAO:0000065
name: enamel
def: "Skeletal tissue that consists of an avascular, noncollagenous, hypermineralized matrix that is deposited by ameloblasts that are excluded from the matrix. Enamel develops from organic pre-enamel tissue that is replaced by a largely inorganic matrix." [VAO:curator]
synonym: "enamel tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: develops_from VAO:0000066 ! pre-enamel

[Term]
id: VAO:0000066
name: pre-enamel
def: "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." [VAO:curator]
synonym: "pre-enamel tissue" EXACT [VAO:curator]
synonym: "preenamel tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000068
name: odontoblast
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [VAO:curator]
xref: CL:0000060
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000041 ! preodontoblast
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla
relationship: OBO_REL:part_of VAO:0000069 ! dentine
relationship: produces VAO:0000069 ! dentine
relationship: produces VAO:0000071 ! pre-dentine

[Term]
id: VAO:0000069
name: dentine
def: "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." [VAO:curator]
synonym: "dental tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: develops_from VAO:0000071 ! pre-dentine

[Term]
id: VAO:0000070
name: elasmoid scale
def: "Multi-tissue integumentary element composed dentine, elasmodine, and hypermineralized tissue." [VAO:curator]
is_a: VAO:0000048 ! scale
relationship: has_part VAO:0000069 ! dentine

[Term]
id: VAO:0000071
name: pre-dentine
def: "Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix." [VAO:curator]
synonym: "pre-dentine tissue" EXACT [VAO:curator]
synonym: "predentine tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000072
name: ligament
def: "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." [VAO:curator]
is_a: VAO:0000050 ! dense regular connective tissue

[Term]
id: VAO:0000073
name: tendon
def: "Dense regular connective tissue that connects muscle to bone." [VAO:curator]
is_a: VAO:0000050 ! dense regular connective tissue

[Term]
id: VAO:0000074
name: palaeoniscoid scale
def: "Multi-tissue structure composed of ganoine, dentine and bone; not known in extant taxa." [VAO:curator]
synonym: "Palaeoniscus-type scale" EXACT [VAO:curator]
is_a: VAO:0000052 ! ganoid scale

[Term]
id: VAO:0000075
name: appendage
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: VAO:0000076
name: appendicular skeleton
def: "Anatomical cluster consisting of the paired appendages (limbs or fins)." [VAO:curator]
synonym: "Appendicular skeletal system" EXACT [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: has_location VAO:0000075 ! appendage
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000077
name: non-mineralized chondroid tissue
is_a: VAO:0000015 ! skeletal tissue

[Term]
id: VAO:0000078
name: chondroid tissue
def: "Skeletal tissue that is mineralized, has large chondrocyte-like cells, sparse extracellular matrix, and minimal perichondrium; develops from non-mineralized chondroid tissue." [TAO:curator]
synonym: "chondroid bone tissue" EXACT [VAO:curator]
is_a: VAO:0000015 ! skeletal tissue
relationship: develops_from VAO:0000077 ! non-mineralized chondroid tissue

[Term]
id: VAO:0000079
name: odontode scale
def: "Multi-tissue structure composed of enameloid, dentine surrounding a pulp cavity, and bone of attachment anchoring the element into the dermis." [VAO:curator]
synonym: "placoid scale" EXACT [VAO:curator]
is_a: VAO:0000048 ! scale

[Term]
id: VAO:0000080
name: keratin-based scale
def: "Fold or elevation of the epidermis rich in keratin proteins; possibly calcified but does not contain skeletal elements." [VAO:curator]
is_a: VAO:0000048 ! scale

[Term]
id: VAO:0000081
name: cosmoid scale
def: "Multi-tissue integumentary element composed of enamel or enameloid, dentine and lamellar bone, and characterized by pore-canal system." [VAO:curator]
is_a: VAO:0000048 ! scale

[Term]
id: VAO:0000082
name: craniofacial skeleton
def: "Cranial skeleton derived from neural crest cells." [VAO:curator]
synonym: "Cranio-facial skeleton" EXACT [VAO:curator]
is_a: VAO:0000049 ! cranial skeleton
relationship: has_location VAO:0000083 ! craniofacial region

[Term]
id: VAO:0000083
name: craniofacial region
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: VAO:0000084
name: cementocyte
def: "Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell." [VAO:curator]
xref: CL:0000141
is_a: VAO:0000012 ! skeletogenic cell
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla
relationship: transformation_of VAO:0000061 ! cementoblast

[Term]
id: VAO:0000085
name: chondrocyte
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [VAO:curator]
xref: CL:0000138
is_a: VAO:0000012 ! skeletogenic cell
relationship: develops_from VAO:0000058 ! chondroblast
relationship: OBO_REL:part_of VAO:0000040 ! cartilage tissue
relationship: OBO_REL:part_of VAO:0000078 ! chondroid tissue
relationship: produces VAO:0000059 ! avascular GAG-rich matrix

[Term]
id: VAO:0000086
name: secondary cartilage tissue
def: "Cartilage tissue that is part of the exoskeleton, deposited adjacent to bone after bone formation." [VAO:curator]
is_a: VAO:0000040 ! cartilage tissue
relationship: OBO_REL:part_of VAO:0000035 ! dermal skeleton

[Term]
id: VAO:0000087
name: cosmine
synonym: "cosmoid scale tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000088
name: mineralized cartilage tissue
def: "Cartilage tissue that is mineralized." [VAO:curator]
is_a: VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000089
name: non-mineralized cartilage tissue
def: "Cartilage tissue that is not mineralized." [VAO:curator]
is_a: VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000090
name: integumentary skeleton
def: "Part of the extra-oral dermal skeletal system that develops and remains invested within the integument, primarily the dermis." [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: has_location VAO:0000029 ! integument
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system
relationship: OBO_REL:part_of VAO:0000035 ! dermal skeleton

[Term]
id: VAO:0000091
name: elastic cartilage tissue
def: "Cartilage tissue that is flexible and contains abundant elastic fibers." [VAO:curator]
is_a: VAO:0000089 ! non-mineralized cartilage tissue
relationship: develops_from VAO:0000092 ! chondrogenic condensation

[Term]
id: VAO:0000092
name: chondrogenic condensation
def: "An aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [GO:curator]
synonym: "cartilaginous condensation" EXACT []
is_a: VAO:0000006 ! cell condensation

[Term]
id: VAO:0000093
name: postcranial axial skeleton
def: "Skeletal system of the central body axis including vertebrae, notochord, ribs, and sternum." [VAO:curator]
is_a: CARO:0000041 ! anatomical cluster
relationship: OBO_REL:part_of VAO:0000056 ! axial skeleton

[Term]
id: VAO:0000094
name: hyaline cartilage tissue
def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [VAO:curator]
synonym: "hyaline cartilage" EXACT [VAO:curator]
is_a: VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000095
name: non-terminally differentiated odontoblast
def: "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." [VAO:curator]
is_a: VAO:0000068 ! odontoblast
relationship: transformation_of VAO:0000068 ! odontoblast

[Term]
id: VAO:0000096
name: terminally differentiated odontoblast
def: "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." [VAO:curator]
is_a: VAO:0000068 ! odontoblast

[Term]
id: VAO:0000097
name: orthodentine
def: "Odontoid tissue that typically contains tubules and is acellular." [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000098
name: hypertrophic chondrocyte
def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [VAO:curator]
xref: CL:0000743
is_a: VAO:0000085 ! chondrocyte

[Term]
id: VAO:0000100
name: periarticular chondrocyte
def: "Chondrocyte that is located on a joint surface; part of articular cartilage." [VAO:curator]
xref: CL:0000742
is_a: VAO:0000085 ! chondrocyte
relationship: has_location VAO:0000101 ! articulation

[Term]
id: VAO:0000101
name: articulation
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: VAO:0000102
name: osteodentine
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000103
name: fibrocartilage
def: "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." [VAO:curator]
is_a: VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000104
name: ganoine
def: "Odontogenic tissue that is hypermineralized acellular, noncollagenous, covered by an epidermis and often deposited in multiple layers." [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: OBO_REL:part_of VAO:0000052 ! ganoid scale

[Term]
id: VAO:0000105
name: limiting layer of elasmoid scale
def: "Hypermineralized tissue lacking collagen (except Sharpey's fibres), developing in close proximity to the basal cells of the overlying epithelium." [VAO:curator]
relationship: OBO_REL:part_of VAO:0000070 ! elasmoid scale

[Term]
id: VAO:0000106
name: vasodentine
def: "Dentine tissue that lacks dentine tubules and that is penetrated by blood capillaries." [VAO:curator]
synonym: "vascular dentine" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000107
name: elasmodine
def: "Odontogenic tissue that consists of multiple layers of collagen fibers organized in orthogonal or twisted arrangements." [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: OBO_REL:part_of VAO:0000070 ! elasmoid scale

[Term]
id: VAO:0000108
name: non-mineralized hyaline cartilage tissue
def: "Hyaline cartilage tissue that is not mineralized." [VAO:curator]
is_a: VAO:0000089 ! non-mineralized cartilage tissue
is_a: VAO:0000094 ! hyaline cartilage tissue

[Term]
id: VAO:0000109
name: mineralized hyaline cartilage tissue
def: "Hyaline cartilage tissue that is mineralized." [VAO:curator]
is_a: VAO:0000013 ! mineralized tissue
is_a: VAO:0000088 ! mineralized cartilage tissue
is_a: VAO:0000094 ! hyaline cartilage tissue
relationship: develops_from VAO:0000094 ! hyaline cartilage tissue

[Term]
id: VAO:0000110
name: columnar chondrocyte
def: "Chondrocyte that is linearly arranged with other columnar chondrocytes." [VAO:curator]
xref: CL:0000744
is_a: VAO:0000085 ! chondrocyte

[Term]
id: VAO:0000112
name: odontocyte
def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [VAO:curator]
xref: CL:0000140
is_a: VAO:0000012 ! skeletogenic cell
relationship: OBO_REL:part_of VAO:0000025 ! odontogenic papilla
relationship: OBO_REL:part_of VAO:0000069 ! dentine
relationship: produces VAO:0000069 ! dentine
relationship: transformation_of VAO:0000095 ! non-terminally differentiated odontoblast

[Term]
id: VAO:0000113
name: enameloid
def: "Skeletal tissue that is hypermineralized and aprismatic and deposited by a combination of ameloblasts and odontoblasts that are excluded from the matrix. Enameloid develops from pre-enameloid tissue." [VAO:curator]
synonym: "bitypic enamel" EXACT [VAO:curator]
synonym: "durodentine" EXACT [VAO:curator]
synonym: "enameloid tissue" EXACT [VAO:curator]
synonym: "vitrodentine" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: develops_from VAO:0000114 ! pre-enameloid

[Term]
id: VAO:0000114
name: pre-enameloid
def: "Odontoid tissue that is avascular non-mineralized matrix that is deposited by odontoblasts and ameloblasts that are excluded from the matrix." [VAO:curator]
synonym: "non-mineralized enameloid tissue" EXACT [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue

[Term]
id: VAO:0000115
name: mineralized bone tissue
def: "Bone tissue mineralized with hydroxyapatite." [VAO:curator]
is_a: VAO:0000013 ! mineralized tissue
is_a: VAO:0000047 ! bone tissue
relationship: develops_from VAO:0000046 ! osteoid
relationship: OBO_REL:part_of VAO:0000020 ! mineralized extracellular matrix

[Term]
id: VAO:0000116
name: terminally differentiated osteoblast
def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VAO:curator]
is_a: VAO:0000060 ! osteoblast

[Term]
id: VAO:0000117
name: non-terminally differentiated osteoblast
def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VAO:curator]
is_a: VAO:0000060 ! osteoblast

[Term]
id: VAO:0000118
name: cellular bone tissue
def: "Mineralized bone tissue that always includes non-terminally differentiated osteoblasts and osteocytes." [VAO:curator]
is_a: VAO:0000115 ! mineralized bone tissue
relationship: has_part VAO:0000117 ! non-terminally differentiated osteoblast

[Term]
id: VAO:0000119
name: non-mineralized avascular GAG-rich matrix
def: "Avascular GAG-rich matrix that is not mineralized." [VAO:curator]
synonym: "non-mineralized cartilage" EXACT [VAO:curator]
is_a: VAO:0000059 ! avascular GAG-rich matrix
relationship: OBO_REL:part_of VAO:0000089 ! non-mineralized cartilage tissue

[Term]
id: VAO:0000120
name: mineralized avascular GAG-rich matrix
def: "Avascular GAG-rich matrix that is mineralized." [VAO:curator]
is_a: VAO:0000020 ! mineralized extracellular matrix
is_a: VAO:0000059 ! avascular GAG-rich matrix
relationship: OBO_REL:part_of VAO:0000088 ! mineralized cartilage tissue

[Term]
id: VAO:0000122
name: acellular bone tissue
def: "Mineralized bone tissue that has terminally differentiated osteoblasts but lacks osteocytes." [VAO:curator]
is_a: VAO:0000115 ! mineralized bone tissue
relationship: has_part VAO:0000116 ! terminally differentiated osteoblast

[Term]
id: VAO:0000123
name: odontode tissue
def: "Skeletal tissue that is avascular tubular mineralized matrix, primarily made of dentine that is deposited by odontoblasts that are excluded from the matrix; develops from pre-dentine tissue." [VAO:curator]
synonym: "dental tissue" RELATED [VAO:curator]
is_a: VAO:0000063 ! odontoid tissue
relationship: develops_from VAO:0000071 ! pre-dentine

[Term]
id: VAO:0000124
name: osteocyte
def: "Skeletogenic cell that secretes and is embedded in lacunae within mineralized bone matrix and that arises from the transformation of non-terminally differentiated osteoblasts. Interconnected with other osteocytes in lacunae by canaliculi." [VAO:curator]
xref: CL:0000137
is_a: VAO:0000012 ! skeletogenic cell
relationship: OBO_REL:part_of VAO:0000118 ! cellular bone tissue
relationship: produces VAO:0000020 ! mineralized extracellular matrix
relationship: transformation_of VAO:0000117 ! non-terminally differentiated osteoblast

[Term]
id: VAO:0000127
name: gastralia
synonym: "abdominal rib" EXACT [VAO:curator]
synonym: "Belly rib" EXACT [VAO:curator]
is_a: VAO:0000128 ! skeletal element

[Term]
id: VAO:0000128
name: skeletal element
def: "Organ entity that may have different tissue compositions at different stages and typically involved in mechanical support." [VAO:curator]
is_a: CARO:0000074 ! solid compound organ
relationship: OBO_REL:part_of VAO:0000027 ! skeletal system

[Term]
id: VAO:0000130
name: dermal bone
def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm." [VAO:curator]
synonym: "dermal element" EXACT [VAO:curator]
synonym: "membrane bone" EXACT [VAO:curator]
is_a: VAO:0000128 ! skeletal element
relationship: participates_in VAO:0000136 ! direct ossification

[Term]
id: VAO:0000131
name: appendicular ossicle
is_a: VAO:0000132 ! ossicle

[Term]
id: VAO:0000132
name: ossicle
def: "Skeletal element that is often isolated, small, and is usually ossified." [VAO:curator]
is_a: VAO:0000128 ! skeletal element

[Term]
id: VAO:0000133
name: axial ossicle
is_a: VAO:0000132 ! ossicle

[Term]
id: VAO:0000134
name: intratendonous ossification
synonym: "Ossified tendon" EXACT [VAO:curator]
is_a: VAO:0000132 ! ossicle

[Term]
id: VAO:0000135
name: replacement element
def: "Skeletal element that forms as a replacement or substitution of another element or tissue." [VAO:curator]
is_a: VAO:0000128 ! skeletal element

[Term]
id: VAO:0000136
name: direct ossification
def: "Ossification that does not require the replacement of pre-existing tissues, most often a cartilaginous model." [VAO:curator]
is_a: VAO:0000002 ! mode of ossification

[Term]
id: VAO:0000137
name: sesamoid
def: "Replacement element; an ossicle; often an endochondral replacement element that has cartilage and bone states that develops in dense regular connective tissue (e.g., tendons and ligaments)." [VAO:curator]
is_a: VAO:0000132 ! ossicle
relationship: develops_in VAO:0000050 ! dense regular connective tissue

[Term]
id: VAO:0000138
name: ligamentous replacement element
is_a: VAO:0000135 ! replacement element
relationship: participates_in VAO:0000140 ! replacement ossification

[Term]
id: VAO:0000139
name: endochondral element
def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." [VAO:curator]
synonym: "endochondral replacement element" EXACT []
is_a: VAO:0000135 ! replacement element
relationship: participates_in VAO:0000143 ! endochondral ossification

[Term]
id: VAO:0000140
name: replacement ossification
def: "Ossification that requires the replacement of a pre-existing tissue prior to bone tissue formation." [VAO:curator]
synonym: "indirect ossification" EXACT []
is_a: VAO:0000002 ! mode of ossification

[Term]
id: VAO:0000141
name: intramembranous ossification
def: "Direct ossification that occurs within mesenchyme with the formation of an osteogenic condensation not associated with a perichondrium." [VAO:curator]
xref: GO:0001957
is_a: VAO:0000136 ! direct ossification

[Term]
id: VAO:0000142
name: metaplastic ossification
def: "Direct ossification in which transformation of the pre-existing tissue occurs without dedifferentiation of cells or reinitiation of cell division; direct transformation of a non-bone tissue into a bone tissue." [VAO:curator]
synonym: "metaplasia" EXACT []
is_a: VAO:0000136 ! direct ossification

[Term]
id: VAO:0000143
name: endochondral ossification
def: "Replacement ossification wherein bone tissue replaces cartilage." [VAO:curator]
xref: GO:0001958
is_a: VAO:0000140 ! replacement ossification

[Term]
id: VAO:0000144
name: perichondral ossification
def: "Direct ossification on the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [VAO:curator]
is_a: VAO:0000141 ! intramembranous ossification

[Term]
id: VAO:0000145
name: endochondral bone
def: "Replacement bone that forms within cartilage." [TAO:curator]
synonym: "ossified chondrogenic bone" EXACT []
intersection_of: VAO:0000139 ! endochondral element
intersection_of: develops_from VAO:0000146 ! transient cartilaginous element
relationship: has_part VAO:0000047 ! bone tissue

[Term]
id: VAO:0000146
name: transient cartilaginous element
def: "Chondrogenic element that is composed of cartilage during development and has the potential to become replaced by another tissue." [VAO:curator]
synonym: "endochondral replacement cartilage" EXACT []
is_a: VAO:0000000 ! chondrogenic element
intersection_of: VAO:0000139 ! endochondral element
intersection_of: develops_from VAO:0000092 ! chondrogenic condensation
relationship: has_part VAO:0000040 ! cartilage tissue

[Term]
id: VAO:0000149
name: pharyngeal arch
relationship: OBO_REL:part_of VAO:0000049 ! cranial skeleton

[Typedef]
id: capable_of_producing
name: capable_of_producing

[Typedef]
id: deposits
name: deposits

[Typedef]
id: develops_from
name: develops_from

[Typedef]
id: develops_in
name: develops_in

[Typedef]
id: has_location
name: has_location

[Typedef]
id: has_part
name: has_part

[Typedef]
id: has_quality
name: has_quality
namespace: caro

[Typedef]
id: OBO_REL:part_of
name: OBO_REL:part_of

[Typedef]
id: overlaps
name: overlaps
namespace: caro

[Typedef]
id: overlies
name: overlies

[Typedef]
id: part_of
name: part_of
namespace: caro
is_transitive: true

[Typedef]
id: participates_in
name: participates_in

[Typedef]
id: produces
name: produces

[Typedef]
id: transformation_of
name: transformation_of